Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6W9_LEIMA

TriTrypDb:

LmjF.30.3210 , LMJLV39_300040600 , LMJSD75_300039800

Length:

793

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6W9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	4
GO:0003824	catalytic activity	1	4
GO:0016853	isomerase activity	2	4
GO:0016859	cis-trans isomerase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.635
CLV_NRD_NRD_1	141	143	PF00675	0.571
CLV_NRD_NRD_1	225	227	PF00675	0.537
CLV_NRD_NRD_1	392	394	PF00675	0.458
CLV_NRD_NRD_1	536	538	PF00675	0.551
CLV_PCSK_FUR_1	122	126	PF00082	0.570
CLV_PCSK_KEX2_1	124	126	PF00082	0.491
CLV_PCSK_KEX2_1	141	143	PF00082	0.600
CLV_PCSK_KEX2_1	225	227	PF00082	0.557
CLV_PCSK_KEX2_1	236	238	PF00082	0.607
CLV_PCSK_KEX2_1	273	275	PF00082	0.563
CLV_PCSK_KEX2_1	392	394	PF00082	0.468
CLV_PCSK_KEX2_1	536	538	PF00082	0.551
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.519
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.662
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.628
CLV_PCSK_SKI1_1	155	159	PF00082	0.690
CLV_PCSK_SKI1_1	171	175	PF00082	0.645
CLV_PCSK_SKI1_1	267	271	PF00082	0.516
CLV_PCSK_SKI1_1	273	277	PF00082	0.528
CLV_PCSK_SKI1_1	290	294	PF00082	0.565
CLV_PCSK_SKI1_1	306	310	PF00082	0.544
CLV_PCSK_SKI1_1	393	397	PF00082	0.484
CLV_PCSK_SKI1_1	43	47	PF00082	0.473
CLV_PCSK_SKI1_1	451	455	PF00082	0.553
CLV_PCSK_SKI1_1	536	540	PF00082	0.569
CLV_PCSK_SKI1_1	676	680	PF00082	0.737
DEG_APCC_DBOX_1	224	232	PF00400	0.559
DEG_APCC_KENBOX_2	39	43	PF00400	0.633
DEG_Nend_UBRbox_3	1	3	PF02207	0.355
DEG_SPOP_SBC_1	692	696	PF00917	0.543
DOC_CKS1_1	728	733	PF01111	0.574
DOC_CYCLIN_RxL_1	390	398	PF00134	0.517
DOC_CYCLIN_yClb3_PxF_3	651	657	PF00134	0.700
DOC_CYCLIN_yCln2_LP_2	653	659	PF00134	0.748
DOC_CYCLIN_yCln2_LP_2	678	684	PF00134	0.749
DOC_MAPK_gen_1	155	165	PF00069	0.684
DOC_MAPK_gen_1	357	365	PF00069	0.500
DOC_MAPK_gen_1	38	47	PF00069	0.602
DOC_MAPK_HePTP_8	121	133	PF00069	0.559
DOC_MAPK_MEF2A_6	100	109	PF00069	0.514
DOC_MAPK_MEF2A_6	124	133	PF00069	0.508
DOC_MAPK_MEF2A_6	359	367	PF00069	0.577
DOC_MAPK_NFAT4_5	362	370	PF00069	0.566
DOC_MAPK_RevD_3	129	143	PF00069	0.482
DOC_PP1_RVXF_1	760	766	PF00149	0.745
DOC_PP2B_LxvP_1	653	656	PF13499	0.717
DOC_PP2B_LxvP_1	725	728	PF13499	0.765
DOC_PP4_FxxP_1	86	89	PF00568	0.622
DOC_USP7_MATH_1	129	133	PF00917	0.352
DOC_USP7_MATH_1	182	186	PF00917	0.708
DOC_USP7_MATH_1	27	31	PF00917	0.528
DOC_USP7_MATH_1	604	608	PF00917	0.590
DOC_USP7_MATH_1	704	708	PF00917	0.720
DOC_USP7_MATH_1	721	725	PF00917	0.744
DOC_USP7_MATH_1	735	739	PF00917	0.457
DOC_WW_Pin1_4	173	178	PF00397	0.704
DOC_WW_Pin1_4	698	703	PF00397	0.785
DOC_WW_Pin1_4	706	711	PF00397	0.638
DOC_WW_Pin1_4	727	732	PF00397	0.733
LIG_14-3-3_CanoR_1	352	358	PF00244	0.516
LIG_14-3-3_CanoR_1	364	368	PF00244	0.514
LIG_14-3-3_CanoR_1	474	480	PF00244	0.560
LIG_14-3-3_CanoR_1	536	545	PF00244	0.516
LIG_Actin_WH2_2	207	224	PF00022	0.591
LIG_Actin_WH2_2	349	366	PF00022	0.562
LIG_Actin_WH2_2	403	419	PF00022	0.528
LIG_AP2alpha_2	612	614	PF02296	0.624
LIG_BRCT_BRCA1_1	131	135	PF00533	0.487
LIG_BRCT_BRCA1_1	147	151	PF00533	0.763
LIG_EH1_1	253	261	PF00400	0.529
LIG_eIF4E_1	254	260	PF01652	0.546
LIG_EVH1_1	727	731	PF00568	0.651
LIG_FHA_1	216	222	PF00498	0.566
LIG_FHA_1	26	32	PF00498	0.570
LIG_FHA_1	296	302	PF00498	0.505
LIG_FHA_1	348	354	PF00498	0.574
LIG_FHA_1	364	370	PF00498	0.462
LIG_FHA_1	419	425	PF00498	0.539
LIG_FHA_1	537	543	PF00498	0.614
LIG_FHA_1	548	554	PF00498	0.424
LIG_FHA_1	673	679	PF00498	0.724
LIG_FHA_1	692	698	PF00498	0.687
LIG_FHA_1	749	755	PF00498	0.753
LIG_FHA_2	164	170	PF00498	0.759
LIG_FHA_2	222	228	PF00498	0.613
LIG_FHA_2	298	304	PF00498	0.527
LIG_FHA_2	368	374	PF00498	0.519
LIG_FHA_2	426	432	PF00498	0.605
LIG_FHA_2	564	570	PF00498	0.548
LIG_LIR_Apic_2	642	647	PF02991	0.663
LIG_LIR_Apic_2	83	89	PF02991	0.371
LIG_LIR_Gen_1	202	210	PF02991	0.600
LIG_LIR_Gen_1	433	439	PF02991	0.557
LIG_LIR_Gen_1	576	585	PF02991	0.475
LIG_LIR_Nem_3	202	207	PF02991	0.593
LIG_LIR_Nem_3	433	438	PF02991	0.558
LIG_LIR_Nem_3	576	581	PF02991	0.481
LIG_LIR_Nem_3	610	614	PF02991	0.607
LIG_MYND_1	651	655	PF01753	0.682
LIG_NRBOX	339	345	PF00104	0.493
LIG_NRBOX	71	77	PF00104	0.568
LIG_PCNA_yPIPBox_3	595	603	PF02747	0.575
LIG_SH2_CRK	435	439	PF00017	0.480
LIG_SH2_CRK	578	582	PF00017	0.548
LIG_SH2_CRK	644	648	PF00017	0.657
LIG_SH2_NCK_1	644	648	PF00017	0.667
LIG_SH2_PTP2	136	139	PF00017	0.495
LIG_SH2_SRC	136	139	PF00017	0.495
LIG_SH2_SRC	468	471	PF00017	0.536
LIG_SH2_STAP1	386	390	PF00017	0.576
LIG_SH2_STAP1	435	439	PF00017	0.513
LIG_SH2_STAT5	136	139	PF00017	0.449
LIG_SH2_STAT5	772	775	PF00017	0.754
LIG_SH3_3	649	655	PF00018	0.602
LIG_SH3_3	707	713	PF00018	0.746
LIG_SH3_3	715	721	PF00018	0.577
LIG_SH3_3	725	731	PF00018	0.688
LIG_SH3_3	760	766	PF00018	0.738
LIG_SUMO_SIM_par_1	161	166	PF11976	0.725
LIG_SUMO_SIM_par_1	179	185	PF11976	0.600
LIG_SUMO_SIM_par_1	365	371	PF11976	0.583
LIG_TRAF2_1	402	405	PF00917	0.513
LIG_TRAF2_1	565	568	PF00917	0.600
LIG_UBA3_1	116	124	PF00899	0.523
LIG_UBA3_1	379	385	PF00899	0.527
MOD_CK1_1	197	203	PF00069	0.650
MOD_CK1_1	30	36	PF00069	0.572
MOD_CK1_1	430	436	PF00069	0.608
MOD_CK1_1	62	68	PF00069	0.670
MOD_CK1_1	669	675	PF00069	0.706
MOD_CK1_1	738	744	PF00069	0.817
MOD_CK1_1	80	86	PF00069	0.558
MOD_CK2_1	221	227	PF00069	0.592
MOD_CK2_1	297	303	PF00069	0.518
MOD_CK2_1	309	315	PF00069	0.453
MOD_CK2_1	367	373	PF00069	0.525
MOD_CK2_1	537	543	PF00069	0.565
MOD_CK2_1	563	569	PF00069	0.554
MOD_CK2_1	604	610	PF00069	0.564
MOD_CK2_1	618	624	PF00069	0.462
MOD_CK2_1	71	77	PF00069	0.638
MOD_GlcNHglycan	184	187	PF01048	0.694
MOD_GlcNHglycan	196	199	PF01048	0.586
MOD_GlcNHglycan	241	244	PF01048	0.613
MOD_GlcNHglycan	310	314	PF01048	0.604
MOD_GlcNHglycan	559	562	PF01048	0.570
MOD_GlcNHglycan	606	609	PF01048	0.618
MOD_GlcNHglycan	620	623	PF01048	0.599
MOD_GlcNHglycan	668	671	PF01048	0.658
MOD_GlcNHglycan	706	709	PF01048	0.798
MOD_GlcNHglycan	775	778	PF01048	0.760
MOD_GSK3_1	146	153	PF00069	0.696
MOD_GSK3_1	169	176	PF00069	0.700
MOD_GSK3_1	239	246	PF00069	0.634
MOD_GSK3_1	347	354	PF00069	0.566
MOD_GSK3_1	363	370	PF00069	0.395
MOD_GSK3_1	537	544	PF00069	0.529
MOD_GSK3_1	59	66	PF00069	0.633
MOD_GSK3_1	688	695	PF00069	0.750
MOD_GSK3_1	80	87	PF00069	0.636
MOD_LATS_1	787	793	PF00433	0.788
MOD_N-GLC_1	129	134	PF02516	0.589
MOD_N-GLC_1	555	560	PF02516	0.600
MOD_N-GLC_1	62	67	PF02516	0.631
MOD_NEK2_1	163	168	PF00069	0.760
MOD_NEK2_1	194	199	PF00069	0.679
MOD_NEK2_1	215	220	PF00069	0.606
MOD_NEK2_1	221	226	PF00069	0.586
MOD_NEK2_1	294	299	PF00069	0.477
MOD_NEK2_1	309	314	PF00069	0.464
MOD_NEK2_1	323	328	PF00069	0.351
MOD_NEK2_1	347	352	PF00069	0.580
MOD_NEK2_1	363	368	PF00069	0.537
MOD_NEK2_1	395	400	PF00069	0.521
MOD_NEK2_1	416	421	PF00069	0.575
MOD_NEK2_1	50	55	PF00069	0.469
MOD_NEK2_1	545	550	PF00069	0.540
MOD_NEK2_1	690	695	PF00069	0.725
MOD_NEK2_1	773	778	PF00069	0.753
MOD_PIKK_1	215	221	PF00454	0.591
MOD_PIKK_1	323	329	PF00454	0.548
MOD_PIKK_1	411	417	PF00454	0.562
MOD_PIKK_1	418	424	PF00454	0.548
MOD_PIKK_1	537	543	PF00454	0.483
MOD_PIKK_1	563	569	PF00454	0.553
MOD_PIKK_1	591	597	PF00454	0.558
MOD_PIKK_1	740	746	PF00454	0.778
MOD_PKA_1	536	542	PF00069	0.613
MOD_PKA_2	221	227	PF00069	0.575
MOD_PKA_2	239	245	PF00069	0.491
MOD_PKA_2	351	357	PF00069	0.568
MOD_PKA_2	363	369	PF00069	0.517
MOD_PKA_2	473	479	PF00069	0.558
MOD_PKA_2	536	542	PF00069	0.595
MOD_Plk_1	129	135	PF00069	0.565
MOD_Plk_1	252	258	PF00069	0.494
MOD_Plk_1	347	353	PF00069	0.543
MOD_Plk_1	411	417	PF00069	0.586
MOD_Plk_1	430	436	PF00069	0.488
MOD_Plk_1	555	561	PF00069	0.512
MOD_Plk_1	80	86	PF00069	0.638
MOD_Plk_2-3	384	390	PF00069	0.565
MOD_Plk_2-3	77	83	PF00069	0.647
MOD_Plk_4	27	33	PF00069	0.512
MOD_Plk_4	50	56	PF00069	0.372
MOD_Plk_4	639	645	PF00069	0.624
MOD_Plk_4	71	77	PF00069	0.592
MOD_ProDKin_1	173	179	PF00069	0.706
MOD_ProDKin_1	698	704	PF00069	0.784
MOD_ProDKin_1	706	712	PF00069	0.637
MOD_ProDKin_1	727	733	PF00069	0.734
MOD_SUMO_for_1	358	361	PF00179	0.469
MOD_SUMO_for_1	426	429	PF00179	0.591
MOD_SUMO_rev_2	303	308	PF00179	0.494
MOD_SUMO_rev_2	35	45	PF00179	0.597
TRG_DiLeu_BaEn_1	202	207	PF01217	0.579
TRG_DiLeu_BaEn_4	360	366	PF01217	0.577
TRG_DiLeu_BaEn_4	405	411	PF01217	0.532
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.510
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.523
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.539
TRG_DiLeu_LyEn_5	159	164	PF01217	0.525
TRG_ENDOCYTIC_2	136	139	PF00928	0.449
TRG_ENDOCYTIC_2	435	438	PF00928	0.469
TRG_ENDOCYTIC_2	578	581	PF00928	0.553
TRG_ER_diArg_1	140	142	PF00400	0.600
TRG_ER_diArg_1	536	538	PF00400	0.558
TRG_ER_diArg_1	760	763	PF00400	0.760
TRG_NES_CRM1_1	49	61	PF08389	0.513
TRG_NLS_MonoExtC_3	265	271	PF00514	0.540
TRG_NLS_MonoExtN_4	122	128	PF00514	0.601
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	378	383	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	536	541	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	771	775	PF00026	0.773

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD41	Leptomonas seymouri	61%	90%
A0A1X0P1A9	Trypanosomatidae	37%	78%
A0A1X0P287	Trypanosomatidae	25%	70%
A0A3S7X3W0	Leishmania donovani	94%	90%
A0A422NMN4	Trypanosoma rangeli	23%	72%
A0A422P0Y3	Trypanosoma rangeli	37%	79%
A4HIQ9	Leishmania braziliensis	79%	90%
A4I604	Leishmania infantum	94%	90%
C9ZRC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	99%
E9B195	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	90%
V5BCD0	Trypanosoma cruzi	22%	71%
V5BMS4	Trypanosoma cruzi	36%	84%