XPG_I_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein mkt1, putative

Species:

Leishmania major

UniProt:

Q4Q6U6_LEIMA

TriTrypDb:

LmjF.30.3430 , LMJLV39_300043100 , LMJSD75_300042300

Length:

796

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6U6

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0010608	post-transcriptional regulation of gene expression	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0034248	regulation of amide metabolic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004519	endonuclease activity	5	2
GO:0004520	DNA endonuclease activity	5	2
GO:0004536	DNA nuclease activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0017108	5'-flap endonuclease activity	7	2
GO:0048256	flap endonuclease activity	6	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.687
CLV_C14_Caspase3-7	457	461	PF00656	0.380
CLV_NRD_NRD_1	166	168	PF00675	0.402
CLV_NRD_NRD_1	241	243	PF00675	0.402
CLV_NRD_NRD_1	270	272	PF00675	0.392
CLV_NRD_NRD_1	305	307	PF00675	0.421
CLV_NRD_NRD_1	33	35	PF00675	0.343
CLV_NRD_NRD_1	333	335	PF00675	0.399
CLV_NRD_NRD_1	384	386	PF00675	0.574
CLV_NRD_NRD_1	715	717	PF00675	0.465
CLV_NRD_NRD_1	86	88	PF00675	0.368
CLV_PCSK_FUR_1	331	335	PF00082	0.416
CLV_PCSK_KEX2_1	240	242	PF00082	0.443
CLV_PCSK_KEX2_1	270	272	PF00082	0.392
CLV_PCSK_KEX2_1	305	307	PF00082	0.421
CLV_PCSK_KEX2_1	33	35	PF00082	0.343
CLV_PCSK_KEX2_1	333	335	PF00082	0.373
CLV_PCSK_KEX2_1	384	386	PF00082	0.574
CLV_PCSK_KEX2_1	715	717	PF00082	0.560
CLV_PCSK_PC7_1	266	272	PF00082	0.391
CLV_PCSK_SKI1_1	101	105	PF00082	0.368
CLV_PCSK_SKI1_1	215	219	PF00082	0.310
CLV_PCSK_SKI1_1	25	29	PF00082	0.402
CLV_PCSK_SKI1_1	301	305	PF00082	0.433
CLV_PCSK_SKI1_1	338	342	PF00082	0.374
CLV_Separin_Metazoa	540	544	PF03568	0.374
CLV_Separin_Metazoa	84	88	PF03568	0.568
DEG_APCC_DBOX_1	304	312	PF00400	0.592
DOC_CYCLIN_yCln2_LP_2	359	365	PF00134	0.519
DOC_MAPK_DCC_7	385	395	PF00069	0.374
DOC_MAPK_DCC_7	435	444	PF00069	0.351
DOC_MAPK_FxFP_2	640	643	PF00069	0.374
DOC_MAPK_MEF2A_6	435	444	PF00069	0.351
DOC_MAPK_MEF2A_6	724	731	PF00069	0.378
DOC_PP1_RVXF_1	494	501	PF00149	0.374
DOC_PP2B_LxvP_1	311	314	PF13499	0.532
DOC_PP2B_LxvP_1	359	362	PF13499	0.510
DOC_PP4_FxxP_1	190	193	PF00568	0.540
DOC_PP4_FxxP_1	341	344	PF00568	0.540
DOC_PP4_FxxP_1	526	529	PF00568	0.374
DOC_PP4_FxxP_1	640	643	PF00568	0.273
DOC_SPAK_OSR1_1	154	158	PF12202	0.530
DOC_USP7_MATH_1	364	368	PF00917	0.340
DOC_USP7_MATH_1	386	390	PF00917	0.374
DOC_USP7_MATH_1	406	410	PF00917	0.330
DOC_USP7_MATH_1	511	515	PF00917	0.330
DOC_USP7_MATH_2	125	131	PF00917	0.645
DOC_USP7_UBL2_3	21	25	PF12436	0.552
DOC_WW_Pin1_4	118	123	PF00397	0.670
DOC_WW_Pin1_4	340	345	PF00397	0.542
DOC_WW_Pin1_4	68	73	PF00397	0.512
LIG_14-3-3_CanoR_1	622	627	PF00244	0.418
LIG_AP_GAE_1	249	255	PF02883	0.614
LIG_BRCT_BRCA1_1	187	191	PF00533	0.593
LIG_BRCT_BRCA1_1	198	202	PF00533	0.599
LIG_BRCT_BRCA1_1	41	45	PF00533	0.562
LIG_BRCT_BRCA1_1	496	500	PF00533	0.374
LIG_BRCT_BRCA1_1	585	589	PF00533	0.409
LIG_BRCT_BRCA1_1	599	603	PF00533	0.309
LIG_BRCT_BRCA1_1	646	650	PF00533	0.355
LIG_deltaCOP1_diTrp_1	410	420	PF00928	0.374
LIG_EH1_1	610	618	PF00400	0.330
LIG_FHA_1	439	445	PF00498	0.411
LIG_FHA_1	465	471	PF00498	0.398
LIG_FHA_1	542	548	PF00498	0.282
LIG_FHA_1	59	65	PF00498	0.585
LIG_FHA_1	604	610	PF00498	0.374
LIG_FHA_1	651	657	PF00498	0.374
LIG_FHA_1	734	740	PF00498	0.432
LIG_FHA_1	81	87	PF00498	0.602
LIG_FHA_2	18	24	PF00498	0.493
LIG_FHA_2	216	222	PF00498	0.607
LIG_FHA_2	271	277	PF00498	0.604
LIG_FHA_2	283	289	PF00498	0.513
LIG_FHA_2	528	534	PF00498	0.281
LIG_FHA_2	544	550	PF00498	0.245
LIG_FHA_2	660	666	PF00498	0.374
LIG_FHA_2	667	673	PF00498	0.297
LIG_LIR_Apic_2	188	193	PF02991	0.530
LIG_LIR_Apic_2	524	529	PF02991	0.374
LIG_LIR_Gen_1	226	235	PF02991	0.543
LIG_LIR_Gen_1	249	258	PF02991	0.609
LIG_LIR_Gen_1	272	281	PF02991	0.573
LIG_LIR_Gen_1	625	635	PF02991	0.383
LIG_LIR_Gen_1	688	699	PF02991	0.374
LIG_LIR_Gen_1	704	713	PF02991	0.284
LIG_LIR_Gen_1	74	82	PF02991	0.516
LIG_LIR_LC3C_4	549	554	PF02991	0.374
LIG_LIR_Nem_3	130	134	PF02991	0.626
LIG_LIR_Nem_3	199	205	PF02991	0.511
LIG_LIR_Nem_3	226	230	PF02991	0.536
LIG_LIR_Nem_3	249	255	PF02991	0.614
LIG_LIR_Nem_3	272	277	PF02991	0.608
LIG_LIR_Nem_3	373	378	PF02991	0.300
LIG_LIR_Nem_3	408	414	PF02991	0.301
LIG_LIR_Nem_3	443	449	PF02991	0.421
LIG_LIR_Nem_3	497	503	PF02991	0.390
LIG_LIR_Nem_3	532	537	PF02991	0.273
LIG_LIR_Nem_3	625	631	PF02991	0.383
LIG_LIR_Nem_3	682	687	PF02991	0.322
LIG_LIR_Nem_3	688	694	PF02991	0.307
LIG_LIR_Nem_3	70	76	PF02991	0.516
LIG_LIR_Nem_3	704	708	PF02991	0.273
LIG_MLH1_MIPbox_1	187	191	PF16413	0.593
LIG_PCNA_yPIPBox_3	484	494	PF02747	0.350
LIG_Pex14_1	413	417	PF04695	0.273
LIG_Pex14_1	585	589	PF04695	0.374
LIG_Pex14_2	100	104	PF04695	0.592
LIG_Pex14_2	151	155	PF04695	0.629
LIG_Pex14_2	349	353	PF04695	0.391
LIG_Pex14_2	500	504	PF04695	0.374
LIG_Pex14_2	642	646	PF04695	0.374
LIG_Pex14_2	687	691	PF04695	0.374
LIG_Pex14_2	730	734	PF04695	0.397
LIG_SH2_CRK	483	487	PF00017	0.384
LIG_SH2_CRK	534	538	PF00017	0.297
LIG_SH2_CRK	705	709	PF00017	0.330
LIG_SH2_CRK	76	80	PF00017	0.550
LIG_SH2_CRK	790	794	PF00017	0.531
LIG_SH2_NCK_1	705	709	PF00017	0.330
LIG_SH2_NCK_1	76	80	PF00017	0.550
LIG_SH2_SRC	699	702	PF00017	0.374
LIG_SH2_SRC	790	793	PF00017	0.528
LIG_SH2_STAP1	243	247	PF00017	0.635
LIG_SH2_STAP1	82	86	PF00017	0.605
LIG_SH2_STAT5	181	184	PF00017	0.492
LIG_SH2_STAT5	351	354	PF00017	0.390
LIG_SH2_STAT5	417	420	PF00017	0.392
LIG_SH2_STAT5	465	468	PF00017	0.394
LIG_SH2_STAT5	494	497	PF00017	0.312
LIG_SH2_STAT5	503	506	PF00017	0.268
LIG_SH2_STAT5	519	522	PF00017	0.178
LIG_SH2_STAT5	654	657	PF00017	0.284
LIG_SH2_STAT5	76	79	PF00017	0.536
LIG_SH2_STAT5	82	85	PF00017	0.545
LIG_SH2_STAT5	92	95	PF00017	0.610
LIG_SH3_2	281	286	PF14604	0.695
LIG_SH3_3	119	125	PF00018	0.648
LIG_SH3_3	278	284	PF00018	0.680
LIG_SH3_3	354	360	PF00018	0.402
LIG_SH3_3	400	406	PF00018	0.330
LIG_SH3_3	474	480	PF00018	0.388
LIG_SH3_3	57	63	PF00018	0.620
LIG_SH3_3	578	584	PF00018	0.288
LIG_SH3_3	585	591	PF00018	0.279
LIG_SH3_3	749	755	PF00018	0.525
LIG_SH3_3	756	762	PF00018	0.590
LIG_SUMO_SIM_anti_2	204	209	PF11976	0.602
LIG_SUMO_SIM_anti_2	549	556	PF11976	0.343
LIG_SUMO_SIM_par_1	535	540	PF11976	0.279
LIG_SUMO_SIM_par_1	61	68	PF11976	0.580
LIG_SxIP_EBH_1	572	583	PF03271	0.284
LIG_TRAF2_1	156	159	PF00917	0.623
LIG_TRAF2_1	662	665	PF00917	0.374
LIG_TRFH_1	399	403	PF08558	0.391
LIG_TYR_ITIM	481	486	PF00017	0.441
LIG_TYR_ITIM	703	708	PF00017	0.391
LIG_UBA3_1	401	407	PF00899	0.453
LIG_WRC_WIRS_1	13	18	PF05994	0.480
LIG_WRC_WIRS_1	446	451	PF05994	0.456
LIG_WRC_WIRS_1	469	474	PF05994	0.438
LIG_WW_3	791	795	PF00397	0.670
MOD_CK1_1	15	21	PF00069	0.491
MOD_CK1_1	185	191	PF00069	0.477
MOD_CK1_1	231	237	PF00069	0.447
MOD_CK1_1	5	11	PF00069	0.610
MOD_CK1_1	514	520	PF00069	0.312
MOD_CK1_1	74	80	PF00069	0.520
MOD_CK2_1	17	23	PF00069	0.452
MOD_CK2_1	445	451	PF00069	0.490
MOD_CK2_1	527	533	PF00069	0.310
MOD_CK2_1	659	665	PF00069	0.453
MOD_CK2_1	666	672	PF00069	0.398
MOD_GlcNHglycan	131	134	PF01048	0.529
MOD_GlcNHglycan	187	190	PF01048	0.360
MOD_GlcNHglycan	249	255	PF01048	0.538
MOD_GlcNHglycan	354	357	PF01048	0.373
MOD_GlcNHglycan	379	383	PF01048	0.453
MOD_GlcNHglycan	512	516	PF01048	0.375
MOD_GlcNHglycan	585	588	PF01048	0.324
MOD_GlcNHglycan	645	649	PF01048	0.373
MOD_GlcNHglycan	73	76	PF01048	0.510
MOD_GSK3_1	191	198	PF00069	0.461
MOD_GSK3_1	35	42	PF00069	0.486
MOD_GSK3_1	434	441	PF00069	0.523
MOD_GSK3_1	464	471	PF00069	0.473
MOD_GSK3_1	482	489	PF00069	0.233
MOD_GSK3_1	5	12	PF00069	0.600
MOD_GSK3_1	510	517	PF00069	0.357
MOD_GSK3_1	568	575	PF00069	0.325
MOD_GSK3_1	58	65	PF00069	0.439
MOD_GSK3_1	597	604	PF00069	0.370
MOD_GSK3_1	67	74	PF00069	0.334
MOD_GSK3_1	675	682	PF00069	0.453
MOD_N-GLC_1	136	141	PF02516	0.483
MOD_N-GLC_2	107	109	PF02516	0.500
MOD_N-GLC_2	580	582	PF02516	0.391
MOD_NEK2_1	182	187	PF00069	0.408
MOD_NEK2_1	257	262	PF00069	0.458
MOD_NEK2_1	352	357	PF00069	0.465
MOD_NEK2_1	377	382	PF00069	0.326
MOD_NEK2_1	454	459	PF00069	0.613
MOD_NEK2_1	541	546	PF00069	0.310
MOD_NEK2_1	603	608	PF00069	0.377
MOD_NEK2_1	650	655	PF00069	0.415
MOD_NEK2_1	666	671	PF00069	0.453
MOD_NEK2_1	67	72	PF00069	0.493
MOD_NEK2_1	9	14	PF00069	0.480
MOD_NEK2_2	173	178	PF00069	0.451
MOD_NEK2_2	324	329	PF00069	0.523
MOD_PIKK_1	182	188	PF00454	0.445
MOD_PIKK_1	364	370	PF00454	0.404
MOD_PIKK_1	426	432	PF00454	0.568
MOD_PK_1	572	578	PF00069	0.310
MOD_PKA_1	270	276	PF00069	0.572
MOD_PKA_2	270	276	PF00069	0.497
MOD_PKA_2	621	627	PF00069	0.459
MOD_Plk_1	136	142	PF00069	0.444
MOD_Plk_1	173	179	PF00069	0.445
MOD_Plk_1	250	256	PF00069	0.507
MOD_Plk_1	378	384	PF00069	0.453
MOD_Plk_1	559	565	PF00069	0.391
MOD_Plk_2-3	223	229	PF00069	0.510
MOD_Plk_2-3	527	533	PF00069	0.453
MOD_Plk_2-3	701	707	PF00069	0.453
MOD_Plk_4	12	18	PF00069	0.450
MOD_Plk_4	231	237	PF00069	0.578
MOD_Plk_4	386	392	PF00069	0.441
MOD_Plk_4	39	45	PF00069	0.565
MOD_Plk_4	514	520	PF00069	0.396
MOD_Plk_4	572	578	PF00069	0.317
MOD_Plk_4	62	68	PF00069	0.476
MOD_Plk_4	650	656	PF00069	0.420
MOD_Plk_4	679	685	PF00069	0.343
MOD_Plk_4	74	80	PF00069	0.421
MOD_ProDKin_1	118	124	PF00069	0.585
MOD_ProDKin_1	340	346	PF00069	0.408
MOD_ProDKin_1	68	74	PF00069	0.362
MOD_SUMO_rev_2	15	22	PF00179	0.440
MOD_SUMO_rev_2	298	303	PF00179	0.543
MOD_SUMO_rev_2	97	103	PF00179	0.514
TRG_DiLeu_BaEn_1	298	303	PF01217	0.480
TRG_DiLeu_BaEn_1	533	538	PF01217	0.310
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.523
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.232
TRG_ENDOCYTIC_2	351	354	PF00928	0.324
TRG_ENDOCYTIC_2	417	420	PF00928	0.431
TRG_ENDOCYTIC_2	446	449	PF00928	0.505
TRG_ENDOCYTIC_2	483	486	PF00928	0.406
TRG_ENDOCYTIC_2	534	537	PF00928	0.310
TRG_ENDOCYTIC_2	705	708	PF00928	0.465
TRG_ENDOCYTIC_2	76	79	PF00928	0.366
TRG_ENDOCYTIC_2	82	85	PF00928	0.358
TRG_ER_diArg_1	239	242	PF00400	0.558
TRG_ER_diArg_1	304	306	PF00400	0.501
TRG_ER_diArg_1	32	34	PF00400	0.417
TRG_ER_diArg_1	331	334	PF00400	0.542
TRG_ER_diArg_1	383	385	PF00400	0.453
TRG_ER_diArg_1	715	717	PF00400	0.299
TRG_NES_CRM1_1	679	692	PF08389	0.453
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	608	612	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	715	720	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P424	Leptomonas seymouri	75%	99%
A0A0S4JHW4	Bodo saltans	30%	100%
A0A1X0P1K6	Trypanosomatidae	37%	100%
A0A3Q8IF24	Leishmania donovani	98%	100%
A0A3R7MIQ4	Trypanosoma rangeli	37%	100%
A4HIT1	Leishmania braziliensis	94%	100%
A4I633	Leishmania infantum	98%	100%
C9ZRF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B1B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q587E3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	37%	100%
V5BX20	Trypanosoma cruzi	38%	100%