Putative mago nashi-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mago nashi-like protein, putative

Species:

Leishmania major

UniProt:

Q4Q6T2_LEIMA

TriTrypDb:

LmjF.30.3560 , LMJLV39_300044400 , LMJSD75_300043500

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0032991	protein-containing complex	1	11
GO:0035145	exon-exon junction complex	3	11
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	11

Expansion

Sequence features

Q4Q6T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6T2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	143	147	PF00082	0.191
DOC_MAPK_gen_1	98	108	PF00069	0.391
DOC_MAPK_MEF2A_6	101	108	PF00069	0.391
DOC_PP1_RVXF_1	144	151	PF00149	0.486
DOC_USP7_MATH_1	127	131	PF00917	0.491
DOC_USP7_MATH_1	151	155	PF00917	0.404
DOC_WW_Pin1_4	66	71	PF00397	0.439
DOC_WW_Pin1_4	8	13	PF00397	0.550
LIG_14-3-3_CanoR_1	137	142	PF00244	0.406
LIG_Actin_WH2_2	35	51	PF00022	0.391
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BRCT_BRCA1_1	153	157	PF00533	0.404
LIG_FHA_1	115	121	PF00498	0.391
LIG_FHA_1	130	136	PF00498	0.391
LIG_FHA_1	43	49	PF00498	0.523
LIG_Integrin_isoDGR_2	99	101	PF01839	0.191
LIG_LIR_Apic_2	90	96	PF02991	0.400
LIG_LIR_Gen_1	36	42	PF02991	0.391
LIG_LIR_Nem_3	36	40	PF02991	0.400
LIG_PTB_Apo_2	50	57	PF02174	0.486
LIG_PTB_Phospho_1	50	56	PF10480	0.486
LIG_SH2_CRK	139	143	PF00017	0.486
LIG_SH2_GRB2like	50	53	PF00017	0.447
LIG_SH2_STAT5	22	25	PF00017	0.395
LIG_SH2_STAT5	50	53	PF00017	0.486
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.404
LIG_SUMO_SIM_anti_2	129	137	PF11976	0.404
LIG_TRAF2_1	2	5	PF00917	0.588
LIG_WRC_WIRS_1	138	143	PF05994	0.398
MOD_CK1_1	114	120	PF00069	0.391
MOD_CK1_1	129	135	PF00069	0.391
MOD_CK1_1	27	33	PF00069	0.462
MOD_CK2_1	8	14	PF00069	0.517
MOD_CK2_1	81	87	PF00069	0.476
MOD_GlcNHglycan	26	29	PF01048	0.286
MOD_GSK3_1	114	121	PF00069	0.391
MOD_GSK3_1	127	134	PF00069	0.391
MOD_GSK3_1	40	47	PF00069	0.496
MOD_GSK3_1	8	15	PF00069	0.555
MOD_GSK3_1	81	88	PF00069	0.495
MOD_N-GLC_1	51	56	PF02516	0.200
MOD_NEK2_1	108	113	PF00069	0.404
MOD_NEK2_2	151	156	PF00069	0.460
MOD_PIKK_1	15	21	PF00454	0.386
MOD_Plk_4	131	137	PF00069	0.415
MOD_ProDKin_1	66	72	PF00069	0.439
MOD_ProDKin_1	8	14	PF00069	0.529
MOD_SUMO_rev_2	140	148	PF00179	0.505
MOD_SUMO_rev_2	69	79	PF00179	0.422
TRG_DiLeu_BaEn_1	131	136	PF01217	0.437
TRG_DiLeu_BaEn_1	75	80	PF01217	0.439
TRG_ENDOCYTIC_2	139	142	PF00928	0.404
TRG_ER_diLys_1	158	162	PF00400	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTJ5	Leptomonas seymouri	78%	97%
A0A0P0XB70	Oryza sativa subsp. japonica	47%	100%
A0A0S4JLH1	Bodo saltans	59%	77%
A0A1X0P189	Trypanosomatidae	67%	98%
A0A3S7X3Y3	Leishmania donovani	97%	100%
A0A422NMN3	Trypanosoma rangeli	67%	98%
A4HIU2	Leishmania braziliensis	91%	100%
A4I647	Leishmania infantum	98%	100%
B9ENE7	Salmo salar	50%	100%
C9ZRG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	97%
E9B1D0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O23676	Arabidopsis thaliana	52%	100%
O42149	Xenopus laevis	51%	100%
O43037	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
O65806	Euphorbia lagascae	49%	100%
P49028	Drosophila melanogaster	50%	100%
P49029	Caenorhabditis elegans	52%	100%
P49030	Oryza sativa subsp. japonica	51%	100%
P50594	Gallus gallus	51%	100%
P61326	Homo sapiens	51%	100%
P61327	Mus musculus	51%	100%
Q0VC92	Bos taurus	51%	100%
Q27W02	Rattus norvegicus	51%	100%
Q3ZBV3	Bos taurus	51%	100%
Q55E21	Dictyostelium discoideum	45%	82%
Q566Y8	Danio rerio	50%	100%
Q96A72	Homo sapiens	51%	100%
Q9CQL1	Mus musculus	51%	100%