Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6U8_LEIMA

TriTrypDb:

LmjF.30.3410 , LMJLV39_300042900 , LMJSD75_300042100

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005840	ribosome	5	13
GO:0005875	microtubule associated complex	2	16
GO:0030286	dynein complex	3	16
GO:0032991	protein-containing complex	1	17
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:1902494	catalytic complex	2	16
GO:1990904	ribonucleoprotein complex	2	13

Expansion

Sequence features

Q4Q6U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6U8

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	16
GO:0007018	microtubule-based movement	3	16
GO:0009987	cellular process	1	16

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	16
GO:0003777	microtubule motor activity	2	16
GO:0008569	minus-end-directed microtubule motor activity	3	16
GO:0140657	ATP-dependent activity	1	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.675
CLV_NRD_NRD_1	289	291	PF00675	0.560
CLV_NRD_NRD_1	574	576	PF00675	0.418
CLV_PCSK_SKI1_1	15	19	PF00082	0.569
CLV_PCSK_SKI1_1	194	198	PF00082	0.301
CLV_PCSK_SKI1_1	220	224	PF00082	0.233
CLV_PCSK_SKI1_1	331	335	PF00082	0.383
CLV_PCSK_SKI1_1	589	593	PF00082	0.420
DEG_APCC_DBOX_1	367	375	PF00400	0.537
DOC_CYCLIN_RxL_1	214	226	PF00134	0.524
DOC_CYCLIN_RxL_1	589	601	PF00134	0.454
DOC_CYCLIN_yClb3_PxF_3	100	106	PF00134	0.529
DOC_MAPK_DCC_7	368	376	PF00069	0.536
DOC_MAPK_gen_1	150	158	PF00069	0.558
DOC_MAPK_gen_1	24	34	PF00069	0.331
DOC_MAPK_gen_1	288	295	PF00069	0.584
DOC_MAPK_gen_1	575	583	PF00069	0.524
DOC_MAPK_MEF2A_6	368	376	PF00069	0.536
DOC_MAPK_MEF2A_6	66	73	PF00069	0.563
DOC_PP2B_LxvP_1	73	76	PF13499	0.540
DOC_PP2B_LxvP_1	93	96	PF13499	0.497
DOC_SPAK_OSR1_1	353	357	PF12202	0.363
DOC_USP7_MATH_1	111	115	PF00917	0.532
DOC_USP7_MATH_1	192	196	PF00917	0.425
DOC_USP7_MATH_1	319	323	PF00917	0.682
DOC_USP7_UBL2_3	11	15	PF12436	0.379
DOC_USP7_UBL2_3	179	183	PF12436	0.457
DOC_USP7_UBL2_3	288	292	PF12436	0.721
LIG_14-3-3_CanoR_1	167	171	PF00244	0.518
LIG_14-3-3_CanoR_1	200	209	PF00244	0.529
LIG_14-3-3_CanoR_1	237	243	PF00244	0.454
LIG_14-3-3_CanoR_1	458	464	PF00244	0.375
LIG_APCC_ABBA_1	185	190	PF00400	0.446
LIG_APCC_ABBAyCdc20_2	267	273	PF00400	0.692
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	388	392	PF00533	0.439
LIG_EVH1_1	99	103	PF00568	0.721
LIG_FHA_1	191	197	PF00498	0.480
LIG_FHA_1	400	406	PF00498	0.360
LIG_FHA_1	415	421	PF00498	0.448
LIG_FHA_1	448	454	PF00498	0.357
LIG_FHA_1	578	584	PF00498	0.402
LIG_FHA_1	590	596	PF00498	0.288
LIG_FHA_1	602	608	PF00498	0.311
LIG_FHA_2	16	22	PF00498	0.496
LIG_FHA_2	306	312	PF00498	0.579
LIG_FHA_2	322	328	PF00498	0.543
LIG_FHA_2	394	400	PF00498	0.343
LIG_FHA_2	489	495	PF00498	0.318
LIG_KLC1_Yacidic_2	154	159	PF13176	0.546
LIG_LIR_Apic_2	431	435	PF02991	0.362
LIG_LIR_Gen_1	3	13	PF02991	0.555
LIG_LIR_Gen_1	307	316	PF02991	0.555
LIG_LIR_Gen_1	360	366	PF02991	0.488
LIG_LIR_Gen_1	523	532	PF02991	0.323
LIG_LIR_LC3C_4	67	72	PF02991	0.610
LIG_LIR_Nem_3	3	8	PF02991	0.575
LIG_LIR_Nem_3	360	365	PF02991	0.490
LIG_LIR_Nem_3	523	529	PF02991	0.445
LIG_MYND_1	100	104	PF01753	0.718
LIG_Pex14_1	384	388	PF04695	0.326
LIG_Pex14_2	388	392	PF04695	0.456
LIG_PTB_Apo_2	422	429	PF02174	0.432
LIG_SH2_CRK	432	436	PF00017	0.525
LIG_SH2_CRK	5	9	PF00017	0.569
LIG_SH2_GRB2like	432	435	PF00017	0.386
LIG_SH2_NCK_1	408	412	PF00017	0.484
LIG_SH2_NCK_1	432	436	PF00017	0.401
LIG_SH2_NCK_1	5	9	PF00017	0.407
LIG_SH2_PTP2	362	365	PF00017	0.356
LIG_SH2_SRC	432	435	PF00017	0.351
LIG_SH2_STAP1	119	123	PF00017	0.512
LIG_SH2_STAT3	188	191	PF00017	0.457
LIG_SH2_STAT5	157	160	PF00017	0.492
LIG_SH2_STAT5	188	191	PF00017	0.457
LIG_SH2_STAT5	348	351	PF00017	0.471
LIG_SH2_STAT5	362	365	PF00017	0.335
LIG_SH2_STAT5	5	8	PF00017	0.494
LIG_SH2_STAT5	560	563	PF00017	0.330
LIG_SH2_STAT5	570	573	PF00017	0.343
LIG_SH3_3	226	232	PF00018	0.446
LIG_SH3_3	568	574	PF00018	0.278
LIG_SH3_3	97	103	PF00018	0.745
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.457
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.514
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.481
LIG_SUMO_SIM_par_1	341	347	PF11976	0.275
LIG_SUMO_SIM_par_1	362	367	PF11976	0.344
LIG_SUMO_SIM_par_1	416	422	PF11976	0.498
LIG_TRAF2_1	411	414	PF00917	0.563
LIG_TYR_ITSM	1	8	PF00017	0.424
LIG_WRC_WIRS_1	420	425	PF05994	0.439
LIG_WW_2	100	103	PF00397	0.735
MOD_CK1_1	277	283	PF00069	0.761
MOD_CK1_1	322	328	PF00069	0.698
MOD_CK1_1	336	342	PF00069	0.547
MOD_CK1_1	387	393	PF00069	0.492
MOD_CK1_1	419	425	PF00069	0.416
MOD_CK1_1	562	568	PF00069	0.414
MOD_CK1_1	64	70	PF00069	0.644
MOD_CK2_1	15	21	PF00069	0.517
MOD_CK2_1	305	311	PF00069	0.573
MOD_CK2_1	393	399	PF00069	0.349
MOD_GlcNHglycan	114	117	PF01048	0.554
MOD_GlcNHglycan	262	265	PF01048	0.674
MOD_GlcNHglycan	311	315	PF01048	0.543
MOD_GlcNHglycan	321	324	PF01048	0.575
MOD_GlcNHglycan	35	38	PF01048	0.490
MOD_GlcNHglycan	359	362	PF01048	0.445
MOD_GlcNHglycan	439	442	PF01048	0.344
MOD_GlcNHglycan	443	446	PF01048	0.304
MOD_GlcNHglycan	447	450	PF01048	0.362
MOD_GlcNHglycan	561	564	PF01048	0.340
MOD_GSK3_1	190	197	PF00069	0.454
MOD_GSK3_1	437	444	PF00069	0.347
MOD_GSK3_1	484	491	PF00069	0.347
MOD_GSK3_1	597	604	PF00069	0.508
MOD_N-GLC_1	106	111	PF02516	0.598
MOD_N-GLC_1	112	117	PF02516	0.445
MOD_N-GLC_1	459	464	PF02516	0.460
MOD_N-GLC_1	64	69	PF02516	0.620
MOD_N-GLC_2	496	498	PF02516	0.524
MOD_NEK2_1	106	111	PF00069	0.687
MOD_NEK2_1	142	147	PF00069	0.561
MOD_NEK2_1	236	241	PF00069	0.454
MOD_NEK2_1	260	265	PF00069	0.597
MOD_NEK2_1	304	309	PF00069	0.538
MOD_NEK2_1	310	315	PF00069	0.504
MOD_NEK2_1	392	397	PF00069	0.281
MOD_NEK2_1	428	433	PF00069	0.383
MOD_NEK2_1	447	452	PF00069	0.362
MOD_NEK2_1	473	478	PF00069	0.382
MOD_NEK2_1	492	497	PF00069	0.207
MOD_NEK2_1	539	544	PF00069	0.383
MOD_NEK2_1	577	582	PF00069	0.486
MOD_NEK2_1	597	602	PF00069	0.366
MOD_NEK2_2	119	124	PF00069	0.487
MOD_NEK2_2	238	243	PF00069	0.457
MOD_PIKK_1	387	393	PF00454	0.477
MOD_PIKK_1	473	479	PF00454	0.430
MOD_PIKK_1	540	546	PF00454	0.375
MOD_PIKK_1	64	70	PF00454	0.573
MOD_PKA_2	166	172	PF00069	0.495
MOD_PKA_2	236	242	PF00069	0.465
MOD_PKA_2	293	299	PF00069	0.619
MOD_PKA_2	466	472	PF00069	0.357
MOD_Plk_1	106	112	PF00069	0.609
MOD_Plk_1	119	125	PF00069	0.454
MOD_Plk_1	304	310	PF00069	0.559
MOD_Plk_1	384	390	PF00069	0.381
MOD_Plk_1	413	419	PF00069	0.467
MOD_Plk_1	459	465	PF00069	0.488
MOD_Plk_1	577	583	PF00069	0.518
MOD_Plk_1	64	70	PF00069	0.654
MOD_Plk_2-3	305	311	PF00069	0.573
MOD_Plk_2-3	82	88	PF00069	0.670
MOD_Plk_4	305	311	PF00069	0.620
MOD_Plk_4	344	350	PF00069	0.461
MOD_Plk_4	400	406	PF00069	0.365
MOD_Plk_4	459	465	PF00069	0.414
MOD_Plk_4	488	494	PF00069	0.314
MOD_Plk_4	565	571	PF00069	0.404
MOD_Plk_4	598	604	PF00069	0.395
MOD_SUMO_for_1	151	154	PF00179	0.526
MOD_SUMO_for_1	282	285	PF00179	0.739
MOD_SUMO_for_1	77	80	PF00179	0.690
TRG_DiLeu_BaEn_2	304	310	PF01217	0.558
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.346
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.416
TRG_ENDOCYTIC_2	362	365	PF00928	0.341
TRG_ENDOCYTIC_2	5	8	PF00928	0.576
TRG_ER_diArg_1	242	245	PF00400	0.529
TRG_NES_CRM1_1	175	190	PF08389	0.504
TRG_NES_CRM1_1	546	558	PF08389	0.445
TRG_NLS_MonoExtC_3	289	294	PF00514	0.584
TRG_NLS_MonoExtN_4	288	295	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.246
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	593	598	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S6	Leptomonas seymouri	83%	100%
A0A0N1PCL0	Leptomonas seymouri	27%	70%
A0A0S4J7X8	Bodo saltans	28%	83%
A0A0S4JKZ2	Bodo saltans	49%	93%
A0A1X0P1Y1	Trypanosomatidae	51%	99%
A0A1X0P3P9	Trypanosomatidae	28%	80%
A0A3R7KEX8	Trypanosoma rangeli	27%	82%
A0A3S7X3V5	Leishmania donovani	98%	100%
A0A3S7X707	Leishmania donovani	27%	71%
A0A422NMN1	Trypanosoma rangeli	51%	100%
A4HIS9	Leishmania braziliensis	88%	100%
A4HLS7	Leishmania braziliensis	27%	71%
A4I631	Leishmania infantum	98%	100%
A4I986	Leishmania infantum	27%	71%
C9ZRE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	99%
D0A6A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	80%
E9B1B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B453	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	71%
Q9GRN2	Leishmania major	28%	71%
V5DNT3	Trypanosoma cruzi	52%	100%
V5DQD1	Trypanosoma cruzi	28%	82%