TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6U3_LEIMA

TriTrypDb:

LmjF.30.3450 , LMJLV39_300043400 , LMJSD75_300042600

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6U3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.324
CLV_C14_Caspase3-7	161	165	PF00656	0.410
CLV_MEL_PAP_1	60	66	PF00089	0.580
CLV_NRD_NRD_1	140	142	PF00675	0.502
CLV_NRD_NRD_1	187	189	PF00675	0.485
CLV_NRD_NRD_1	198	200	PF00675	0.509
CLV_NRD_NRD_1	95	97	PF00675	0.322
CLV_PCSK_KEX2_1	15	17	PF00082	0.551
CLV_PCSK_KEX2_1	268	270	PF00082	0.524
CLV_PCSK_KEX2_1	95	97	PF00082	0.321
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.583
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.496
CLV_PCSK_SKI1_1	188	192	PF00082	0.453
CLV_PCSK_SKI1_1	211	215	PF00082	0.476
CLV_PCSK_SKI1_1	251	255	PF00082	0.488
CLV_PCSK_SKI1_1	376	380	PF00082	0.507
CLV_PCSK_SKI1_1	49	53	PF00082	0.377
CLV_PCSK_SKI1_1	96	100	PF00082	0.305
DEG_APCC_DBOX_1	187	195	PF00400	0.504
DEG_SCF_FBW7_1	341	348	PF00400	0.464
DOC_ANK_TNKS_1	129	136	PF00023	0.338
DOC_CKS1_1	342	347	PF01111	0.502
DOC_CYCLIN_RxL_1	46	55	PF00134	0.426
DOC_MAPK_MEF2A_6	316	324	PF00069	0.314
DOC_PP2B_LxvP_1	59	62	PF13499	0.455
DOC_USP7_MATH_1	155	159	PF00917	0.452
DOC_USP7_MATH_1	384	388	PF00917	0.504
DOC_USP7_MATH_1	62	66	PF00917	0.599
DOC_USP7_UBL2_3	236	240	PF12436	0.509
DOC_WW_Pin1_4	34	39	PF00397	0.489
DOC_WW_Pin1_4	341	346	PF00397	0.480
LIG_14-3-3_CanoR_1	243	252	PF00244	0.508
LIG_14-3-3_CanoR_1	259	266	PF00244	0.523
LIG_14-3-3_CanoR_1	30	36	PF00244	0.552
LIG_14-3-3_CanoR_1	54	60	PF00244	0.509
LIG_APCC_ABBA_1	17	22	PF00400	0.471
LIG_APCC_ABBAyCdc20_2	16	22	PF00400	0.452
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BRCT_BRCA1_1	396	400	PF00533	0.528
LIG_FHA_1	115	121	PF00498	0.487
LIG_FHA_1	166	172	PF00498	0.467
LIG_FHA_1	240	246	PF00498	0.465
LIG_FHA_1	307	313	PF00498	0.462
LIG_FHA_1	341	347	PF00498	0.468
LIG_FHA_1	348	354	PF00498	0.460
LIG_FHA_1	56	62	PF00498	0.447
LIG_FHA_1	82	88	PF00498	0.452
LIG_FHA_2	24	30	PF00498	0.534
LIG_FHA_2	274	280	PF00498	0.509
LIG_FHA_2	342	348	PF00498	0.517
LIG_FHA_2	83	89	PF00498	0.432
LIG_LIR_Apic_2	369	375	PF02991	0.362
LIG_LIR_Gen_1	164	174	PF02991	0.434
LIG_LIR_Gen_1	270	278	PF02991	0.500
LIG_LIR_Gen_1	318	327	PF02991	0.302
LIG_LIR_Gen_1	84	94	PF02991	0.304
LIG_LIR_Nem_3	164	169	PF02991	0.357
LIG_LIR_Nem_3	183	187	PF02991	0.422
LIG_LIR_Nem_3	270	274	PF02991	0.520
LIG_LIR_Nem_3	318	322	PF02991	0.411
LIG_LIR_Nem_3	84	89	PF02991	0.304
LIG_MAD2	30	38	PF02301	0.577
LIG_NRBOX	213	219	PF00104	0.465
LIG_PDZ_Class_2	396	401	PF00595	0.567
LIG_SH2_CRK	123	127	PF00017	0.361
LIG_SH2_NCK_1	123	127	PF00017	0.482
LIG_SH2_STAT5	144	147	PF00017	0.467
LIG_SH2_STAT5	285	288	PF00017	0.595
LIG_SH3_1	199	205	PF00018	0.475
LIG_SH3_3	199	205	PF00018	0.434
LIG_SH3_3	297	303	PF00018	0.431
LIG_SH3_3	339	345	PF00018	0.466
LIG_SH3_3	351	357	PF00018	0.408
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.332
LIG_SUMO_SIM_par_1	167	172	PF11976	0.465
LIG_SUMO_SIM_par_1	295	302	PF11976	0.377
LIG_SUMO_SIM_par_1	308	314	PF11976	0.366
LIG_SUMO_SIM_par_1	320	326	PF11976	0.376
LIG_SUMO_SIM_par_1	49	55	PF11976	0.454
MOD_CK1_1	172	178	PF00069	0.460
MOD_CK1_1	34	40	PF00069	0.516
MOD_CK1_1	55	61	PF00069	0.495
MOD_CK1_1	82	88	PF00069	0.414
MOD_CK2_1	23	29	PF00069	0.507
MOD_CK2_1	273	279	PF00069	0.510
MOD_CK2_1	341	347	PF00069	0.508
MOD_CK2_1	82	88	PF00069	0.432
MOD_Cter_Amidation	266	269	PF01082	0.459
MOD_GlcNHglycan	263	266	PF01048	0.524
MOD_GlcNHglycan	289	292	PF01048	0.571
MOD_GlcNHglycan	387	390	PF01048	0.526
MOD_GlcNHglycan	81	84	PF01048	0.342
MOD_GSK3_1	165	172	PF00069	0.404
MOD_GSK3_1	239	246	PF00069	0.560
MOD_GSK3_1	255	262	PF00069	0.437
MOD_GSK3_1	283	290	PF00069	0.563
MOD_GSK3_1	306	313	PF00069	0.497
MOD_GSK3_1	341	348	PF00069	0.448
MOD_N-GLC_1	20	25	PF02516	0.549
MOD_N-GLC_2	129	131	PF02516	0.507
MOD_NEK2_1	169	174	PF00069	0.458
MOD_NEK2_1	20	25	PF00069	0.527
MOD_NEK2_1	239	244	PF00069	0.466
MOD_NEK2_1	260	265	PF00069	0.538
MOD_NEK2_1	364	369	PF00069	0.475
MOD_NEK2_1	393	398	PF00069	0.576
MOD_NEK2_1	52	57	PF00069	0.469
MOD_PIKK_1	121	127	PF00454	0.428
MOD_PIKK_1	283	289	PF00454	0.574
MOD_PIKK_1	52	58	PF00454	0.497
MOD_PKA_1	283	289	PF00069	0.602
MOD_PKA_2	260	266	PF00069	0.549
MOD_PKA_2	327	333	PF00069	0.403
MOD_PKA_2	62	68	PF00069	0.582
MOD_PKB_1	259	267	PF00069	0.536
MOD_Plk_1	20	26	PF00069	0.547
MOD_Plk_2-3	180	186	PF00069	0.511
MOD_Plk_4	169	175	PF00069	0.462
MOD_Plk_4	213	219	PF00069	0.465
MOD_Plk_4	306	312	PF00069	0.499
MOD_Plk_4	374	380	PF00069	0.321
MOD_Plk_4	55	61	PF00069	0.400
MOD_Plk_4	82	88	PF00069	0.390
MOD_ProDKin_1	34	40	PF00069	0.494
MOD_ProDKin_1	341	347	PF00069	0.476
MOD_SUMO_rev_2	8	17	PF00179	0.474
TRG_DiLeu_BaEn_4	361	367	PF01217	0.534
TRG_ENDOCYTIC_2	123	126	PF00928	0.362
TRG_ER_diArg_1	16	19	PF00400	0.528
TRG_ER_diArg_1	94	96	PF00400	0.364
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P422	Leptomonas seymouri	74%	100%
A0A0S4JKF4	Bodo saltans	36%	95%
A0A1X0P1J7	Trypanosomatidae	40%	97%
A0A3Q8IF79	Leishmania donovani	97%	100%
A0A422NMP4	Trypanosoma rangeli	40%	97%
A4HIT4	Leishmania braziliensis	88%	100%
A4I636	Leishmania infantum	97%	100%
C9ZRF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B1C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q0P5H9	Bos taurus	23%	91%
Q5BK48	Rattus norvegicus	24%	91%
Q8N0Z6	Homo sapiens	26%	91%
Q99LG4	Mus musculus	23%	91%
V5DNS8	Trypanosoma cruzi	45%	100%