MORN repeat-containing protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat-containing protein 1

Species:

Leishmania major

UniProt:

Q4Q6V8_LEIMA

TriTrypDb:

LmjF.30.3310 , LMJLV39_300041900 , LMJSD75_300041100

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 38
NetGPI	no	yes: 0, no: 40

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005816	spindle pole body	3	1
GO:0036064	ciliary basal body	3	1
GO:0044732	mitotic spindle pole body	4	1

Expansion

Sequence features

Q4Q6V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6V8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0016192	vesicle-mediated transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.294
CLV_C14_Caspase3-7	333	337	PF00656	0.334
CLV_C14_Caspase3-7	42	46	PF00656	0.347
CLV_C14_Caspase3-7	88	92	PF00656	0.362
CLV_C14_Caspase3-7	98	102	PF00656	0.309
CLV_NRD_NRD_1	292	294	PF00675	0.370
CLV_PCSK_KEX2_1	126	128	PF00082	0.347
CLV_PCSK_KEX2_1	292	294	PF00082	0.329
CLV_PCSK_KEX2_1	34	36	PF00082	0.288
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.347
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.291
CLV_PCSK_SKI1_1	273	277	PF00082	0.480
CLV_PCSK_SKI1_1	321	325	PF00082	0.448
DEG_MDM2_SWIB_1	330	338	PF02201	0.201
DOC_ANK_TNKS_1	291	298	PF00023	0.398
DOC_MAPK_gen_1	315	324	PF00069	0.469
DOC_PP2B_LxvP_1	299	302	PF13499	0.294
DOC_USP7_MATH_1	138	142	PF00917	0.495
DOC_USP7_MATH_1	302	306	PF00917	0.331
DOC_USP7_MATH_1	44	48	PF00917	0.338
DOC_USP7_UBL2_3	126	130	PF12436	0.304
DOC_USP7_UBL2_3	177	181	PF12436	0.327
DOC_USP7_UBL2_3	57	61	PF12436	0.363
LIG_BRCT_BRCA1_1	142	146	PF00533	0.518
LIG_deltaCOP1_diTrp_1	75	78	PF00928	0.338
LIG_FHA_1	2	8	PF00498	0.462
LIG_FHA_1	225	231	PF00498	0.449
LIG_FHA_2	331	337	PF00498	0.313
LIG_FHA_2	40	46	PF00498	0.351
LIG_Integrin_isoDGR_2	82	84	PF01839	0.319
LIG_LIR_Apic_2	132	138	PF02991	0.342
LIG_LIR_Apic_2	183	187	PF02991	0.384
LIG_LIR_Nem_3	213	218	PF02991	0.342
LIG_LIR_Nem_3	75	81	PF02991	0.333
LIG_Pex14_1	158	162	PF04695	0.286
LIG_Pex14_2	146	150	PF04695	0.238
LIG_Pex14_2	330	334	PF04695	0.382
LIG_PTB_Phospho_1	352	358	PF10480	0.483
LIG_SH2_CRK	204	208	PF00017	0.314
LIG_SH2_GRB2like	112	115	PF00017	0.304
LIG_SH2_GRB2like	209	212	PF00017	0.332
LIG_SH2_GRB2like	255	258	PF00017	0.292
LIG_SH2_GRB2like	278	281	PF00017	0.304
LIG_SH2_PTP2	184	187	PF00017	0.336
LIG_SH2_SRC	163	166	PF00017	0.278
LIG_SH2_SRC	209	212	PF00017	0.305
LIG_SH2_SRC	278	281	PF00017	0.304
LIG_SH2_SRC	43	46	PF00017	0.315
LIG_SH2_SRC	89	92	PF00017	0.479
LIG_SH2_STAT5	184	187	PF00017	0.334
LIG_SH2_STAT5	209	212	PF00017	0.365
LIG_SH2_STAT5	232	235	PF00017	0.361
LIG_SH2_STAT5	238	241	PF00017	0.348
LIG_SH2_STAT5	3	6	PF00017	0.449
LIG_SH2_STAT5	346	349	PF00017	0.572
LIG_SH2_STAT5	41	44	PF00017	0.354
MOD_CK2_1	138	144	PF00069	0.451
MOD_CK2_1	302	308	PF00069	0.290
MOD_Cter_Amidation	244	247	PF01082	0.274
MOD_Cter_Amidation	313	316	PF01082	0.299
MOD_Cter_Amidation	32	35	PF01082	0.362
MOD_GlcNHglycan	268	271	PF01048	0.287
MOD_GlcNHglycan	67	70	PF01048	0.340
MOD_GlcNHglycan	72	75	PF01048	0.359
MOD_GSK3_1	224	231	PF00069	0.373
MOD_GSK3_1	249	256	PF00069	0.378
MOD_GSK3_1	70	77	PF00069	0.399
MOD_N-GLC_1	266	271	PF02516	0.317
MOD_N-GLC_2	280	282	PF02516	0.304
MOD_NEK2_1	253	258	PF00069	0.345
MOD_NEK2_1	330	335	PF00069	0.417
MOD_NEK2_2	60	65	PF00069	0.334
MOD_PKA_2	236	242	PF00069	0.444
MOD_PKA_2	249	255	PF00069	0.431
MOD_PKA_2	70	76	PF00069	0.449
MOD_PKA_2	83	89	PF00069	0.452
MOD_Plk_1	74	80	PF00069	0.363
MOD_Plk_2-3	303	309	PF00069	0.292
MOD_Plk_4	180	186	PF00069	0.343
MOD_Plk_4	205	211	PF00069	0.395
MOD_Plk_4	228	234	PF00069	0.291
MOD_SUMO_rev_2	170	178	PF00179	0.363
MOD_SUMO_rev_2	216	224	PF00179	0.418
MOD_SUMO_rev_2	50	58	PF00179	0.338
TRG_DiLeu_BaEn_1	296	301	PF01217	0.440
TRG_ENDOCYTIC_2	204	207	PF00928	0.314
TRG_ER_diArg_1	319	322	PF00400	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIK8	Leptomonas seymouri	94%	100%
A0A0N1PBP4	Leptomonas seymouri	28%	100%
A0A0S4J443	Bodo saltans	27%	81%
A0A0S4JES9	Bodo saltans	27%	71%
A0A0S4JF26	Bodo saltans	30%	100%
A0A0S4JFV2	Bodo saltans	30%	82%
A0A0S4KIY0	Bodo saltans	81%	100%
A0A0S4KKM9	Bodo saltans	28%	67%
A0A1X0NTG8	Trypanosomatidae	36%	82%
A0A1X0P1A5	Trypanosomatidae	78%	100%
A0A1X0P3N0	Trypanosomatidae	27%	100%
A0A3R7M394	Trypanosoma rangeli	25%	100%
A0A3R7NAK8	Trypanosoma rangeli	38%	87%
A0A3S7WVR3	Leishmania donovani	31%	81%
A0A3S7WXA1	Leishmania donovani	36%	68%
A0A3S7X3U7	Leishmania donovani	99%	100%
A0A3S7XBA2	Leishmania donovani	27%	100%
A0A422P0W0	Trypanosoma rangeli	78%	100%
A4H3Q9	Leishmania braziliensis	29%	100%
A4HCH7	Leishmania braziliensis	37%	86%
A4HIR9	Leishmania braziliensis	96%	100%
A4HPP6	Leishmania braziliensis	28%	100%
A4HYK3	Leishmania infantum	31%	81%
A4HZZ9	Leishmania infantum	36%	68%
A4I615	Leishmania infantum	99%	100%
A4ID18	Leishmania infantum	26%	100%
C9ZRE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
C9ZSQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	82%
D0A8G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AJY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ATG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	86%
E9B1A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q137	Leishmania major	26%	100%
Q4QBK7	Leishmania major	35%	86%
Q4QD31	Leishmania major	31%	81%
V5AUB0	Trypanosoma cruzi	30%	100%
V5B9Q7	Trypanosoma cruzi	29%	69%
V5BX28	Trypanosoma cruzi	76%	100%