Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6Y0_LEIMA

TriTrypDb:

LmjF.30.3100 , LMJLV39_300039300 , LMJSD75_300038400

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Y0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.662
CLV_C14_Caspase3-7	606	610	PF00656	0.596
CLV_NRD_NRD_1	15	17	PF00675	0.683
CLV_NRD_NRD_1	414	416	PF00675	0.551
CLV_NRD_NRD_1	595	597	PF00675	0.459
CLV_PCSK_KEX2_1	15	17	PF00082	0.669
CLV_PCSK_KEX2_1	414	416	PF00082	0.590
CLV_PCSK_KEX2_1	484	486	PF00082	0.463
CLV_PCSK_KEX2_1	595	597	PF00082	0.459
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.463
CLV_PCSK_SKI1_1	121	125	PF00082	0.414
CLV_PCSK_SKI1_1	16	20	PF00082	0.583
CLV_PCSK_SKI1_1	2	6	PF00082	0.671
CLV_PCSK_SKI1_1	280	284	PF00082	0.548
CLV_PCSK_SKI1_1	33	37	PF00082	0.433
CLV_PCSK_SKI1_1	337	341	PF00082	0.406
CLV_PCSK_SKI1_1	386	390	PF00082	0.440
CLV_PCSK_SKI1_1	408	412	PF00082	0.522
CLV_PCSK_SKI1_1	595	599	PF00082	0.481
CLV_PCSK_SKI1_1	88	92	PF00082	0.514
DEG_APCC_DBOX_1	214	222	PF00400	0.530
DEG_APCC_DBOX_1	385	393	PF00400	0.529
DEG_APCC_DBOX_1	594	602	PF00400	0.485
DEG_APCC_KENBOX_2	364	368	PF00400	0.602
DEG_Nend_UBRbox_1	1	4	PF02207	0.721
DEG_SPOP_SBC_1	305	309	PF00917	0.786
DEG_SPOP_SBC_1	499	503	PF00917	0.552
DEG_SPOP_SBC_1	62	66	PF00917	0.715
DEG_SPOP_SBC_1	67	71	PF00917	0.767
DOC_CKS1_1	271	276	PF01111	0.557
DOC_CYCLIN_RxL_1	408	422	PF00134	0.624
DOC_CYCLIN_RxL_1	593	604	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	623	629	PF00134	0.505
DOC_MAPK_DCC_7	215	223	PF00069	0.518
DOC_MAPK_gen_1	381	391	PF00069	0.535
DOC_MAPK_gen_1	484	492	PF00069	0.539
DOC_MAPK_MEF2A_6	201	208	PF00069	0.470
DOC_MAPK_MEF2A_6	215	223	PF00069	0.345
DOC_MAPK_MEF2A_6	254	261	PF00069	0.508
DOC_MAPK_MEF2A_6	402	411	PF00069	0.660
DOC_PP2B_LxvP_1	522	525	PF13499	0.577
DOC_PP2B_LxvP_1	623	626	PF13499	0.559
DOC_USP7_MATH_1	305	309	PF00917	0.738
DOC_USP7_MATH_1	443	447	PF00917	0.484
DOC_USP7_MATH_1	464	468	PF00917	0.471
DOC_USP7_MATH_1	568	572	PF00917	0.595
DOC_USP7_MATH_1	63	67	PF00917	0.724
DOC_WW_Pin1_4	132	137	PF00397	0.435
DOC_WW_Pin1_4	16	21	PF00397	0.568
DOC_WW_Pin1_4	253	258	PF00397	0.513
DOC_WW_Pin1_4	270	275	PF00397	0.419
DOC_WW_Pin1_4	292	297	PF00397	0.682
DOC_WW_Pin1_4	429	434	PF00397	0.540
LIG_14-3-3_CanoR_1	121	131	PF00244	0.481
LIG_14-3-3_CanoR_1	15	19	PF00244	0.347
LIG_14-3-3_CanoR_1	2	7	PF00244	0.637
LIG_14-3-3_CanoR_1	290	296	PF00244	0.724
LIG_14-3-3_CanoR_1	384	392	PF00244	0.553
LIG_14-3-3_CanoR_1	414	419	PF00244	0.516
LIG_14-3-3_CanoR_1	47	53	PF00244	0.533
LIG_Actin_WH2_2	172	189	PF00022	0.465
LIG_APCC_ABBA_1	231	236	PF00400	0.448
LIG_Clathr_ClatBox_1	128	132	PF01394	0.524
LIG_Clathr_ClatBox_1	373	377	PF01394	0.398
LIG_CSL_BTD_1	195	198	PF09270	0.443
LIG_EH1_1	156	164	PF00400	0.547
LIG_eIF4E_1	157	163	PF01652	0.542
LIG_FHA_1	102	108	PF00498	0.467
LIG_FHA_1	123	129	PF00498	0.465
LIG_FHA_1	133	139	PF00498	0.468
LIG_FHA_1	208	214	PF00498	0.511
LIG_FHA_1	235	241	PF00498	0.519
LIG_FHA_1	254	260	PF00498	0.519
LIG_FHA_1	3	9	PF00498	0.710
LIG_FHA_1	419	425	PF00498	0.531
LIG_FHA_1	430	436	PF00498	0.534
LIG_FHA_1	467	473	PF00498	0.433
LIG_FHA_1	502	508	PF00498	0.392
LIG_FHA_1	513	519	PF00498	0.418
LIG_FHA_1	615	621	PF00498	0.528
LIG_FHA_2	63	69	PF00498	0.718
LIG_FHA_2	70	76	PF00498	0.684
LIG_GBD_Chelix_1	175	183	PF00786	0.480
LIG_IRF3_LxIS_1	143	149	PF10401	0.387
LIG_LIR_Gen_1	139	148	PF02991	0.521
LIG_LIR_Gen_1	19	28	PF02991	0.512
LIG_LIR_Gen_1	242	252	PF02991	0.426
LIG_LIR_Gen_1	273	284	PF02991	0.315
LIG_LIR_Gen_1	502	513	PF02991	0.405
LIG_LIR_Nem_3	139	144	PF02991	0.375
LIG_LIR_Nem_3	151	157	PF02991	0.442
LIG_LIR_Nem_3	17	21	PF02991	0.511
LIG_LIR_Nem_3	180	185	PF02991	0.353
LIG_LIR_Nem_3	242	247	PF02991	0.410
LIG_LIR_Nem_3	273	279	PF02991	0.302
LIG_LIR_Nem_3	330	335	PF02991	0.498
LIG_LIR_Nem_3	40	45	PF02991	0.411
LIG_LIR_Nem_3	502	508	PF02991	0.393
LIG_LYPXL_yS_3	216	219	PF13949	0.462
LIG_NRBOX	469	475	PF00104	0.485
LIG_PCNA_yPIPBox_3	156	169	PF02747	0.439
LIG_PCNA_yPIPBox_3	365	374	PF02747	0.542
LIG_SH2_CRK	21	25	PF00017	0.484
LIG_SH2_CRK	400	404	PF00017	0.600
LIG_SH2_CRK	505	509	PF00017	0.455
LIG_SH2_GRB2like	353	356	PF00017	0.409
LIG_SH2_NCK_1	400	404	PF00017	0.600
LIG_SH2_NCK_1	496	500	PF00017	0.574
LIG_SH2_SRC	375	378	PF00017	0.465
LIG_SH2_STAP1	235	239	PF00017	0.525
LIG_SH2_STAP1	505	509	PF00017	0.490
LIG_SH2_STAP1	512	516	PF00017	0.511
LIG_SH2_STAT5	185	188	PF00017	0.389
LIG_SH2_STAT5	263	266	PF00017	0.520
LIG_SH2_STAT5	353	356	PF00017	0.444
LIG_SH2_STAT5	375	378	PF00017	0.458
LIG_SH3_2	217	222	PF14604	0.512
LIG_SH3_3	214	220	PF00018	0.538
LIG_SH3_3	393	399	PF00018	0.598
LIG_SH3_3	437	443	PF00018	0.576
LIG_SH3_3	629	635	PF00018	0.615
LIG_SH3_3	83	89	PF00018	0.606
LIG_SH3_4	88	95	PF00018	0.538
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.532
LIG_SUMO_SIM_anti_2	202	211	PF11976	0.551
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.484
LIG_SUMO_SIM_par_1	144	149	PF11976	0.431
LIG_TRAF2_1	319	322	PF00917	0.650
LIG_TRFH_1	216	220	PF08558	0.519
LIG_TYR_ITIM	183	188	PF00017	0.383
LIG_TYR_ITIM	261	266	PF00017	0.429
LIG_TYR_ITSM	17	24	PF00017	0.582
LIG_UBA3_1	107	116	PF00899	0.428
MOD_CDC14_SPxK_1	295	298	PF00782	0.705
MOD_CDK_SPxK_1	292	298	PF00069	0.677
MOD_CK1_1	292	298	PF00069	0.691
MOD_CK1_1	301	307	PF00069	0.704
MOD_CK1_1	308	314	PF00069	0.693
MOD_CK1_1	327	333	PF00069	0.339
MOD_CK1_1	417	423	PF00069	0.551
MOD_CK1_1	446	452	PF00069	0.527
MOD_CK1_1	603	609	PF00069	0.544
MOD_CK1_1	66	72	PF00069	0.726
MOD_CK2_1	62	68	PF00069	0.739
MOD_Cter_Amidation	13	16	PF01082	0.662
MOD_DYRK1A_RPxSP_1	16	20	PF00069	0.567
MOD_GlcNHglycan	266	269	PF01048	0.441
MOD_GlcNHglycan	386	389	PF01048	0.551
MOD_GlcNHglycan	452	455	PF01048	0.668
MOD_GlcNHglycan	481	484	PF01048	0.452
MOD_GlcNHglycan	65	68	PF01048	0.692
MOD_GSK3_1	146	153	PF00069	0.421
MOD_GSK3_1	2	9	PF00069	0.694
MOD_GSK3_1	290	297	PF00069	0.600
MOD_GSK3_1	301	308	PF00069	0.719
MOD_GSK3_1	309	316	PF00069	0.746
MOD_GSK3_1	323	330	PF00069	0.390
MOD_GSK3_1	349	356	PF00069	0.563
MOD_GSK3_1	410	417	PF00069	0.546
MOD_GSK3_1	446	453	PF00069	0.589
MOD_GSK3_1	495	502	PF00069	0.495
MOD_GSK3_1	57	64	PF00069	0.604
MOD_GSK3_1	600	607	PF00069	0.537
MOD_GSK3_1	66	73	PF00069	0.692
MOD_N-GLC_1	269	274	PF02516	0.568
MOD_N-GLC_1	604	609	PF02516	0.596
MOD_N-GLC_1	76	81	PF02516	0.789
MOD_NEK2_1	122	127	PF00069	0.467
MOD_NEK2_1	146	151	PF00069	0.412
MOD_NEK2_1	165	170	PF00069	0.449
MOD_NEK2_1	264	269	PF00069	0.421
MOD_NEK2_1	410	415	PF00069	0.549
MOD_NEK2_1	479	484	PF00069	0.526
MOD_NEK2_1	48	53	PF00069	0.582
MOD_NEK2_1	6	11	PF00069	0.679
MOD_NEK2_1	600	605	PF00069	0.501
MOD_PIKK_1	122	128	PF00454	0.477
MOD_PIKK_1	317	323	PF00454	0.575
MOD_PIKK_1	7	13	PF00454	0.716
MOD_PIKK_1	88	94	PF00454	0.494
MOD_PK_1	134	140	PF00069	0.532
MOD_PKA_1	414	420	PF00069	0.518
MOD_PKA_2	14	20	PF00069	0.604
MOD_PKA_2	289	295	PF00069	0.624
MOD_PKA_2	414	420	PF00069	0.559
MOD_PKA_2	6	12	PF00069	0.629
MOD_PKA_2	601	607	PF00069	0.488
MOD_PKB_1	288	296	PF00069	0.703
MOD_PKB_1	59	67	PF00069	0.487
MOD_Plk_1	327	333	PF00069	0.435
MOD_Plk_1	563	569	PF00069	0.520
MOD_Plk_1	604	610	PF00069	0.599
MOD_Plk_4	101	107	PF00069	0.472
MOD_Plk_4	177	183	PF00069	0.361
MOD_Plk_4	226	232	PF00069	0.389
MOD_Plk_4	414	420	PF00069	0.526
MOD_Plk_4	443	449	PF00069	0.527
MOD_ProDKin_1	132	138	PF00069	0.430
MOD_ProDKin_1	16	22	PF00069	0.564
MOD_ProDKin_1	253	259	PF00069	0.505
MOD_ProDKin_1	270	276	PF00069	0.424
MOD_ProDKin_1	292	298	PF00069	0.687
MOD_ProDKin_1	429	435	PF00069	0.535
TRG_DiLeu_BaEn_1	158	163	PF01217	0.535
TRG_DiLeu_BaEn_1	242	247	PF01217	0.400
TRG_DiLeu_BaEn_2	117	123	PF01217	0.418
TRG_DiLeu_BaEn_3	202	208	PF01217	0.456
TRG_DiLeu_BaEn_4	487	493	PF01217	0.470
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.441
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.521
TRG_DiLeu_BaLyEn_6	577	582	PF01217	0.451
TRG_ENDOCYTIC_2	185	188	PF00928	0.389
TRG_ENDOCYTIC_2	21	24	PF00928	0.463
TRG_ENDOCYTIC_2	216	219	PF00928	0.447
TRG_ENDOCYTIC_2	263	266	PF00928	0.416
TRG_ENDOCYTIC_2	496	499	PF00928	0.534
TRG_ENDOCYTIC_2	505	508	PF00928	0.448
TRG_ER_diArg_1	414	416	PF00400	0.590
TRG_ER_diArg_1	594	596	PF00400	0.455
TRG_NES_CRM1_1	139	152	PF08389	0.404
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	390	395	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D3	Leptomonas seymouri	66%	100%
A0A0S4J3H1	Bodo saltans	22%	100%
A0A1X0P1N4	Trypanosomatidae	41%	100%
A0A3S7X3S8	Leishmania donovani	95%	92%
A0A422P0R1	Trypanosoma rangeli	40%	100%
A4HIP4	Leishmania braziliensis	84%	100%
A4I5Z1	Leishmania infantum	95%	100%
C9ZRB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B184	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BSF5	Trypanosoma cruzi	38%	100%