LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative serine/threonine phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine/threonine phosphatase
Gene product:
kinetoplastid-specific phospho-protein phosphatase, putative
Species:
Leishmania major
UniProt:
Q4Q6W1_LEIMA
TriTrypDb:
LmjF.30.3280 , LMJLV39_300041400 , LMJSD75_300040600
Length:
371

Annotations

LeishMANIAdb annotations

A metalloenzyme with the catalytic domain facing outwards. Related to plant Shewanella-like protein phosphatases. Kinetoplastids have multiple copies of these genes but probably from a very ancient gene duplication.. The cluster might merge two separate, very distantly related groups.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 7, no: 13
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16

Expansion

Sequence features

Q4Q6W1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6W1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 21
GO:0016787 hydrolase activity 2 21

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 152 154 PF00675 0.236
CLV_NRD_NRD_1 31 33 PF00675 0.218
CLV_PCSK_KEX2_1 31 33 PF00082 0.218
CLV_PCSK_KEX2_1 58 60 PF00082 0.211
CLV_PCSK_PC1ET2_1 58 60 PF00082 0.211
CLV_PCSK_PC7_1 54 60 PF00082 0.150
CLV_PCSK_SKI1_1 136 140 PF00082 0.236
CLV_PCSK_SKI1_1 154 158 PF00082 0.124
CLV_PCSK_SKI1_1 192 196 PF00082 0.397
CLV_PCSK_SKI1_1 224 228 PF00082 0.419
DOC_CYCLIN_RxL_1 189 198 PF00134 0.172
DOC_MAPK_gen_1 6 13 PF00069 0.421
DOC_MAPK_MEF2A_6 6 13 PF00069 0.399
DOC_USP7_UBL2_3 120 124 PF12436 0.393
DOC_USP7_UBL2_3 236 240 PF12436 0.239
DOC_WW_Pin1_4 197 202 PF00397 0.267
LIG_14-3-3_CanoR_1 224 230 PF00244 0.276
LIG_Clathr_ClatBox_1 270 274 PF01394 0.243
LIG_FHA_1 189 195 PF00498 0.357
LIG_FHA_1 295 301 PF00498 0.265
LIG_FHA_1 44 50 PF00498 0.440
LIG_FHA_1 51 57 PF00498 0.451
LIG_FHA_2 208 214 PF00498 0.295
LIG_Integrin_RGD_1 116 118 PF01839 0.285
LIG_LIR_Gen_1 330 339 PF02991 0.377
LIG_LIR_Nem_3 118 122 PF02991 0.422
LIG_LIR_Nem_3 239 245 PF02991 0.233
LIG_LIR_Nem_3 330 334 PF02991 0.368
LIG_LIR_Nem_3 365 371 PF02991 0.639
LIG_NRBOX 8 14 PF00104 0.275
LIG_SH2_CRK 347 351 PF00017 0.473
LIG_SH2_STAP1 43 47 PF00017 0.520
LIG_SH2_STAT5 149 152 PF00017 0.407
LIG_SH2_STAT5 327 330 PF00017 0.214
LIG_SH2_STAT5 347 350 PF00017 0.563
LIG_SH3_3 214 220 PF00018 0.209
LIG_SH3_3 251 257 PF00018 0.346
LIG_SUMO_SIM_anti_2 102 108 PF11976 0.446
LIG_SUMO_SIM_anti_2 332 338 PF11976 0.329
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.429
LIG_SUMO_SIM_anti_2 8 14 PF11976 0.296
LIG_SUMO_SIM_anti_2 81 87 PF11976 0.434
LIG_SUMO_SIM_par_1 219 225 PF11976 0.212
LIG_SUMO_SIM_par_1 269 274 PF11976 0.229
LIG_SUMO_SIM_par_1 32 38 PF11976 0.450
LIG_UBA3_1 176 182 PF00899 0.290
LIG_WRC_WIRS_1 328 333 PF05994 0.206
MOD_CDK_SPxxK_3 197 204 PF00069 0.349
MOD_CK1_1 141 147 PF00069 0.264
MOD_CK1_1 170 176 PF00069 0.256
MOD_CK1_1 188 194 PF00069 0.272
MOD_CK1_1 225 231 PF00069 0.362
MOD_CK1_1 306 312 PF00069 0.479
MOD_CK2_1 178 184 PF00069 0.221
MOD_GlcNHglycan 129 132 PF01048 0.328
MOD_GlcNHglycan 13 16 PF01048 0.439
MOD_GlcNHglycan 26 29 PF01048 0.522
MOD_GlcNHglycan 312 315 PF01048 0.628
MOD_GSK3_1 123 130 PF00069 0.263
MOD_GSK3_1 302 309 PF00069 0.567
MOD_GSK3_1 7 14 PF00069 0.573
MOD_N-GLC_1 141 146 PF02516 0.293
MOD_N-GLC_1 195 200 PF02516 0.292
MOD_NEK2_1 127 132 PF00069 0.284
MOD_NEK2_1 176 181 PF00069 0.316
MOD_NEK2_1 195 200 PF00069 0.237
MOD_NEK2_1 222 227 PF00069 0.312
MOD_NEK2_1 275 280 PF00069 0.301
MOD_NEK2_1 302 307 PF00069 0.407
MOD_NEK2_1 50 55 PF00069 0.319
MOD_PK_1 7 13 PF00069 0.301
MOD_PKA_2 50 56 PF00069 0.335
MOD_Plk_1 294 300 PF00069 0.358
MOD_Plk_1 43 49 PF00069 0.274
MOD_Plk_4 244 250 PF00069 0.224
MOD_Plk_4 307 313 PF00069 0.641
MOD_Plk_4 45 51 PF00069 0.271
MOD_Plk_4 7 13 PF00069 0.478
MOD_ProDKin_1 197 203 PF00069 0.325
MOD_SUMO_rev_2 235 243 PF00179 0.352
TRG_DiLeu_BaEn_1 29 34 PF01217 0.297
TRG_DiLeu_BaEn_1 65 70 PF01217 0.398
TRG_DiLeu_BaLyEn_6 266 271 PF01217 0.323
TRG_DiLeu_BaLyEn_6 356 361 PF01217 0.467
TRG_DiLeu_BaLyEn_6 51 56 PF01217 0.420
TRG_DiLeu_BaLyEn_6 84 89 PF01217 0.349
TRG_ENDOCYTIC_2 119 122 PF00928 0.286
TRG_ENDOCYTIC_2 159 162 PF00928 0.398
TRG_ENDOCYTIC_2 326 329 PF00928 0.401
TRG_ENDOCYTIC_2 368 371 PF00928 0.512
TRG_ER_diArg_1 150 153 PF00400 0.248
TRG_ER_diArg_1 31 33 PF00400 0.256
TRG_NES_CRM1_1 66 82 PF08389 0.376

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3V2 Leptomonas seymouri 75% 99%
A0A0N1P9R1 Leptomonas seymouri 26% 100%
A0A0S4JBT9 Bodo saltans 33% 95%
A0A0S4JMN0 Bodo saltans 29% 92%
A0A0S4KJG1 Bodo saltans 51% 100%
A0A1X0NU01 Trypanosomatidae 25% 99%
A0A1X0NZX7 Trypanosomatidae 29% 83%
A0A1X0P2G6 Trypanosomatidae 65% 100%
A0A3Q8IBB4 Leishmania donovani 27% 100%
A0A3Q8IIK0 Leishmania donovani 30% 98%
A0A3R7NTC0 Trypanosoma rangeli 64% 100%
A0A3S5IRW3 Trypanosoma rangeli 28% 90%
A0A3S7X3U9 Leishmania donovani 93% 100%
A4HCJ2 Leishmania braziliensis 28% 100%
A4HH45 Leishmania braziliensis 31% 98%
A4HIR7 Leishmania braziliensis 81% 88%
A4I008 Leishmania infantum 27% 100%
A4I498 Leishmania infantum 30% 98%
A4I612 Leishmania infantum 93% 100%
C9ZQ86 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 99%
C9ZRD7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 84%
E9ADP5 Leishmania major 31% 100%
E9AM35 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 98%
E9AVY1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B1A3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O74480 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
Q4QBJ8 Leishmania major 27% 100%
Q944L7 Arabidopsis thaliana 26% 95%
V5ARZ9 Trypanosoma cruzi 26% 99%
V5BPY7 Trypanosoma cruzi 30% 85%
V5BX32 Trypanosoma cruzi 64% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS