CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania major

UniProt:

Q4Q6Y7_LEIMA

TriTrypDb:

LmjF.30.3030 , LMJLV39_300038600 , LMJSD75_300037700

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q6Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Y7

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	11
GO:0042592	homeostatic process	3	11
GO:0048878	chemical homeostasis	4	11
GO:0050801	monoatomic ion homeostasis	5	11
GO:0055065	obsolete metal ion homeostasis	7	11
GO:0055080	monoatomic cation homeostasis	6	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11
GO:0072507	obsolete divalent inorganic cation homeostasis	7	11
GO:0098771	inorganic ion homeostasis	6	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.472
CLV_NRD_NRD_1	287	289	PF00675	0.577
CLV_NRD_NRD_1	384	386	PF00675	0.592
CLV_PCSK_KEX2_1	287	289	PF00082	0.539
CLV_PCSK_KEX2_1	384	386	PF00082	0.593
CLV_PCSK_KEX2_1	403	405	PF00082	0.609
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.658
CLV_PCSK_SKI1_1	319	323	PF00082	0.577
CLV_PCSK_SKI1_1	48	52	PF00082	0.286
CLV_PCSK_SKI1_1	67	71	PF00082	0.136
CLV_Separin_Metazoa	320	324	PF03568	0.314
DEG_APCC_DBOX_1	172	180	PF00400	0.289
DEG_APCC_DBOX_1	47	55	PF00400	0.489
DEG_Nend_UBRbox_2	1	3	PF02207	0.561
DEG_SPOP_SBC_1	53	57	PF00917	0.538
DOC_ANK_TNKS_1	413	420	PF00023	0.391
DOC_MAPK_gen_1	287	295	PF00069	0.346
DOC_MAPK_gen_1	384	392	PF00069	0.377
DOC_MAPK_gen_1	403	410	PF00069	0.514
DOC_MAPK_MEF2A_6	287	295	PF00069	0.389
DOC_MAPK_MEF2A_6	403	410	PF00069	0.498
DOC_PP4_FxxP_1	304	307	PF00568	0.376
DOC_USP7_MATH_1	133	137	PF00917	0.354
DOC_USP7_MATH_1	311	315	PF00917	0.410
DOC_WW_Pin1_4	217	222	PF00397	0.530
DOC_WW_Pin1_4	56	61	PF00397	0.510
LIG_14-3-3_CanoR_1	323	331	PF00244	0.290
LIG_14-3-3_CanoR_1	52	60	PF00244	0.489
LIG_BRCT_BRCA1_1	300	304	PF00533	0.437
LIG_BRCT_BRCA1_1	31	35	PF00533	0.430
LIG_Clathr_ClatBox_1	43	47	PF01394	0.458
LIG_EH1_1	288	296	PF00400	0.373
LIG_FHA_1	104	110	PF00498	0.204
LIG_FHA_1	111	117	PF00498	0.125
LIG_FHA_1	147	153	PF00498	0.321
LIG_FHA_1	15	21	PF00498	0.338
LIG_FHA_1	238	244	PF00498	0.356
LIG_FHA_1	400	406	PF00498	0.482
LIG_FHA_1	410	416	PF00498	0.517
LIG_FHA_1	91	97	PF00498	0.370
LIG_FHA_2	191	197	PF00498	0.562
LIG_FHA_2	247	253	PF00498	0.341
LIG_FHA_2	357	363	PF00498	0.297
LIG_FHA_2	375	381	PF00498	0.414
LIG_FHA_2	57	63	PF00498	0.538
LIG_FHA_2	98	104	PF00498	0.328
LIG_LIR_Apic_2	301	307	PF02991	0.426
LIG_LIR_Gen_1	273	283	PF02991	0.393
LIG_LIR_Gen_1	332	341	PF02991	0.390
LIG_LIR_Gen_1	47	54	PF02991	0.489
LIG_LIR_Gen_1	99	110	PF02991	0.262
LIG_LIR_Nem_3	273	279	PF02991	0.402
LIG_LIR_Nem_3	329	334	PF02991	0.315
LIG_LIR_Nem_3	47	53	PF02991	0.472
LIG_LIR_Nem_3	99	105	PF02991	0.262
LIG_MAD2	162	170	PF02301	0.278
LIG_MAD2	52	60	PF02301	0.510
LIG_NBox_RRM_1	138	148	PF00076	0.456
LIG_PCNA_yPIPBox_3	384	393	PF02747	0.372
LIG_PTB_Apo_2	84	91	PF02174	0.423
LIG_SH2_CRK	276	280	PF00017	0.297
LIG_SH2_NCK_1	22	26	PF00017	0.417
LIG_SH2_NCK_1	276	280	PF00017	0.309
LIG_SH2_SRC	348	351	PF00017	0.370
LIG_SH2_STAP1	22	26	PF00017	0.417
LIG_SH2_STAP1	331	335	PF00017	0.364
LIG_SH2_STAT5	137	140	PF00017	0.423
LIG_SH2_STAT5	282	285	PF00017	0.319
LIG_SH2_STAT5	334	337	PF00017	0.330
LIG_SH3_3	145	151	PF00018	0.335
LIG_SH3_3	304	310	PF00018	0.374
LIG_SH3_3	369	375	PF00018	0.455
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.497
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.264
LIG_SUMO_SIM_par_1	108	113	PF11976	0.266
LIG_SUMO_SIM_par_1	292	298	PF11976	0.331
LIG_SUMO_SIM_par_1	356	362	PF11976	0.348
LIG_SUMO_SIM_par_1	388	394	PF11976	0.448
LIG_SUMO_SIM_par_1	406	413	PF11976	0.503
LIG_SUMO_SIM_par_1	93	100	PF11976	0.327
LIG_TYR_ITSM	272	279	PF00017	0.462
LIG_UBA3_1	69	74	PF00899	0.384
MOD_CDK_SPK_2	56	61	PF00069	0.423
MOD_CDK_SPxxK_3	56	63	PF00069	0.384
MOD_CK1_1	13	19	PF00069	0.461
MOD_CK1_1	239	245	PF00069	0.492
MOD_CK1_1	259	265	PF00069	0.214
MOD_CK1_1	298	304	PF00069	0.515
MOD_CK1_1	314	320	PF00069	0.497
MOD_CK1_1	409	415	PF00069	0.639
MOD_CK2_1	190	196	PF00069	0.733
MOD_CK2_1	246	252	PF00069	0.500
MOD_CK2_1	314	320	PF00069	0.596
MOD_CK2_1	374	380	PF00069	0.559
MOD_CK2_1	56	62	PF00069	0.354
MOD_GlcNHglycan	210	213	PF01048	0.761
MOD_GlcNHglycan	31	34	PF01048	0.398
MOD_GlcNHglycan	349	353	PF01048	0.546
MOD_GSK3_1	10	17	PF00069	0.580
MOD_GSK3_1	146	153	PF00069	0.311
MOD_GSK3_1	255	262	PF00069	0.483
MOD_GSK3_1	270	277	PF00069	0.475
MOD_GSK3_1	298	305	PF00069	0.522
MOD_GSK3_1	322	329	PF00069	0.384
MOD_GSK3_1	406	413	PF00069	0.719
MOD_GSK3_1	52	59	PF00069	0.331
MOD_NEK2_1	1	6	PF00069	0.751
MOD_NEK2_1	108	113	PF00069	0.168
MOD_NEK2_1	14	19	PF00069	0.440
MOD_NEK2_1	195	200	PF00069	0.682
MOD_NEK2_1	20	25	PF00069	0.157
MOD_NEK2_1	255	260	PF00069	0.494
MOD_NEK2_1	302	307	PF00069	0.442
MOD_NEK2_1	399	404	PF00069	0.577
MOD_NEK2_1	54	59	PF00069	0.331
MOD_NEK2_1	90	95	PF00069	0.353
MOD_NEK2_1	97	102	PF00069	0.352
MOD_PIKK_1	14	20	PF00454	0.486
MOD_PIKK_1	322	328	PF00454	0.482
MOD_PKA_2	224	230	PF00069	0.530
MOD_PKA_2	264	270	PF00069	0.492
MOD_PKA_2	322	328	PF00069	0.419
MOD_Plk_1	10	16	PF00069	0.602
MOD_Plk_1	103	109	PF00069	0.398
MOD_Plk_1	189	195	PF00069	0.701
MOD_Plk_1	314	320	PF00069	0.585
MOD_Plk_1	326	332	PF00069	0.355
MOD_Plk_2-3	190	196	PF00069	0.675
MOD_Plk_4	133	139	PF00069	0.358
MOD_Plk_4	190	196	PF00069	0.718
MOD_Plk_4	264	270	PF00069	0.460
MOD_Plk_4	295	301	PF00069	0.373
MOD_Plk_4	326	332	PF00069	0.371
MOD_Plk_4	363	369	PF00069	0.332
MOD_Plk_4	65	71	PF00069	0.404
MOD_Plk_4	97	103	PF00069	0.410
MOD_ProDKin_1	217	223	PF00069	0.688
MOD_ProDKin_1	56	62	PF00069	0.384
MOD_SUMO_rev_2	226	232	PF00179	0.547
TRG_DiLeu_BaEn_1	104	109	PF01217	0.384
TRG_DiLeu_BaEn_3	189	195	PF01217	0.631
TRG_ENDOCYTIC_2	276	279	PF00928	0.376
TRG_ENDOCYTIC_2	334	337	PF00928	0.371
TRG_ER_diArg_1	383	385	PF00400	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M9	Leptomonas seymouri	26%	99%
A0A0N1I470	Leptomonas seymouri	71%	82%
A0A0N1PDI6	Leptomonas seymouri	24%	70%
A0A0S4IPA6	Bodo saltans	42%	100%
A0A0S4IPI7	Bodo saltans	28%	84%
A0A0S4JSF9	Bodo saltans	25%	78%
A0A1X0NRR8	Trypanosomatidae	22%	96%
A0A1X0P1F1	Trypanosomatidae	48%	100%
A0A1X0PAL3	Trypanosomatidae	26%	74%
A0A3Q8IC75	Leishmania donovani	97%	84%
A0A3Q8IL77	Leishmania donovani	24%	69%
A0A3Q8ITK0	Leishmania donovani	24%	100%
A0A3R7LBY6	Trypanosoma rangeli	46%	100%
A0A422NS01	Trypanosoma rangeli	24%	74%
A0A422NYJ0	Trypanosoma rangeli	25%	90%
A4HAY2	Leishmania braziliensis	24%	71%
A4HIN7	Leishmania braziliensis	82%	93%
A4I5Y4	Leishmania infantum	97%	84%
A4I8C4	Leishmania infantum	25%	100%
A4IA41	Leishmania infantum	24%	69%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	75%
E9B177	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	84%
E9B383	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B555	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	69%
Q17586	Caenorhabditis elegans	24%	90%
Q4Q2T0	Leishmania major	24%	69%
Q4V3C7	Arabidopsis thaliana	32%	85%
Q67XQ0	Arabidopsis thaliana	32%	85%
Q8RY60	Arabidopsis thaliana	30%	80%
Q8VZI2	Arabidopsis thaliana	28%	99%
Q9LTD8	Arabidopsis thaliana	27%	84%
Q9ZQR4	Arabidopsis thaliana	28%	99%
Q9ZVS8	Arabidopsis thaliana	34%	84%
V5BKR5	Trypanosoma cruzi	24%	73%
V5DM70	Trypanosoma cruzi	25%	93%
V5DNW3	Trypanosoma cruzi	47%	100%