SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lorien protein

Species:

Leishmania major

UniProt:

Q4Q6T7_LEIMA

TriTrypDb:

LmjF.30.3490 , LMJLV39_300043900 , LMJSD75_300043000

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6T7

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016925	protein sumoylation	7	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0019789	SUMO transferase activity	4	2
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0061665	SUMO ligase activity	5	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.593
CLV_C14_Caspase3-7	32	36	PF00656	0.780
CLV_NRD_NRD_1	113	115	PF00675	0.324
CLV_NRD_NRD_1	233	235	PF00675	0.476
CLV_NRD_NRD_1	239	241	PF00675	0.488
CLV_NRD_NRD_1	51	53	PF00675	0.444
CLV_PCSK_KEX2_1	113	115	PF00082	0.328
CLV_PCSK_KEX2_1	16	18	PF00082	0.642
CLV_PCSK_KEX2_1	232	234	PF00082	0.487
CLV_PCSK_KEX2_1	239	241	PF00082	0.482
CLV_PCSK_KEX2_1	51	53	PF00082	0.413
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.594
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.497
CLV_PCSK_PC7_1	12	18	PF00082	0.594
CLV_PCSK_SKI1_1	113	117	PF00082	0.301
CLV_PCSK_SKI1_1	186	190	PF00082	0.404
CLV_PCSK_SKI1_1	345	349	PF00082	0.507
CLV_PCSK_SKI1_1	52	56	PF00082	0.405
CLV_PCSK_SKI1_1	68	72	PF00082	0.219
CLV_Separin_Metazoa	56	60	PF03568	0.461
DEG_APCC_DBOX_1	113	121	PF00400	0.313
DEG_APCC_DBOX_1	51	59	PF00400	0.482
DEG_APCC_DBOX_1	67	75	PF00400	0.226
DOC_CYCLIN_RxL_1	111	121	PF00134	0.356
DOC_CYCLIN_yClb5_NLxxxL_5	86	95	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.461
DOC_MAPK_gen_1	113	120	PF00069	0.312
DOC_MAPK_gen_1	48	57	PF00069	0.380
DOC_MAPK_MEF2A_6	113	120	PF00069	0.312
DOC_MAPK_MEF2A_6	170	177	PF00069	0.398
DOC_MAPK_MEF2A_6	186	195	PF00069	0.207
DOC_PP2B_LxvP_1	116	119	PF13499	0.326
DOC_PP2B_LxvP_1	95	98	PF13499	0.392
DOC_PP4_FxxP_1	63	66	PF00568	0.439
DOC_USP7_MATH_1	10	14	PF00917	0.652
DOC_USP7_MATH_1	242	246	PF00917	0.636
DOC_USP7_MATH_1	303	307	PF00917	0.448
DOC_USP7_MATH_1	325	329	PF00917	0.394
DOC_USP7_UBL2_3	348	352	PF12436	0.500
DOC_WW_Pin1_4	107	112	PF00397	0.494
DOC_WW_Pin1_4	147	152	PF00397	0.359
DOC_WW_Pin1_4	158	163	PF00397	0.365
DOC_WW_Pin1_4	175	180	PF00397	0.302
DOC_WW_Pin1_4	238	243	PF00397	0.650
DOC_WW_Pin1_4	69	74	PF00397	0.301
LIG_14-3-3_CanoR_1	21	26	PF00244	0.720
LIG_14-3-3_CanoR_1	225	231	PF00244	0.401
LIG_Actin_WH2_2	332	350	PF00022	0.409
LIG_BIR_III_2	42	46	PF00653	0.458
LIG_FHA_1	176	182	PF00498	0.306
LIG_FHA_1	267	273	PF00498	0.453
LIG_FHA_1	359	365	PF00498	0.549
LIG_FHA_1	90	96	PF00498	0.358
LIG_FHA_2	132	138	PF00498	0.438
LIG_FHA_2	98	104	PF00498	0.462
LIG_GBD_Chelix_1	180	188	PF00786	0.281
LIG_LIR_Apic_2	127	133	PF02991	0.389
LIG_LIR_Apic_2	61	66	PF02991	0.436
LIG_LIR_Gen_1	72	83	PF02991	0.430
LIG_LIR_Nem_3	203	208	PF02991	0.322
LIG_MAD2	348	356	PF02301	0.431
LIG_PCNA_yPIPBox_3	310	324	PF02747	0.404
LIG_SH2_GRB2like	146	149	PF00017	0.317
LIG_SH2_STAT5	146	149	PF00017	0.368
LIG_SH2_STAT5	278	281	PF00017	0.512
LIG_SH2_STAT5	337	340	PF00017	0.355
LIG_SH3_3	149	155	PF00018	0.341
LIG_SH3_3	67	73	PF00018	0.342
LIG_SUMO_SIM_anti_2	360	369	PF11976	0.552
LIG_SUMO_SIM_par_1	178	183	PF11976	0.424
LIG_SUMO_SIM_par_1	250	256	PF11976	0.439
LIG_SUMO_SIM_par_1	360	369	PF11976	0.551
LIG_TRAF2_1	36	39	PF00917	0.616
LIG_TRFH_1	69	73	PF08558	0.310
MOD_CDC14_SPxK_1	110	113	PF00782	0.489
MOD_CDC14_SPxK_1	161	164	PF00782	0.434
MOD_CDK_SPxK_1	107	113	PF00069	0.511
MOD_CDK_SPxK_1	158	164	PF00069	0.423
MOD_CDK_SPxxK_3	107	114	PF00069	0.504
MOD_CK1_1	19	25	PF00069	0.623
MOD_CK1_1	241	247	PF00069	0.648
MOD_CK1_1	89	95	PF00069	0.458
MOD_CK2_1	131	137	PF00069	0.528
MOD_CK2_1	242	248	PF00069	0.647
MOD_CK2_1	357	363	PF00069	0.513
MOD_CK2_1	97	103	PF00069	0.446
MOD_GlcNHglycan	12	15	PF01048	0.504
MOD_GlcNHglycan	18	21	PF01048	0.651
MOD_GlcNHglycan	195	198	PF01048	0.543
MOD_GlcNHglycan	26	29	PF01048	0.649
MOD_GlcNHglycan	305	308	PF01048	0.248
MOD_GSK3_1	15	22	PF00069	0.643
MOD_GSK3_1	238	245	PF00069	0.675
MOD_GSK3_1	86	93	PF00069	0.362
MOD_N-GLC_1	147	152	PF02516	0.381
MOD_N-GLC_1	89	94	PF02516	0.358
MOD_NEK2_1	141	146	PF00069	0.452
MOD_NEK2_1	91	96	PF00069	0.454
MOD_PKA_1	16	22	PF00069	0.596
MOD_PKA_2	16	22	PF00069	0.678
MOD_Plk_1	255	261	PF00069	0.396
MOD_Plk_4	141	147	PF00069	0.440
MOD_Plk_4	21	27	PF00069	0.515
MOD_ProDKin_1	107	113	PF00069	0.484
MOD_ProDKin_1	147	153	PF00069	0.366
MOD_ProDKin_1	158	164	PF00069	0.364
MOD_ProDKin_1	175	181	PF00069	0.298
MOD_ProDKin_1	238	244	PF00069	0.649
MOD_ProDKin_1	69	75	PF00069	0.304
MOD_SUMO_for_1	309	312	PF00179	0.342
TRG_ENDOCYTIC_2	75	78	PF00928	0.325
TRG_ER_diArg_1	113	115	PF00400	0.328
TRG_ER_diArg_1	238	240	PF00400	0.444
TRG_NES_CRM1_1	203	218	PF08389	0.328
TRG_NLS_MonoExtC_3	231	236	PF00514	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JLR1	Bodo saltans	36%	66%
A0A1X0P185	Trypanosomatidae	48%	67%
A0A3R7KHL3	Trypanosoma rangeli	48%	72%
A0A3S7X3Z5	Leishmania donovani	92%	100%
C9ZRF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	70%
E9B1C5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BSC2	Trypanosoma cruzi	48%	72%