PhoLip_ATPase_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6W2_LEIMA

TriTrypDb:

LmjF.30.3270 , LMJLV39_300041300 , LMJSD75_300040500

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q6W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6W2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	36	38	PF00675	0.371
CLV_PCSK_FUR_1	37	41	PF00082	0.336
CLV_PCSK_KEX2_1	138	140	PF00082	0.504
CLV_PCSK_KEX2_1	36	38	PF00082	0.371
CLV_PCSK_KEX2_1	39	41	PF00082	0.361
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.504
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.335
CLV_PCSK_PC7_1	134	140	PF00082	0.477
CLV_PCSK_SKI1_1	154	158	PF00082	0.470
CLV_PCSK_SKI1_1	27	31	PF00082	0.527
CLV_PCSK_SKI1_1	3	7	PF00082	0.341
CLV_PCSK_SKI1_1	45	49	PF00082	0.484
DEG_Nend_UBRbox_2	1	3	PF02207	0.552
DOC_CDC14_PxL_1	97	105	PF14671	0.547
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.535
DOC_MAPK_gen_1	68	78	PF00069	0.599
DOC_MAPK_MEF2A_6	115	124	PF00069	0.346
DOC_MAPK_MEF2A_6	154	163	PF00069	0.715
DOC_PP1_RVXF_1	1	7	PF00149	0.545
DOC_PP2B_LxvP_1	98	101	PF13499	0.564
DOC_SPAK_OSR1_1	139	143	PF12202	0.669
DOC_USP7_MATH_1	199	203	PF00917	0.736
DOC_USP7_MATH_1	81	85	PF00917	0.391
LIG_14-3-3_CanoR_1	115	120	PF00244	0.360
LIG_14-3-3_CanoR_1	27	32	PF00244	0.527
LIG_Actin_WH2_2	14	29	PF00022	0.526
LIG_APCC_ABBA_1	107	112	PF00400	0.437
LIG_BRCT_BRCA1_1	71	75	PF00533	0.624
LIG_BRCT_BRCA1_1	83	87	PF00533	0.391
LIG_eIF4E_1	73	79	PF01652	0.587
LIG_FHA_1	167	173	PF00498	0.627
LIG_FHA_1	36	42	PF00498	0.534
LIG_FHA_2	202	208	PF00498	0.703
LIG_LIR_Gen_1	108	117	PF02991	0.342
LIG_LIR_Gen_1	70	81	PF02991	0.589
LIG_LIR_Gen_1	84	93	PF02991	0.393
LIG_LIR_Nem_3	108	113	PF02991	0.341
LIG_LIR_Nem_3	185	190	PF02991	0.719
LIG_LIR_Nem_3	2	8	PF02991	0.542
LIG_LIR_Nem_3	70	76	PF02991	0.599
LIG_LIR_Nem_3	84	88	PF02991	0.393
LIG_MYND_1	101	105	PF01753	0.450
LIG_NRBOX	126	132	PF00104	0.438
LIG_NRBOX	93	99	PF00104	0.492
LIG_SH2_CRK	64	68	PF00017	0.671
LIG_SH2_CRK	73	77	PF00017	0.590
LIG_SH2_STAP1	188	192	PF00017	0.691
LIG_SH2_STAT5	110	113	PF00017	0.315
LIG_SH2_STAT5	192	195	PF00017	0.700
LIG_SH3_3	138	144	PF00018	0.695
LIG_SH3_3	153	159	PF00018	0.607
LIG_SH3_3	193	199	PF00018	0.720
LIG_SH3_3	96	102	PF00018	0.438
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.438
LIG_SUMO_SIM_par_1	120	126	PF11976	0.507
LIG_SUMO_SIM_par_1	6	12	PF11976	0.529
LIG_TYR_ITIM	62	67	PF00017	0.626
LIG_UBA3_1	130	138	PF00899	0.560
LIG_WRC_WIRS_1	82	87	PF05994	0.438
MOD_CK1_1	89	95	PF00069	0.492
MOD_CK1_1	9	15	PF00069	0.527
MOD_CK2_1	199	205	PF00069	0.784
MOD_CK2_1	43	49	PF00069	0.527
MOD_GlcNHglycan	201	204	PF01048	0.532
MOD_GlcNHglycan	27	30	PF01048	0.328
MOD_GSK3_1	15	22	PF00069	0.527
MOD_GSK3_1	77	84	PF00069	0.438
MOD_LATS_1	25	31	PF00433	0.530
MOD_NEK2_1	17	22	PF00069	0.555
MOD_NEK2_1	62	67	PF00069	0.629
MOD_NEK2_2	43	48	PF00069	0.527
MOD_PIKK_1	86	92	PF00454	0.438
MOD_PKA_2	133	139	PF00069	0.663
MOD_PKA_2	35	41	PF00069	0.531
MOD_Plk_1	145	151	PF00069	0.623
MOD_Plk_1	69	75	PF00069	0.584
MOD_Plk_4	123	129	PF00069	0.397
MOD_Plk_4	27	33	PF00069	0.526
MOD_Plk_4	62	68	PF00069	0.646
MOD_Plk_4	81	87	PF00069	0.342
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.475
TRG_ENDOCYTIC_2	110	113	PF00928	0.340
TRG_ENDOCYTIC_2	187	190	PF00928	0.721
TRG_ENDOCYTIC_2	64	67	PF00928	0.635
TRG_ENDOCYTIC_2	73	76	PF00928	0.591
TRG_ER_diArg_1	181	184	PF00400	0.713
TRG_ER_diArg_1	35	37	PF00400	0.564
TRG_NLS_MonoExtN_4	134	141	PF00514	0.681
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K3	Leptomonas seymouri	82%	100%
A0A1X0P2W0	Trypanosomatidae	46%	100%
A0A3S7X3X3	Leishmania donovani	96%	100%
A4HIR6	Leishmania braziliensis	94%	100%
A4I611	Leishmania infantum	96%	100%
C9ZRD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B1A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%