C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6V2_LEIMA

TriTrypDb:

LmjF.30.3370 , LMJLV39_300042500 , LMJSD75_300041700

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6V2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.681
CLV_C14_Caspase3-7	585	589	PF00656	0.566
CLV_C14_Caspase3-7	66	70	PF00656	0.675
CLV_NRD_NRD_1	143	145	PF00675	0.694
CLV_NRD_NRD_1	293	295	PF00675	0.705
CLV_PCSK_KEX2_1	143	145	PF00082	0.694
CLV_PCSK_KEX2_1	194	196	PF00082	0.714
CLV_PCSK_KEX2_1	293	295	PF00082	0.705
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.714
CLV_PCSK_SKI1_1	287	291	PF00082	0.670
CLV_PCSK_SKI1_1	350	354	PF00082	0.788
CLV_PCSK_SKI1_1	366	370	PF00082	0.753
CLV_PCSK_SKI1_1	591	595	PF00082	0.596
DEG_SCF_FBW7_1	521	527	PF00400	0.534
DEG_SPOP_SBC_1	101	105	PF00917	0.633
DEG_SPOP_SBC_1	130	134	PF00917	0.617
DEG_SPOP_SBC_1	42	46	PF00917	0.767
DEG_SPOP_SBC_1	494	498	PF00917	0.657
DEG_SPOP_SBC_1	64	68	PF00917	0.667
DOC_CKS1_1	521	526	PF01111	0.558
DOC_CKS1_1	571	576	PF01111	0.608
DOC_MAPK_DCC_7	144	154	PF00069	0.701
DOC_PP1_RVXF_1	239	246	PF00149	0.669
DOC_PP1_RVXF_1	285	291	PF00149	0.634
DOC_PP2B_LxvP_1	152	155	PF13499	0.700
DOC_USP7_MATH_1	101	105	PF00917	0.677
DOC_USP7_MATH_1	110	114	PF00917	0.611
DOC_USP7_MATH_1	215	219	PF00917	0.658
DOC_USP7_MATH_1	259	263	PF00917	0.670
DOC_USP7_MATH_1	276	280	PF00917	0.561
DOC_USP7_MATH_1	329	333	PF00917	0.665
DOC_USP7_MATH_1	345	349	PF00917	0.600
DOC_USP7_MATH_1	352	356	PF00917	0.651
DOC_USP7_MATH_1	41	45	PF00917	0.624
DOC_USP7_MATH_1	48	52	PF00917	0.594
DOC_USP7_MATH_1	495	499	PF00917	0.664
DOC_USP7_MATH_1	526	530	PF00917	0.574
DOC_USP7_MATH_1	582	586	PF00917	0.666
DOC_USP7_MATH_1	62	66	PF00917	0.778
DOC_USP7_MATH_1	75	79	PF00917	0.574
DOC_WW_Pin1_4	122	127	PF00397	0.617
DOC_WW_Pin1_4	147	152	PF00397	0.704
DOC_WW_Pin1_4	180	185	PF00397	0.682
DOC_WW_Pin1_4	274	279	PF00397	0.612
DOC_WW_Pin1_4	295	300	PF00397	0.747
DOC_WW_Pin1_4	301	306	PF00397	0.773
DOC_WW_Pin1_4	327	332	PF00397	0.638
DOC_WW_Pin1_4	338	343	PF00397	0.669
DOC_WW_Pin1_4	397	402	PF00397	0.802
DOC_WW_Pin1_4	46	51	PF00397	0.547
DOC_WW_Pin1_4	496	501	PF00397	0.693
DOC_WW_Pin1_4	520	525	PF00397	0.638
DOC_WW_Pin1_4	529	534	PF00397	0.607
DOC_WW_Pin1_4	570	575	PF00397	0.596
DOC_WW_Pin1_4	615	620	PF00397	0.615
DOC_WW_Pin1_4	73	78	PF00397	0.661
LIG_14-3-3_CanoR_1	143	151	PF00244	0.647
LIG_14-3-3_CanoR_1	227	236	PF00244	0.673
LIG_14-3-3_CanoR_1	241	246	PF00244	0.603
LIG_14-3-3_CanoR_1	268	274	PF00244	0.715
LIG_14-3-3_CanoR_1	312	320	PF00244	0.635
LIG_14-3-3_CanoR_1	350	358	PF00244	0.586
LIG_14-3-3_CanoR_1	40	50	PF00244	0.638
LIG_14-3-3_CanoR_1	407	417	PF00244	0.674
LIG_14-3-3_CanoR_1	493	501	PF00244	0.706
LIG_14-3-3_CanoR_1	544	550	PF00244	0.642
LIG_14-3-3_CanoR_1	9	19	PF00244	0.543
LIG_BIR_III_4	25	29	PF00653	0.535
LIG_BRCT_BRCA1_1	124	128	PF00533	0.525
LIG_BRCT_BRCA1_1	51	55	PF00533	0.546
LIG_FHA_1	109	115	PF00498	0.703
LIG_FHA_1	125	131	PF00498	0.615
LIG_FHA_1	375	381	PF00498	0.625
LIG_FHA_1	530	536	PF00498	0.646
LIG_FHA_1	544	550	PF00498	0.490
LIG_FHA_1	598	604	PF00498	0.551
LIG_FHA_1	610	616	PF00498	0.533
LIG_FHA_1	66	72	PF00498	0.674
LIG_FHA_2	290	296	PF00498	0.665
LIG_FHA_2	369	375	PF00498	0.706
LIG_GBD_Chelix_1	206	214	PF00786	0.785
LIG_LIR_Apic_2	568	574	PF02991	0.630
LIG_LIR_Gen_1	546	555	PF02991	0.602
LIG_LIR_Gen_1	598	609	PF02991	0.607
LIG_LIR_Nem_3	546	550	PF02991	0.633
LIG_LIR_Nem_3	598	604	PF02991	0.594
LIG_PAM2_1	86	98	PF00658	0.670
LIG_Pex14_2	55	59	PF04695	0.550
LIG_PTAP_UEV_1	330	335	PF05743	0.597
LIG_SH2_CRK	197	201	PF00017	0.702
LIG_SH2_CRK	547	551	PF00017	0.642
LIG_SH2_CRK	571	575	PF00017	0.646
LIG_SH2_NCK_1	515	519	PF00017	0.670
LIG_SH2_NCK_1	571	575	PF00017	0.581
LIG_SH2_SRC	197	200	PF00017	0.596
LIG_SH2_STAP1	515	519	PF00017	0.703
LIG_SH2_STAT5	30	33	PF00017	0.590
LIG_SH2_STAT5	313	316	PF00017	0.645
LIG_SH2_STAT5	515	518	PF00017	0.668
LIG_SH2_STAT5	547	550	PF00017	0.656
LIG_SH3_1	179	185	PF00018	0.641
LIG_SH3_1	197	203	PF00018	0.656
LIG_SH3_1	415	421	PF00018	0.656
LIG_SH3_3	14	20	PF00018	0.633
LIG_SH3_3	179	185	PF00018	0.701
LIG_SH3_3	197	203	PF00018	0.656
LIG_SH3_3	230	236	PF00018	0.730
LIG_SH3_3	328	334	PF00018	0.658
LIG_SH3_3	395	401	PF00018	0.735
LIG_SH3_3	413	419	PF00018	0.662
LIG_SH3_3	473	479	PF00018	0.583
LIG_SH3_3	518	524	PF00018	0.629
LIG_SH3_CIN85_PxpxPR_1	199	204	PF14604	0.583
LIG_SUMO_SIM_par_1	532	538	PF11976	0.626
LIG_SUMO_SIM_par_1	591	598	PF11976	0.559
LIG_TRAF2_1	437	440	PF00917	0.454
LIG_WRC_WIRS_1	260	265	PF05994	0.683
LIG_WRC_WIRS_1	559	564	PF05994	0.624
LIG_WW_1	310	313	PF00397	0.545
LIG_WW_1	401	404	PF00397	0.627
LIG_WW_3	309	313	PF00397	0.552
MOD_CDK_SPxxK_3	46	53	PF00069	0.553
MOD_CK1_1	100	106	PF00069	0.649
MOD_CK1_1	113	119	PF00069	0.630
MOD_CK1_1	131	137	PF00069	0.671
MOD_CK1_1	174	180	PF00069	0.659
MOD_CK1_1	218	224	PF00069	0.706
MOD_CK1_1	249	255	PF00069	0.690
MOD_CK1_1	280	286	PF00069	0.679
MOD_CK1_1	332	338	PF00069	0.697
MOD_CK1_1	348	354	PF00069	0.597
MOD_CK1_1	411	417	PF00069	0.694
MOD_CK1_1	44	50	PF00069	0.564
MOD_CK1_1	51	57	PF00069	0.592
MOD_CK1_1	522	528	PF00069	0.571
MOD_CK1_1	529	535	PF00069	0.541
MOD_CK1_1	561	567	PF00069	0.654
MOD_CK1_1	65	71	PF00069	0.775
MOD_CK1_1	76	82	PF00069	0.653
MOD_CK2_1	368	374	PF00069	0.742
MOD_GlcNHglycan	105	108	PF01048	0.519
MOD_GlcNHglycan	138	141	PF01048	0.804
MOD_GlcNHglycan	210	213	PF01048	0.708
MOD_GlcNHglycan	219	223	PF01048	0.631
MOD_GlcNHglycan	229	232	PF01048	0.547
MOD_GlcNHglycan	25	29	PF01048	0.664
MOD_GlcNHglycan	251	254	PF01048	0.687
MOD_GlcNHglycan	274	277	PF01048	0.640
MOD_GlcNHglycan	279	282	PF01048	0.607
MOD_GlcNHglycan	32	35	PF01048	0.646
MOD_GlcNHglycan	331	334	PF01048	0.621
MOD_GlcNHglycan	350	353	PF01048	0.612
MOD_GlcNHglycan	387	390	PF01048	0.646
MOD_GlcNHglycan	392	395	PF01048	0.609
MOD_GlcNHglycan	410	413	PF01048	0.653
MOD_GlcNHglycan	528	531	PF01048	0.565
MOD_GlcNHglycan	540	543	PF01048	0.547
MOD_GlcNHglycan	88	91	PF01048	0.721
MOD_GlcNHglycan	99	102	PF01048	0.629
MOD_GSK3_1	106	113	PF00069	0.630
MOD_GSK3_1	124	131	PF00069	0.687
MOD_GSK3_1	154	161	PF00069	0.675
MOD_GSK3_1	167	174	PF00069	0.580
MOD_GSK3_1	223	230	PF00069	0.680
MOD_GSK3_1	239	246	PF00069	0.625
MOD_GSK3_1	249	256	PF00069	0.636
MOD_GSK3_1	268	275	PF00069	0.562
MOD_GSK3_1	276	283	PF00069	0.627
MOD_GSK3_1	316	323	PF00069	0.652
MOD_GSK3_1	332	339	PF00069	0.602
MOD_GSK3_1	346	353	PF00069	0.593
MOD_GSK3_1	403	410	PF00069	0.680
MOD_GSK3_1	42	49	PF00069	0.702
MOD_GSK3_1	489	496	PF00069	0.584
MOD_GSK3_1	520	527	PF00069	0.595
MOD_GSK3_1	534	541	PF00069	0.559
MOD_GSK3_1	545	552	PF00069	0.520
MOD_GSK3_1	554	561	PF00069	0.572
MOD_GSK3_1	60	67	PF00069	0.670
MOD_GSK3_1	605	612	PF00069	0.564
MOD_GSK3_1	69	76	PF00069	0.560
MOD_GSK3_1	80	87	PF00069	0.559
MOD_GSK3_1	97	104	PF00069	0.683
MOD_N-GLC_1	215	220	PF02516	0.705
MOD_N-GLC_1	249	254	PF02516	0.648
MOD_NEK2_1	128	133	PF00069	0.618
MOD_NEK2_1	142	147	PF00069	0.696
MOD_NEK2_1	245	250	PF00069	0.850
MOD_NEK2_1	320	325	PF00069	0.651
MOD_NEK2_1	488	493	PF00069	0.701
MOD_NEK2_1	513	518	PF00069	0.663
MOD_NEK2_1	549	554	PF00069	0.667
MOD_NEK2_1	609	614	PF00069	0.620
MOD_NEK2_2	259	264	PF00069	0.643
MOD_NEK2_2	482	487	PF00069	0.583
MOD_PIKK_1	154	160	PF00454	0.687
MOD_PIKK_1	167	173	PF00454	0.626
MOD_PIKK_1	174	180	PF00454	0.645
MOD_PIKK_1	243	249	PF00454	0.666
MOD_PIKK_1	280	286	PF00454	0.754
MOD_PIKK_1	352	358	PF00454	0.672
MOD_PIKK_1	383	389	PF00454	0.579
MOD_PIKK_1	420	426	PF00454	0.629
MOD_PIKK_1	554	560	PF00454	0.657
MOD_PIKK_1	576	582	PF00454	0.644
MOD_PKA_2	142	148	PF00069	0.805
MOD_PKA_2	158	164	PF00069	0.618
MOD_PKA_2	226	232	PF00069	0.720
MOD_PKA_2	267	273	PF00069	0.650
MOD_PKA_2	311	317	PF00069	0.627
MOD_PKA_2	543	549	PF00069	0.601
MOD_Plk_4	259	265	PF00069	0.645
MOD_Plk_4	482	488	PF00069	0.707
MOD_Plk_4	545	551	PF00069	0.640
MOD_Plk_4	565	571	PF00069	0.564
MOD_Plk_4	617	623	PF00069	0.557
MOD_ProDKin_1	122	128	PF00069	0.619
MOD_ProDKin_1	147	153	PF00069	0.702
MOD_ProDKin_1	180	186	PF00069	0.685
MOD_ProDKin_1	274	280	PF00069	0.613
MOD_ProDKin_1	295	301	PF00069	0.750
MOD_ProDKin_1	327	333	PF00069	0.640
MOD_ProDKin_1	338	344	PF00069	0.668
MOD_ProDKin_1	397	403	PF00069	0.804
MOD_ProDKin_1	46	52	PF00069	0.550
MOD_ProDKin_1	496	502	PF00069	0.695
MOD_ProDKin_1	520	526	PF00069	0.637
MOD_ProDKin_1	529	535	PF00069	0.603
MOD_ProDKin_1	570	576	PF00069	0.602
MOD_ProDKin_1	615	621	PF00069	0.614
MOD_ProDKin_1	73	79	PF00069	0.660
TRG_DiLeu_BaLyEn_6	588	593	PF01217	0.565
TRG_ENDOCYTIC_2	547	550	PF00928	0.641
TRG_ER_diArg_1	142	144	PF00400	0.645
TRG_ER_diArg_1	363	366	PF00400	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEI9	Leishmania donovani	85%	100%
A4HIS5	Leishmania braziliensis	67%	100%
A4I621	Leishmania infantum	85%	100%
E9B1B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%