Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6U4_LEIMA

TriTrypDb:

LmjF.30.3445 , LMJLV39_300043300 , LMJSD75_300042500

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6U4

Function

Biological processes
Term	Name	Level	Count
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000213	tRNA-intron endonuclease activity	6	1
GO:0003676	nucleic acid binding	3	2
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0004549	tRNA-specific ribonuclease activity	5	1
GO:0005488	binding	1	2
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016892	RNA endonuclease activity, producing 3'-phosphomonoesters	6	1
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	6	1
GO:0097159	organic cyclic compound binding	2	2
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.583
CLV_C14_Caspase3-7	34	38	PF00656	0.568
CLV_C14_Caspase3-7	72	76	PF00656	0.643
CLV_NRD_NRD_1	116	118	PF00675	0.570
CLV_NRD_NRD_1	165	167	PF00675	0.468
CLV_NRD_NRD_1	53	55	PF00675	0.639
CLV_NRD_NRD_1	57	59	PF00675	0.617
CLV_PCSK_KEX2_1	116	118	PF00082	0.570
CLV_PCSK_KEX2_1	55	57	PF00082	0.669
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.767
CLV_PCSK_SKI1_1	10	14	PF00082	0.670
DEG_SCF_FBW7_2	170	177	PF00400	0.549
DOC_CKS1_1	171	176	PF01111	0.551
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.538
DOC_MAPK_MEF2A_6	36	44	PF00069	0.444
DOC_MAPK_RevD_3	40	55	PF00069	0.469
DOC_PP4_FxxP_1	146	149	PF00568	0.636
DOC_USP7_MATH_1	38	42	PF00917	0.421
DOC_USP7_MATH_1	69	73	PF00917	0.770
DOC_USP7_MATH_1	80	84	PF00917	0.427
DOC_USP7_MATH_1	96	100	PF00917	0.558
DOC_USP7_UBL2_3	55	59	PF12436	0.568
DOC_WW_Pin1_4	14	19	PF00397	0.538
DOC_WW_Pin1_4	145	150	PF00397	0.534
DOC_WW_Pin1_4	170	175	PF00397	0.541
DOC_WW_Pin1_4	94	99	PF00397	0.635
LIG_14-3-3_CanoR_1	10	16	PF00244	0.535
LIG_14-3-3_CanoR_1	116	120	PF00244	0.568
LIG_14-3-3_CanoR_1	160	170	PF00244	0.420
LIG_BRCT_BRCA1_1	31	35	PF00533	0.772
LIG_FHA_1	126	132	PF00498	0.564
LIG_LIR_Apic_2	144	149	PF02991	0.635
LIG_LIR_Gen_1	47	53	PF02991	0.683
LIG_LIR_Nem_3	47	51	PF02991	0.735
LIG_SH2_STAP1	183	187	PF00017	0.586
LIG_SH2_STAT5	183	186	PF00017	0.537
LIG_SH2_STAT5	48	51	PF00017	0.684
LIG_SH3_3	15	21	PF00018	0.538
LIG_SH3_3	168	174	PF00018	0.528
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.493
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.609
MOD_CDC14_SPxK_1	97	100	PF00782	0.628
MOD_CDK_SPK_2	170	175	PF00069	0.475
MOD_CDK_SPxK_1	94	100	PF00069	0.631
MOD_CK1_1	14	20	PF00069	0.539
MOD_CK1_1	148	154	PF00069	0.490
MOD_CK1_1	82	88	PF00069	0.509
MOD_CK2_1	105	111	PF00069	0.526
MOD_GlcNHglycan	150	153	PF01048	0.486
MOD_GlcNHglycan	31	34	PF01048	0.516
MOD_GlcNHglycan	66	69	PF01048	0.743
MOD_GlcNHglycan	71	74	PF01048	0.622
MOD_GSK3_1	127	134	PF00069	0.535
MOD_GSK3_1	166	173	PF00069	0.506
MOD_GSK3_1	20	27	PF00069	0.540
MOD_GSK3_1	59	66	PF00069	0.738
MOD_GSK3_1	71	78	PF00069	0.532
MOD_GSK3_1	96	103	PF00069	0.611
MOD_N-GLC_2	163	165	PF02516	0.465
MOD_NEK2_1	13	18	PF00069	0.538
MOD_NEK2_1	181	186	PF00069	0.493
MOD_NEK2_1	44	49	PF00069	0.499
MOD_OFUCOSY	159	165	PF10250	0.447
MOD_PKA_1	166	172	PF00069	0.504
MOD_PKA_2	115	121	PF00069	0.550
MOD_Plk_2-3	127	133	PF00069	0.593
MOD_Plk_4	151	157	PF00069	0.511
MOD_Plk_4	166	172	PF00069	0.504
MOD_Plk_4	44	50	PF00069	0.664
MOD_ProDKin_1	14	20	PF00069	0.539
MOD_ProDKin_1	145	151	PF00069	0.529
MOD_ProDKin_1	170	176	PF00069	0.544
MOD_ProDKin_1	94	100	PF00069	0.631
MOD_SUMO_for_1	174	177	PF00179	0.514
TRG_ENDOCYTIC_2	48	51	PF00928	0.662
TRG_ER_diArg_1	51	54	PF00400	0.622
TRG_ER_diArg_1	89	92	PF00400	0.459
TRG_NLS_MonoCore_2	54	59	PF00514	0.705
TRG_NLS_MonoExtC_3	53	58	PF00514	0.715
TRG_NLS_MonoExtN_4	52	59	PF00514	0.708

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G2	Leptomonas seymouri	54%	100%
A0A3S7X3W7	Leishmania donovani	94%	100%
A4HIT3	Leishmania braziliensis	79%	100%
A4I635	Leishmania infantum	94%	100%
C9ZRF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B1C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%