TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania major

UniProt:

Q4Q6Z1_LEIMA

TriTrypDb:

LmjF.30.3010 , LMJLV39_300038200 , LMJSD75_300037300

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.768
CLV_C14_Caspase3-7	315	319	PF00656	0.762
CLV_NRD_NRD_1	121	123	PF00675	0.494
CLV_NRD_NRD_1	167	169	PF00675	0.646
CLV_NRD_NRD_1	173	175	PF00675	0.637
CLV_NRD_NRD_1	182	184	PF00675	0.688
CLV_NRD_NRD_1	255	257	PF00675	0.725
CLV_NRD_NRD_1	292	294	PF00675	0.826
CLV_NRD_NRD_1	421	423	PF00675	0.394
CLV_NRD_NRD_1	521	523	PF00675	0.411
CLV_NRD_NRD_1	691	693	PF00675	0.411
CLV_PCSK_KEX2_1	167	169	PF00082	0.646
CLV_PCSK_KEX2_1	172	174	PF00082	0.632
CLV_PCSK_KEX2_1	182	184	PF00082	0.688
CLV_PCSK_KEX2_1	254	256	PF00082	0.739
CLV_PCSK_KEX2_1	292	294	PF00082	0.821
CLV_PCSK_KEX2_1	40	42	PF00082	0.608
CLV_PCSK_KEX2_1	420	422	PF00082	0.394
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.636
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.608
CLV_PCSK_PC7_1	168	174	PF00082	0.621
CLV_PCSK_SKI1_1	444	448	PF00082	0.411
CLV_PCSK_SKI1_1	517	521	PF00082	0.450
CLV_PCSK_SKI1_1	543	547	PF00082	0.512
CLV_PCSK_SKI1_1	811	815	PF00082	0.466
DEG_APCC_DBOX_1	102	110	PF00400	0.512
DEG_APCC_DBOX_1	182	190	PF00400	0.736
DEG_APCC_DBOX_1	796	804	PF00400	0.512
DEG_SCF_FBW7_2	217	223	PF00400	0.764
DEG_SPOP_SBC_1	11	15	PF00917	0.737
DEG_SPOP_SBC_1	309	313	PF00917	0.657
DOC_CKS1_1	217	222	PF01111	0.760
DOC_CKS1_1	236	241	PF01111	0.674
DOC_CYCLIN_RxL_1	430	441	PF00134	0.398
DOC_MAPK_DCC_7	190	198	PF00069	0.788
DOC_MAPK_gen_1	190	198	PF00069	0.809
DOC_MAPK_gen_1	49	59	PF00069	0.474
DOC_MAPK_gen_1	604	614	PF00069	0.411
DOC_MAPK_MEF2A_6	607	614	PF00069	0.585
DOC_MAPK_MEF2A_6	658	667	PF00069	0.411
DOC_MAPK_MEF2A_6	811	818	PF00069	0.480
DOC_MAPK_NFAT4_5	811	819	PF00069	0.486
DOC_PP1_RVXF_1	609	615	PF00149	0.574
DOC_PP1_RVXF_1	754	761	PF00149	0.512
DOC_USP7_MATH_1	11	15	PF00917	0.798
DOC_USP7_MATH_1	197	201	PF00917	0.677
DOC_USP7_MATH_1	234	238	PF00917	0.825
DOC_USP7_MATH_1	248	252	PF00917	0.679
DOC_USP7_MATH_1	261	265	PF00917	0.702
DOC_USP7_MATH_1	267	271	PF00917	0.748
DOC_USP7_MATH_1	88	92	PF00917	0.571
DOC_USP7_UBL2_3	811	815	PF12436	0.448
DOC_WW_Pin1_4	208	213	PF00397	0.701
DOC_WW_Pin1_4	216	221	PF00397	0.674
DOC_WW_Pin1_4	235	240	PF00397	0.732
DOC_WW_Pin1_4	281	286	PF00397	0.695
DOC_WW_Pin1_4	436	441	PF00397	0.411
LIG_14-3-3_CanoR_1	103	113	PF00244	0.423
LIG_14-3-3_CanoR_1	16	26	PF00244	0.713
LIG_14-3-3_CanoR_1	172	181	PF00244	0.770
LIG_14-3-3_CanoR_1	214	220	PF00244	0.679
LIG_14-3-3_CanoR_1	255	259	PF00244	0.807
LIG_14-3-3_CanoR_1	475	485	PF00244	0.512
LIG_14-3-3_CanoR_1	653	658	PF00244	0.411
LIG_14-3-3_CanoR_1	756	761	PF00244	0.411
LIG_Actin_WH2_2	796	813	PF00022	0.492
LIG_APCC_ABBA_1	729	734	PF00400	0.459
LIG_APCC_ABBAyCdc20_2	728	734	PF00400	0.457
LIG_BRCT_BRCA1_1	294	298	PF00533	0.723
LIG_EH_1	475	479	PF12763	0.512
LIG_FHA_1	115	121	PF00498	0.448
LIG_FHA_1	266	272	PF00498	0.749
LIG_FHA_1	281	287	PF00498	0.662
LIG_FHA_1	3	9	PF00498	0.710
LIG_FHA_1	311	317	PF00498	0.735
LIG_FHA_1	334	340	PF00498	0.769
LIG_FHA_1	34	40	PF00498	0.627
LIG_FHA_1	431	437	PF00498	0.411
LIG_FHA_1	458	464	PF00498	0.490
LIG_FHA_1	46	52	PF00498	0.595
LIG_FHA_1	465	471	PF00498	0.418
LIG_FHA_1	499	505	PF00498	0.411
LIG_FHA_1	533	539	PF00498	0.406
LIG_FHA_1	611	617	PF00498	0.480
LIG_FHA_1	635	641	PF00498	0.411
LIG_FHA_1	703	709	PF00498	0.411
LIG_FHA_1	714	720	PF00498	0.497
LIG_FHA_1	738	744	PF00498	0.470
LIG_FHA_1	74	80	PF00498	0.520
LIG_FHA_1	772	778	PF00498	0.411
LIG_FHA_1	793	799	PF00498	0.483
LIG_FHA_1	91	97	PF00498	0.425
LIG_FHA_2	325	331	PF00498	0.728
LIG_LIR_Apic_2	272	277	PF02991	0.685
LIG_LIR_Gen_1	115	124	PF02991	0.512
LIG_LIR_Gen_1	162	169	PF02991	0.498
LIG_LIR_Gen_1	738	747	PF02991	0.486
LIG_LIR_Nem_3	115	119	PF02991	0.415
LIG_LIR_Nem_3	162	166	PF02991	0.495
LIG_LIR_Nem_3	441	446	PF02991	0.465
LIG_LIR_Nem_3	738	742	PF02991	0.466
LIG_LYPXL_SIV_4	723	731	PF13949	0.457
LIG_MYND_1	187	191	PF01753	0.693
LIG_MYND_1	24	28	PF01753	0.686
LIG_NRBOX	46	52	PF00104	0.597
LIG_Pex14_2	443	447	PF04695	0.411
LIG_PTB_Apo_2	445	452	PF02174	0.411
LIG_PTB_Apo_2	513	520	PF02174	0.411
LIG_PTB_Apo_2	649	656	PF02174	0.394
LIG_PTB_Apo_2	683	690	PF02174	0.394
LIG_PTB_Apo_2	718	725	PF02174	0.428
LIG_PTB_Phospho_1	649	655	PF10480	0.394
LIG_PTB_Phospho_1	718	724	PF10480	0.431
LIG_RPA_C_Fungi	682	694	PF08784	0.394
LIG_SH2_CRK	274	278	PF00017	0.711
LIG_SH2_CRK	623	627	PF00017	0.411
LIG_SH2_CRK	98	102	PF00017	0.404
LIG_SH2_GRB2like	514	517	PF00017	0.312
LIG_SH2_GRB2like	582	585	PF00017	0.411
LIG_SH2_GRB2like	684	687	PF00017	0.450
LIG_SH2_NCK_1	131	135	PF00017	0.411
LIG_SH2_NCK_1	274	278	PF00017	0.711
LIG_SH2_NCK_1	549	553	PF00017	0.445
LIG_SH2_PTP2	56	59	PF00017	0.481
LIG_SH2_SRC	561	564	PF00017	0.411
LIG_SH2_STAP1	131	135	PF00017	0.411
LIG_SH2_STAP1	150	154	PF00017	0.411
LIG_SH2_STAP1	35	39	PF00017	0.512
LIG_SH2_STAP1	408	412	PF00017	0.394
LIG_SH2_STAP1	432	436	PF00017	0.411
LIG_SH2_STAP1	459	463	PF00017	0.443
LIG_SH2_STAP1	466	470	PF00017	0.375
LIG_SH2_STAP1	527	531	PF00017	0.443
LIG_SH2_STAP1	534	538	PF00017	0.375
LIG_SH2_STAP1	561	565	PF00017	0.443
LIG_SH2_STAP1	568	572	PF00017	0.375
LIG_SH2_STAP1	629	633	PF00017	0.411
LIG_SH2_STAP1	670	674	PF00017	0.411
LIG_SH2_STAP1	684	688	PF00017	0.411
LIG_SH2_STAP1	697	701	PF00017	0.322
LIG_SH2_STAP1	704	708	PF00017	0.183
LIG_SH2_STAP1	739	743	PF00017	0.469
LIG_SH2_STAT5	274	277	PF00017	0.712
LIG_SH2_STAT5	35	38	PF00017	0.617
LIG_SH2_STAT5	432	435	PF00017	0.411
LIG_SH2_STAT5	459	462	PF00017	0.490
LIG_SH2_STAT5	466	469	PF00017	0.418
LIG_SH2_STAT5	534	537	PF00017	0.406
LIG_SH2_STAT5	553	556	PF00017	0.445
LIG_SH2_STAT5	56	59	PF00017	0.481
LIG_SH2_STAT5	655	658	PF00017	0.394
LIG_SH2_STAT5	684	687	PF00017	0.475
LIG_SH2_STAT5	704	707	PF00017	0.274
LIG_SH2_STAT5	724	727	PF00017	0.212
LIG_SH2_STAT5	739	742	PF00017	0.472
LIG_SH3_1	778	784	PF00018	0.512
LIG_SH3_3	200	206	PF00018	0.781
LIG_SH3_3	21	27	PF00018	0.603
LIG_SH3_3	214	220	PF00018	0.636
LIG_SH3_3	236	242	PF00018	0.716
LIG_SH3_3	471	477	PF00018	0.512
LIG_SH3_3	778	784	PF00018	0.512
LIG_SH3_4	123	130	PF00018	0.286
LIG_SUMO_SIM_par_1	267	273	PF11976	0.713
LIG_TYR_ITIM	621	626	PF00017	0.411
LIG_TYR_ITIM	96	101	PF00017	0.404
MOD_CDC14_SPxK_1	211	214	PF00782	0.762
MOD_CDK_SPxK_1	208	214	PF00069	0.765
MOD_CK1_1	241	247	PF00069	0.753
MOD_CK1_1	272	278	PF00069	0.691
MOD_CK1_1	299	305	PF00069	0.761
MOD_CK1_1	308	314	PF00069	0.654
MOD_CK1_1	390	396	PF00069	0.748
MOD_CK1_1	4	10	PF00069	0.710
MOD_CK1_1	789	795	PF00069	0.487
MOD_CK2_1	254	260	PF00069	0.761
MOD_CK2_1	267	273	PF00069	0.702
MOD_CK2_1	308	314	PF00069	0.686
MOD_CK2_1	366	372	PF00069	0.686
MOD_CK2_1	88	94	PF00069	0.630
MOD_Cter_Amidation	290	293	PF01082	0.827
MOD_GlcNHglycan	144	147	PF01048	0.286
MOD_GlcNHglycan	263	266	PF01048	0.765
MOD_GlcNHglycan	286	289	PF01048	0.740
MOD_GlcNHglycan	329	334	PF01048	0.739
MOD_GlcNHglycan	63	66	PF01048	0.470
MOD_GlcNHglycan	646	649	PF01048	0.338
MOD_GlcNHglycan	669	673	PF01048	0.512
MOD_GlcNHglycan	83	86	PF01048	0.690
MOD_GSK3_1	2	9	PF00069	0.786
MOD_GSK3_1	204	211	PF00069	0.746
MOD_GSK3_1	215	222	PF00069	0.809
MOD_GSK3_1	234	241	PF00069	0.763
MOD_GSK3_1	250	257	PF00069	0.622
MOD_GSK3_1	261	268	PF00069	0.747
MOD_GSK3_1	280	287	PF00069	0.548
MOD_GSK3_1	292	299	PF00069	0.752
MOD_GSK3_1	304	311	PF00069	0.605
MOD_GSK3_1	329	336	PF00069	0.777
MOD_GSK3_1	360	367	PF00069	0.781
MOD_GSK3_1	383	390	PF00069	0.767
MOD_GSK3_1	494	501	PF00069	0.313
MOD_GSK3_1	532	539	PF00069	0.434
MOD_GSK3_1	782	789	PF00069	0.545
MOD_LATS_1	515	521	PF00433	0.394
MOD_LATS_1	651	657	PF00433	0.411
MOD_N-GLC_1	304	309	PF02516	0.720
MOD_N-GLC_1	457	462	PF02516	0.450
MOD_NEK2_1	1	6	PF00069	0.731
MOD_NEK2_1	198	203	PF00069	0.662
MOD_NEK2_1	249	254	PF00069	0.806
MOD_NEK2_1	317	322	PF00069	0.763
MOD_NEK2_1	457	462	PF00069	0.286
MOD_NEK2_2	670	675	PF00069	0.394
MOD_PIKK_1	104	110	PF00454	0.512
MOD_PIKK_1	292	298	PF00454	0.717
MOD_PIKK_1	494	500	PF00454	0.286
MOD_PIKK_1	517	523	PF00454	0.394
MOD_PKA_1	173	179	PF00069	0.604
MOD_PKA_1	254	260	PF00069	0.726
MOD_PKA_1	292	298	PF00069	0.809
MOD_PKA_2	104	110	PF00069	0.483
MOD_PKA_2	173	179	PF00069	0.604
MOD_PKA_2	254	260	PF00069	0.693
MOD_PKA_2	292	298	PF00069	0.809
MOD_PKA_2	33	39	PF00069	0.488
MOD_PKA_2	365	371	PF00069	0.587
MOD_PKA_2	45	51	PF00069	0.539
MOD_PKA_2	494	500	PF00069	0.326
MOD_PKA_2	644	650	PF00069	0.286
MOD_PKA_2	792	798	PF00069	0.475
MOD_PKB_1	183	191	PF00069	0.760
MOD_Plk_1	228	234	PF00069	0.607
MOD_Plk_1	272	278	PF00069	0.715
MOD_Plk_1	304	310	PF00069	0.738
MOD_Plk_1	324	330	PF00069	0.560
MOD_Plk_4	312	318	PF00069	0.797
MOD_Plk_4	786	792	PF00069	0.529
MOD_ProDKin_1	208	214	PF00069	0.703
MOD_ProDKin_1	216	222	PF00069	0.675
MOD_ProDKin_1	235	241	PF00069	0.733
MOD_ProDKin_1	281	287	PF00069	0.693
MOD_ProDKin_1	436	442	PF00069	0.411
MOD_SUMO_rev_2	539	545	PF00179	0.450
MOD_SUMO_rev_2	808	813	PF00179	0.504
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.600
TRG_DiLeu_BaLyEn_6	836	841	PF01217	0.486
TRG_ENDOCYTIC_2	137	140	PF00928	0.286
TRG_ENDOCYTIC_2	35	38	PF00928	0.499
TRG_ENDOCYTIC_2	56	59	PF00928	0.481
TRG_ENDOCYTIC_2	623	626	PF00928	0.411
TRG_ENDOCYTIC_2	657	660	PF00928	0.411
TRG_ENDOCYTIC_2	739	742	PF00928	0.472
TRG_ENDOCYTIC_2	98	101	PF00928	0.408
TRG_ER_diArg_1	103	106	PF00400	0.552
TRG_ER_diArg_1	166	168	PF00400	0.621
TRG_ER_diArg_1	172	174	PF00400	0.622
TRG_ER_diArg_1	181	183	PF00400	0.703
TRG_ER_diArg_1	189	192	PF00400	0.661
TRG_ER_diArg_1	292	294	PF00400	0.785
TRG_ER_diArg_1	343	346	PF00400	0.650
TRG_ER_diArg_1	420	422	PF00400	0.394
TRG_NLS_MonoExtC_3	253	259	PF00514	0.624
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	619	624	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	839	843	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXB6	Leptomonas seymouri	58%	98%
A0A3S7X3S0	Leishmania donovani	91%	100%
A4HIN3	Leishmania braziliensis	73%	100%
A4I5Y0	Leishmania infantum	91%	100%
E9B173	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%