UV excision repair protein RAD23

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UV excision repair RAD23-like protein

Species:

Leishmania major

UniProt:

Q4Q6V9_LEIMA

TriTrypDb:

LmjF.30.3300 , LMJLV39_300041600 , LMJSD75_300040800

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	11
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	11
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q6V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6V9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006289	nucleotide-excision repair	6	12
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0030163	protein catabolic process	4	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	11
GO:0031593	polyubiquitin modification-dependent protein binding	4	11
GO:0032182	ubiquitin-like protein binding	3	11
GO:0043130	ubiquitin binding	4	11
GO:0044877	protein-containing complex binding	2	2
GO:0070628	proteasome binding	3	2
GO:0097159	organic cyclic compound binding	2	12
GO:0140030	modification-dependent protein binding	3	11
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	69	71	PF00675	0.241
CLV_PCSK_KEX2_1	27	29	PF00082	0.350
CLV_PCSK_KEX2_1	71	73	PF00082	0.222
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.350
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.222
CLV_PCSK_SKI1_1	186	190	PF00082	0.376
CLV_PCSK_SKI1_1	2	6	PF00082	0.232
CLV_PCSK_SKI1_1	258	262	PF00082	0.262
CLV_PCSK_SKI1_1	27	31	PF00082	0.263
DEG_APCC_DBOX_1	257	265	PF00400	0.262
DEG_Nend_UBRbox_1	1	4	PF02207	0.345
DEG_SPOP_SBC_1	110	114	PF00917	0.732
DEG_SPOP_SBC_1	137	141	PF00917	0.745
DEG_SPOP_SBC_1	153	157	PF00917	0.464
DEG_SPOP_SBC_1	97	101	PF00917	0.610
DOC_CDC14_PxL_1	160	168	PF14671	0.376
DOC_CYCLIN_yCln2_LP_2	290	296	PF00134	0.532
DOC_MAPK_MEF2A_6	178	185	PF00069	0.230
DOC_MAPK_MEF2A_6	301	309	PF00069	0.421
DOC_MAPK_NFAT4_5	178	186	PF00069	0.280
DOC_PP1_RVXF_1	38	44	PF00149	0.434
DOC_PP4_FxxP_1	214	217	PF00568	0.572
DOC_USP7_MATH_1	104	108	PF00917	0.426
DOC_USP7_MATH_1	116	120	PF00917	0.574
DOC_USP7_MATH_1	137	141	PF00917	0.622
DOC_USP7_MATH_1	152	156	PF00917	0.479
DOC_USP7_MATH_1	224	228	PF00917	0.569
DOC_USP7_MATH_1	229	233	PF00917	0.547
DOC_USP7_MATH_1	248	252	PF00917	0.401
DOC_USP7_MATH_1	322	326	PF00917	0.727
DOC_USP7_MATH_1	338	342	PF00917	0.685
DOC_USP7_MATH_1	92	96	PF00917	0.640
DOC_USP7_MATH_1	97	101	PF00917	0.660
DOC_USP7_UBL2_3	2	6	PF12436	0.322
DOC_WW_Pin1_4	112	117	PF00397	0.713
DOC_WW_Pin1_4	139	144	PF00397	0.677
DOC_WW_Pin1_4	240	245	PF00397	0.634
DOC_WW_Pin1_4	246	251	PF00397	0.565
DOC_WW_Pin1_4	82	87	PF00397	0.549
DOC_WW_Pin1_4	98	103	PF00397	0.654
LIG_BRCT_BRCA1_1	171	175	PF00533	0.357
LIG_BRCT_BRCA1_1	392	396	PF00533	0.424
LIG_FHA_1	157	163	PF00498	0.536
LIG_FHA_1	18	24	PF00498	0.445
LIG_FHA_1	276	282	PF00498	0.503
LIG_FHA_1	409	415	PF00498	0.562
LIG_FHA_2	20	26	PF00498	0.405
LIG_FHA_2	352	358	PF00498	0.523
LIG_LIR_Gen_1	304	310	PF02991	0.414
LIG_LIR_Nem_3	197	203	PF02991	0.486
LIG_LIR_Nem_3	304	309	PF02991	0.445
LIG_SH2_NCK_1	296	300	PF00017	0.516
LIG_SH2_NCK_1	34	38	PF00017	0.464
LIG_SH2_SRC	34	37	PF00017	0.503
LIG_SH2_STAT5	198	201	PF00017	0.432
LIG_SH2_STAT5	381	384	PF00017	0.428
LIG_SH3_1	72	78	PF00018	0.607
LIG_SH3_3	119	125	PF00018	0.672
LIG_SH3_3	140	146	PF00018	0.554
LIG_SH3_3	214	220	PF00018	0.614
LIG_SH3_3	72	78	PF00018	0.551
LIG_UBA3_1	4	11	PF00899	0.439
MOD_CK1_1	115	121	PF00069	0.598
MOD_CK1_1	227	233	PF00069	0.589
MOD_CK1_1	252	258	PF00069	0.509
MOD_CK1_1	308	314	PF00069	0.467
MOD_CK2_1	248	254	PF00069	0.663
MOD_CK2_1	346	352	PF00069	0.461
MOD_Cter_Amidation	68	71	PF01082	0.208
MOD_GlcNHglycan	106	109	PF01048	0.584
MOD_GlcNHglycan	118	121	PF01048	0.688
MOD_GlcNHglycan	214	217	PF01048	0.512
MOD_GlcNHglycan	229	232	PF01048	0.510
MOD_GlcNHglycan	240	243	PF01048	0.508
MOD_GlcNHglycan	251	254	PF01048	0.392
MOD_GlcNHglycan	312	315	PF01048	0.465
MOD_GlcNHglycan	319	322	PF01048	0.594
MOD_GlcNHglycan	324	327	PF01048	0.564
MOD_GlcNHglycan	348	351	PF01048	0.600
MOD_GlcNHglycan	373	378	PF01048	0.387
MOD_GlcNHglycan	93	97	PF01048	0.602
MOD_GSK3_1	111	118	PF00069	0.600
MOD_GSK3_1	152	159	PF00069	0.519
MOD_GSK3_1	248	255	PF00069	0.605
MOD_GSK3_1	322	329	PF00069	0.554
MOD_GSK3_1	92	99	PF00069	0.611
MOD_N-GLC_1	61	66	PF02516	0.207
MOD_NEK2_1	111	116	PF00069	0.684
MOD_NEK2_1	310	315	PF00069	0.420
MOD_NEK2_1	48	53	PF00069	0.464
MOD_PIKK_1	176	182	PF00454	0.167
MOD_PIKK_1	381	387	PF00454	0.398
MOD_PIKK_1	408	414	PF00454	0.476
MOD_Plk_1	176	182	PF00069	0.375
MOD_Plk_1	338	344	PF00069	0.466
MOD_Plk_1	356	362	PF00069	0.278
MOD_Plk_1	48	54	PF00069	0.526
MOD_Plk_1	61	67	PF00069	0.444
MOD_Plk_4	19	25	PF00069	0.503
MOD_Plk_4	305	311	PF00069	0.545
MOD_Plk_4	339	345	PF00069	0.516
MOD_Plk_4	390	396	PF00069	0.479
MOD_Plk_4	48	54	PF00069	0.476
MOD_Plk_4	61	67	PF00069	0.431
MOD_ProDKin_1	112	118	PF00069	0.715
MOD_ProDKin_1	139	145	PF00069	0.676
MOD_ProDKin_1	240	246	PF00069	0.636
MOD_ProDKin_1	82	88	PF00069	0.549
MOD_ProDKin_1	98	104	PF00069	0.653
MOD_SUMO_rev_2	21	29	PF00179	0.454
TRG_DiLeu_BaEn_2	338	344	PF01217	0.521
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.394
TRG_ENDOCYTIC_2	296	299	PF00928	0.487
TRG_NLS_MonoCore_2	69	74	PF00514	0.464
TRG_NLS_MonoExtC_3	70	75	PF00514	0.619
TRG_NLS_MonoExtN_4	70	75	PF00514	0.618
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	271	276	PF00026	0.222

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC65	Leptomonas seymouri	57%	97%
A0A0S4KFK0	Bodo saltans	35%	100%
A0A1X0P199	Trypanosomatidae	34%	100%
A0A3R7KQ25	Trypanosoma rangeli	34%	100%
A0A3S7X3W6	Leishmania donovani	91%	99%
A3KMV2	Bos taurus	27%	100%
A4HIR8	Leishmania braziliensis	76%	98%
A4I614	Leishmania infantum	90%	99%
C9ZRD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B1A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
O74803	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P32628	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P54725	Homo sapiens	27%	100%
P54726	Mus musculus	26%	100%
P54727	Homo sapiens	28%	100%
P54728	Mus musculus	27%	100%
Q29RK4	Bos taurus	26%	100%
Q40742	Oryza sativa subsp. japonica	29%	100%
Q4KMA2	Rattus norvegicus	27%	100%
Q84L30	Arabidopsis thaliana	29%	100%
Q84L31	Arabidopsis thaliana	27%	100%
Q84L32	Arabidopsis thaliana	25%	100%
Q84L33	Arabidopsis thaliana	28%	100%
V5B773	Trypanosoma cruzi	36%	100%