Reverse transcriptase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

T-complex protein 11, putative

Species:

Leishmania major

UniProt:

Q4Q6U7_LEIMA

TriTrypDb:

LmjF.30.3420 , LMJLV39_300043000 , LMJSD75_300042200

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6U7

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	2
GO:0009987	cellular process	1	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.608
CLV_C14_Caspase3-7	742	746	PF00656	0.487
CLV_MEL_PAP_1	119	125	PF00089	0.437
CLV_NRD_NRD_1	133	135	PF00675	0.453
CLV_NRD_NRD_1	169	171	PF00675	0.651
CLV_NRD_NRD_1	282	284	PF00675	0.495
CLV_NRD_NRD_1	316	318	PF00675	0.547
CLV_NRD_NRD_1	328	330	PF00675	0.646
CLV_NRD_NRD_1	374	376	PF00675	0.730
CLV_NRD_NRD_1	401	403	PF00675	0.545
CLV_NRD_NRD_1	404	406	PF00675	0.524
CLV_NRD_NRD_1	606	608	PF00675	0.474
CLV_NRD_NRD_1	645	647	PF00675	0.362
CLV_NRD_NRD_1	711	713	PF00675	0.411
CLV_NRD_NRD_1	808	810	PF00675	0.331
CLV_NRD_NRD_1	92	94	PF00675	0.399
CLV_PCSK_FUR_1	402	406	PF00082	0.564
CLV_PCSK_KEX2_1	121	123	PF00082	0.600
CLV_PCSK_KEX2_1	133	135	PF00082	0.396
CLV_PCSK_KEX2_1	230	232	PF00082	0.634
CLV_PCSK_KEX2_1	292	294	PF00082	0.456
CLV_PCSK_KEX2_1	315	317	PF00082	0.525
CLV_PCSK_KEX2_1	328	330	PF00082	0.592
CLV_PCSK_KEX2_1	374	376	PF00082	0.732
CLV_PCSK_KEX2_1	403	405	PF00082	0.516
CLV_PCSK_KEX2_1	645	647	PF00082	0.360
CLV_PCSK_KEX2_1	711	713	PF00082	0.411
CLV_PCSK_KEX2_1	808	810	PF00082	0.300
CLV_PCSK_KEX2_1	91	93	PF00082	0.420
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.522
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.412
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.456
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.525
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.568
CLV_PCSK_SKI1_1	133	137	PF00082	0.473
CLV_PCSK_SKI1_1	189	193	PF00082	0.470
CLV_PCSK_SKI1_1	196	200	PF00082	0.490
CLV_PCSK_SKI1_1	227	231	PF00082	0.487
CLV_PCSK_SKI1_1	292	296	PF00082	0.527
CLV_PCSK_SKI1_1	411	415	PF00082	0.431
CLV_PCSK_SKI1_1	531	535	PF00082	0.447
CLV_PCSK_SKI1_1	624	628	PF00082	0.417
CLV_PCSK_SKI1_1	648	652	PF00082	0.325
CLV_PCSK_SKI1_1	712	716	PF00082	0.360
CLV_PCSK_SKI1_1	808	812	PF00082	0.305
CLV_PCSK_SKI1_1	843	847	PF00082	0.290
CLV_PCSK_SKI1_1	858	862	PF00082	0.237
DEG_APCC_DBOX_1	188	196	PF00400	0.464
DEG_APCC_DBOX_1	807	815	PF00400	0.331
DEG_APCC_DBOX_1	857	865	PF00400	0.411
DEG_APCC_DBOX_1	90	98	PF00400	0.398
DEG_SPOP_SBC_1	359	363	PF00917	0.792
DOC_CKS1_1	332	337	PF01111	0.764
DOC_CYCLIN_RxL_1	186	193	PF00134	0.478
DOC_MAPK_DCC_7	820	830	PF00069	0.364
DOC_MAPK_DCC_7	858	866	PF00069	0.431
DOC_MAPK_gen_1	121	129	PF00069	0.678
DOC_MAPK_gen_1	607	615	PF00069	0.484
DOC_MAPK_gen_1	645	653	PF00069	0.325
DOC_MAPK_gen_1	88	97	PF00069	0.392
DOC_MAPK_HePTP_8	119	131	PF00069	0.439
DOC_MAPK_MEF2A_6	122	131	PF00069	0.687
DOC_MAPK_MEF2A_6	858	866	PF00069	0.431
DOC_MAPK_RevD_3	697	712	PF00069	0.364
DOC_PP1_RVXF_1	622	629	PF00149	0.331
DOC_PP1_RVXF_1	680	687	PF00149	0.281
DOC_PP1_RVXF_1	807	814	PF00149	0.281
DOC_PP2B_LxvP_1	53	56	PF13499	0.499
DOC_PP2B_LxvP_1	603	606	PF13499	0.331
DOC_PP4_FxxP_1	241	244	PF00568	0.499
DOC_USP7_MATH_1	234	238	PF00917	0.554
DOC_USP7_MATH_1	359	363	PF00917	0.731
DOC_USP7_MATH_1	367	371	PF00917	0.691
DOC_USP7_MATH_1	537	541	PF00917	0.448
DOC_USP7_MATH_1	636	640	PF00917	0.303
DOC_USP7_MATH_1	704	708	PF00917	0.460
DOC_WW_Pin1_4	171	176	PF00397	0.791
DOC_WW_Pin1_4	201	206	PF00397	0.549
DOC_WW_Pin1_4	240	245	PF00397	0.622
DOC_WW_Pin1_4	253	258	PF00397	0.730
DOC_WW_Pin1_4	331	336	PF00397	0.684
DOC_WW_Pin1_4	360	365	PF00397	0.709
DOC_WW_Pin1_4	455	460	PF00397	0.360
DOC_WW_Pin1_4	525	530	PF00397	0.411
DOC_WW_Pin1_4	547	552	PF00397	0.325
LIG_14-3-3_CanoR_1	133	138	PF00244	0.489
LIG_14-3-3_CanoR_1	26	36	PF00244	0.632
LIG_14-3-3_CanoR_1	272	276	PF00244	0.535
LIG_14-3-3_CanoR_1	293	299	PF00244	0.461
LIG_14-3-3_CanoR_1	304	311	PF00244	0.421
LIG_14-3-3_CanoR_1	538	546	PF00244	0.402
LIG_14-3-3_CanoR_1	54	64	PF00244	0.594
LIG_14-3-3_CanoR_1	663	668	PF00244	0.265
LIG_14-3-3_CanoR_1	724	734	PF00244	0.407
LIG_14-3-3_CanoR_1	820	828	PF00244	0.451
LIG_Actin_WH2_2	644	662	PF00022	0.291
LIG_Actin_WH2_2	731	746	PF00022	0.329
LIG_Actin_WH2_2	90	105	PF00022	0.349
LIG_BIR_II_1	1	5	PF00653	0.697
LIG_BIR_III_4	6	10	PF00653	0.593
LIG_BRCT_BRCA1_1	611	615	PF00533	0.281
LIG_Clathr_ClatBox_1	698	702	PF01394	0.411
LIG_EVH1_2	674	678	PF00568	0.411
LIG_FHA_1	139	145	PF00498	0.484
LIG_FHA_1	293	299	PF00498	0.509
LIG_FHA_1	325	331	PF00498	0.669
LIG_FHA_1	353	359	PF00498	0.782
LIG_FHA_1	548	554	PF00498	0.411
LIG_FHA_1	653	659	PF00498	0.331
LIG_FHA_1	694	700	PF00498	0.370
LIG_FHA_1	766	772	PF00498	0.331
LIG_FHA_1	820	826	PF00498	0.307
LIG_FHA_1	830	836	PF00498	0.234
LIG_FHA_1	867	873	PF00498	0.666
LIG_FHA_2	1	7	PF00498	0.706
LIG_FHA_2	152	158	PF00498	0.462
LIG_FHA_2	272	278	PF00498	0.526
LIG_FHA_2	305	311	PF00498	0.465
LIG_FHA_2	343	349	PF00498	0.678
LIG_FHA_2	425	431	PF00498	0.629
LIG_FHA_2	442	448	PF00498	0.433
LIG_FHA_2	639	645	PF00498	0.281
LIG_FHA_2	663	669	PF00498	0.416
LIG_FHA_2	689	695	PF00498	0.337
LIG_FHA_2	740	746	PF00498	0.457
LIG_FHA_2	777	783	PF00498	0.337
LIG_FHA_2	794	800	PF00498	0.293
LIG_LIR_Apic_2	239	244	PF02991	0.493
LIG_LIR_Apic_2	331	335	PF02991	0.715
LIG_LIR_Gen_1	309	318	PF02991	0.528
LIG_LIR_Gen_1	491	500	PF02991	0.373
LIG_LIR_Gen_1	668	678	PF02991	0.362
LIG_LIR_Gen_1	800	811	PF02991	0.330
LIG_LIR_Nem_3	309	314	PF02991	0.511
LIG_LIR_Nem_3	491	495	PF02991	0.290
LIG_LIR_Nem_3	497	501	PF02991	0.243
LIG_LIR_Nem_3	668	673	PF02991	0.296
LIG_LIR_Nem_3	800	806	PF02991	0.344
LIG_LIR_Nem_3	856	860	PF02991	0.273
LIG_MYND_1	379	383	PF01753	0.553
LIG_MYND_1	482	486	PF01753	0.287
LIG_NRBOX	464	470	PF00104	0.411
LIG_NRBOX	696	702	PF00104	0.281
LIG_Pex14_2	142	146	PF04695	0.474
LIG_Pex14_2	561	565	PF04695	0.302
LIG_Pex14_2	615	619	PF04695	0.331
LIG_SH2_CRK	299	303	PF00017	0.449
LIG_SH2_CRK	332	336	PF00017	0.694
LIG_SH2_NCK_1	332	336	PF00017	0.694
LIG_SH2_PTP2	113	116	PF00017	0.612
LIG_SH2_STAP1	225	229	PF00017	0.481
LIG_SH2_STAP1	419	423	PF00017	0.402
LIG_SH2_STAT3	225	228	PF00017	0.508
LIG_SH2_STAT5	113	116	PF00017	0.636
LIG_SH2_STAT5	147	150	PF00017	0.496
LIG_SH2_STAT5	210	213	PF00017	0.574
LIG_SH2_STAT5	386	389	PF00017	0.533
LIG_SH2_STAT5	408	411	PF00017	0.479
LIG_SH2_STAT5	594	597	PF00017	0.355
LIG_SH2_STAT5	679	682	PF00017	0.312
LIG_SH2_STAT5	803	806	PF00017	0.300
LIG_SH3_1	429	435	PF00018	0.287
LIG_SH3_3	11	17	PF00018	0.623
LIG_SH3_3	376	382	PF00018	0.537
LIG_SH3_3	429	435	PF00018	0.421
LIG_SH3_3	49	55	PF00018	0.500
LIG_SH3_3	628	634	PF00018	0.415
LIG_SH3_3	668	674	PF00018	0.331
LIG_SH3_3	849	855	PF00018	0.320
LIG_SUMO_SIM_anti_2	655	661	PF11976	0.408
LIG_SUMO_SIM_anti_2	696	702	PF11976	0.329
LIG_SUMO_SIM_par_1	467	474	PF11976	0.397
LIG_SUMO_SIM_par_1	696	702	PF11976	0.295
LIG_TRAF2_1	641	644	PF00917	0.337
LIG_TRAF2_1	691	694	PF00917	0.281
LIG_TYR_ITIM	297	302	PF00017	0.441
LIG_UBA3_1	104	111	PF00899	0.461
LIG_WRC_WIRS_1	803	808	PF05994	0.320
LIG_WW_3	480	484	PF00397	0.393
MOD_CDC14_SPxK_1	528	531	PF00782	0.411
MOD_CDK_SPK_2	240	245	PF00069	0.578
MOD_CDK_SPxK_1	525	531	PF00069	0.411
MOD_CDK_SPxxK_3	171	178	PF00069	0.570
MOD_CDK_SPxxK_3	240	247	PF00069	0.605
MOD_CK1_1	150	156	PF00069	0.630
MOD_CK1_1	169	175	PF00069	0.575
MOD_CK1_1	177	183	PF00069	0.552
MOD_CK1_1	243	249	PF00069	0.667
MOD_CK1_1	57	63	PF00069	0.625
MOD_CK1_1	629	635	PF00069	0.451
MOD_CK1_1	717	723	PF00069	0.326
MOD_CK1_1	865	871	PF00069	0.616
MOD_CK2_1	151	157	PF00069	0.486
MOD_CK2_1	234	240	PF00069	0.651
MOD_CK2_1	271	277	PF00069	0.551
MOD_CK2_1	29	35	PF00069	0.511
MOD_CK2_1	304	310	PF00069	0.487
MOD_CK2_1	342	348	PF00069	0.602
MOD_CK2_1	367	373	PF00069	0.557
MOD_CK2_1	441	447	PF00069	0.399
MOD_CK2_1	638	644	PF00069	0.297
MOD_CK2_1	688	694	PF00069	0.337
MOD_CK2_1	793	799	PF00069	0.351
MOD_CK2_1	853	859	PF00069	0.396
MOD_GlcNHglycan	171	174	PF01048	0.711
MOD_GlcNHglycan	179	182	PF01048	0.513
MOD_GlcNHglycan	236	239	PF01048	0.574
MOD_GlcNHglycan	35	39	PF01048	0.484
MOD_GlcNHglycan	369	372	PF01048	0.653
MOD_GlcNHglycan	539	542	PF01048	0.437
MOD_GlcNHglycan	599	602	PF01048	0.435
MOD_GlcNHglycan	660	663	PF01048	0.321
MOD_GSK3_1	147	154	PF00069	0.407
MOD_GSK3_1	177	184	PF00069	0.440
MOD_GSK3_1	210	217	PF00069	0.446
MOD_GSK3_1	232	239	PF00069	0.619
MOD_GSK3_1	249	256	PF00069	0.752
MOD_GSK3_1	300	307	PF00069	0.458
MOD_GSK3_1	450	457	PF00069	0.331
MOD_GSK3_1	64	71	PF00069	0.482
MOD_GSK3_1	658	665	PF00069	0.395
MOD_GSK3_1	714	721	PF00069	0.389
MOD_GSK3_1	725	732	PF00069	0.335
MOD_GSK3_1	739	746	PF00069	0.254
MOD_GSK3_1	776	783	PF00069	0.348
MOD_GSK3_1	784	791	PF00069	0.323
MOD_GSK3_1	862	869	PF00069	0.497
MOD_N-GLC_1	342	347	PF02516	0.598
MOD_N-GLC_1	455	460	PF02516	0.360
MOD_N-GLC_1	510	515	PF02516	0.373
MOD_N-GLC_1	583	588	PF02516	0.331
MOD_NEK2_1	214	219	PF00069	0.387
MOD_NEK2_1	223	228	PF00069	0.419
MOD_NEK2_1	358	363	PF00069	0.587
MOD_NEK2_1	626	631	PF00069	0.345
MOD_NEK2_1	635	640	PF00069	0.411
MOD_NEK2_1	658	663	PF00069	0.285
MOD_NEK2_1	74	79	PF00069	0.401
MOD_NEK2_1	743	748	PF00069	0.285
MOD_NEK2_1	750	755	PF00069	0.297
MOD_NEK2_1	866	871	PF00069	0.491
MOD_PIKK_1	147	153	PF00454	0.594
MOD_PIKK_1	250	256	PF00454	0.629
MOD_PIKK_1	441	447	PF00454	0.465
MOD_PIKK_1	725	731	PF00454	0.435
MOD_PIKK_1	750	756	PF00454	0.371
MOD_PK_1	93	99	PF00069	0.396
MOD_PKA_1	133	139	PF00069	0.451
MOD_PKA_1	292	298	PF00069	0.417
MOD_PKA_2	133	139	PF00069	0.451
MOD_PKA_2	169	175	PF00069	0.606
MOD_PKA_2	177	183	PF00069	0.445
MOD_PKA_2	27	33	PF00069	0.612
MOD_PKA_2	271	277	PF00069	0.573
MOD_PKA_2	292	298	PF00069	0.434
MOD_PKA_2	300	306	PF00069	0.350
MOD_PKA_2	537	543	PF00069	0.366
MOD_PKA_2	662	668	PF00069	0.325
MOD_PKA_2	788	794	PF00069	0.379
MOD_PKA_2	819	825	PF00069	0.287
MOD_PKB_1	91	99	PF00069	0.530
MOD_Plk_1	531	537	PF00069	0.329
MOD_Plk_1	583	589	PF00069	0.447
MOD_Plk_1	693	699	PF00069	0.331
MOD_Plk_2-3	236	242	PF00069	0.547
MOD_Plk_4	138	144	PF00069	0.494
MOD_Plk_4	210	216	PF00069	0.493
MOD_Plk_4	271	277	PF00069	0.538
MOD_Plk_4	531	537	PF00069	0.287
MOD_Plk_4	693	699	PF00069	0.314
MOD_Plk_4	704	710	PF00069	0.287
MOD_Plk_4	718	724	PF00069	0.373
MOD_Plk_4	729	735	PF00069	0.343
MOD_Plk_4	743	749	PF00069	0.291
MOD_ProDKin_1	171	177	PF00069	0.784
MOD_ProDKin_1	201	207	PF00069	0.548
MOD_ProDKin_1	240	246	PF00069	0.625
MOD_ProDKin_1	253	259	PF00069	0.723
MOD_ProDKin_1	331	337	PF00069	0.686
MOD_ProDKin_1	360	366	PF00069	0.711
MOD_ProDKin_1	455	461	PF00069	0.360
MOD_ProDKin_1	525	531	PF00069	0.411
MOD_ProDKin_1	547	553	PF00069	0.325
MOD_SUMO_for_1	229	232	PF00179	0.545
MOD_SUMO_rev_2	193	200	PF00179	0.547
MOD_SUMO_rev_2	285	294	PF00179	0.480
MOD_SUMO_rev_2	406	415	PF00179	0.557
TRG_DiLeu_BaEn_1	694	699	PF01217	0.293
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.382
TRG_ENDOCYTIC_2	299	302	PF00928	0.442
TRG_ENDOCYTIC_2	419	422	PF00928	0.420
TRG_ENDOCYTIC_2	803	806	PF00928	0.266
TRG_ENDOCYTIC_2	857	860	PF00928	0.278
TRG_ER_diArg_1	133	135	PF00400	0.491
TRG_ER_diArg_1	26	29	PF00400	0.654
TRG_ER_diArg_1	316	318	PF00400	0.596
TRG_ER_diArg_1	328	330	PF00400	0.482
TRG_ER_diArg_1	402	405	PF00400	0.568
TRG_ER_diArg_1	482	485	PF00400	0.314
TRG_ER_diArg_1	486	489	PF00400	0.311
TRG_ER_diArg_1	645	648	PF00400	0.411
TRG_ER_diArg_1	808	810	PF00400	0.331
TRG_ER_diArg_1	91	93	PF00400	0.479
TRG_NES_CRM1_1	39	51	PF08389	0.447
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	724	729	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ54	Leptomonas seymouri	62%	100%
A0A0S4JLJ6	Bodo saltans	29%	91%
A0A1X0P1B7	Trypanosomatidae	38%	100%
A0A3S7X411	Leishmania donovani	94%	100%
A0A422NMF0	Trypanosoma rangeli	37%	100%
A4HIT0	Leishmania braziliensis	84%	100%
A4I632	Leishmania infantum	94%	100%
C9ZRF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B1B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B765	Trypanosoma cruzi	37%	100%