NTF2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 42 (RNA-binding motif protein 42), putative

Species:

Leishmania major

UniProt:

Q4Q6Y1_LEIMA

TriTrypDb:

LmjF.30.3090 , LMJLV39_300039200 , LMJSD75_300038300

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q6Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Y1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	254	256	PF00675	0.771
CLV_PCSK_KEX2_1	248	250	PF00082	0.769
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.766
CLV_PCSK_SKI1_1	18	22	PF00082	0.511
CLV_PCSK_SKI1_1	264	268	PF00082	0.500
CLV_PCSK_SKI1_1	279	283	PF00082	0.479
CLV_PCSK_SKI1_1	32	36	PF00082	0.503
DEG_APCC_DBOX_1	278	286	PF00400	0.572
DEG_SCF_FBW7_2	155	161	PF00400	0.866
DOC_CKS1_1	155	160	PF01111	0.794
DOC_PP1_RVXF_1	262	268	PF00149	0.476
DOC_USP7_MATH_1	144	148	PF00917	0.747
DOC_USP7_MATH_1	150	154	PF00917	0.704
DOC_USP7_MATH_1	197	201	PF00917	0.676
DOC_WW_Pin1_4	128	133	PF00397	0.656
DOC_WW_Pin1_4	137	142	PF00397	0.662
DOC_WW_Pin1_4	154	159	PF00397	0.808
LIG_14-3-3_CanoR_1	293	302	PF00244	0.466
LIG_14-3-3_CanoR_1	32	37	PF00244	0.580
LIG_APCC_ABBA_1	309	314	PF00400	0.528
LIG_APCC_ABBAyCdc20_2	298	304	PF00400	0.540
LIG_APCC_ABBAyCdc20_2	308	314	PF00400	0.539
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_BIR_III_3	1	5	PF00653	0.553
LIG_FHA_1	267	273	PF00498	0.703
LIG_FHA_1	33	39	PF00498	0.418
LIG_FHA_2	101	107	PF00498	0.508
LIG_FHA_2	272	278	PF00498	0.565
LIG_FHA_2	35	41	PF00498	0.430
LIG_IRF3_LxIS_1	41	46	PF10401	0.575
LIG_LIR_Gen_1	204	213	PF02991	0.597
LIG_LIR_Nem_3	204	208	PF02991	0.617
LIG_LIR_Nem_3	50	55	PF02991	0.516
LIG_Pex14_2	11	15	PF04695	0.389
LIG_SH2_CRK	80	84	PF00017	0.450
LIG_SH2_CRK	99	103	PF00017	0.472
LIG_SH2_PTP2	52	55	PF00017	0.486
LIG_SH2_SRC	52	55	PF00017	0.486
LIG_SH2_STAT5	118	121	PF00017	0.420
LIG_SH2_STAT5	52	55	PF00017	0.530
LIG_SH3_1	152	158	PF00018	0.656
LIG_SH3_3	129	135	PF00018	0.651
LIG_SH3_3	152	158	PF00018	0.743
LIG_SH3_3	161	167	PF00018	0.813
LIG_SUMO_SIM_par_1	34	40	PF11976	0.488
LIG_TRAF2_1	173	176	PF00917	0.854
LIG_WRC_WIRS_1	105	110	PF05994	0.508
LIG_WW_3	250	254	PF00397	0.697
MOD_CK1_1	204	210	PF00069	0.661
MOD_CK2_1	100	106	PF00069	0.509
MOD_CK2_1	271	277	PF00069	0.490
MOD_Cter_Amidation	229	232	PF01082	0.751
MOD_GlcNHglycan	178	181	PF01048	0.780
MOD_GlcNHglycan	285	288	PF01048	0.696
MOD_GlcNHglycan	295	298	PF01048	0.453
MOD_GSK3_1	100	107	PF00069	0.511
MOD_GSK3_1	150	157	PF00069	0.791
MOD_GSK3_1	197	204	PF00069	0.637
MOD_GSK3_1	267	274	PF00069	0.644
MOD_GSK3_1	60	67	PF00069	0.524
MOD_N-GLC_1	267	272	PF02516	0.595
MOD_N-GLC_1	293	298	PF02516	0.480
MOD_NEK2_1	108	113	PF00069	0.564
MOD_NEK2_1	266	271	PF00069	0.640
MOD_NEK2_1	327	332	PF00069	0.496
MOD_NEK2_1	64	69	PF00069	0.543
MOD_PK_1	70	76	PF00069	0.532
MOD_PKA_1	231	237	PF00069	0.755
MOD_PKA_1	255	261	PF00069	0.731
MOD_PKB_1	253	261	PF00069	0.684
MOD_PKB_1	68	76	PF00069	0.502
MOD_Plk_4	204	210	PF00069	0.675
MOD_Plk_4	327	333	PF00069	0.530
MOD_Plk_4	48	54	PF00069	0.604
MOD_ProDKin_1	128	134	PF00069	0.663
MOD_ProDKin_1	137	143	PF00069	0.665
MOD_ProDKin_1	154	160	PF00069	0.805
MOD_SUMO_for_1	169	172	PF00179	0.743
MOD_SUMO_rev_2	185	194	PF00179	0.781
TRG_ENDOCYTIC_2	52	55	PF00928	0.530
TRG_ENDOCYTIC_2	80	83	PF00928	0.472
TRG_ENDOCYTIC_2	98	101	PF00928	0.445
TRG_ER_diArg_1	332	335	PF00400	0.556
TRG_ER_diArg_1	68	71	PF00400	0.510
TRG_NLS_MonoExtC_3	150	155	PF00514	0.658
TRG_NLS_MonoExtN_4	150	155	PF00514	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL25	Leptomonas seymouri	64%	97%
A0A3R7N1J6	Trypanosoma rangeli	37%	87%
A0A3S5H7N8	Leishmania donovani	93%	100%
A4HIP3	Leishmania braziliensis	87%	100%
A4I5Z0	Leishmania infantum	93%	100%
E9B183	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BX42	Trypanosoma cruzi	38%	81%