ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6X4_LEIMA

TriTrypDb:

LmjF.30.3160 , LMJLV39_300040100 , LMJSD75_300039300

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6X4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	79	81	PF00675	0.607
CLV_PCSK_KEX2_1	161	163	PF00082	0.451
CLV_PCSK_KEX2_1	289	291	PF00082	0.478
CLV_PCSK_KEX2_1	79	81	PF00082	0.663
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.473
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.511
CLV_PCSK_SKI1_1	276	280	PF00082	0.411
CLV_Separin_Metazoa	194	198	PF03568	0.483
DEG_APCC_DBOX_1	176	184	PF00400	0.556
DEG_Nend_UBRbox_1	1	4	PF02207	0.676
DOC_CKS1_1	38	43	PF01111	0.667
DOC_MAPK_gen_1	64	73	PF00069	0.526
DOC_PP1_RVXF_1	62	68	PF00149	0.596
DOC_USP7_MATH_1	109	113	PF00917	0.558
DOC_USP7_MATH_1	20	24	PF00917	0.560
DOC_USP7_UBL2_3	129	133	PF12436	0.577
DOC_USP7_UBL2_3	96	100	PF12436	0.490
DOC_WW_Pin1_4	269	274	PF00397	0.483
DOC_WW_Pin1_4	37	42	PF00397	0.663
LIG_14-3-3_CanoR_1	150	154	PF00244	0.521
LIG_14-3-3_CanoR_1	174	184	PF00244	0.429
LIG_14-3-3_CanoR_1	72	78	PF00244	0.636
LIG_14-3-3_CanoR_1	79	87	PF00244	0.591
LIG_Actin_WH2_2	82	97	PF00022	0.444
LIG_BRCT_BRCA1_1	311	315	PF00533	0.547
LIG_deltaCOP1_diTrp_1	83	91	PF00928	0.419
LIG_FHA_1	113	119	PF00498	0.530
LIG_FHA_1	135	141	PF00498	0.535
LIG_FHA_1	43	49	PF00498	0.523
LIG_FHA_2	174	180	PF00498	0.505
LIG_FHA_2	189	195	PF00498	0.472
LIG_FHA_2	223	229	PF00498	0.547
LIG_FHA_2	304	310	PF00498	0.523
LIG_LIR_Gen_1	142	153	PF02991	0.463
LIG_LIR_Gen_1	191	199	PF02991	0.439
LIG_LIR_Gen_1	44	53	PF02991	0.499
LIG_LIR_Gen_1	84	94	PF02991	0.406
LIG_LIR_Nem_3	142	148	PF02991	0.461
LIG_LIR_Nem_3	191	195	PF02991	0.424
LIG_LIR_Nem_3	253	258	PF02991	0.372
LIG_LIR_Nem_3	277	282	PF02991	0.496
LIG_LIR_Nem_3	44	49	PF02991	0.510
LIG_LIR_Nem_3	84	90	PF02991	0.414
LIG_PDZ_Class_2	310	315	PF00595	0.416
LIG_SH2_CRK	38	42	PF00017	0.557
LIG_SH2_CRK	55	59	PF00017	0.527
LIG_SH2_STAP1	248	252	PF00017	0.531
LIG_SH2_STAT5	257	260	PF00017	0.448
LIG_SH2_STAT5	55	58	PF00017	0.633
LIG_SH3_3	238	244	PF00018	0.382
LIG_TRAF2_1	191	194	PF00917	0.537
MOD_CDK_SPxxK_3	269	276	PF00069	0.475
MOD_CK1_1	107	113	PF00069	0.530
MOD_CK1_1	146	152	PF00069	0.539
MOD_CK1_1	178	184	PF00069	0.537
MOD_CK1_1	222	228	PF00069	0.524
MOD_CK1_1	303	309	PF00069	0.526
MOD_CK2_1	188	194	PF00069	0.547
MOD_CK2_1	222	228	PF00069	0.547
MOD_CK2_1	271	277	PF00069	0.472
MOD_GlcNHglycan	106	109	PF01048	0.467
MOD_GlcNHglycan	111	114	PF01048	0.503
MOD_GlcNHglycan	199	202	PF01048	0.371
MOD_GlcNHglycan	22	25	PF01048	0.615
MOD_GlcNHglycan	273	276	PF01048	0.521
MOD_GlcNHglycan	73	76	PF01048	0.578
MOD_GSK3_1	100	107	PF00069	0.477
MOD_GSK3_1	175	182	PF00069	0.428
MOD_NEK2_1	53	58	PF00069	0.510
MOD_NEK2_1	71	76	PF00069	0.476
MOD_PIKK_1	112	118	PF00454	0.511
MOD_PKA_1	79	85	PF00069	0.659
MOD_PKA_2	149	155	PF00069	0.530
MOD_PKA_2	173	179	PF00069	0.470
MOD_PKA_2	71	77	PF00069	0.547
MOD_PKA_2	79	85	PF00069	0.520
MOD_Plk_1	178	184	PF00069	0.511
MOD_Plk_1	300	306	PF00069	0.529
MOD_Plk_1	85	91	PF00069	0.418
MOD_Plk_4	149	155	PF00069	0.528
MOD_Plk_4	179	185	PF00069	0.400
MOD_ProDKin_1	269	275	PF00069	0.474
MOD_ProDKin_1	37	43	PF00069	0.667
MOD_SUMO_rev_2	61	65	PF00179	0.521
MOD_SUMO_rev_2	92	102	PF00179	0.448
TRG_DiLeu_BaEn_3	193	199	PF01217	0.525
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.358
TRG_ENDOCYTIC_2	55	58	PF00928	0.633
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I463	Leptomonas seymouri	72%	99%
A0A0S4JPV6	Bodo saltans	55%	98%
A0A1X0P1E1	Trypanosomatidae	63%	97%
A0A3S7X3T4	Leishmania donovani	99%	100%
A0A422P0S4	Trypanosoma rangeli	62%	97%
A4HIQ0	Leishmania braziliensis	92%	100%
A4I661	Leishmania infantum	99%	100%
C9ZRC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	97%
E9B190	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BMS9	Trypanosoma cruzi	63%	97%