Putative zinc finger-domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger CCCH domain-containing protein

Species:

Leishmania major

UniProt:

Q4Q6T1_LEIMA

TriTrypDb:

LmjF.30.3570 , LMJLV39_300044500 , LMJSD75_300043600

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q6T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6T1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003723	RNA binding	4	4
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4
GO:0003729	mRNA binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.676
CLV_MEL_PAP_1	50	56	PF00089	0.708
CLV_NRD_NRD_1	164	166	PF00675	0.577
CLV_NRD_NRD_1	198	200	PF00675	0.576
CLV_PCSK_KEX2_1	164	166	PF00082	0.614
CLV_PCSK_KEX2_1	52	54	PF00082	0.724
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.724
CLV_PCSK_SKI1_1	140	144	PF00082	0.557
CLV_PCSK_SKI1_1	189	193	PF00082	0.507
CLV_PCSK_SKI1_1	209	213	PF00082	0.282
CLV_Separin_Metazoa	259	263	PF03568	0.571
DEG_SPOP_SBC_1	238	242	PF00917	0.733
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.589
DOC_MAPK_MEF2A_6	146	153	PF00069	0.486
DOC_PP2B_LxvP_1	89	92	PF13499	0.518
DOC_USP7_MATH_1	201	205	PF00917	0.628
DOC_USP7_MATH_1	238	242	PF00917	0.728
DOC_WW_Pin1_4	105	110	PF00397	0.558
DOC_WW_Pin1_4	13	18	PF00397	0.636
DOC_WW_Pin1_4	202	207	PF00397	0.568
DOC_WW_Pin1_4	21	26	PF00397	0.660
DOC_WW_Pin1_4	96	101	PF00397	0.668
LIG_14-3-3_CanoR_1	116	120	PF00244	0.733
LIG_14-3-3_CanoR_1	78	83	PF00244	0.402
LIG_Actin_WH2_2	184	201	PF00022	0.577
LIG_APCC_ABBA_1	149	154	PF00400	0.485
LIG_deltaCOP1_diTrp_1	213	222	PF00928	0.591
LIG_eIF4E_1	129	135	PF01652	0.585
LIG_eIF4E_1	22	28	PF01652	0.727
LIG_FAT_LD_1	131	139	PF03623	0.573
LIG_FHA_1	110	116	PF00498	0.535
LIG_FHA_1	148	154	PF00498	0.500
LIG_FHA_1	97	103	PF00498	0.695
LIG_FHA_2	155	161	PF00498	0.556
LIG_LIR_Nem_3	136	142	PF02991	0.482
LIG_LIR_Nem_3	44	50	PF02991	0.696
LIG_MYND_1	100	104	PF01753	0.714
LIG_MYND_1	25	29	PF01753	0.758
LIG_NRBOX	130	136	PF00104	0.581
LIG_PCNA_yPIPBox_3	156	165	PF02747	0.479
LIG_SH2_PTP2	22	25	PF00017	0.687
LIG_SH2_PTP2	47	50	PF00017	0.719
LIG_SH2_STAT5	129	132	PF00017	0.570
LIG_SH2_STAT5	22	25	PF00017	0.657
LIG_SH2_STAT5	47	50	PF00017	0.719
LIG_SH3_3	117	123	PF00018	0.389
LIG_SH3_3	45	51	PF00018	0.736
LIG_SH3_3	89	95	PF00018	0.658
LIG_SH3_3	98	104	PF00018	0.702
LIG_UBA3_1	134	140	PF00899	0.564
LIG_WRC_WIRS_1	219	224	PF05994	0.604
MOD_CDK_SPxxK_3	109	116	PF00069	0.685
MOD_CDK_SPxxK_3	202	209	PF00069	0.588
MOD_CDK_SPxxK_3	96	103	PF00069	0.718
MOD_CK1_1	108	114	PF00069	0.629
MOD_CK1_1	9	15	PF00069	0.636
MOD_CK2_1	154	160	PF00069	0.561
MOD_CK2_1	201	207	PF00069	0.523
MOD_CK2_1	218	224	PF00069	0.438
MOD_CK2_1	245	251	PF00069	0.659
MOD_GlcNHglycan	125	128	PF01048	0.602
MOD_GlcNHglycan	247	250	PF01048	0.714
MOD_GlcNHglycan	253	256	PF01048	0.672
MOD_GSK3_1	105	112	PF00069	0.616
MOD_GSK3_1	123	130	PF00069	0.678
MOD_GSK3_1	214	221	PF00069	0.493
MOD_GSK3_1	232	239	PF00069	0.565
MOD_GSK3_1	56	63	PF00069	0.507
MOD_GSK3_1	6	13	PF00069	0.659
MOD_N-GLC_1	155	160	PF02516	0.485
MOD_NEK2_1	1	6	PF00069	0.616
MOD_NEK2_1	115	120	PF00069	0.708
MOD_PIKK_1	115	121	PF00454	0.708
MOD_PIKK_1	178	184	PF00454	0.577
MOD_PIKK_1	214	220	PF00454	0.553
MOD_PKA_2	115	121	PF00069	0.722
MOD_Plk_1	155	161	PF00069	0.483
MOD_Plk_4	23	29	PF00069	0.696
MOD_ProDKin_1	105	111	PF00069	0.552
MOD_ProDKin_1	13	19	PF00069	0.637
MOD_ProDKin_1	202	208	PF00069	0.567
MOD_ProDKin_1	21	27	PF00069	0.662
MOD_ProDKin_1	96	102	PF00069	0.671
MOD_SUMO_rev_2	173	181	PF00179	0.597
MOD_SUMO_rev_2	203	211	PF00179	0.569
TRG_DiLeu_BaEn_1	207	212	PF01217	0.514
TRG_ENDOCYTIC_2	139	142	PF00928	0.450
TRG_ENDOCYTIC_2	47	50	PF00928	0.719
TRG_ER_diArg_1	163	165	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I028	Leptomonas seymouri	84%	100%
A0A1X0P164	Trypanosomatidae	40%	93%
A0A3Q8IFW3	Leishmania donovani	96%	99%
A0A3R7M044	Trypanosoma rangeli	42%	100%
A4HIU3	Leishmania braziliensis	89%	100%
A4I648	Leishmania infantum	96%	99%
C9ZRG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	85%
E9B1D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5DNR8	Trypanosoma cruzi	39%	100%