Meiosis-specific nuclear structural protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tumour suppressor, Mitostatin, putative

Species:

Leishmania major

UniProt:

Q4Q6X3_LEIMA

TriTrypDb:

LmjF.30.3170 , LMJLV39_300040200 , LMJSD75_300039400

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005930	axoneme	2	2
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	9

Expansion

Sequence features

Q4Q6X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6X3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.336
CLV_NRD_NRD_1	155	157	PF00675	0.310
CLV_NRD_NRD_1	160	162	PF00675	0.303
CLV_NRD_NRD_1	200	202	PF00675	0.283
CLV_NRD_NRD_1	225	227	PF00675	0.342
CLV_NRD_NRD_1	231	233	PF00675	0.324
CLV_NRD_NRD_1	282	284	PF00675	0.362
CLV_NRD_NRD_1	337	339	PF00675	0.308
CLV_NRD_NRD_1	347	349	PF00675	0.303
CLV_NRD_NRD_1	354	356	PF00675	0.212
CLV_NRD_NRD_1	366	368	PF00675	0.290
CLV_NRD_NRD_1	54	56	PF00675	0.313
CLV_NRD_NRD_1	77	79	PF00675	0.346
CLV_PCSK_FUR_1	104	108	PF00082	0.351
CLV_PCSK_FUR_1	158	162	PF00082	0.378
CLV_PCSK_FUR_1	232	236	PF00082	0.323
CLV_PCSK_KEX2_1	106	108	PF00082	0.324
CLV_PCSK_KEX2_1	155	157	PF00082	0.308
CLV_PCSK_KEX2_1	160	162	PF00082	0.301
CLV_PCSK_KEX2_1	200	202	PF00082	0.282
CLV_PCSK_KEX2_1	225	227	PF00082	0.299
CLV_PCSK_KEX2_1	234	236	PF00082	0.260
CLV_PCSK_KEX2_1	282	284	PF00082	0.354
CLV_PCSK_KEX2_1	322	324	PF00082	0.304
CLV_PCSK_KEX2_1	336	338	PF00082	0.242
CLV_PCSK_KEX2_1	366	368	PF00082	0.365
CLV_PCSK_KEX2_1	77	79	PF00082	0.336
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.291
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.316
CLV_PCSK_PC7_1	156	162	PF00082	0.353
CLV_PCSK_PC7_1	332	338	PF00082	0.344
CLV_PCSK_SKI1_1	183	187	PF00082	0.346
CLV_PCSK_SKI1_1	2	6	PF00082	0.672
CLV_PCSK_SKI1_1	283	287	PF00082	0.386
CLV_PCSK_SKI1_1	337	341	PF00082	0.335
CLV_PCSK_SKI1_1	88	92	PF00082	0.316
DEG_Nend_UBRbox_1	1	4	PF02207	0.608
DOC_MAPK_gen_1	128	137	PF00069	0.539
DOC_MAPK_gen_1	249	257	PF00069	0.570
DOC_MAPK_gen_1	286	296	PF00069	0.419
DOC_PP1_RVXF_1	392	398	PF00149	0.582
DOC_USP7_MATH_1	44	48	PF00917	0.502
DOC_USP7_UBL2_3	340	344	PF12436	0.562
LIG_Actin_WH2_2	42	57	PF00022	0.562
LIG_FHA_1	28	34	PF00498	0.563
LIG_LIR_Gen_1	167	176	PF02991	0.534
LIG_LIR_Nem_3	167	172	PF02991	0.496
LIG_LIR_Nem_3	38	42	PF02991	0.507
LIG_LIR_Nem_3	382	386	PF02991	0.562
LIG_LYPXL_yS_3	39	42	PF13949	0.586
LIG_NRBOX	236	242	PF00104	0.496
LIG_SH2_CRK	383	387	PF00017	0.559
LIG_SH2_NCK_1	383	387	PF00017	0.530
LIG_SH2_SRC	383	386	PF00017	0.562
LIG_SH2_STAT5	194	197	PF00017	0.496
LIG_SH2_STAT5	364	367	PF00017	0.482
LIG_SH2_STAT5	53	56	PF00017	0.542
LIG_SH2_STAT5	82	85	PF00017	0.487
LIG_TRAF2_1	123	126	PF00917	0.544
LIG_TRAF2_1	185	188	PF00917	0.534
LIG_TRAF2_1	285	288	PF00917	0.563
LIG_TRAF2_1	92	95	PF00917	0.493
MOD_CK2_1	54	60	PF00069	0.493
MOD_Cter_Amidation	223	226	PF01082	0.447
MOD_GlcNHglycan	64	68	PF01048	0.385
MOD_NEK2_1	149	154	PF00069	0.408
MOD_NEK2_1	54	59	PF00069	0.493
MOD_PIKK_1	44	50	PF00454	0.428
MOD_PKA_2	248	254	PF00069	0.441
MOD_PKA_2	54	60	PF00069	0.480
MOD_SUMO_for_1	185	188	PF00179	0.422
MOD_SUMO_for_1	285	288	PF00179	0.401
MOD_SUMO_for_1	90	93	PF00179	0.415
MOD_SUMO_rev_2	203	209	PF00179	0.335
MOD_SUMO_rev_2	21	30	PF00179	0.493
MOD_SUMO_rev_2	302	310	PF00179	0.436
MOD_SUMO_rev_2	341	350	PF00179	0.459
MOD_SUMO_rev_2	391	395	PF00179	0.586
TRG_DiLeu_BaEn_1	236	241	PF01217	0.335
TRG_DiLeu_BaEn_1	274	279	PF01217	0.355
TRG_DiLeu_BaEn_3	392	398	PF01217	0.587
TRG_DiLeu_BaEn_4	334	340	PF01217	0.447
TRG_ENDOCYTIC_2	383	386	PF00928	0.442
TRG_ENDOCYTIC_2	39	42	PF00928	0.490
TRG_ER_diArg_1	105	107	PF00400	0.435
TRG_ER_diArg_1	158	161	PF00400	0.370
TRG_ER_diArg_1	225	227	PF00400	0.447
TRG_ER_diArg_1	282	284	PF00400	0.419
TRG_ER_diArg_1	336	338	PF00400	0.398
TRG_ER_diArg_1	365	367	PF00400	0.348
TRG_ER_diArg_1	77	79	PF00400	0.424
TRG_NLS_MonoExtC_3	54	60	PF00514	0.408
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	43	48	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF3	Leptomonas seymouri	76%	93%
A0A0S4JLP4	Bodo saltans	38%	94%
A0A1X0P1N3	Trypanosomatidae	50%	94%
A0A3Q8IF15	Leishmania donovani	96%	100%
A0A422P0U0	Trypanosoma rangeli	51%	94%
A4HIQ1	Leishmania braziliensis	87%	100%
A4I5Z6	Leishmania infantum	96%	100%
C9ZRC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	94%
E9B191	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%