Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6W8_LEIMA

TriTrypDb:

LmjF.30.3220 , LMJLV39_300040700 , LMJSD75_300039900

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6W8

PDB structure(s): 7ane_ai

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.463
CLV_C14_Caspase3-7	242	246	PF00656	0.450
CLV_NRD_NRD_1	282	284	PF00675	0.397
CLV_NRD_NRD_1	298	300	PF00675	0.273
CLV_NRD_NRD_1	329	331	PF00675	0.483
CLV_PCSK_KEX2_1	284	286	PF00082	0.431
CLV_PCSK_KEX2_1	298	300	PF00082	0.276
CLV_PCSK_KEX2_1	329	331	PF00082	0.483
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.514
CLV_PCSK_SKI1_1	116	120	PF00082	0.325
CLV_PCSK_SKI1_1	228	232	PF00082	0.352
CLV_PCSK_SKI1_1	314	318	PF00082	0.297
CLV_PCSK_SKI1_1	329	333	PF00082	0.336
CLV_PCSK_SKI1_1	48	52	PF00082	0.403
CLV_PCSK_SKI1_1	68	72	PF00082	0.224
DEG_Nend_Nbox_1	1	3	PF02207	0.391
DEG_SPOP_SBC_1	323	327	PF00917	0.336
DOC_CYCLIN_RxL_1	54	65	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	317	320	PF00134	0.296
DOC_MAPK_DCC_7	344	352	PF00069	0.361
DOC_MAPK_gen_1	113	122	PF00069	0.361
DOC_MAPK_gen_1	298	306	PF00069	0.360
DOC_MAPK_gen_1	310	318	PF00069	0.319
DOC_MAPK_HePTP_8	296	308	PF00069	0.391
DOC_MAPK_MEF2A_6	116	124	PF00069	0.365
DOC_MAPK_MEF2A_6	266	274	PF00069	0.281
DOC_MAPK_MEF2A_6	299	308	PF00069	0.396
DOC_MAPK_MEF2A_6	344	352	PF00069	0.392
DOC_PP1_RVXF_1	100	106	PF00149	0.376
DOC_PP2B_LxvP_1	304	307	PF13499	0.353
DOC_PP2B_LxvP_1	316	319	PF13499	0.276
DOC_PP4_FxxP_1	35	38	PF00568	0.435
DOC_SPAK_OSR1_1	208	212	PF12202	0.456
DOC_USP7_UBL2_3	102	106	PF12436	0.497
DOC_WW_Pin1_4	336	341	PF00397	0.441
DOC_WW_Pin1_4	81	86	PF00397	0.506
LIG_14-3-3_CanoR_1	298	303	PF00244	0.379
LIG_14-3-3_CanoR_1	329	338	PF00244	0.452
LIG_DLG_GKlike_1	298	306	PF00625	0.378
LIG_EH_1	170	174	PF12763	0.366
LIG_eIF4E_1	184	190	PF01652	0.367
LIG_FHA_1	160	166	PF00498	0.423
LIG_FHA_1	288	294	PF00498	0.543
LIG_FHA_1	330	336	PF00498	0.438
LIG_FHA_2	14	20	PF00498	0.451
LIG_FHA_2	145	151	PF00498	0.392
LIG_FHA_2	233	239	PF00498	0.389
LIG_FHA_2	332	338	PF00498	0.475
LIG_FHA_2	368	374	PF00498	0.372
LIG_Integrin_isoDGR_2	226	228	PF01839	0.470
LIG_LIR_Apic_2	254	260	PF02991	0.521
LIG_LIR_Apic_2	34	38	PF02991	0.439
LIG_LIR_Gen_1	117	125	PF02991	0.332
LIG_LIR_Gen_1	149	160	PF02991	0.461
LIG_LIR_Gen_1	261	270	PF02991	0.308
LIG_LIR_Gen_1	361	371	PF02991	0.382
LIG_LIR_Gen_1	373	379	PF02991	0.377
LIG_LIR_Nem_3	117	122	PF02991	0.319
LIG_LIR_Nem_3	149	155	PF02991	0.352
LIG_LIR_Nem_3	182	187	PF02991	0.377
LIG_LIR_Nem_3	192	196	PF02991	0.296
LIG_LIR_Nem_3	261	265	PF02991	0.304
LIG_LIR_Nem_3	269	274	PF02991	0.301
LIG_LIR_Nem_3	361	367	PF02991	0.382
LIG_LIR_Nem_3	373	379	PF02991	0.361
LIG_LYPXL_S_1	41	45	PF13949	0.298
LIG_LYPXL_yS_3	184	187	PF13949	0.328
LIG_LYPXL_yS_3	42	45	PF13949	0.304
LIG_MYND_1	39	43	PF01753	0.470
LIG_PDZ_Class_2	374	379	PF00595	0.374
LIG_Pex14_1	349	353	PF04695	0.330
LIG_Pex14_2	148	152	PF04695	0.331
LIG_SH2_SRC	322	325	PF00017	0.433
LIG_SH2_STAT5	179	182	PF00017	0.406
LIG_SH2_STAT5	24	27	PF00017	0.478
LIG_SH2_STAT5	264	267	PF00017	0.352
LIG_SH2_STAT5	322	325	PF00017	0.305
LIG_SH2_STAT5	364	367	PF00017	0.401
LIG_SH3_3	154	160	PF00018	0.514
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.463
LIG_TYR_ITIM	362	367	PF00017	0.457
LIG_TYR_ITIM	40	45	PF00017	0.303
LIG_UBA3_1	210	217	PF00899	0.457
LIG_WW_1	319	322	PF00397	0.315
MOD_CK1_1	236	242	PF00069	0.430
MOD_CK1_1	339	345	PF00069	0.500
MOD_CK1_1	84	90	PF00069	0.395
MOD_CK2_1	13	19	PF00069	0.400
MOD_CK2_1	144	150	PF00069	0.430
MOD_CK2_1	232	238	PF00069	0.380
MOD_CK2_1	339	345	PF00069	0.410
MOD_CK2_1	348	354	PF00069	0.376
MOD_CK2_1	367	373	PF00069	0.285
MOD_CK2_1	84	90	PF00069	0.386
MOD_GlcNHglycan	199	202	PF01048	0.475
MOD_GSK3_1	218	225	PF00069	0.389
MOD_GSK3_1	232	239	PF00069	0.378
MOD_N-GLC_1	218	223	PF02516	0.554
MOD_NEK2_1	231	236	PF00069	0.433
MOD_NEK2_1	331	336	PF00069	0.391
MOD_NEK2_1	367	372	PF00069	0.358
MOD_NEK2_2	348	353	PF00069	0.481
MOD_PKA_1	298	304	PF00069	0.362
MOD_PKA_1	329	335	PF00069	0.465
MOD_PKA_2	202	208	PF00069	0.302
MOD_PKA_2	298	304	PF00069	0.361
MOD_PKA_2	329	335	PF00069	0.425
MOD_Plk_1	13	19	PF00069	0.327
MOD_Plk_1	252	258	PF00069	0.461
MOD_Plk_1	323	329	PF00069	0.481
MOD_Plk_1	367	373	PF00069	0.421
MOD_Plk_1	6	12	PF00069	0.479
MOD_Plk_2-3	13	19	PF00069	0.402
MOD_Plk_4	13	19	PF00069	0.518
MOD_Plk_4	20	26	PF00069	0.242
MOD_Plk_4	236	242	PF00069	0.422
MOD_Plk_4	252	258	PF00069	0.338
MOD_Plk_4	298	304	PF00069	0.362
MOD_Plk_4	331	337	PF00069	0.414
MOD_Plk_4	6	12	PF00069	0.580
MOD_ProDKin_1	336	342	PF00069	0.437
MOD_ProDKin_1	81	87	PF00069	0.502
MOD_SUMO_rev_2	65	70	PF00179	0.481
TRG_DiLeu_BaEn_4	98	104	PF01217	0.363
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.465
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.383
TRG_ENDOCYTIC_2	184	187	PF00928	0.313
TRG_ENDOCYTIC_2	364	367	PF00928	0.412
TRG_ENDOCYTIC_2	42	45	PF00928	0.304
TRG_ENDOCYTIC_2	5	8	PF00928	0.587
TRG_ER_diArg_1	282	285	PF00400	0.357
TRG_ER_diArg_1	311	314	PF00400	0.312
TRG_ER_diArg_1	328	330	PF00400	0.336
TRG_NES_CRM1_1	134	145	PF08389	0.330
TRG_NES_CRM1_1	7	19	PF08389	0.439
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A9	Leptomonas seymouri	78%	91%
A0A0S4JLK9	Bodo saltans	48%	90%
A0A1X0P1F3	Trypanosomatidae	56%	98%
A0A3Q8IS88	Leishmania donovani	96%	100%
A0A422P0Y0	Trypanosoma rangeli	54%	93%
A4HIR0	Leishmania braziliensis	86%	92%
A4I605	Leishmania infantum	95%	100%
C9ZRC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	93%
E9B196	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BMY6	Trypanosoma cruzi	54%	92%