Putative CAS/CSE/importin domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CAS/CSE/importin domain protein, putative

Species:

Leishmania major

UniProt:

Q4Q6V0_LEIMA

TriTrypDb:

LmjF.30.3390 , LMJLV39_300042700 , LMJSD75_300041900

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005643	nuclear pore	3	2
GO:0005829	cytosol	2	2
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	3
GO:0140513	nuclear protein-containing complex	2	2
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q6V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6V0

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	2
GO:0006611	protein export from nucleus	5	2
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006913	nucleocytoplasmic transport	5	2
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	2
GO:0034504	protein localization to nucleus	6	2
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051170	import into nucleus	6	2
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	2

Molecular functions
Term	Name	Level	Count
GO:0005049	nuclear export signal receptor activity	3	2
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0019899	enzyme binding	3	12
GO:0031267	small GTPase binding	5	12
GO:0051020	GTPase binding	4	12
GO:0140104	molecular carrier activity	1	2
GO:0140142	nucleocytoplasmic carrier activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.527
CLV_NRD_NRD_1	386	388	PF00675	0.265
CLV_NRD_NRD_1	806	808	PF00675	0.267
CLV_NRD_NRD_1	844	846	PF00675	0.247
CLV_PCSK_KEX2_1	385	387	PF00082	0.257
CLV_PCSK_KEX2_1	806	808	PF00082	0.267
CLV_PCSK_SKI1_1	141	145	PF00082	0.439
CLV_PCSK_SKI1_1	153	157	PF00082	0.296
CLV_PCSK_SKI1_1	214	218	PF00082	0.271
CLV_PCSK_SKI1_1	224	228	PF00082	0.220
CLV_PCSK_SKI1_1	35	39	PF00082	0.551
CLV_PCSK_SKI1_1	394	398	PF00082	0.339
CLV_PCSK_SKI1_1	405	409	PF00082	0.339
CLV_PCSK_SKI1_1	447	451	PF00082	0.271
CLV_PCSK_SKI1_1	531	535	PF00082	0.342
CLV_Separin_Metazoa	391	395	PF03568	0.486
DEG_APCC_DBOX_1	339	347	PF00400	0.549
DEG_APCC_DBOX_1	34	42	PF00400	0.468
DEG_APCC_DBOX_1	393	401	PF00400	0.501
DEG_APCC_DBOX_1	404	412	PF00400	0.420
DEG_Nend_UBRbox_3	1	3	PF02207	0.671
DEG_SCF_FBW7_1	890	897	PF00400	0.398
DEG_SPOP_SBC_1	155	159	PF00917	0.406
DOC_CDC14_PxL_1	349	357	PF14671	0.501
DOC_CKS1_1	29	34	PF01111	0.452
DOC_CKS1_1	600	605	PF01111	0.501
DOC_CKS1_1	968	973	PF01111	0.523
DOC_CYCLIN_RxL_1	30	42	PF00134	0.469
DOC_CYCLIN_RxL_1	391	402	PF00134	0.489
DOC_CYCLIN_RxL_1	790	800	PF00134	0.596
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	588	594	PF00134	0.398
DOC_CYCLIN_yCln2_LP_2	761	767	PF00134	0.501
DOC_MAPK_DCC_7	705	714	PF00069	0.501
DOC_MAPK_FxFP_2	583	586	PF00069	0.549
DOC_MAPK_gen_1	340	349	PF00069	0.501
DOC_MAPK_gen_1	385	392	PF00069	0.548
DOC_MAPK_gen_1	424	432	PF00069	0.458
DOC_MAPK_gen_1	790	799	PF00069	0.486
DOC_MAPK_gen_1	845	852	PF00069	0.447
DOC_MAPK_MEF2A_6	238	245	PF00069	0.467
DOC_MAPK_MEF2A_6	426	434	PF00069	0.478
DOC_MAPK_MEF2A_6	790	799	PF00069	0.485
DOC_MAPK_RevD_3	792	807	PF00069	0.467
DOC_PP2B_LxvP_1	398	401	PF13499	0.501
DOC_PP2B_LxvP_1	588	591	PF13499	0.501
DOC_PP4_FxxP_1	506	509	PF00568	0.501
DOC_PP4_FxxP_1	583	586	PF00568	0.541
DOC_USP7_MATH_1	241	245	PF00917	0.467
DOC_USP7_MATH_1	262	266	PF00917	0.486
DOC_USP7_MATH_1	82	86	PF00917	0.627
DOC_USP7_MATH_1	861	865	PF00917	0.535
DOC_USP7_MATH_1	894	898	PF00917	0.542
DOC_USP7_UBL2_3	73	77	PF12436	0.379
DOC_WW_Pin1_4	21	26	PF00397	0.475
DOC_WW_Pin1_4	28	33	PF00397	0.412
DOC_WW_Pin1_4	477	482	PF00397	0.460
DOC_WW_Pin1_4	59	64	PF00397	0.481
DOC_WW_Pin1_4	599	604	PF00397	0.591
DOC_WW_Pin1_4	785	790	PF00397	0.486
DOC_WW_Pin1_4	890	895	PF00397	0.458
DOC_WW_Pin1_4	925	930	PF00397	0.398
DOC_WW_Pin1_4	967	972	PF00397	0.621
LIG_14-3-3_CanoR_1	153	163	PF00244	0.492
LIG_14-3-3_CanoR_1	181	187	PF00244	0.490
LIG_14-3-3_CanoR_1	252	256	PF00244	0.467
LIG_14-3-3_CanoR_1	447	454	PF00244	0.471
LIG_14-3-3_CanoR_1	563	573	PF00244	0.398
LIG_14-3-3_CanoR_1	782	792	PF00244	0.471
LIG_14-3-3_CanoR_1	845	852	PF00244	0.475
LIG_14-3-3_CanoR_1	9	16	PF00244	0.477
LIG_Actin_WH2_2	209	226	PF00022	0.501
LIG_Actin_WH2_2	94	109	PF00022	0.426
LIG_APCC_ABBA_1	768	773	PF00400	0.549
LIG_BRCT_BRCA1_1	579	583	PF00533	0.567
LIG_CSL_BTD_1	831	834	PF09270	0.458
LIG_CSL_BTD_1	972	975	PF09270	0.393
LIG_eIF4E_1	431	437	PF01652	0.501
LIG_eIF4E_1	573	579	PF01652	0.458
LIG_FHA_1	171	177	PF00498	0.408
LIG_FHA_1	215	221	PF00498	0.458
LIG_FHA_1	277	283	PF00498	0.466
LIG_FHA_1	410	416	PF00498	0.502
LIG_FHA_1	510	516	PF00498	0.489
LIG_FHA_1	755	761	PF00498	0.447
LIG_FHA_1	838	844	PF00498	0.477
LIG_FHA_1	845	851	PF00498	0.464
LIG_FHA_2	225	231	PF00498	0.451
LIG_FHA_2	29	35	PF00498	0.583
LIG_FHA_2	500	506	PF00498	0.467
LIG_FHA_2	56	62	PF00498	0.467
LIG_FHA_2	98	104	PF00498	0.450
LIG_GBD_Chelix_1	392	400	PF00786	0.349
LIG_HP1_1	241	245	PF01393	0.467
LIG_IBAR_NPY_1	571	573	PF08397	0.549
LIG_LIR_Apic_2	505	509	PF02991	0.501
LIG_LIR_Apic_2	580	586	PF02991	0.598
LIG_LIR_Gen_1	286	297	PF02991	0.535
LIG_LIR_Gen_1	428	438	PF02991	0.501
LIG_LIR_Gen_1	501	511	PF02991	0.551
LIG_LIR_Gen_1	687	696	PF02991	0.544
LIG_LIR_Gen_1	788	799	PF02991	0.485
LIG_LIR_LC3C_4	315	319	PF02991	0.467
LIG_LIR_LC3C_4	487	492	PF02991	0.501
LIG_LIR_Nem_3	210	216	PF02991	0.576
LIG_LIR_Nem_3	286	292	PF02991	0.486
LIG_LIR_Nem_3	428	434	PF02991	0.501
LIG_LIR_Nem_3	501	507	PF02991	0.551
LIG_LIR_Nem_3	602	608	PF02991	0.501
LIG_LIR_Nem_3	65	70	PF02991	0.374
LIG_LIR_Nem_3	656	660	PF02991	0.447
LIG_LIR_Nem_3	687	692	PF02991	0.549
LIG_LIR_Nem_3	720	725	PF02991	0.458
LIG_LIR_Nem_3	773	779	PF02991	0.455
LIG_LIR_Nem_3	788	794	PF02991	0.434
LIG_LIR_Nem_3	916	922	PF02991	0.468
LIG_MAD2	826	834	PF02301	0.501
LIG_NRBOX	851	857	PF00104	0.458
LIG_PCNA_PIPBox_1	944	953	PF02747	0.501
LIG_PCNA_yPIPBox_3	944	954	PF02747	0.501
LIG_Pex14_1	281	285	PF04695	0.501
LIG_Pex14_2	128	132	PF04695	0.355
LIG_Pex14_2	285	289	PF04695	0.458
LIG_Pex14_2	292	296	PF04695	0.465
LIG_Pex14_2	68	72	PF04695	0.402
LIG_RPA_C_Fungi	381	393	PF08784	0.284
LIG_SH2_CRK	184	188	PF00017	0.373
LIG_SH2_CRK	213	217	PF00017	0.465
LIG_SH2_CRK	605	609	PF00017	0.360
LIG_SH2_CRK	689	693	PF00017	0.318
LIG_SH2_GRB2like	748	751	PF00017	0.360
LIG_SH2_PTP2	791	794	PF00017	0.309
LIG_SH2_SRC	40	43	PF00017	0.498
LIG_SH2_STAP1	504	508	PF00017	0.424
LIG_SH2_STAP1	616	620	PF00017	0.360
LIG_SH2_STAT3	166	169	PF00017	0.414
LIG_SH2_STAT3	260	263	PF00017	0.312
LIG_SH2_STAT3	345	348	PF00017	0.360
LIG_SH2_STAT3	573	576	PF00017	0.318
LIG_SH2_STAT3	660	663	PF00017	0.284
LIG_SH2_STAT5	345	348	PF00017	0.457
LIG_SH2_STAT5	365	368	PF00017	0.216
LIG_SH2_STAT5	372	375	PF00017	0.310
LIG_SH2_STAT5	399	402	PF00017	0.360
LIG_SH2_STAT5	40	43	PF00017	0.393
LIG_SH2_STAT5	431	434	PF00017	0.299
LIG_SH2_STAT5	573	576	PF00017	0.334
LIG_SH2_STAT5	577	580	PF00017	0.331
LIG_SH2_STAT5	657	660	PF00017	0.293
LIG_SH2_STAT5	791	794	PF00017	0.318
LIG_SH2_STAT5	811	814	PF00017	0.155
LIG_SH3_3	123	129	PF00018	0.399
LIG_SH3_3	250	256	PF00018	0.312
LIG_SH3_3	26	32	PF00018	0.470
LIG_SH3_3	400	406	PF00018	0.443
LIG_SH3_3	605	611	PF00018	0.313
LIG_SH3_3	828	834	PF00018	0.277
LIG_SH3_3	965	971	PF00018	0.481
LIG_SUMO_SIM_anti_2	118	124	PF11976	0.399
LIG_SUMO_SIM_anti_2	134	140	PF11976	0.443
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.357
LIG_SUMO_SIM_anti_2	800	805	PF11976	0.343
LIG_SUMO_SIM_par_1	434	439	PF11976	0.360
LIG_SUMO_SIM_par_1	53	58	PF11976	0.429
LIG_SxIP_EBH_1	705	714	PF03271	0.312
LIG_UBA3_1	741	746	PF00899	0.333
LIG_WRC_WIRS_1	282	287	PF05994	0.360
LIG_WRC_WIRS_1	947	952	PF05994	0.336
MOD_CDK_SPK_2	785	790	PF00069	0.284
MOD_CDK_SPK_2	925	930	PF00069	0.215
MOD_CDK_SPxxK_3	28	35	PF00069	0.484
MOD_CDK_SPxxK_3	599	606	PF00069	0.360
MOD_CK1_1	194	200	PF00069	0.424
MOD_CK1_1	251	257	PF00069	0.429
MOD_CK1_1	310	316	PF00069	0.313
MOD_CK1_1	477	483	PF00069	0.305
MOD_CK1_1	599	605	PF00069	0.360
MOD_CK1_1	785	791	PF00069	0.360
MOD_CK1_1	872	878	PF00069	0.443
MOD_CK2_1	28	34	PF00069	0.567
MOD_CK2_1	281	287	PF00069	0.486
MOD_CK2_1	499	505	PF00069	0.481
MOD_CK2_1	532	538	PF00069	0.551
MOD_CK2_1	55	61	PF00069	0.462
MOD_CK2_1	552	558	PF00069	0.360
MOD_CK2_1	80	86	PF00069	0.494
MOD_CK2_1	97	103	PF00069	0.443
MOD_DYRK1A_RPxSP_1	21	25	PF00069	0.473
MOD_GlcNHglycan	108	111	PF01048	0.536
MOD_GlcNHglycan	144	147	PF01048	0.509
MOD_GlcNHglycan	253	256	PF01048	0.390
MOD_GlcNHglycan	264	267	PF01048	0.316
MOD_GlcNHglycan	271	274	PF01048	0.233
MOD_GlcNHglycan	326	329	PF01048	0.324
MOD_GlcNHglycan	47	50	PF01048	0.386
MOD_GlcNHglycan	475	479	PF01048	0.386
MOD_GlcNHglycan	538	542	PF01048	0.429
MOD_GlcNHglycan	871	874	PF01048	0.360
MOD_GlcNHglycan	896	899	PF01048	0.345
MOD_GlcNHglycan	907	910	PF01048	0.306
MOD_GlcNHglycan	958	961	PF01048	0.374
MOD_GSK3_1	154	161	PF00069	0.408
MOD_GSK3_1	194	201	PF00069	0.354
MOD_GSK3_1	21	28	PF00069	0.443
MOD_GSK3_1	306	313	PF00069	0.345
MOD_GSK3_1	377	384	PF00069	0.308
MOD_GSK3_1	411	418	PF00069	0.474
MOD_GSK3_1	55	62	PF00069	0.453
MOD_GSK3_1	668	675	PF00069	0.360
MOD_GSK3_1	857	864	PF00069	0.365
MOD_GSK3_1	868	875	PF00069	0.296
MOD_GSK3_1	890	897	PF00069	0.329
MOD_GSK3_1	901	908	PF00069	0.393
MOD_GSK3_1	942	949	PF00069	0.215
MOD_GSK3_1	97	104	PF00069	0.343
MOD_N-GLC_1	207	212	PF02516	0.426
MOD_N-GLC_2	247	249	PF02516	0.360
MOD_NEK2_1	105	110	PF00069	0.567
MOD_NEK2_1	156	161	PF00069	0.552
MOD_NEK2_1	324	329	PF00069	0.450
MOD_NEK2_1	392	397	PF00069	0.286
MOD_NEK2_1	415	420	PF00069	0.345
MOD_NEK2_1	442	447	PF00069	0.430
MOD_NEK2_1	498	503	PF00069	0.320
MOD_NEK2_1	55	60	PF00069	0.516
MOD_NEK2_1	621	626	PF00069	0.337
MOD_NEK2_1	668	673	PF00069	0.318
MOD_NEK2_1	68	73	PF00069	0.253
MOD_NEK2_1	726	731	PF00069	0.321
MOD_NEK2_1	783	788	PF00069	0.326
MOD_NEK2_1	797	802	PF00069	0.354
MOD_NEK2_1	856	861	PF00069	0.360
MOD_NEK2_1	905	910	PF00069	0.331
MOD_NEK2_1	915	920	PF00069	0.266
MOD_NEK2_1	958	963	PF00069	0.388
MOD_NEK2_2	241	246	PF00069	0.312
MOD_NEK2_2	526	531	PF00069	0.436
MOD_NEK2_2	63	68	PF00069	0.497
MOD_NEK2_2	771	776	PF00069	0.410
MOD_PIKK_1	201	207	PF00454	0.465
MOD_PIKK_1	442	448	PF00454	0.291
MOD_PIKK_1	694	700	PF00454	0.427
MOD_PIKK_1	703	709	PF00454	0.427
MOD_PIKK_1	8	14	PF00454	0.488
MOD_PKA_2	106	112	PF00069	0.441
MOD_PKA_2	251	257	PF00069	0.312
MOD_PKA_2	329	335	PF00069	0.343
MOD_PKA_2	8	14	PF00069	0.488
MOD_PKA_2	844	850	PF00069	0.323
MOD_PKA_2	97	103	PF00069	0.408
MOD_Plk_1	224	230	PF00069	0.317
MOD_Plk_1	857	863	PF00069	0.454
MOD_Plk_1	945	951	PF00069	0.336
MOD_Plk_2-3	225	231	PF00069	0.318
MOD_Plk_4	134	140	PF00069	0.428
MOD_Plk_4	158	164	PF00069	0.436
MOD_Plk_4	182	188	PF00069	0.399
MOD_Plk_4	194	200	PF00069	0.292
MOD_Plk_4	241	247	PF00069	0.377
MOD_Plk_4	411	417	PF00069	0.295
MOD_Plk_4	552	558	PF00069	0.413
MOD_Plk_4	63	69	PF00069	0.351
MOD_Plk_4	755	761	PF00069	0.355
MOD_Plk_4	771	777	PF00069	0.302
MOD_Plk_4	797	803	PF00069	0.308
MOD_Plk_4	901	907	PF00069	0.403
MOD_Plk_4	946	952	PF00069	0.419
MOD_Plk_4	969	975	PF00069	0.529
MOD_Plk_4	97	103	PF00069	0.478
MOD_ProDKin_1	21	27	PF00069	0.481
MOD_ProDKin_1	28	34	PF00069	0.414
MOD_ProDKin_1	477	483	PF00069	0.302
MOD_ProDKin_1	59	65	PF00069	0.472
MOD_ProDKin_1	599	605	PF00069	0.486
MOD_ProDKin_1	785	791	PF00069	0.338
MOD_ProDKin_1	890	896	PF00069	0.299
MOD_ProDKin_1	925	931	PF00069	0.215
MOD_ProDKin_1	967	973	PF00069	0.523
MOD_SUMO_rev_2	842	847	PF00179	0.368
TRG_DiLeu_BaEn_1	118	123	PF01217	0.391
TRG_DiLeu_BaEn_2	819	825	PF01217	0.360
TRG_DiLeu_BaEn_2	945	951	PF01217	0.360
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.414
TRG_DiLeu_BaLyEn_6	851	856	PF01217	0.450
TRG_ENDOCYTIC_2	184	187	PF00928	0.292
TRG_ENDOCYTIC_2	213	216	PF00928	0.465
TRG_ENDOCYTIC_2	431	434	PF00928	0.433
TRG_ENDOCYTIC_2	504	507	PF00928	0.427
TRG_ENDOCYTIC_2	605	608	PF00928	0.360
TRG_ENDOCYTIC_2	689	692	PF00928	0.299
TRG_ENDOCYTIC_2	791	794	PF00928	0.401
TRG_ER_diArg_1	385	387	PF00400	0.309
TRG_NES_CRM1_1	221	234	PF08389	0.284
TRG_NES_CRM1_1	766	781	PF08389	0.427
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	405	410	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	854	858	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	878	882	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVU8	Leptomonas seymouri	51%	100%
A0A0S4JLP3	Bodo saltans	36%	100%
A0A1X0P1D2	Trypanosomatidae	43%	100%
A0A3R7KF83	Trypanosoma rangeli	44%	100%
A0A3S7X3V7	Leishmania donovani	96%	100%
A4HIS7	Leishmania braziliensis	88%	100%
A4I629	Leishmania infantum	96%	100%
A5D785	Bos taurus	27%	100%
C9ZRE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B1B4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13671	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P33307	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P55060	Homo sapiens	27%	100%
Q54E36	Dictyostelium discoideum	26%	100%
Q5R9J2	Pongo abelii	26%	100%
Q6GMY9	Xenopus laevis	27%	100%
Q7SZC2	Danio rerio	26%	100%
Q8AY73	Oreochromis niloticus	27%	100%
Q9ERK4	Mus musculus	26%	100%
Q9PTU3	Pagrus major	27%	100%
Q9XZU1	Drosophila melanogaster	26%	100%
Q9ZPY7	Arabidopsis thaliana	26%	100%
V5BSD2	Trypanosoma cruzi	42%	100%