Putative calmodulin-related protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calmodulin-related protein, putative

Species:

Leishmania major

UniProt:

Q4Q6V3_LEIMA

TriTrypDb:

LmjF.30.3360 , LMJLV39_300042400 , LMJSD75_300041600

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q6V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6V3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.280
CLV_C14_Caspase3-7	338	342	PF00656	0.400
CLV_C14_Caspase3-7	400	404	PF00656	0.595
CLV_C14_Caspase3-7	440	444	PF00656	0.539
CLV_C14_Caspase3-7	9	13	PF00656	0.633
CLV_NRD_NRD_1	421	423	PF00675	0.638
CLV_NRD_NRD_1	500	502	PF00675	0.485
CLV_NRD_NRD_1	546	548	PF00675	0.666
CLV_NRD_NRD_1	698	700	PF00675	0.580
CLV_NRD_NRD_1	701	703	PF00675	0.593
CLV_PCSK_FUR_1	699	703	PF00082	0.539
CLV_PCSK_KEX2_1	421	423	PF00082	0.638
CLV_PCSK_KEX2_1	5	7	PF00082	0.625
CLV_PCSK_KEX2_1	546	548	PF00082	0.666
CLV_PCSK_KEX2_1	615	617	PF00082	0.566
CLV_PCSK_KEX2_1	635	637	PF00082	0.585
CLV_PCSK_KEX2_1	698	700	PF00082	0.580
CLV_PCSK_KEX2_1	701	703	PF00082	0.593
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.625
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.516
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.557
CLV_PCSK_SKI1_1	220	224	PF00082	0.566
CLV_PCSK_SKI1_1	231	235	PF00082	0.254
CLV_PCSK_SKI1_1	294	298	PF00082	0.464
CLV_PCSK_SKI1_1	332	336	PF00082	0.312
CLV_PCSK_SKI1_1	355	359	PF00082	0.474
CLV_PCSK_SKI1_1	709	713	PF00082	0.456
DEG_APCC_DBOX_1	293	301	PF00400	0.530
DEG_APCC_DBOX_1	349	357	PF00400	0.360
DEG_SCF_FBW7_1	622	627	PF00400	0.687
DOC_ANK_TNKS_1	398	405	PF00023	0.553
DOC_CYCLIN_RxL_1	355	363	PF00134	0.522
DOC_MAPK_gen_1	281	289	PF00069	0.286
DOC_MAPK_gen_1	546	554	PF00069	0.602
DOC_MAPK_gen_1	701	712	PF00069	0.491
DOC_MAPK_gen_1	83	91	PF00069	0.405
DOC_MAPK_MEF2A_6	170	177	PF00069	0.400
DOC_MAPK_MEF2A_6	298	307	PF00069	0.481
DOC_PP1_RVXF_1	356	362	PF00149	0.471
DOC_PP1_RVXF_1	707	713	PF00149	0.468
DOC_PP4_FxxP_1	497	500	PF00568	0.527
DOC_USP7_MATH_1	128	132	PF00917	0.312
DOC_USP7_MATH_1	257	261	PF00917	0.312
DOC_USP7_MATH_1	532	536	PF00917	0.648
DOC_USP7_MATH_1	548	552	PF00917	0.489
DOC_USP7_MATH_1	562	566	PF00917	0.512
DOC_USP7_MATH_1	571	575	PF00917	0.541
DOC_USP7_MATH_1	624	628	PF00917	0.637
DOC_WW_Pin1_4	560	565	PF00397	0.768
DOC_WW_Pin1_4	575	580	PF00397	0.708
DOC_WW_Pin1_4	582	587	PF00397	0.735
DOC_WW_Pin1_4	620	625	PF00397	0.731
DOC_WW_Pin1_4	689	694	PF00397	0.616
LIG_14-3-3_CanoR_1	120	126	PF00244	0.461
LIG_14-3-3_CanoR_1	220	229	PF00244	0.554
LIG_14-3-3_CanoR_1	391	395	PF00244	0.498
LIG_14-3-3_CanoR_1	422	431	PF00244	0.648
LIG_14-3-3_CanoR_1	437	446	PF00244	0.606
LIG_14-3-3_CanoR_1	539	548	PF00244	0.695
LIG_14-3-3_CanoR_1	549	553	PF00244	0.539
LIG_14-3-3_CanoR_1	636	641	PF00244	0.669
LIG_14-3-3_CanoR_1	705	712	PF00244	0.582
LIG_14-3-3_CanoR_1	88	98	PF00244	0.441
LIG_Actin_WH2_2	19	37	PF00022	0.446
LIG_AP2alpha_1	361	365	PF02296	0.403
LIG_APCC_ABBA_1	334	339	PF00400	0.400
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BIR_III_2	363	367	PF00653	0.547
LIG_BIR_III_4	256	260	PF00653	0.379
LIG_BRCT_BRCA1_1	44	48	PF00533	0.360
LIG_FHA_1	288	294	PF00498	0.391
LIG_FHA_1	376	382	PF00498	0.541
LIG_FHA_1	652	658	PF00498	0.449
LIG_FHA_1	90	96	PF00498	0.445
LIG_FHA_2	120	126	PF00498	0.454
LIG_FHA_2	136	142	PF00498	0.284
LIG_FHA_2	158	164	PF00498	0.288
LIG_FHA_2	205	211	PF00498	0.576
LIG_FHA_2	221	227	PF00498	0.397
LIG_FHA_2	260	266	PF00498	0.332
LIG_FHA_2	286	292	PF00498	0.284
LIG_FHA_2	438	444	PF00498	0.504
LIG_FHA_2	465	471	PF00498	0.475
LIG_KLC1_Yacidic_2	477	481	PF13176	0.450
LIG_LIR_Apic_2	155	159	PF02991	0.384
LIG_LIR_Apic_2	207	211	PF02991	0.612
LIG_LIR_Apic_2	608	614	PF02991	0.508
LIG_LIR_Apic_2	72	76	PF02991	0.417
LIG_LIR_Gen_1	131	137	PF02991	0.360
LIG_LIR_Gen_1	232	238	PF02991	0.295
LIG_LIR_Gen_1	242	252	PF02991	0.267
LIG_LIR_Gen_1	36	44	PF02991	0.284
LIG_LIR_Gen_1	714	723	PF02991	0.391
LIG_LIR_Nem_3	131	136	PF02991	0.284
LIG_LIR_Nem_3	160	164	PF02991	0.300
LIG_LIR_Nem_3	166	172	PF02991	0.270
LIG_LIR_Nem_3	232	237	PF02991	0.295
LIG_LIR_Nem_3	242	247	PF02991	0.267
LIG_LIR_Nem_3	248	254	PF02991	0.248
LIG_LIR_Nem_3	65	70	PF02991	0.425
LIG_LIR_Nem_3	662	666	PF02991	0.435
LIG_LIR_Nem_3	675	680	PF02991	0.499
LIG_LIR_Nem_3	697	703	PF02991	0.529
LIG_LIR_Nem_3	714	718	PF02991	0.373
LIG_MAD2	358	366	PF02301	0.490
LIG_PCNA_TLS_4	391	398	PF02747	0.393
LIG_PCNA_yPIPBox_3	281	293	PF02747	0.317
LIG_Pex14_2	292	296	PF04695	0.284
LIG_Pex14_2	361	365	PF04695	0.418
LIG_Pex14_2	397	401	PF04695	0.420
LIG_Pex14_2	711	715	PF04695	0.455
LIG_Pex14_2	94	98	PF04695	0.383
LIG_PTAP_UEV_1	563	568	PF05743	0.529
LIG_SH2_CRK	611	615	PF00017	0.527
LIG_SH2_SRC	208	211	PF00017	0.515
LIG_SH2_STAT5	156	159	PF00017	0.448
LIG_SH2_STAT5	208	211	PF00017	0.515
LIG_SH2_STAT5	251	254	PF00017	0.265
LIG_SH2_STAT5	479	482	PF00017	0.508
LIG_SH2_STAT5	671	674	PF00017	0.419
LIG_SH2_STAT5	73	76	PF00017	0.409
LIG_SH3_1	156	162	PF00018	0.312
LIG_SH3_2	564	569	PF14604	0.534
LIG_SH3_3	156	162	PF00018	0.321
LIG_SH3_3	399	405	PF00018	0.546
LIG_SH3_3	477	483	PF00018	0.570
LIG_SH3_3	556	562	PF00018	0.722
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.284
LIG_SUMO_SIM_par_1	186	192	PF11976	0.360
LIG_SUMO_SIM_par_1	636	642	PF11976	0.508
LIG_TRAF2_1	122	125	PF00917	0.462
LIG_TRAF2_1	196	199	PF00917	0.284
LIG_TRAF2_1	261	264	PF00917	0.215
LIG_TRAF2_1	27	30	PF00917	0.455
LIG_TRAF2_1	393	396	PF00917	0.498
LIG_TRAF2_1	50	53	PF00917	0.360
LIG_TRAF2_1	69	72	PF00917	0.300
LIG_TRFH_1	687	691	PF08558	0.553
LIG_WRC_WIRS_1	293	298	PF05994	0.490
LIG_WRC_WIRS_1	398	403	PF05994	0.560
LIG_WRC_WIRS_1	643	648	PF05994	0.527
MOD_CDK_SPK_2	575	580	PF00069	0.629
MOD_CK1_1	279	285	PF00069	0.312
MOD_CK1_1	375	381	PF00069	0.511
MOD_CK1_1	424	430	PF00069	0.697
MOD_CK1_1	439	445	PF00069	0.480
MOD_CK1_1	540	546	PF00069	0.751
MOD_CK1_1	565	571	PF00069	0.810
MOD_CK1_1	575	581	PF00069	0.689
MOD_CK1_1	599	605	PF00069	0.698
MOD_CK1_1	704	710	PF00069	0.596
MOD_CK2_1	119	125	PF00069	0.461
MOD_CK2_1	186	192	PF00069	0.321
MOD_CK2_1	193	199	PF00069	0.251
MOD_CK2_1	204	210	PF00069	0.402
MOD_CK2_1	220	226	PF00069	0.410
MOD_CK2_1	257	263	PF00069	0.421
MOD_CK2_1	390	396	PF00069	0.504
MOD_CK2_1	464	470	PF00069	0.484
MOD_CK2_1	47	53	PF00069	0.400
MOD_CK2_1	552	558	PF00069	0.653
MOD_CK2_1	636	642	PF00069	0.544
MOD_CK2_1	689	695	PF00069	0.508
MOD_CK2_1	87	93	PF00069	0.386
MOD_GlcNHglycan	123	129	PF01048	0.569
MOD_GlcNHglycan	178	181	PF01048	0.284
MOD_GlcNHglycan	259	262	PF01048	0.370
MOD_GlcNHglycan	283	286	PF01048	0.400
MOD_GlcNHglycan	326	329	PF01048	0.492
MOD_GlcNHglycan	472	475	PF01048	0.428
MOD_GlcNHglycan	508	511	PF01048	0.613
MOD_GlcNHglycan	527	530	PF01048	0.531
MOD_GlcNHglycan	534	537	PF01048	0.694
MOD_GlcNHglycan	554	557	PF01048	0.477
MOD_GlcNHglycan	564	567	PF01048	0.734
MOD_GSK3_1	124	131	PF00069	0.596
MOD_GSK3_1	18	25	PF00069	0.501
MOD_GSK3_1	259	266	PF00069	0.328
MOD_GSK3_1	275	282	PF00069	0.264
MOD_GSK3_1	371	378	PF00069	0.489
MOD_GSK3_1	537	544	PF00069	0.689
MOD_GSK3_1	548	555	PF00069	0.663
MOD_GSK3_1	567	574	PF00069	0.629
MOD_GSK3_1	596	603	PF00069	0.677
MOD_GSK3_1	620	627	PF00069	0.679
MOD_GSK3_1	647	654	PF00069	0.518
MOD_N-GLC_2	111	113	PF02516	0.495
MOD_NEK2_1	1	6	PF00069	0.618
MOD_NEK2_1	193	198	PF00069	0.289
MOD_NEK2_1	292	297	PF00069	0.589
MOD_NEK2_1	34	39	PF00069	0.360
MOD_NEK2_1	372	377	PF00069	0.492
MOD_NEK2_1	397	402	PF00069	0.536
MOD_NEK2_1	431	436	PF00069	0.709
MOD_NEK2_1	506	511	PF00069	0.506
MOD_NEK2_1	525	530	PF00069	0.631
MOD_NEK2_1	538	543	PF00069	0.731
MOD_NEK2_1	573	578	PF00069	0.624
MOD_NEK2_1	591	596	PF00069	0.591
MOD_NEK2_1	607	612	PF00069	0.583
MOD_PIKK_1	209	215	PF00454	0.570
MOD_PIKK_1	263	269	PF00454	0.288
MOD_PIKK_1	573	579	PF00454	0.692
MOD_PIKK_1	596	602	PF00454	0.673
MOD_PK_1	415	421	PF00069	0.586
MOD_PK_1	636	642	PF00069	0.510
MOD_PKA_1	421	427	PF00069	0.638
MOD_PKA_1	701	707	PF00069	0.495
MOD_PKA_2	119	125	PF00069	0.461
MOD_PKA_2	276	282	PF00069	0.312
MOD_PKA_2	34	40	PF00069	0.434
MOD_PKA_2	390	396	PF00069	0.517
MOD_PKA_2	42	48	PF00069	0.359
MOD_PKA_2	421	427	PF00069	0.638
MOD_PKA_2	436	442	PF00069	0.652
MOD_PKA_2	525	531	PF00069	0.668
MOD_PKA_2	538	544	PF00069	0.628
MOD_PKA_2	548	554	PF00069	0.574
MOD_PKA_2	673	679	PF00069	0.558
MOD_PKA_2	701	707	PF00069	0.563
MOD_PKA_2	87	93	PF00069	0.446
MOD_PKB_1	699	707	PF00069	0.489
MOD_Plk_1	124	130	PF00069	0.564
MOD_Plk_1	225	231	PF00069	0.400
MOD_Plk_1	263	269	PF00069	0.284
MOD_Plk_1	648	654	PF00069	0.482
MOD_Plk_2-3	339	345	PF00069	0.400
MOD_Plk_2-3	87	93	PF00069	0.481
MOD_Plk_4	171	177	PF00069	0.400
MOD_Plk_4	18	24	PF00069	0.526
MOD_Plk_4	204	210	PF00069	0.607
MOD_Plk_4	212	218	PF00069	0.662
MOD_Plk_4	225	231	PF00069	0.321
MOD_Plk_4	34	40	PF00069	0.398
MOD_Plk_4	372	378	PF00069	0.406
MOD_Plk_4	548	554	PF00069	0.616
MOD_Plk_4	624	630	PF00069	0.657
MOD_Plk_4	648	654	PF00069	0.553
MOD_ProDKin_1	560	566	PF00069	0.768
MOD_ProDKin_1	575	581	PF00069	0.709
MOD_ProDKin_1	582	588	PF00069	0.734
MOD_ProDKin_1	620	626	PF00069	0.732
MOD_ProDKin_1	689	695	PF00069	0.611
TRG_DiLeu_BaEn_1	248	253	PF01217	0.215
TRG_DiLeu_BaEn_1	329	334	PF01217	0.500
TRG_DiLeu_BaEn_1	714	719	PF01217	0.485
TRG_DiLeu_BaEn_4	124	130	PF01217	0.448
TRG_DiLeu_BaEn_4	29	35	PF01217	0.417
TRG_ENDOCYTIC_2	251	254	PF00928	0.288
TRG_ENDOCYTIC_2	663	666	PF00928	0.573
TRG_ENDOCYTIC_2	681	684	PF00928	0.364
TRG_ENDOCYTIC_2	703	706	PF00928	0.585
TRG_ER_diArg_1	313	316	PF00400	0.518
TRG_ER_diArg_1	420	422	PF00400	0.606
TRG_ER_diArg_1	546	549	PF00400	0.660
TRG_ER_diArg_1	698	700	PF00400	0.552
TRG_ER_diArg_1	701	703	PF00400	0.560
TRG_ER_diArg_1	722	725	PF00400	0.471
TRG_NES_CRM1_1	267	280	PF08389	0.400
TRG_NES_CRM1_1	469	482	PF08389	0.501
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.582
TRG_PTS1	722	725	PF00515	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB40	Leptomonas seymouri	56%	100%
A0A1X0P1B1	Trypanosomatidae	41%	100%
A0A3R7R5F4	Trypanosoma rangeli	40%	100%
A0A3S7X3V3	Leishmania donovani	95%	100%
A4HIS4	Leishmania braziliensis	72%	100%
A4I620	Leishmania infantum	95%	100%
E9B1B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BMR3	Trypanosoma cruzi	40%	100%