RF_PROK_I domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RF-1 domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q6T4_LEIMA

TriTrypDb:

LmjF.30.3540 , LMJLV39_300044200 , LMJSD75_300043300

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6T4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003747	translation release factor activity	5	3
GO:0005488	binding	1	3
GO:0008079	translation termination factor activity	4	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.594
CLV_NRD_NRD_1	137	139	PF00675	0.510
CLV_NRD_NRD_1	165	167	PF00675	0.397
CLV_NRD_NRD_1	196	198	PF00675	0.490
CLV_NRD_NRD_1	2	4	PF00675	0.760
CLV_NRD_NRD_1	200	202	PF00675	0.517
CLV_NRD_NRD_1	221	223	PF00675	0.644
CLV_NRD_NRD_1	328	330	PF00675	0.489
CLV_NRD_NRD_1	37	39	PF00675	0.596
CLV_NRD_NRD_1	437	439	PF00675	0.536
CLV_NRD_NRD_1	88	90	PF00675	0.475
CLV_PCSK_FUR_1	194	198	PF00082	0.531
CLV_PCSK_FUR_1	89	93	PF00082	0.558
CLV_PCSK_KEX2_1	137	139	PF00082	0.510
CLV_PCSK_KEX2_1	165	167	PF00082	0.412
CLV_PCSK_KEX2_1	196	198	PF00082	0.488
CLV_PCSK_KEX2_1	199	201	PF00082	0.494
CLV_PCSK_KEX2_1	2	4	PF00082	0.760
CLV_PCSK_KEX2_1	221	223	PF00082	0.609
CLV_PCSK_KEX2_1	32	34	PF00082	0.585
CLV_PCSK_KEX2_1	328	330	PF00082	0.501
CLV_PCSK_KEX2_1	36	38	PF00082	0.580
CLV_PCSK_KEX2_1	437	439	PF00082	0.517
CLV_PCSK_KEX2_1	88	90	PF00082	0.480
CLV_PCSK_KEX2_1	91	93	PF00082	0.525
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.626
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.616
CLV_PCSK_PC7_1	196	202	PF00082	0.508
CLV_PCSK_PC7_1	33	39	PF00082	0.566
CLV_PCSK_SKI1_1	112	116	PF00082	0.421
CLV_PCSK_SKI1_1	169	173	PF00082	0.391
CLV_PCSK_SKI1_1	272	276	PF00082	0.492
CLV_PCSK_SKI1_1	328	332	PF00082	0.494
CLV_PCSK_SKI1_1	343	347	PF00082	0.565
CLV_PCSK_SKI1_1	355	359	PF00082	0.491
DEG_APCC_DBOX_1	342	350	PF00400	0.413
DEG_APCC_DBOX_1	75	83	PF00400	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.665
DEG_SPOP_SBC_1	283	287	PF00917	0.465
DOC_MAPK_gen_1	154	163	PF00069	0.452
DOC_MAPK_gen_1	165	176	PF00069	0.360
DOC_MAPK_gen_1	218	228	PF00069	0.592
DOC_MAPK_gen_1	437	447	PF00069	0.668
DOC_MAPK_gen_1	76	84	PF00069	0.495
DOC_MAPK_HePTP_8	151	163	PF00069	0.496
DOC_MAPK_MEF2A_6	154	163	PF00069	0.463
DOC_MAPK_MEF2A_6	169	176	PF00069	0.325
DOC_MAPK_MEF2A_6	383	391	PF00069	0.519
DOC_MAPK_MEF2A_6	437	445	PF00069	0.535
DOC_MAPK_NFAT4_5	169	177	PF00069	0.430
DOC_USP7_MATH_1	234	238	PF00917	0.572
DOC_USP7_MATH_1	26	30	PF00917	0.717
DOC_USP7_MATH_1	274	278	PF00917	0.561
DOC_USP7_MATH_1	316	320	PF00917	0.588
DOC_USP7_MATH_1	351	355	PF00917	0.623
DOC_USP7_MATH_1	374	378	PF00917	0.460
DOC_USP7_MATH_1	416	420	PF00917	0.614
DOC_USP7_MATH_1	8	12	PF00917	0.626
DOC_WW_Pin1_4	230	235	PF00397	0.564
DOC_WW_Pin1_4	396	401	PF00397	0.457
DOC_WW_Pin1_4	450	455	PF00397	0.697
LIG_14-3-3_CanoR_1	137	147	PF00244	0.493
LIG_14-3-3_CanoR_1	200	206	PF00244	0.535
LIG_14-3-3_CanoR_1	328	338	PF00244	0.486
LIG_14-3-3_CanoR_1	380	390	PF00244	0.501
LIG_14-3-3_CanoR_1	9	13	PF00244	0.629
LIG_Actin_WH2_2	330	345	PF00022	0.518
LIG_BRCT_BRCA1_1	105	109	PF00533	0.417
LIG_BRCT_BRCA1_1	9	13	PF00533	0.758
LIG_BRCT_BRCA1_2	105	111	PF00533	0.509
LIG_CSL_BTD_1	266	269	PF09270	0.513
LIG_FHA_1	139	145	PF00498	0.421
LIG_FHA_1	253	259	PF00498	0.447
LIG_FHA_1	424	430	PF00498	0.414
LIG_FHA_1	442	448	PF00498	0.632
LIG_FHA_2	14	20	PF00498	0.731
LIG_FHA_2	284	290	PF00498	0.557
LIG_LIR_Apic_2	102	108	PF02991	0.583
LIG_LIR_Gen_1	332	342	PF02991	0.509
LIG_LIR_Nem_3	102	107	PF02991	0.582
LIG_LIR_Nem_3	156	161	PF02991	0.424
LIG_LIR_Nem_3	266	271	PF02991	0.437
LIG_LIR_Nem_3	332	337	PF02991	0.514
LIG_LIR_Nem_3	384	389	PF02991	0.432
LIG_Pex14_1	386	390	PF04695	0.483
LIG_Pex14_2	158	162	PF04695	0.430
LIG_Pex14_2	334	338	PF04695	0.374
LIG_REV1ctd_RIR_1	112	120	PF16727	0.428
LIG_REV1ctd_RIR_1	406	415	PF16727	0.425
LIG_RPA_C_Fungi	160	172	PF08784	0.474
LIG_RPA_C_Insects	160	175	PF08784	0.514
LIG_SH2_CRK	105	109	PF00017	0.502
LIG_SH2_CRK	390	394	PF00017	0.489
LIG_SH2_NCK_1	105	109	PF00017	0.537
LIG_SH2_SRC	303	306	PF00017	0.541
LIG_SH2_STAT5	113	116	PF00017	0.378
LIG_SH2_STAT5	207	210	PF00017	0.596
LIG_SH2_STAT5	297	300	PF00017	0.348
LIG_SH3_3	448	454	PF00018	0.627
LIG_SUMO_SIM_anti_2	53	59	PF11976	0.491
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.433
LIG_TYR_ITSM	100	107	PF00017	0.599
LIG_UBA3_1	81	90	PF00899	0.531
MOD_CDK_SPxxK_3	396	403	PF00069	0.461
MOD_CK1_1	11	17	PF00069	0.731
MOD_CK1_1	449	455	PF00069	0.669
MOD_CK1_1	99	105	PF00069	0.570
MOD_CK2_1	389	395	PF00069	0.493
MOD_Cter_Amidation	197	200	PF01082	0.522
MOD_GlcNHglycan	148	151	PF01048	0.474
MOD_GlcNHglycan	236	239	PF01048	0.565
MOD_GlcNHglycan	276	279	PF01048	0.556
MOD_GlcNHglycan	305	308	PF01048	0.554
MOD_GlcNHglycan	418	421	PF01048	0.612
MOD_GlcNHglycan	44	47	PF01048	0.492
MOD_GlcNHglycan	61	64	PF01048	0.605
MOD_GSK3_1	153	160	PF00069	0.416
MOD_GSK3_1	206	213	PF00069	0.463
MOD_GSK3_1	230	237	PF00069	0.585
MOD_GSK3_1	259	266	PF00069	0.533
MOD_GSK3_1	412	419	PF00069	0.589
MOD_GSK3_1	441	448	PF00069	0.706
MOD_GSK3_1	449	456	PF00069	0.704
MOD_GSK3_1	7	14	PF00069	0.706
MOD_GSK3_1	91	98	PF00069	0.651
MOD_GSK3_1	99	106	PF00069	0.592
MOD_N-GLC_1	374	379	PF02516	0.570
MOD_N-GLC_1	42	47	PF02516	0.554
MOD_NEK2_1	13	18	PF00069	0.629
MOD_NEK2_1	367	372	PF00069	0.445
MOD_NEK2_1	381	386	PF00069	0.365
MOD_NEK2_1	42	47	PF00069	0.658
MOD_NEK2_2	8	13	PF00069	0.715
MOD_PIKK_1	238	244	PF00454	0.589
MOD_PK_1	103	109	PF00069	0.568
MOD_PKA_1	32	38	PF00069	0.575
MOD_PKA_1	59	65	PF00069	0.605
MOD_PKA_1	91	97	PF00069	0.656
MOD_PKA_2	32	38	PF00069	0.579
MOD_PKA_2	436	442	PF00069	0.563
MOD_PKA_2	8	14	PF00069	0.694
MOD_PKA_2	91	97	PF00069	0.603
MOD_PKB_1	199	207	PF00069	0.573
MOD_Plk_1	121	127	PF00069	0.486
MOD_Plk_1	351	357	PF00069	0.578
MOD_Plk_2-3	284	290	PF00069	0.513
MOD_Plk_4	157	163	PF00069	0.419
MOD_Plk_4	263	269	PF00069	0.528
MOD_Plk_4	8	14	PF00069	0.728
MOD_ProDKin_1	230	236	PF00069	0.566
MOD_ProDKin_1	396	402	PF00069	0.453
MOD_ProDKin_1	450	456	PF00069	0.704
MOD_SUMO_for_1	409	412	PF00179	0.522
MOD_SUMO_rev_2	106	114	PF00179	0.483
MOD_SUMO_rev_2	62	69	PF00179	0.557
TRG_DiLeu_BaEn_4	121	127	PF01217	0.606
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.459
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.546
TRG_ENDOCYTIC_2	104	107	PF00928	0.512
TRG_ENDOCYTIC_2	39	42	PF00928	0.692
TRG_ENDOCYTIC_2	390	393	PF00928	0.482
TRG_ENDOCYTIC_2	70	73	PF00928	0.556
TRG_ER_diArg_1	1	3	PF00400	0.717
TRG_ER_diArg_1	137	139	PF00400	0.526
TRG_ER_diArg_1	196	199	PF00400	0.502
TRG_ER_diArg_1	200	203	PF00400	0.517
TRG_ER_diArg_1	327	329	PF00400	0.503
TRG_ER_diArg_1	340	343	PF00400	0.335
TRG_ER_diArg_1	36	38	PF00400	0.593
TRG_ER_diArg_1	369	372	PF00400	0.418
TRG_ER_diArg_1	436	438	PF00400	0.533
TRG_NLS_MonoCore_2	88	93	PF00514	0.602
TRG_NLS_MonoExtC_3	89	95	PF00514	0.626
TRG_NLS_MonoExtN_4	88	94	PF00514	0.615
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ29	Leptomonas seymouri	58%	98%
A0A0S4JPR1	Bodo saltans	32%	84%
A0A1X0P2E4	Trypanosomatidae	39%	97%
A0A3R7MQL4	Trypanosoma rangeli	43%	95%
A0A3S7X3Z9	Leishmania donovani	93%	100%
A4HIU0	Leishmania braziliensis	81%	98%
A4I645	Leishmania infantum	94%	100%
C9ZRG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	97%
E9B1C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BX14	Trypanosoma cruzi	40%	94%