LeishMANIAdb
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Putative casein kinase 1 isoform 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative casein kinase 1 isoform 2
Gene product:
casein kinase 1 isoform 2, putative
Species:
Leishmania major
UniProt:
Q4Q6U1_LEIMA
TriTrypDb:
LmjF.30.3470 , LMJLV39_300043600 * , LMJSD75_300042800 *
Length:
376

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1

Expansion

Sequence features

Q4Q6U1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6U1

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 14
GO:0006793 phosphorus metabolic process 3 14
GO:0006796 phosphate-containing compound metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0006810 transport 3 2
GO:0006897 endocytosis 5 2
GO:0007165 signal transduction 2 2
GO:0008152 metabolic process 1 14
GO:0009987 cellular process 1 14
GO:0016192 vesicle-mediated transport 4 2
GO:0016310 phosphorylation 5 14
GO:0018105 peptidyl-serine phosphorylation 6 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018209 peptidyl-serine modification 6 2
GO:0019538 protein metabolic process 3 14
GO:0036211 protein modification process 4 14
GO:0043170 macromolecule metabolic process 3 14
GO:0043412 macromolecule modification 4 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0065007 biological regulation 1 2
GO:0071704 organic substance metabolic process 2 14
GO:1901564 organonitrogen compound metabolic process 3 14
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 14
GO:0003824 catalytic activity 1 14
GO:0004672 protein kinase activity 3 14
GO:0004674 protein serine/threonine kinase activity 4 14
GO:0005488 binding 1 14
GO:0005524 ATP binding 5 14
GO:0016301 kinase activity 4 14
GO:0016740 transferase activity 2 14
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 14
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 14
GO:0017076 purine nucleotide binding 4 14
GO:0030554 adenyl nucleotide binding 5 14
GO:0032553 ribonucleotide binding 3 14
GO:0032555 purine ribonucleotide binding 4 14
GO:0032559 adenyl ribonucleotide binding 5 14
GO:0035639 purine ribonucleoside triphosphate binding 4 14
GO:0036094 small molecule binding 2 14
GO:0043167 ion binding 2 14
GO:0043168 anion binding 3 14
GO:0097159 organic cyclic compound binding 2 14
GO:0097367 carbohydrate derivative binding 2 14
GO:0140096 catalytic activity, acting on a protein 2 14
GO:1901265 nucleoside phosphate binding 3 14
GO:1901363 heterocyclic compound binding 2 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 311 315 PF00656 0.594
CLV_NRD_NRD_1 203 205 PF00675 0.239
CLV_PCSK_FUR_1 4 8 PF00082 0.690
CLV_PCSK_KEX2_1 203 205 PF00082 0.239
CLV_PCSK_KEX2_1 6 8 PF00082 0.643
CLV_PCSK_PC1ET2_1 6 8 PF00082 0.656
CLV_PCSK_SKI1_1 139 143 PF00082 0.271
CLV_PCSK_SKI1_1 174 178 PF00082 0.293
CLV_PCSK_SKI1_1 182 186 PF00082 0.246
CLV_PCSK_SKI1_1 240 244 PF00082 0.395
CLV_PCSK_SKI1_1 355 359 PF00082 0.542
DEG_APCC_DBOX_1 203 211 PF00400 0.250
DOC_CYCLIN_RxL_1 264 274 PF00134 0.321
DOC_CYCLIN_RxL_1 352 360 PF00134 0.535
DOC_MAPK_gen_1 4 13 PF00069 0.642
DOC_MAPK_MEF2A_6 115 124 PF00069 0.298
DOC_PP1_RVXF_1 265 272 PF00149 0.310
DOC_SPAK_OSR1_1 16 20 PF12202 0.298
DOC_USP7_MATH_1 315 319 PF00917 0.582
DOC_USP7_MATH_1 327 331 PF00917 0.505
DOC_USP7_UBL2_3 111 115 PF12436 0.298
DOC_USP7_UBL2_3 228 232 PF12436 0.187
DOC_WW_Pin1_4 226 231 PF00397 0.381
DOC_WW_Pin1_4 244 249 PF00397 0.255
LIG_Actin_WH2_2 309 325 PF00022 0.578
LIG_APCC_ABBAyCdc20_2 174 180 PF00400 0.239
LIG_BIR_III_4 314 318 PF00653 0.488
LIG_BRCT_BRCA1_1 132 136 PF00533 0.252
LIG_BRCT_BRCA1_1 267 271 PF00533 0.361
LIG_BRCT_BRCA1_1 340 344 PF00533 0.633
LIG_FHA_1 264 270 PF00498 0.413
LIG_FHA_1 317 323 PF00498 0.528
LIG_FHA_1 72 78 PF00498 0.305
LIG_FHA_1 88 94 PF00498 0.338
LIG_GBD_Chelix_1 156 164 PF00786 0.400
LIG_LIR_Gen_1 233 242 PF02991 0.376
LIG_LIR_Gen_1 296 307 PF02991 0.431
LIG_LIR_Gen_1 88 97 PF02991 0.256
LIG_LIR_Nem_3 113 117 PF02991 0.253
LIG_LIR_Nem_3 187 193 PF02991 0.250
LIG_LIR_Nem_3 233 239 PF02991 0.407
LIG_LIR_Nem_3 261 265 PF02991 0.343
LIG_LIR_Nem_3 296 302 PF02991 0.398
LIG_LIR_Nem_3 30 35 PF02991 0.335
LIG_LIR_Nem_3 368 372 PF02991 0.612
LIG_PDZ_Class_3 371 376 PF00595 0.619
LIG_Pex14_2 28 32 PF04695 0.365
LIG_PTB_Apo_2 356 363 PF02174 0.697
LIG_PTB_Apo_2 59 66 PF02174 0.424
LIG_PTB_Phospho_1 59 65 PF10480 0.436
LIG_SH2_CRK 65 69 PF00017 0.208
LIG_SH2_PTP2 190 193 PF00017 0.298
LIG_SH2_SRC 130 133 PF00017 0.400
LIG_SH2_SRC 178 181 PF00017 0.307
LIG_SH2_STAP1 265 269 PF00017 0.309
LIG_SH2_STAP1 277 281 PF00017 0.264
LIG_SH2_STAP1 295 299 PF00017 0.485
LIG_SH2_STAP1 89 93 PF00017 0.400
LIG_SH2_STAT3 255 258 PF00017 0.322
LIG_SH2_STAT3 297 300 PF00017 0.399
LIG_SH2_STAT5 130 133 PF00017 0.341
LIG_SH2_STAT5 158 161 PF00017 0.284
LIG_SH2_STAT5 190 193 PF00017 0.239
LIG_SH2_STAT5 212 215 PF00017 0.237
LIG_SH2_STAT5 216 219 PF00017 0.241
LIG_SH2_STAT5 262 265 PF00017 0.315
LIG_SH2_STAT5 279 282 PF00017 0.248
LIG_SH2_STAT5 297 300 PF00017 0.459
LIG_SH2_STAT5 82 85 PF00017 0.348
LIG_SH2_STAT5 89 92 PF00017 0.327
LIG_SH3_3 72 78 PF00018 0.228
LIG_SUMO_SIM_anti_2 90 95 PF11976 0.307
LIG_SUMO_SIM_par_1 88 95 PF11976 0.405
LIG_TRAF2_2 256 261 PF00917 0.442
MOD_CDC14_SPxK_1 229 232 PF00782 0.400
MOD_CDK_SPK_2 226 231 PF00069 0.400
MOD_CDK_SPxK_1 226 232 PF00069 0.400
MOD_CK1_1 113 119 PF00069 0.262
MOD_CK1_1 192 198 PF00069 0.263
MOD_CK1_1 318 324 PF00069 0.609
MOD_CK2_1 244 250 PF00069 0.362
MOD_CK2_1 302 308 PF00069 0.455
MOD_GlcNHglycan 285 288 PF01048 0.346
MOD_GlcNHglycan 324 327 PF01048 0.698
MOD_GlcNHglycan 347 350 PF01048 0.663
MOD_GlcNHglycan 38 41 PF01048 0.323
MOD_GSK3_1 180 187 PF00069 0.298
MOD_GSK3_1 318 325 PF00069 0.664
MOD_GSK3_1 353 360 PF00069 0.581
MOD_N-GLC_2 69 71 PF02516 0.323
MOD_NEK2_1 184 189 PF00069 0.239
MOD_NEK2_1 283 288 PF00069 0.488
MOD_NEK2_1 316 321 PF00069 0.582
MOD_NEK2_1 322 327 PF00069 0.654
MOD_NEK2_1 338 343 PF00069 0.622
MOD_NEK2_1 345 350 PF00069 0.690
MOD_NEK2_1 353 358 PF00069 0.411
MOD_PK_1 189 195 PF00069 0.250
MOD_PKA_2 322 328 PF00069 0.633
MOD_Plk_1 275 281 PF00069 0.324
MOD_Plk_1 87 93 PF00069 0.457
MOD_Plk_2-3 308 314 PF00069 0.461
MOD_Plk_4 208 214 PF00069 0.393
MOD_Plk_4 339 345 PF00069 0.626
MOD_Plk_4 353 359 PF00069 0.616
MOD_Plk_4 77 83 PF00069 0.385
MOD_Plk_4 87 93 PF00069 0.355
MOD_ProDKin_1 226 232 PF00069 0.381
MOD_ProDKin_1 244 250 PF00069 0.256
MOD_SUMO_for_1 141 144 PF00179 0.298
MOD_SUMO_for_1 309 312 PF00179 0.309
MOD_SUMO_for_1 45 48 PF00179 0.250
MOD_SUMO_rev_2 237 245 PF00179 0.383
MOD_SUMO_rev_2 303 311 PF00179 0.571
TRG_ENDOCYTIC_2 190 193 PF00928 0.239
TRG_ENDOCYTIC_2 299 302 PF00928 0.428
TRG_ENDOCYTIC_2 369 372 PF00928 0.608
TRG_ENDOCYTIC_2 65 68 PF00928 0.239
TRG_ENDOCYTIC_2 89 92 PF00928 0.259
TRG_Pf-PMV_PEXEL_1 197 201 PF00026 0.334
TRG_Pf-PMV_PEXEL_1 267 272 PF00026 0.321
TRG_Pf-PMV_PEXEL_1 66 70 PF00026 0.221

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3F5 Leptomonas seymouri 48% 100%
A0A0N1HU44 Leptomonas seymouri 46% 100%
A0A0N1HU45 Leptomonas seymouri 72% 97%
A0A0N1I2H3 Leptomonas seymouri 38% 100%
A0A0N1IKB0 Leptomonas seymouri 33% 66%
A0A0N1PDW7 Leptomonas seymouri 24% 95%
A0A0S4IQ75 Bodo saltans 23% 75%
A0A0S4IVY6 Bodo saltans 43% 91%
A0A0S4JA30 Bodo saltans 45% 100%
A0A0S4JCG2 Bodo saltans 23% 84%
A0A0S4JN06 Bodo saltans 51% 100%
A0A0S4JP58 Bodo saltans 52% 88%
A0A0S4JXJ0 Bodo saltans 39% 100%
A0A1X0NIT3 Trypanosomatidae 50% 100%
A0A1X0NXJ1 Trypanosomatidae 39% 100%
A0A1X0NZS9 Trypanosomatidae 45% 85%
A0A1X0P176 Trypanosomatidae 57% 97%
A0A3Q8IJ66 Leishmania donovani 48% 100%
A0A3Q8ISA0 Leishmania donovani 94% 100%
A0A3S7WNZ6 Leishmania donovani 37% 100%
A0A3S7WZA2 Leishmania donovani 41% 73%
A0A3S7X0V1 Leishmania donovani 31% 66%
A0A3S7X8X3 Leishmania donovani 47% 100%
A0A422MSV5 Trypanosoma rangeli 40% 100%
A0A422N5C9 Trypanosoma rangeli 50% 100%
A0A422NL83 Trypanosoma rangeli 40% 95%
A4H436 Leishmania braziliensis 37% 100%
A4HEI6 Leishmania braziliensis 40% 73%
A4HFV0 Leishmania braziliensis 31% 67%
A4HIT6 Leishmania braziliensis 78% 96%
A4HMD0 Leishmania braziliensis 46% 100%
A4HMD1 Leishmania braziliensis 48% 100%
A4HSC0 Leishmania infantum 37% 100%
A4I1K4 Leishmania infantum 41% 73%
A4I2Y4 Leishmania infantum 31% 66%
A4I638 Leishmania infantum 94% 100%
A4IAZ7 Leishmania infantum 47% 100%
A4IAZ8 Leishmania infantum 48% 100%
A7E3X2 Bos taurus 45% 82%
B9VVJ6 Trypanosoma brucei brucei 51% 100%
C9ZK43 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 94%
C9ZNJ6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
C9ZNJ8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
D0A1R2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 99%
D3ZBE5 Rattus norvegicus 25% 100%
E9ADF5 Leishmania major 31% 67%
E9AKA2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AXN8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 72%
E9AZ78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 66%
E9B1C3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 96%
E9B5Y0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E9B5Y1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
O15726 Plasmodium falciparum (isolate Dd2) 42% 100%
O57252 Vaccinia virus (strain Ankara) 26% 100%
O74135 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 45% 86%
O76324 Drosophila melanogaster 46% 85%
O96999 Leishmania major 34% 100%
P16913 Vaccinia virus (strain Western Reserve) 26% 100%
P20505 Vaccinia virus (strain Copenhagen) 26% 100%
P23291 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 70%
P23292 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 69%
P25323 Dictyostelium discoideum 25% 100%
P29295 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 46% 76%
P33800 Variola virus (isolate Human/India/Ind3/1967) 25% 100%
P34516 Caenorhabditis elegans 29% 100%
P35507 Bos taurus 41% 100%
P35508 Bos taurus 49% 91%
P35509 Bos taurus 46% 100%
P39962 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 72%
P40230 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 41% 70%
P40233 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 43% 84%
P40234 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 86%
P40235 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 48% 100%
P40236 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 47% 94%
P42158 Arabidopsis thaliana 47% 84%
P42168 Caenorhabditis elegans 41% 100%
P48729 Homo sapiens 42% 100%
P48730 Homo sapiens 49% 91%
P49674 Homo sapiens 48% 90%
P54367 Drosophila melanogaster 45% 100%
P67827 Bos taurus 44% 100%
P67828 Oryctolagus cuniculus 44% 100%
P67829 Ovis aries 44% 100%
P67962 Gallus gallus 42% 100%
P67963 Xenopus laevis 42% 100%
P78368 Homo sapiens 46% 91%
P97633 Rattus norvegicus 44% 100%
P9WI62 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 26% 94%
P9WI63 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 26% 94%
Q06486 Rattus norvegicus 49% 91%
Q20471 Caenorhabditis elegans 47% 76%
Q2YDN8 Bos taurus 23% 83%
Q39050 Arabidopsis thaliana 49% 82%
Q4Q9T3 Leishmania major 44% 74%
Q4R9A9 Macaca fascicularis 45% 99%
Q54DF7 Dictyostelium discoideum 36% 76%
Q556Y4 Dictyostelium discoideum 47% 88%
Q5BP74 Xenopus laevis 49% 91%
Q5PRD4 Danio rerio 45% 89%
Q5R4V3 Pongo abelii 45% 82%
Q5RC72 Pongo abelii 49% 91%
Q5XF24 Arabidopsis thaliana 47% 80%
Q5ZJS0 Gallus gallus 45% 82%
Q5ZLL1 Gallus gallus 48% 90%
Q62761 Rattus norvegicus 44% 96%
Q62762 Rattus norvegicus 45% 91%
Q62763 Rattus norvegicus 46% 84%
Q6K9N1 Oryza sativa subsp. japonica 47% 81%
Q6NRT0 Xenopus laevis 45% 82%
Q6P3K7 Danio rerio 49% 92%
Q6P647 Xenopus tropicalis 49% 91%
Q6QNL9 Eimeria tenella 46% 100%
Q6QNM1 Toxoplasma gondii 47% 100%
Q7RBX5 Plasmodium yoelii yoelii 43% 100%
Q7T2E3 Danio rerio 49% 93%
Q7TYY6 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 26% 94%
Q7ZUS1 Danio rerio 27% 88%
Q80X41 Mus musculus 29% 85%
Q86Y07 Homo sapiens 30% 74%
Q8BK63 Mus musculus 42% 100%
Q8BN21 Mus musculus 28% 75%
Q8BTH8 Mus musculus 45% 82%
Q8BVP5 Mus musculus 45% 91%
Q8C4X2 Mus musculus 46% 89%
Q8IHZ9 Plasmodium falciparum (isolate 3D7) 43% 100%
Q8LPI7 Arabidopsis thaliana 42% 91%
Q8LPJ1 Arabidopsis thaliana 49% 78%
Q8N752 Homo sapiens 43% 100%
Q8SQR2 Encephalitozoon cuniculi (strain GB-M1) 34% 100%
Q8SS96 Encephalitozoon cuniculi (strain GB-M1) 38% 100%
Q8TDX7 Homo sapiens 25% 100%
Q8VYK9 Arabidopsis thaliana 46% 86%
Q8WQ99 Caenorhabditis elegans 44% 92%
Q91FD5 Invertebrate iridescent virus 6 28% 91%
Q93Z18 Arabidopsis thaliana 42% 91%
Q95PZ9 Caenorhabditis elegans 27% 99%
Q9CAI5 Arabidopsis thaliana 48% 81%
Q9DC28 Mus musculus 49% 91%
Q9ES74 Mus musculus 25% 100%
Q9FFH8 Arabidopsis thaliana 47% 79%
Q9HCP0 Homo sapiens 45% 89%
Q9J509 Fowlpox virus (strain NVSL) 27% 100%
Q9J523 Fowlpox virus (strain NVSL) 26% 100%
Q9JMK2 Mus musculus 48% 90%
Q9LSX4 Arabidopsis thaliana 46% 78%
Q9LW62 Arabidopsis thaliana 46% 85%
Q9NHE1 Leishmania major 48% 100%
Q9NHE2 Leishmania major 47% 100%
Q9XF67 Arabidopsis thaliana 28% 77%
Q9Y6M4 Homo sapiens 45% 84%
Q9ZUP4 Arabidopsis thaliana 48% 87%
Q9ZWB3 Arabidopsis thaliana 47% 80%
V5AIW9 Trypanosoma cruzi 42% 100%
V5BMQ3 Trypanosoma cruzi 59% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS