RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q6X2_LEIMA

TriTrypDb:

LmjF.30.3180 , LMJLV39_300040300 , LMJSD75_300039500

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

Q4Q6X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6X2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	17
GO:0003723	RNA binding	4	17
GO:0005488	binding	1	17
GO:0097159	organic cyclic compound binding	2	17
GO:1901363	heterocyclic compound binding	2	17
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.462
CLV_PCSK_KEX2_1	109	111	PF00082	0.548
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.565
CLV_PCSK_SKI1_1	10	14	PF00082	0.444
DEG_Nend_UBRbox_2	1	3	PF02207	0.434
DOC_CYCLIN_RxL_1	109	121	PF00134	0.492
DOC_MAPK_DCC_7	109	117	PF00069	0.566
DOC_MAPK_gen_1	109	117	PF00069	0.516
DOC_MAPK_MEF2A_6	76	83	PF00069	0.418
DOC_PP1_RVXF_1	8	15	PF00149	0.498
DOC_USP7_MATH_1	133	137	PF00917	0.689
DOC_USP7_MATH_1	89	93	PF00917	0.404
DOC_WW_Pin1_4	141	146	PF00397	0.554
DOC_WW_Pin1_4	85	90	PF00397	0.485
LIG_14-3-3_CanoR_1	29	37	PF00244	0.518
LIG_APCC_ABBA_1	40	45	PF00400	0.521
LIG_FHA_2	55	61	PF00498	0.575
LIG_LIR_Gen_1	121	132	PF02991	0.520
LIG_LIR_Nem_3	121	127	PF02991	0.681
LIG_LIR_Nem_3	28	34	PF02991	0.493
LIG_LIR_Nem_3	52	58	PF02991	0.452
LIG_PTB_Apo_2	20	27	PF02174	0.479
LIG_PTB_Phospho_1	20	26	PF10480	0.479
LIG_SH2_CRK	124	128	PF00017	0.526
LIG_SH2_CRK	34	38	PF00017	0.555
LIG_SH2_NCK_1	50	54	PF00017	0.468
LIG_SH2_SRC	50	53	PF00017	0.497
LIG_SH2_STAT3	94	97	PF00017	0.478
LIG_SH2_STAT5	26	29	PF00017	0.465
LIG_SH3_3	108	114	PF00018	0.531
LIG_SH3_3	126	132	PF00018	0.478
LIG_SUMO_SIM_par_1	113	119	PF11976	0.500
LIG_SUMO_SIM_par_1	79	85	PF11976	0.433
LIG_TRAF2_1	105	108	PF00917	0.565
LIG_TYR_ITIM	53	58	PF00017	0.479
LIG_UBA3_1	80	87	PF00899	0.467
LIG_WRC_WIRS_1	1	6	PF05994	0.420
LIG_WW_3	110	114	PF00397	0.563
MOD_CK1_1	16	22	PF00069	0.540
MOD_CK1_1	85	91	PF00069	0.452
MOD_CK2_1	131	137	PF00069	0.561
MOD_GlcNHglycan	31	34	PF01048	0.312
MOD_GSK3_1	13	20	PF00069	0.540
MOD_GSK3_1	29	36	PF00069	0.492
MOD_GSK3_1	85	92	PF00069	0.418
MOD_N-GLC_1	16	21	PF02516	0.321
MOD_NEK2_1	13	18	PF00069	0.536
MOD_NEK2_2	33	38	PF00069	0.477
MOD_NEK2_2	89	94	PF00069	0.501
MOD_OFUCOSY	70	75	PF10250	0.534
MOD_PIKK_1	82	88	PF00454	0.450
MOD_Plk_1	16	22	PF00069	0.521
MOD_Plk_1	51	57	PF00069	0.497
MOD_Plk_4	89	95	PF00069	0.509
MOD_ProDKin_1	141	147	PF00069	0.556
MOD_ProDKin_1	85	91	PF00069	0.485
MOD_SUMO_rev_2	101	111	PF00179	0.537
TRG_ENDOCYTIC_2	124	127	PF00928	0.686
TRG_ENDOCYTIC_2	34	37	PF00928	0.485
TRG_ENDOCYTIC_2	50	53	PF00928	0.356
TRG_ENDOCYTIC_2	55	58	PF00928	0.472
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z2	Leptomonas seymouri	86%	100%
A0A0S4J311	Bodo saltans	32%	100%
A0A0S4JKJ5	Bodo saltans	47%	79%
A0A1X0P0Y7	Trypanosomatidae	29%	100%
A0A1X0P2H6	Trypanosomatidae	52%	100%
A0A3Q8IC83	Leishmania donovani	32%	67%
A0A3Q8II67	Leishmania donovani	99%	100%
A4HF08	Leishmania braziliensis	32%	67%
A4HIQ2	Leishmania braziliensis	91%	100%
A4I287	Leishmania infantum	32%	67%
A4I5Z5	Leishmania infantum	99%	100%
C9ZRC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	96%
E9B192	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q941	Leishmania major	32%	67%
V5BSJ4	Trypanosoma cruzi	55%	97%