40S ribosomal protein S14

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S14

Species:

Leishmania major

UniProt:

Q4Q6S9_LEIMA

TriTrypDb:

LmjF.30.3590 , LMJLV39_280015700 , LMJSD75_300043800

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0015935	small ribosomal subunit	4	3
GO:0022627	cytosolic small ribosomal subunit	5	3
GO:0032991	protein-containing complex	1	9
GO:0044391	ribosomal subunit	3	3
GO:1990904	ribonucleoprotein complex	2	9
GO:0005840	ribosome	5	6
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q6S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6S9

PDB structure(s): 6az1_O

Function

Biological processes
Term	Name	Level	Count
GO:0000028	ribosomal small subunit assembly	7	3
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006364	rRNA processing	8	3
GO:0006396	RNA processing	6	3
GO:0006412	translation	4	9
GO:0006518	peptide metabolic process	4	9
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009058	biosynthetic process	2	9
GO:0009059	macromolecule biosynthetic process	4	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	3
GO:0016070	RNA metabolic process	5	3
GO:0016072	rRNA metabolic process	7	3
GO:0019538	protein metabolic process	3	9
GO:0022607	cellular component assembly	4	3
GO:0022618	ribonucleoprotein complex assembly	6	3
GO:0030490	maturation of SSU-rRNA	9	3
GO:0034470	ncRNA processing	7	3
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	9
GO:0034660	ncRNA metabolic process	6	3
GO:0043043	peptide biosynthetic process	5	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043603	amide metabolic process	3	9
GO:0043604	amide biosynthetic process	4	9
GO:0043933	protein-containing complex organization	4	3
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0044271	cellular nitrogen compound biosynthetic process	4	9
GO:0046483	heterocycle metabolic process	3	3
GO:0065003	protein-containing complex assembly	5	3
GO:0071704	organic substance metabolic process	2	9
GO:0071826	ribonucleoprotein complex subunit organization	5	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901566	organonitrogen compound biosynthetic process	4	9
GO:1901576	organic substance biosynthetic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0003729	mRNA binding	5	3
GO:0003735	structural constituent of ribosome	2	9
GO:0005198	structural molecule activity	1	9
GO:0005488	binding	1	3
GO:0019843	rRNA binding	5	3
GO:0048027	mRNA 5'-UTR binding	6	3
GO:0070181	small ribosomal subunit rRNA binding	6	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.489
CLV_PCSK_FUR_1	122	126	PF00082	0.485
CLV_PCSK_KEX2_1	124	126	PF00082	0.496
CLV_PCSK_PC7_1	120	126	PF00082	0.484
DEG_Nend_Nbox_1	1	3	PF02207	0.419
DOC_PP2B_LxvP_1	141	144	PF13499	0.466
DOC_USP7_MATH_1	153	157	PF00917	0.502
DOC_USP7_MATH_1	165	169	PF00917	0.418
DOC_USP7_UBL2_3	13	17	PF12436	0.571
DOC_WW_Pin1_4	106	111	PF00397	0.497
DOC_WW_Pin1_4	148	153	PF00397	0.484
DOC_WW_Pin1_4	69	74	PF00397	0.497
LIG_14-3-3_CanoR_1	160	170	PF00244	0.508
LIG_Actin_WH2_2	150	165	PF00022	0.462
LIG_AP2alpha_1	39	43	PF02296	0.497
LIG_CSL_BTD_1	149	152	PF09270	0.458
LIG_EVH1_2	143	147	PF00568	0.473
LIG_LIR_Gen_1	41	49	PF02991	0.497
LIG_LIR_Gen_1	53	62	PF02991	0.419
LIG_LIR_Gen_1	71	80	PF02991	0.379
LIG_LIR_Nem_3	27	33	PF02991	0.421
LIG_LIR_Nem_3	41	46	PF02991	0.497
LIG_LIR_Nem_3	53	58	PF02991	0.419
LIG_Pex14_2	39	43	PF04695	0.497
LIG_SH2_CRK	30	34	PF00017	0.350
LIG_SH2_PTP2	55	58	PF00017	0.497
LIG_SH2_STAP1	74	78	PF00017	0.497
LIG_SH2_STAT5	188	191	PF00017	0.417
LIG_SH2_STAT5	55	58	PF00017	0.497
LIG_SH3_2	112	117	PF14604	0.541
LIG_SH3_3	109	115	PF00018	0.374
LIG_SH3_3	146	152	PF00018	0.461
LIG_SH3_CIN85_PxpxPR_1	119	124	PF14604	0.489
LIG_SUMO_SIM_anti_2	168	174	PF11976	0.409
LIG_TYR_ITIM	28	33	PF00017	0.414
LIG_WRC_WIRS_1	184	189	PF05994	0.401
LIG_WRC_WIRS_1	36	41	PF05994	0.497
LIG_WW_3	117	121	PF00397	0.470
MOD_CDK_SPxxK_3	148	155	PF00069	0.457
MOD_CK1_1	168	174	PF00069	0.409
MOD_CK2_1	47	53	PF00069	0.497
MOD_GlcNHglycan	48	52	PF01048	0.297
MOD_GSK3_1	161	168	PF00069	0.447
MOD_GSK3_1	35	42	PF00069	0.497
MOD_GSK3_1	47	54	PF00069	0.419
MOD_N-GLC_1	39	44	PF02516	0.297
MOD_NEK2_1	39	44	PF00069	0.497
MOD_NEK2_2	153	158	PF00069	0.465
MOD_PKA_2	51	57	PF00069	0.518
MOD_PKA_2	8	14	PF00069	0.408
MOD_Plk_1	168	174	PF00069	0.466
MOD_Plk_1	39	45	PF00069	0.497
MOD_Plk_4	168	174	PF00069	0.523
MOD_Plk_4	183	189	PF00069	0.402
MOD_Plk_4	39	45	PF00069	0.569
MOD_Plk_4	51	57	PF00069	0.490
MOD_ProDKin_1	106	112	PF00069	0.497
MOD_ProDKin_1	148	154	PF00069	0.484
MOD_ProDKin_1	69	75	PF00069	0.497
MOD_SUMO_rev_2	11	18	PF00179	0.530
TRG_ENDOCYTIC_2	30	33	PF00928	0.350
TRG_ENDOCYTIC_2	55	58	PF00928	0.474
TRG_ENDOCYTIC_2	74	77	PF00928	0.373
TRG_ER_diArg_1	119	122	PF00400	0.490
TRG_ER_diArg_1	123	125	PF00400	0.487
TRG_ER_diArg_1	157	160	PF00400	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X1E9	Leishmania donovani	98%	100%
A0A3S7X3Z7	Leishmania donovani	98%	100%
A4HGE0	Leishmania braziliensis	98%	100%
A4I3H3	Leishmania infantum	98%	100%
A4I650	Leishmania infantum	98%	100%
A4QJE8	Aethionema cordifolium	33%	100%
A4QJN2	Aethionema grandiflorum	33%	100%
A4QL52	Draba nemorosa	33%	100%
E9AZR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q8H1	Leishmania major	100%	100%