DNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA ligase

Gene product:

DNA ligase I, putative

Species:

Leishmania major

UniProt:

Q4Q6U5_LEIMA

TriTrypDb:

LmjF.30.3440 , LMJLV39_300043200 , LMJSD75_300042400

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6U5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006266	DNA ligation	5	2
GO:0006271	DNA strand elongation involved in DNA replication	6	2
GO:0006273	lagging strand elongation	7	2
GO:0006281	DNA repair	5	12
GO:0006310	DNA recombination	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0022616	DNA strand elongation	5	2
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0071897	DNA biosynthetic process	5	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006260	DNA replication	5	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003909	DNA ligase activity	4	12
GO:0003910	DNA ligase (ATP) activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016886	ligase activity, forming phosphoric ester bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.369
CLV_C14_Caspase3-7	466	470	PF00656	0.257
CLV_C14_Caspase3-7	483	487	PF00656	0.234
CLV_C14_Caspase3-7	517	521	PF00656	0.451
CLV_NRD_NRD_1	187	189	PF00675	0.250
CLV_NRD_NRD_1	411	413	PF00675	0.281
CLV_NRD_NRD_1	447	449	PF00675	0.251
CLV_PCSK_KEX2_1	186	188	PF00082	0.250
CLV_PCSK_KEX2_1	447	449	PF00082	0.266
CLV_PCSK_KEX2_1	506	508	PF00082	0.250
CLV_PCSK_KEX2_1	539	541	PF00082	0.250
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.250
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.250
CLV_PCSK_PC7_1	182	188	PF00082	0.278
CLV_PCSK_SKI1_1	167	171	PF00082	0.352
CLV_PCSK_SKI1_1	193	197	PF00082	0.285
CLV_PCSK_SKI1_1	329	333	PF00082	0.281
CLV_PCSK_SKI1_1	448	452	PF00082	0.309
CLV_PCSK_SKI1_1	75	79	PF00082	0.265
DOC_ANK_TNKS_1	481	488	PF00023	0.278
DOC_CDC14_PxL_1	265	273	PF14671	0.293
DOC_CYCLIN_RxL_1	187	198	PF00134	0.285
DOC_CYCLIN_yClb1_LxF_4	459	464	PF00134	0.326
DOC_MAPK_DCC_7	263	273	PF00069	0.297
DOC_MAPK_gen_1	506	514	PF00069	0.250
DOC_MAPK_MEF2A_6	197	206	PF00069	0.265
DOC_MAPK_MEF2A_6	75	84	PF00069	0.285
DOC_PP1_RVXF_1	446	453	PF00149	0.398
DOC_PP1_RVXF_1	459	465	PF00149	0.413
DOC_PP1_RVXF_1	73	80	PF00149	0.353
DOC_USP7_MATH_1	177	181	PF00917	0.278
DOC_USP7_MATH_1	220	224	PF00917	0.260
DOC_USP7_MATH_1	288	292	PF00917	0.456
DOC_USP7_MATH_1	315	319	PF00917	0.395
DOC_USP7_MATH_1	393	397	PF00917	0.374
DOC_USP7_MATH_1	46	50	PF00917	0.610
DOC_USP7_MATH_1	505	509	PF00917	0.265
DOC_USP7_MATH_1	66	70	PF00917	0.171
DOC_USP7_MATH_2	379	385	PF00917	0.278
DOC_USP7_UBL2_3	294	298	PF12436	0.525
DOC_WW_Pin1_4	500	505	PF00397	0.265
DOC_WW_Pin1_4	617	622	PF00397	0.250
LIG_14-3-3_CanoR_1	186	195	PF00244	0.388
LIG_Actin_WH2_2	425	443	PF00022	0.326
LIG_AP_GAE_1	21	27	PF02883	0.470
LIG_APCC_ABBA_1	392	397	PF00400	0.326
LIG_APCC_ABBAyCdc20_2	341	347	PF00400	0.376
LIG_BIR_II_1	1	5	PF00653	0.434
LIG_BIR_III_4	198	202	PF00653	0.250
LIG_BIR_III_4	675	679	PF00653	0.541
LIG_CSL_BTD_1	33	36	PF09270	0.432
LIG_CtBP_PxDLS_1	89	93	PF00389	0.393
LIG_deltaCOP1_diTrp_1	601	610	PF00928	0.250
LIG_FHA_1	314	320	PF00498	0.250
LIG_FHA_1	396	402	PF00498	0.331
LIG_FHA_1	521	527	PF00498	0.372
LIG_FHA_1	576	582	PF00498	0.253
LIG_FHA_1	76	82	PF00498	0.353
LIG_FHA_2	170	176	PF00498	0.376
LIG_FHA_2	254	260	PF00498	0.423
LIG_FHA_2	26	32	PF00498	0.516
LIG_FHA_2	464	470	PF00498	0.331
LIG_FHA_2	476	482	PF00498	0.263
LIG_FHA_2	493	499	PF00498	0.190
LIG_GBD_Chelix_1	207	215	PF00786	0.265
LIG_LIR_Apic_2	31	37	PF02991	0.378
LIG_LIR_Gen_1	28	37	PF02991	0.511
LIG_LIR_Gen_1	508	519	PF02991	0.286
LIG_LIR_Gen_1	557	565	PF02991	0.253
LIG_LIR_Gen_1	78	85	PF02991	0.299
LIG_LIR_Nem_3	168	173	PF02991	0.351
LIG_LIR_Nem_3	21	27	PF02991	0.407
LIG_LIR_Nem_3	28	33	PF02991	0.363
LIG_LIR_Nem_3	349	355	PF02991	0.273
LIG_LIR_Nem_3	363	369	PF02991	0.207
LIG_LIR_Nem_3	449	455	PF02991	0.306
LIG_LIR_Nem_3	508	514	PF02991	0.286
LIG_LIR_Nem_3	541	547	PF02991	0.250
LIG_LIR_Nem_3	557	562	PF02991	0.250
LIG_LIR_Nem_3	78	82	PF02991	0.303
LIG_LYPXL_yS_3	366	369	PF13949	0.250
LIG_NRBOX	249	255	PF00104	0.402
LIG_NRBOX	76	82	PF00104	0.393
LIG_Pex14_2	232	236	PF04695	0.432
LIG_Pex14_2	30	34	PF04695	0.407
LIG_SH2_CRK	559	563	PF00017	0.285
LIG_SH2_GRB2like	433	436	PF00017	0.250
LIG_SH2_NCK_1	266	270	PF00017	0.369
LIG_SH2_STAP1	230	234	PF00017	0.286
LIG_SH2_STAP1	296	300	PF00017	0.376
LIG_SH2_STAT3	643	646	PF00017	0.326
LIG_SH2_STAT3	665	668	PF00017	0.396
LIG_SH2_STAT5	433	436	PF00017	0.286
LIG_SH2_STAT5	502	505	PF00017	0.262
LIG_SH2_STAT5	643	646	PF00017	0.393
LIG_SH2_STAT5	97	100	PF00017	0.250
LIG_SH3_2	304	309	PF14604	0.302
LIG_SH3_3	30	36	PF00018	0.469
LIG_SH3_3	301	307	PF00018	0.391
LIG_SH3_3	37	43	PF00018	0.571
LIG_SH3_3	373	379	PF00018	0.278
LIG_SH3_3	4	10	PF00018	0.626
LIG_SH3_3	417	423	PF00018	0.243
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.378
LIG_SUMO_SIM_anti_2	316	324	PF11976	0.344
LIG_SUMO_SIM_anti_2	523	530	PF11976	0.308
LIG_SUMO_SIM_par_1	316	324	PF11976	0.401
LIG_SUMO_SIM_par_1	378	384	PF11976	0.321
LIG_SUMO_SIM_par_1	388	398	PF11976	0.203
LIG_SUMO_SIM_par_1	80	86	PF11976	0.326
LIG_TRAF2_1	134	137	PF00917	0.307
LIG_TRAF2_1	495	498	PF00917	0.272
LIG_TYR_ITIM	95	100	PF00017	0.265
LIG_UBA3_1	322	330	PF00899	0.393
LIG_WRC_WIRS_1	27	32	PF05994	0.500
LIG_WRC_WIRS_1	382	387	PF05994	0.265
LIG_WRC_WIRS_1	476	481	PF05994	0.286
LIG_WW_3	35	39	PF00397	0.502
MOD_CDK_SPxK_1	500	506	PF00069	0.265
MOD_CDK_SPxxK_3	500	507	PF00069	0.265
MOD_CK1_1	165	171	PF00069	0.326
MOD_CK1_1	317	323	PF00069	0.344
MOD_CK1_1	356	362	PF00069	0.265
MOD_CK1_1	463	469	PF00069	0.383
MOD_CK2_1	169	175	PF00069	0.336
MOD_CK2_1	25	31	PF00069	0.418
MOD_CK2_1	475	481	PF00069	0.339
MOD_CK2_1	492	498	PF00069	0.190
MOD_CK2_1	66	72	PF00069	0.250
MOD_Cter_Amidation	327	330	PF01082	0.393
MOD_Cter_Amidation	410	413	PF01082	0.250
MOD_Cter_Amidation	537	540	PF01082	0.363
MOD_GlcNHglycan	140	143	PF01048	0.326
MOD_GlcNHglycan	164	167	PF01048	0.291
MOD_GlcNHglycan	179	182	PF01048	0.329
MOD_GlcNHglycan	221	225	PF01048	0.285
MOD_GlcNHglycan	275	278	PF01048	0.465
MOD_GlcNHglycan	63	67	PF01048	0.250
MOD_GSK3_1	165	172	PF00069	0.326
MOD_GSK3_1	249	256	PF00069	0.455
MOD_GSK3_1	313	320	PF00069	0.285
MOD_GSK3_1	356	363	PF00069	0.265
MOD_GSK3_1	42	49	PF00069	0.624
MOD_GSK3_1	463	470	PF00069	0.376
MOD_GSK3_1	62	69	PF00069	0.250
MOD_N-GLC_1	440	445	PF02516	0.413
MOD_N-GLC_1	500	505	PF02516	0.278
MOD_NEK2_1	129	134	PF00069	0.254
MOD_NEK2_1	19	24	PF00069	0.449
MOD_NEK2_1	253	258	PF00069	0.375
MOD_NEK2_1	440	445	PF00069	0.299
MOD_NEK2_1	480	485	PF00069	0.286
MOD_NEK2_1	577	582	PF00069	0.355
MOD_PIKK_1	575	581	PF00454	0.310
MOD_PK_1	298	304	PF00069	0.427
MOD_PKA_1	186	192	PF00069	0.393
MOD_PKA_1	329	335	PF00069	0.344
MOD_PKA_2	138	144	PF00069	0.285
MOD_PKA_2	186	192	PF00069	0.393
MOD_PKA_2	356	362	PF00069	0.300
MOD_Plk_1	20	26	PF00069	0.487
MOD_Plk_1	298	304	PF00069	0.358
MOD_Plk_1	418	424	PF00069	0.326
MOD_Plk_1	440	446	PF00069	0.326
MOD_Plk_1	480	486	PF00069	0.298
MOD_Plk_1	615	621	PF00069	0.258
MOD_Plk_2-3	267	273	PF00069	0.337
MOD_Plk_2-3	475	481	PF00069	0.286
MOD_Plk_4	154	160	PF00069	0.250
MOD_Plk_4	249	255	PF00069	0.483
MOD_Plk_4	282	288	PF00069	0.477
MOD_Plk_4	381	387	PF00069	0.257
MOD_Plk_4	475	481	PF00069	0.223
MOD_Plk_4	75	81	PF00069	0.364
MOD_ProDKin_1	500	506	PF00069	0.265
MOD_ProDKin_1	617	623	PF00069	0.250
MOD_SUMO_for_1	134	137	PF00179	0.307
MOD_SUMO_rev_2	606	615	PF00179	0.270
MOD_SUMO_rev_2	648	653	PF00179	0.404
TRG_DiLeu_BaEn_2	380	386	PF01217	0.326
TRG_DiLeu_BaEn_4	572	578	PF01217	0.393
TRG_ENDOCYTIC_2	173	176	PF00928	0.393
TRG_ENDOCYTIC_2	366	369	PF00928	0.273
TRG_ENDOCYTIC_2	559	562	PF00928	0.285
TRG_ENDOCYTIC_2	97	100	PF00928	0.250
TRG_ER_diArg_1	185	188	PF00400	0.253
TRG_ER_diArg_1	644	647	PF00400	0.265
TRG_NES_CRM1_1	72	86	PF08389	0.283
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.238
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB08	Leptomonas seymouri	80%	89%
A0A0S4JHN9	Bodo saltans	63%	97%
A0A1X0P2U4	Trypanosomatidae	65%	96%
A0A3Q8II77	Leishmania donovani	97%	89%
A0A422NMG1	Trypanosoma rangeli	66%	98%
A0B7F9	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	28%	100%
A0PTC0	Mycobacterium ulcerans (strain Agy99)	28%	100%
A0RWD6	Cenarchaeum symbiosum (strain A)	34%	100%
A1RTK4	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	33%	100%
A1RXA6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	29%	100%
A1RY72	Thermofilum pendens (strain DSM 2475 / Hrk 5)	32%	100%
A2BJX6	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	34%	100%
A2SR38	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	28%	100%
A3CWP1	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	29%	100%
A3DP49	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	33%	100%
A3MS62	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	33%	100%
A4F870	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	25%	100%
A4FY19	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	26%	100%
A4HIT2	Leishmania braziliensis	90%	88%
A4I634	Leishmania infantum	97%	100%
A4TDS2	Mycolicibacterium gilvum (strain PYR-GCK)	27%	100%
A4WH24	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	32%	100%
A4YD25	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	32%	100%
A5UKX2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	27%	100%
A6UNY0	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	26%	100%
A6UVC4	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	26%	100%
A6VFQ9	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	25%	100%
A7IAA9	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	28%	100%
A8AB20	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	35%	100%
A8MDU6	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	33%	100%
A8N936	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	25%	66%
A9A3K1	Nitrosopumilus maritimus (strain SCM1)	33%	100%
A9AAX4	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	25%	100%
B0R4C9	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	26%	100%
B1L3K8	Korarchaeum cryptofilum (strain OPF8)	26%	100%
B1L3V2	Korarchaeum cryptofilum (strain OPF8)	33%	100%
B1YA52	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	33%	100%
B2HHE1	Mycobacterium marinum (strain ATCC BAA-535 / M)	29%	100%
B5YD88	Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)	29%	100%
B6YTR4	Thermococcus onnurineus (strain NA1)	31%	100%
B8DZX8	Dictyoglomus turgidum (strain DSM 6724 / Z-1310)	29%	100%
B8GGB8	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	29%	100%
B9LUZ9	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	26%	100%
C0QSL7	Persephonella marina (strain DSM 14350 / EX-H1)	32%	100%
C3MJ14	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	34%	100%
C3MYD2	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	34%	100%
C3MZR1	Sulfolobus islandicus (strain M.16.27)	34%	100%
C3N834	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	34%	100%
C3NF77	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	34%	100%
C4KIZ2	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	34%	100%
C9ZRF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	91%
D2CJS7	Sulfophobococcus zilligii	34%	100%
D4GYZ4	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	26%	100%
E9B1B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	89%
G3GTP0	Cricetulus griseus	24%	75%
O29632	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	100%
O59288	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	100%
O67398	Aquifex aeolicus (strain VF5)	32%	100%
O93723	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	33%	100%
P04819	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	90%
P0CL74	Pyrococcus abyssi	30%	100%
P0CL75	Pyrococcus abyssi (strain GE5 / Orsay)	30%	100%
P12000	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	89%
P18858	Homo sapiens	45%	74%
P37913	Mus musculus	44%	74%
P49917	Homo sapiens	24%	75%
P54875	Methanothermobacter thermautotrophicus	27%	100%
P56709	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	30%	100%
Q02093	Acidianus ambivalens	34%	100%
Q0W0X1	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	28%	100%
Q12X08	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	28%	100%
Q18GX5	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	27%	100%
Q18HT7	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	26%	100%
Q1II25	Koribacter versatilis (strain Ellin345)	26%	100%
Q27474	Caenorhabditis elegans	43%	88%
Q2FTH4	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	27%	100%
Q2NHF9	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	26%	100%
Q3IPX0	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	29%	100%
Q42572	Arabidopsis thaliana	45%	86%
Q46BA3	Methanosarcina barkeri (strain Fusaro / DSM 804)	27%	100%
Q46C04	Methanosarcina barkeri (strain Fusaro / DSM 804)	31%	100%
Q4JAM1	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	32%	100%
Q50566	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	100%
Q57635	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	27%	100%
Q5R6L3	Pongo abelii	24%	75%
Q5V4R0	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	26%	100%
Q6L195	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	32%	100%
Q6LYM1	Methanococcus maripaludis (strain S2 / LL)	26%	100%
Q74M64	Nanoarchaeum equitans (strain Kin4-M)	27%	100%
Q75CA4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	69%
Q7Z7W5	Coprinopsis cinerea	25%	66%
Q8BTF7	Mus musculus	24%	75%
Q8PTK1	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	28%	100%
Q8PVR7	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	31%	100%
Q8TMT1	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	28%	100%
Q8TSR7	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	32%	100%
Q8TWN3	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	30%	100%
Q976G4	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	32%	100%
Q979A1	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	32%	100%
Q980T8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	34%	100%
Q9C1W9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	88%
Q9HH07	Thermococcus fumicolans	30%	100%
Q9HHC4	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	30%	100%
Q9HJ26	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	32%	100%
Q9HR35	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	26%	100%
Q9JHY8	Rattus norvegicus	43%	74%
Q9P9K9	Saccharolobus shibatae	34%	100%
Q9W1H4	Drosophila melanogaster	42%	91%
Q9YD18	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	35%	100%
V5BSC7	Trypanosoma cruzi	66%	97%