Putative S-adenosylmethionine decarboxylase proenzyme-like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

S-adenosylmethionine decarboxylase proenzyme- like, putative

Species:

Leishmania major

UniProt:

Q4Q6X8_LEIMA

TriTrypDb:

LmjF.30.3120 , LMJLV39_300039700 , LMJSD75_300038900

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q6X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6X8

Function

Biological processes
Term	Name	Level	Count
GO:0006576	biogenic amine metabolic process	5	23
GO:0006595	polyamine metabolic process	6	23
GO:0006596	polyamine biosynthetic process	7	23
GO:0006597	spermine biosynthetic process	8	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0008152	metabolic process	1	23
GO:0008215	spermine metabolic process	7	23
GO:0008216	spermidine metabolic process	7	23
GO:0008295	spermidine biosynthetic process	8	23
GO:0009058	biosynthetic process	2	23
GO:0009308	amine metabolic process	4	23
GO:0009309	amine biosynthetic process	5	23
GO:0009987	cellular process	1	23
GO:0034641	cellular nitrogen compound metabolic process	3	23
GO:0042401	biogenic amine biosynthetic process	6	23
GO:0044237	cellular metabolic process	2	23
GO:0044249	cellular biosynthetic process	3	23
GO:0044271	cellular nitrogen compound biosynthetic process	4	23
GO:0071704	organic substance metabolic process	2	23
GO:1901564	organonitrogen compound metabolic process	3	23
GO:1901566	organonitrogen compound biosynthetic process	4	23
GO:1901576	organic substance biosynthetic process	3	23

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	23
GO:0016829	lyase activity	2	23
GO:0004014	adenosylmethionine decarboxylase activity	5	21
GO:0016830	carbon-carbon lyase activity	3	21
GO:0016831	carboxy-lyase activity	4	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.503
CLV_NRD_NRD_1	111	113	PF00675	0.454
CLV_NRD_NRD_1	169	171	PF00675	0.473
CLV_PCSK_KEX2_1	20	22	PF00082	0.316
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.316
CLV_PCSK_SKI1_1	137	141	PF00082	0.383
CLV_PCSK_SKI1_1	144	148	PF00082	0.398
CLV_Separin_Metazoa	207	211	PF03568	0.354
DOC_CKS1_1	71	76	PF01111	0.412
DOC_CKS1_1	90	95	PF01111	0.523
DOC_CYCLIN_RxL_1	17	25	PF00134	0.358
DOC_MAPK_DCC_7	210	220	PF00069	0.335
DOC_MAPK_gen_1	170	177	PF00069	0.431
DOC_MAPK_HePTP_8	167	179	PF00069	0.300
DOC_MAPK_MEF2A_6	170	179	PF00069	0.401
DOC_PP1_RVXF_1	102	108	PF00149	0.320
DOC_PP1_RVXF_1	18	25	PF00149	0.255
DOC_PP4_FxxP_1	7	10	PF00568	0.476
DOC_USP7_MATH_1	142	146	PF00917	0.395
DOC_USP7_MATH_1	200	204	PF00917	0.504
DOC_USP7_MATH_1	256	260	PF00917	0.323
DOC_WW_Pin1_4	114	119	PF00397	0.383
DOC_WW_Pin1_4	227	232	PF00397	0.467
DOC_WW_Pin1_4	266	271	PF00397	0.516
DOC_WW_Pin1_4	70	75	PF00397	0.411
DOC_WW_Pin1_4	89	94	PF00397	0.527
LIG_14-3-3_CanoR_1	112	118	PF00244	0.420
LIG_Actin_WH2_2	121	139	PF00022	0.384
LIG_APCC_ABBA_1	278	283	PF00400	0.336
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_Clathr_ClatBox_1	60	64	PF01394	0.291
LIG_eIF4E_1	285	291	PF01652	0.473
LIG_FHA_1	146	152	PF00498	0.407
LIG_FHA_1	275	281	PF00498	0.510
LIG_FHA_1	32	38	PF00498	0.411
LIG_FHA_1	64	70	PF00498	0.414
LIG_FHA_1	90	96	PF00498	0.422
LIG_LIR_Gen_1	132	141	PF02991	0.390
LIG_LIR_Gen_1	195	206	PF02991	0.502
LIG_LIR_Nem_3	106	110	PF02991	0.326
LIG_LIR_Nem_3	132	136	PF02991	0.354
LIG_LIR_Nem_3	195	201	PF02991	0.514
LIG_LIR_Nem_3	2	7	PF02991	0.567
LIG_LIR_Nem_3	211	215	PF02991	0.403
LIG_SH2_GRB2like	161	164	PF00017	0.450
LIG_SH2_NCK_1	161	165	PF00017	0.398
LIG_SH2_SRC	161	164	PF00017	0.401
LIG_SH2_STAT3	271	274	PF00017	0.405
LIG_SH2_STAT5	110	113	PF00017	0.468
LIG_SH2_STAT5	271	274	PF00017	0.406
LIG_SH3_3	225	231	PF00018	0.501
LIG_SH3_3	87	93	PF00018	0.407
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.479
LIG_SUMO_SIM_par_1	58	64	PF11976	0.449
LIG_SUMO_SIM_par_1	68	73	PF11976	0.312
LIG_SUMO_SIM_par_1	92	100	PF11976	0.472
LIG_TRAF2_1	36	39	PF00917	0.525
LIG_UBA3_1	69	76	PF00899	0.404
LIG_WRC_WIRS_1	209	214	PF05994	0.466
LIG_WRC_WIRS_1	238	243	PF05994	0.504
LIG_WRC_WIRS_1	32	37	PF05994	0.482
MOD_CDC14_SPxK_1	230	233	PF00782	0.494
MOD_CDK_SPxK_1	227	233	PF00069	0.508
MOD_CDK_SPxK_1	70	76	PF00069	0.440
MOD_CK1_1	123	129	PF00069	0.391
MOD_CK1_1	145	151	PF00069	0.487
MOD_CK1_1	219	225	PF00069	0.363
MOD_CK1_1	8	14	PF00069	0.548
MOD_CK2_1	13	19	PF00069	0.462
MOD_CK2_1	78	84	PF00069	0.459
MOD_Cter_Amidation	168	171	PF01082	0.379
MOD_GlcNHglycan	15	18	PF01048	0.427
MOD_GlcNHglycan	202	205	PF01048	0.585
MOD_GlcNHglycan	257	261	PF01048	0.444
MOD_GlcNHglycan	294	297	PF01048	0.514
MOD_GlcNHglycan	55	58	PF01048	0.486
MOD_GlcNHglycan	80	83	PF01048	0.420
MOD_GSK3_1	237	244	PF00069	0.531
MOD_GSK3_1	5	12	PF00069	0.618
MOD_GSK3_1	59	66	PF00069	0.358
MOD_N-GLC_1	113	118	PF02516	0.390
MOD_N-GLC_1	191	196	PF02516	0.493
MOD_N-GLC_1	274	279	PF02516	0.416
MOD_NEK2_1	237	242	PF00069	0.444
MOD_NEK2_1	63	68	PF00069	0.338
MOD_NEK2_1	77	82	PF00069	0.313
MOD_NEK2_1	97	102	PF00069	0.416
MOD_PIKK_1	192	198	PF00454	0.599
MOD_PIKK_1	63	69	PF00454	0.430
MOD_PKA_1	112	118	PF00069	0.471
MOD_Plk_1	256	262	PF00069	0.305
MOD_Plk_1	274	280	PF00069	0.434
MOD_Plk_4	106	112	PF00069	0.326
MOD_Plk_4	142	148	PF00069	0.431
MOD_ProDKin_1	114	120	PF00069	0.386
MOD_ProDKin_1	227	233	PF00069	0.467
MOD_ProDKin_1	266	272	PF00069	0.516
MOD_ProDKin_1	70	76	PF00069	0.409
MOD_ProDKin_1	89	95	PF00069	0.528
MOD_SUMO_rev_2	132	139	PF00179	0.358
TRG_ENDOCYTIC_2	133	136	PF00928	0.343
TRG_ENDOCYTIC_2	161	164	PF00928	0.384
TRG_ENDOCYTIC_2	206	209	PF00928	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z0	Leptomonas seymouri	23%	76%
A0A0N1PCH0	Leptomonas seymouri	71%	94%
A0A0S4JHX8	Bodo saltans	26%	78%
A0A0S4JRG8	Bodo saltans	39%	90%
A0A1X0P1C0	Trypanosomatidae	42%	91%
A0A1X0P1E2	Trypanosomatidae	25%	81%
A0A3Q8IEH8	Leishmania donovani	25%	78%
A0A3S7X3S7	Leishmania donovani	95%	100%
A0A422P0Q5	Trypanosoma rangeli	41%	91%
A0A422P0V0	Trypanosoma rangeli	24%	80%
A4HIP5	Leishmania braziliensis	23%	80%
A4HIP6	Leishmania braziliensis	79%	100%
A4I5Z2	Leishmania infantum	25%	78%
A4I5Z3	Leishmania infantum	95%	100%
A5HNV6	Trypanosoma brucei brucei	42%	91%
C9ZRB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	80%
C9ZRB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	91%
E9B185	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	78%
E9B186	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O76240	Trypanosoma cruzi	26%	80%
P50244	Trypanosoma brucei brucei	21%	80%
Q25264	Leishmania donovani	25%	78%
Q4Q6X9	Leishmania major	24%	100%
Q9NGA0	Leishmania infantum	25%	76%
V5B784	Trypanosoma cruzi	42%	91%
V5DNV4	Trypanosoma cruzi	26%	80%