Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6V6_LEIMA

TriTrypDb:

LmjF.30.3330 , LMJLV39_300042100 , LMJSD75_300041300

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6V6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.649
CLV_NRD_NRD_1	276	278	PF00675	0.538
CLV_NRD_NRD_1	282	284	PF00675	0.531
CLV_NRD_NRD_1	382	384	PF00675	0.623
CLV_NRD_NRD_1	385	387	PF00675	0.581
CLV_NRD_NRD_1	8	10	PF00675	0.683
CLV_PCSK_FUR_1	179	183	PF00082	0.515
CLV_PCSK_FUR_1	276	280	PF00082	0.538
CLV_PCSK_FUR_1	380	384	PF00082	0.643
CLV_PCSK_KEX2_1	128	130	PF00082	0.755
CLV_PCSK_KEX2_1	179	181	PF00082	0.703
CLV_PCSK_KEX2_1	202	204	PF00082	0.675
CLV_PCSK_KEX2_1	276	278	PF00082	0.538
CLV_PCSK_KEX2_1	282	284	PF00082	0.533
CLV_PCSK_KEX2_1	382	384	PF00082	0.623
CLV_PCSK_KEX2_1	385	387	PF00082	0.581
CLV_PCSK_KEX2_1	8	10	PF00082	0.656
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.715
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.683
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.484
CLV_PCSK_SKI1_1	3	7	PF00082	0.610
CLV_PCSK_SKI1_1	302	306	PF00082	0.748
CLV_PCSK_SKI1_1	386	390	PF00082	0.539
DEG_Nend_UBRbox_3	1	3	PF02207	0.674
DOC_CKS1_1	197	202	PF01111	0.704
DOC_PP1_RVXF_1	249	256	PF00149	0.618
DOC_PP2B_LxvP_1	305	308	PF13499	0.738
DOC_PP4_FxxP_1	357	360	PF00568	0.609
DOC_PP4_FxxP_1	65	68	PF00568	0.658
DOC_USP7_MATH_1	105	109	PF00917	0.729
DOC_USP7_MATH_1	132	136	PF00917	0.735
DOC_USP7_MATH_1	219	223	PF00917	0.714
DOC_USP7_MATH_1	230	234	PF00917	0.788
DOC_USP7_MATH_1	257	261	PF00917	0.667
DOC_USP7_MATH_1	66	70	PF00917	0.625
DOC_USP7_MATH_1	92	96	PF00917	0.708
DOC_USP7_UBL2_3	302	306	PF12436	0.743
DOC_WW_Pin1_4	196	201	PF00397	0.598
DOC_WW_Pin1_4	267	272	PF00397	0.567
DOC_WW_Pin1_4	338	343	PF00397	0.652
DOC_WW_Pin1_4	70	75	PF00397	0.726
LIG_14-3-3_CanoR_1	276	285	PF00244	0.590
LIG_14-3-3_CanoR_1	324	328	PF00244	0.702
LIG_14-3-3_CanoR_1	70	74	PF00244	0.674
LIG_14-3-3_CanoR_1	97	101	PF00244	0.617
LIG_14-3-3_CterR_2	385	390	PF00244	0.619
LIG_BRCT_BRCA1_1	259	263	PF00533	0.576
LIG_BRCT_BRCA1_1	353	357	PF00533	0.595
LIG_FHA_1	15	21	PF00498	0.650
LIG_FHA_1	43	49	PF00498	0.590
LIG_FHA_2	164	170	PF00498	0.673
LIG_FHA_2	360	366	PF00498	0.516
LIG_LIR_Apic_2	354	360	PF02991	0.558
LIG_LIR_Apic_2	63	68	PF02991	0.641
LIG_LIR_Gen_1	187	197	PF02991	0.610
LIG_LIR_Gen_1	53	64	PF02991	0.545
LIG_LIR_Nem_3	187	192	PF02991	0.599
LIG_LIR_Nem_3	53	59	PF02991	0.523
LIG_PCNA_yPIPBox_3	35	48	PF02747	0.501
LIG_PTB_Apo_2	372	379	PF02174	0.722
LIG_PTB_Phospho_1	372	378	PF10480	0.721
LIG_SH2_CRK	56	60	PF00017	0.525
LIG_SH2_STAT5	26	29	PF00017	0.552
LIG_SH2_STAT5	267	270	PF00017	0.562
LIG_SH2_STAT5	363	366	PF00017	0.575
LIG_SH3_3	167	173	PF00018	0.770
LIG_SH3_3	265	271	PF00018	0.611
LIG_SH3_3	341	347	PF00018	0.561
LIG_SH3_3	71	77	PF00018	0.702
LIG_SH3_5	374	378	PF00018	0.725
LIG_SUMO_SIM_anti_2	17	24	PF11976	0.562
LIG_TRFH_1	189	193	PF08558	0.527
LIG_TYR_ITIM	54	59	PF00017	0.519
MOD_CDC14_SPxK_1	270	273	PF00782	0.551
MOD_CDK_SPxK_1	196	202	PF00069	0.632
MOD_CDK_SPxK_1	267	273	PF00069	0.566
MOD_CDK_SPxxK_3	196	203	PF00069	0.673
MOD_CK1_1	114	120	PF00069	0.608
MOD_CK1_1	144	150	PF00069	0.747
MOD_CK1_1	288	294	PF00069	0.719
MOD_CK1_1	69	75	PF00069	0.587
MOD_CK1_1	84	90	PF00069	0.760
MOD_CK1_1	95	101	PF00069	0.628
MOD_CK2_1	114	120	PF00069	0.615
MOD_CK2_1	163	169	PF00069	0.758
MOD_CK2_1	219	225	PF00069	0.754
MOD_CK2_1	266	272	PF00069	0.631
MOD_Cter_Amidation	200	203	PF01082	0.732
MOD_GlcNHglycan	113	116	PF01048	0.687
MOD_GlcNHglycan	129	132	PF01048	0.663
MOD_GlcNHglycan	143	146	PF01048	0.722
MOD_GlcNHglycan	214	217	PF01048	0.736
MOD_GlcNHglycan	286	290	PF01048	0.664
MOD_GlcNHglycan	302	305	PF01048	0.682
MOD_GlcNHglycan	62	65	PF01048	0.650
MOD_GlcNHglycan	84	87	PF01048	0.580
MOD_GSK3_1	101	108	PF00069	0.732
MOD_GSK3_1	127	134	PF00069	0.650
MOD_GSK3_1	144	151	PF00069	0.793
MOD_GSK3_1	206	213	PF00069	0.782
MOD_GSK3_1	219	226	PF00069	0.722
MOD_GSK3_1	66	73	PF00069	0.691
MOD_GSK3_1	78	85	PF00069	0.582
MOD_GSK3_1	92	99	PF00069	0.685
MOD_LATS_1	384	390	PF00433	0.622
MOD_N-GLC_1	81	86	PF02516	0.754
MOD_NEK2_1	111	116	PF00069	0.712
MOD_NEK2_1	376	381	PF00069	0.643
MOD_NEK2_1	4	9	PF00069	0.670
MOD_NEK2_2	351	356	PF00069	0.594
MOD_PIKK_1	148	154	PF00454	0.790
MOD_PIKK_1	277	283	PF00454	0.590
MOD_PIKK_1	42	48	PF00454	0.526
MOD_PIKK_1	96	102	PF00454	0.721
MOD_PKA_1	211	217	PF00069	0.695
MOD_PKA_1	277	283	PF00069	0.415
MOD_PKA_2	323	329	PF00069	0.718
MOD_PKA_2	351	357	PF00069	0.610
MOD_PKA_2	69	75	PF00069	0.594
MOD_PKA_2	96	102	PF00069	0.641
MOD_Plk_2-3	359	365	PF00069	0.512
MOD_Plk_4	106	112	PF00069	0.712
MOD_ProDKin_1	196	202	PF00069	0.601
MOD_ProDKin_1	267	273	PF00069	0.566
MOD_ProDKin_1	338	344	PF00069	0.647
MOD_ProDKin_1	70	76	PF00069	0.722
MOD_SUMO_for_1	173	176	PF00179	0.770
MOD_SUMO_for_1	34	37	PF00179	0.610
MOD_SUMO_for_1	50	53	PF00179	0.408
MOD_SUMO_rev_2	120	130	PF00179	0.703
MOD_SUMO_rev_2	209	214	PF00179	0.708
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.702
TRG_ENDOCYTIC_2	189	192	PF00928	0.614
TRG_ENDOCYTIC_2	56	59	PF00928	0.518
TRG_ER_diArg_1	178	181	PF00400	0.687
TRG_ER_diArg_1	203	206	PF00400	0.684
TRG_ER_diArg_1	276	279	PF00400	0.622
TRG_ER_diArg_1	282	284	PF00400	0.616
TRG_ER_diArg_1	380	383	PF00400	0.616
TRG_ER_diArg_1	385	387	PF00400	0.579
TRG_NLS_MonoCore_2	201	206	PF00514	0.739
TRG_NLS_MonoExtN_4	200	206	PF00514	0.698
TRG_NLS_MonoExtN_4	276	281	PF00514	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU67	Leptomonas seymouri	46%	86%
A0A0S4JF36	Bodo saltans	25%	95%
A0A3Q8IFV3	Leishmania donovani	87%	100%
A4HIS1	Leishmania braziliensis	65%	100%
A4I617	Leishmania infantum	88%	100%
C9ZQY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	79%
E9B1A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BPG9	Trypanosoma cruzi	31%	71%