Putative chromosomal passenger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chromosomal passenger complex protein 1

Species:

Leishmania major

UniProt:

Q4Q6U0_LEIMA

TriTrypDb:

LmjF.30.3480 , LMJLV39_300043800 , LMJSD75_300042900

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005875	microtubule associated complex	2	2
GO:0032133	chromosome passenger complex	3	2
GO:0032991	protein-containing complex	1	2

Expansion

Sequence features

Q4Q6U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6U0

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0000281	mitotic cytokinesis	4	2
GO:0000910	cytokinesis	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0007051	spindle organization	3	2
GO:0007059	chromosome segregation	2	2
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0022607	cellular component assembly	4	2
GO:0051225	spindle assembly	4	2
GO:0061640	cytoskeleton-dependent cytokinesis	4	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0140694	non-membrane-bounded organelle assembly	6	2
GO:1903047	mitotic cell cycle process	3	2
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	134	136	PF00082	0.621
CLV_PCSK_KEX2_1	164	166	PF00082	0.487
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.701
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.487
CLV_PCSK_SKI1_1	105	109	PF00082	0.740
CLV_PCSK_SKI1_1	196	200	PF00082	0.591
CLV_PCSK_SKI1_1	49	53	PF00082	0.558
DEG_Nend_UBRbox_2	1	3	PF02207	0.648
DEG_SPOP_SBC_1	123	127	PF00917	0.559
DOC_PP1_RVXF_1	135	141	PF00149	0.538
DOC_PP1_RVXF_1	47	53	PF00149	0.558
DOC_USP7_MATH_1	123	127	PF00917	0.682
DOC_USP7_MATH_1	197	201	PF00917	0.516
DOC_USP7_MATH_1	33	37	PF00917	0.671
DOC_USP7_MATH_1	62	66	PF00917	0.623
DOC_USP7_MATH_1	97	101	PF00917	0.704
DOC_WW_Pin1_4	105	110	PF00397	0.680
DOC_WW_Pin1_4	124	129	PF00397	0.741
DOC_WW_Pin1_4	4	9	PF00397	0.525
DOC_WW_Pin1_4	77	82	PF00397	0.617
DOC_WW_Pin1_4	86	91	PF00397	0.651
LIG_14-3-3_CanoR_1	239	245	PF00244	0.443
LIG_Actin_WH2_2	183	201	PF00022	0.560
LIG_BRCT_BRCA1_1	36	40	PF00533	0.662
LIG_BRCT_BRCA1_1	99	103	PF00533	0.765
LIG_CSL_BTD_1	5	8	PF09270	0.546
LIG_deltaCOP1_diTrp_1	210	216	PF00928	0.541
LIG_EVH1_1	29	33	PF00568	0.524
LIG_FHA_1	213	219	PF00498	0.614
LIG_FHA_1	46	52	PF00498	0.502
LIG_FHA_1	5	11	PF00498	0.599
LIG_FHA_1	68	74	PF00498	0.732
LIG_FHA_2	215	221	PF00498	0.508
LIG_LIR_Nem_3	13	19	PF02991	0.432
LIG_SH2_STAP1	240	244	PF00017	0.442
LIG_SH2_STAT5	230	233	PF00017	0.572
LIG_SH2_STAT5	54	57	PF00017	0.535
LIG_SH3_1	27	33	PF00018	0.631
LIG_SH3_3	135	141	PF00018	0.601
LIG_SH3_3	27	33	PF00018	0.499
LIG_SH3_3	91	97	PF00018	0.722
LIG_TRAF2_1	217	220	PF00917	0.499
MOD_CDK_SPxK_1	77	83	PF00069	0.614
MOD_CDK_SPxxK_3	86	93	PF00069	0.760
MOD_CK1_1	99	105	PF00069	0.781
MOD_CK2_1	214	220	PF00069	0.528
MOD_GlcNHglycan	201	204	PF01048	0.537
MOD_GlcNHglycan	207	210	PF01048	0.494
MOD_GSK3_1	112	119	PF00069	0.586
MOD_GSK3_1	149	156	PF00069	0.532
MOD_GSK3_1	210	217	PF00069	0.674
MOD_GSK3_1	99	106	PF00069	0.774
MOD_N-GLC_1	205	210	PF02516	0.649
MOD_NEK2_1	103	108	PF00069	0.747
MOD_NEK2_1	149	154	PF00069	0.536
MOD_NEK2_1	176	181	PF00069	0.658
MOD_PIKK_1	176	182	PF00454	0.661
MOD_PIKK_1	233	239	PF00454	0.468
MOD_PIKK_1	62	68	PF00454	0.570
MOD_PKA_2	238	244	PF00069	0.425
MOD_Plk_1	220	226	PF00069	0.572
MOD_Plk_2-3	214	220	PF00069	0.573
MOD_ProDKin_1	105	111	PF00069	0.678
MOD_ProDKin_1	124	130	PF00069	0.738
MOD_ProDKin_1	4	10	PF00069	0.517
MOD_ProDKin_1	77	83	PF00069	0.619
MOD_ProDKin_1	86	92	PF00069	0.653
MOD_SUMO_for_1	20	23	PF00179	0.505
TRG_ER_diArg_1	135	138	PF00400	0.605
TRG_NLS_MonoExtC_3	133	139	PF00514	0.652
TRG_NLS_MonoExtN_4	132	138	PF00514	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC57	Leptomonas seymouri	71%	96%
A0A0S4JHT6	Bodo saltans	41%	87%
A0A1X0P1C3	Trypanosomatidae	54%	95%
A0A3Q8IC98	Leishmania donovani	94%	100%
A0A3R7L355	Trypanosoma rangeli	52%	96%
A4I639	Leishmania infantum	94%	100%
C9ZRF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	94%
E9AIU2	Leishmania braziliensis	90%	100%
E9B1C4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BX18	Trypanosoma cruzi	51%	96%