Translocon-associated protein subunit beta

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translocon-associated protein beta (TRAPB), putative

Species:

Leishmania major

UniProt:

Q4Q6X5_LEIMA

TriTrypDb:

LmjF.30.3150 , LMJLV39_300040000 , LMJSD75_300039200

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 1
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q6X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6X5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.718
CLV_NRD_NRD_1	128	130	PF00675	0.581
CLV_NRD_NRD_1	207	209	PF00675	0.468
CLV_PCSK_SKI1_1	129	133	PF00082	0.526
CLV_PCSK_SKI1_1	171	175	PF00082	0.733
CLV_PCSK_SKI1_1	5	9	PF00082	0.648
DEG_APCC_DBOX_1	128	136	PF00400	0.570
DOC_CDC14_PxL_1	182	190	PF14671	0.363
DOC_MAPK_MEF2A_6	5	12	PF00069	0.570
DOC_MAPK_NFAT4_5	5	13	PF00069	0.634
DOC_USP7_MATH_1	125	129	PF00917	0.270
DOC_WW_Pin1_4	62	67	PF00397	0.287
DOC_WW_Pin1_4	99	104	PF00397	0.301
LIG_14-3-3_CanoR_1	154	160	PF00244	0.446
LIG_14-3-3_CanoR_1	195	205	PF00244	0.701
LIG_14-3-3_CanoR_1	98	102	PF00244	0.358
LIG_14-3-3_CterR_2	208	212	PF00244	0.697
LIG_Actin_WH2_2	82	100	PF00022	0.358
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BRCT_BRCA1_1	64	68	PF00533	0.322
LIG_FHA_1	115	121	PF00498	0.285
LIG_FHA_1	175	181	PF00498	0.347
LIG_FHA_2	40	46	PF00498	0.362
LIG_LIR_Gen_1	163	173	PF02991	0.461
LIG_LIR_Gen_1	176	187	PF02991	0.328
LIG_LIR_Gen_1	18	28	PF02991	0.423
LIG_LIR_Nem_3	150	156	PF02991	0.448
LIG_LIR_Nem_3	163	168	PF02991	0.420
LIG_LIR_Nem_3	176	182	PF02991	0.269
LIG_LIR_Nem_3	18	24	PF02991	0.423
LIG_LIR_Nem_3	85	91	PF02991	0.335
LIG_LRP6_Inhibitor_1	131	137	PF00058	0.658
LIG_MYND_1	186	190	PF01753	0.363
LIG_NRBOX	3	9	PF00104	0.554
LIG_PCNA_yPIPBox_3	195	205	PF02747	0.726
LIG_SH2_CRK	165	169	PF00017	0.455
LIG_SH2_PTP2	179	182	PF00017	0.437
LIG_SH2_STAP1	109	113	PF00017	0.350
LIG_SH2_STAT5	172	175	PF00017	0.456
LIG_SH2_STAT5	179	182	PF00017	0.413
LIG_SH2_STAT5	191	194	PF00017	0.385
LIG_SH2_STAT5	88	91	PF00017	0.317
LIG_SH2_STAT5	99	102	PF00017	0.247
LIG_SUMO_SIM_anti_2	51	58	PF11976	0.328
LIG_SUMO_SIM_par_1	155	161	PF11976	0.430
LIG_SUMO_SIM_par_1	54	60	PF11976	0.324
MOD_CK1_1	158	164	PF00069	0.556
MOD_CK1_1	39	45	PF00069	0.383
MOD_CK1_1	80	86	PF00069	0.413
MOD_CK2_1	109	115	PF00069	0.433
MOD_CK2_1	48	54	PF00069	0.413
MOD_CK2_1	89	95	PF00069	0.291
MOD_GlcNHglycan	91	94	PF01048	0.315
MOD_GSK3_1	11	18	PF00069	0.608
MOD_GSK3_1	36	43	PF00069	0.359
MOD_GSK3_1	89	96	PF00069	0.342
MOD_GSK3_1	97	104	PF00069	0.338
MOD_NEK2_1	15	20	PF00069	0.606
MOD_NEK2_1	36	41	PF00069	0.322
MOD_NEK2_1	97	102	PF00069	0.321
MOD_NEK2_2	93	98	PF00069	0.444
MOD_PKA_2	97	103	PF00069	0.444
MOD_Plk_1	114	120	PF00069	0.385
MOD_Plk_1	149	155	PF00069	0.615
MOD_Plk_1	174	180	PF00069	0.420
MOD_Plk_4	11	17	PF00069	0.610
MOD_ProDKin_1	62	68	PF00069	0.344
MOD_ProDKin_1	99	105	PF00069	0.363
TRG_DiLeu_BaEn_1	200	205	PF01217	0.689
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.364
TRG_ENDOCYTIC_2	165	168	PF00928	0.582
TRG_ENDOCYTIC_2	179	182	PF00928	0.328
TRG_ER_diArg_1	205	208	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC54	Leptomonas seymouri	80%	100%
A0A0S4JI19	Bodo saltans	48%	100%
A0A1X0P213	Trypanosomatidae	57%	100%
A0A3R7RRG4	Trypanosoma rangeli	53%	100%
A0A3S7X3S9	Leishmania donovani	97%	100%
A4HIP9	Leishmania braziliensis	84%	100%
A4I662	Leishmania infantum	97%	100%
C9ZRC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B189	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B7D0	Trypanosoma cruzi	51%	100%