Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6X6_LEIMA

TriTrypDb:

LmjF.30.3140 , LMJLV39_300039900 , LMJSD75_300039100

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6X6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.544
CLV_NRD_NRD_1	155	157	PF00675	0.464
CLV_NRD_NRD_1	211	213	PF00675	0.553
CLV_NRD_NRD_1	83	85	PF00675	0.498
CLV_PCSK_KEX2_1	155	157	PF00082	0.464
CLV_PCSK_KEX2_1	210	212	PF00082	0.502
CLV_PCSK_KEX2_1	83	85	PF00082	0.503
CLV_PCSK_PC7_1	151	157	PF00082	0.455
CLV_PCSK_SKI1_1	120	124	PF00082	0.627
CLV_PCSK_SKI1_1	169	173	PF00082	0.549
DOC_PP4_FxxP_1	142	145	PF00568	0.537
DOC_USP7_MATH_1	122	126	PF00917	0.549
DOC_USP7_MATH_1	178	182	PF00917	0.510
DOC_USP7_MATH_1	94	98	PF00917	0.616
DOC_WW_Pin1_4	172	177	PF00397	0.527
DOC_WW_Pin1_4	19	24	PF00397	0.559
DOC_WW_Pin1_4	68	73	PF00397	0.577
LIG_14-3-3_CanoR_1	134	142	PF00244	0.463
LIG_14-3-3_CanoR_1	93	103	PF00244	0.731
LIG_BRCT_BRCA1_1	47	51	PF00533	0.745
LIG_Clathr_ClatBox_1	57	61	PF01394	0.581
LIG_FHA_2	69	75	PF00498	0.607
LIG_GBD_Chelix_1	182	190	PF00786	0.590
LIG_LIR_Gen_1	177	186	PF02991	0.531
LIG_LIR_Gen_1	30	38	PF02991	0.578
LIG_LIR_Nem_3	177	182	PF02991	0.525
LIG_LIR_Nem_3	30	34	PF02991	0.578
LIG_LYPXL_SIV_4	178	186	PF13949	0.517
LIG_PCNA_yPIPBox_3	107	115	PF02747	0.544
LIG_PDZ_Class_2	225	230	PF00595	0.477
LIG_Pex14_1	199	203	PF04695	0.525
LIG_SH2_CRK	179	183	PF00017	0.513
LIG_SH2_STAP1	179	183	PF00017	0.514
LIG_SH2_STAT5	141	144	PF00017	0.526
LIG_SH2_STAT5	203	206	PF00017	0.504
LIG_SUMO_SIM_par_1	10	18	PF11976	0.574
LIG_TRFH_1	172	176	PF08558	0.530
LIG_UBA3_1	157	163	PF00899	0.444
MOD_CK1_1	102	108	PF00069	0.595
MOD_CK1_1	15	21	PF00069	0.591
MOD_CK1_1	206	212	PF00069	0.510
MOD_CK1_1	30	36	PF00069	0.656
MOD_CK1_1	37	43	PF00069	0.585
MOD_CK1_1	65	71	PF00069	0.651
MOD_CK2_1	47	53	PF00069	0.560
MOD_CK2_1	68	74	PF00069	0.669
MOD_GlcNHglycan	104	107	PF01048	0.629
MOD_GlcNHglycan	137	140	PF01048	0.504
MOD_GlcNHglycan	223	227	PF01048	0.482
MOD_GSK3_1	116	123	PF00069	0.609
MOD_GSK3_1	15	22	PF00069	0.621
MOD_GSK3_1	30	37	PF00069	0.675
MOD_GSK3_1	41	48	PF00069	0.611
MOD_N-GLC_1	18	23	PF02516	0.597
MOD_N-GLC_1	94	99	PF02516	0.616
MOD_NEK2_1	222	227	PF00069	0.480
MOD_NEK2_1	27	32	PF00069	0.597
MOD_PIKK_1	37	43	PF00454	0.507
MOD_PKA_2	116	122	PF00069	0.551
MOD_PKA_2	146	152	PF00069	0.486
MOD_PKA_2	99	105	PF00069	0.584
MOD_Plk_1	120	126	PF00069	0.643
MOD_Plk_2-3	47	53	PF00069	0.648
MOD_Plk_2-3	62	68	PF00069	0.561
MOD_Plk_4	178	184	PF00069	0.511
MOD_Plk_4	185	191	PF00069	0.531
MOD_Plk_4	99	105	PF00069	0.547
MOD_ProDKin_1	172	178	PF00069	0.523
MOD_ProDKin_1	19	25	PF00069	0.559
MOD_ProDKin_1	68	74	PF00069	0.575
MOD_SUMO_rev_2	113	122	PF00179	0.599
TRG_DiLeu_BaEn_4	4	10	PF01217	0.591
TRG_ENDOCYTIC_2	179	182	PF00928	0.530
TRG_ER_diArg_1	154	156	PF00400	0.455
TRG_ER_diArg_1	210	212	PF00400	0.546
TRG_ER_diArg_1	83	85	PF00400	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXB3	Leptomonas seymouri	71%	97%
A0A3S7X3W4	Leishmania donovani	94%	100%
A4HIP8	Leishmania braziliensis	77%	100%
A4I663	Leishmania infantum	95%	100%
E9B188	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%