Dynein regulatory complex subunit 7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF773), putative

Species:

Leishmania major

UniProt:

Q4Q6S7_LEIMA

TriTrypDb:

LmjF.30.3610 , LMJLV39_300044900 , LMJSD75_300044000

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6S7

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	2
GO:0001932	regulation of protein phosphorylation	7	2
GO:0007346	regulation of mitotic cell cycle	5	2
GO:0019220	regulation of phosphate metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031399	regulation of protein modification process	6	2
GO:0042325	regulation of phosphorylation	7	2
GO:0043549	regulation of kinase activity	5	2
GO:0045859	regulation of protein kinase activity	6	2
GO:0050789	regulation of biological process	2	2
GO:0050790	regulation of catalytic activity	3	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051174	regulation of phosphorus metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051338	regulation of transferase activity	4	2
GO:0051726	regulation of cell cycle	4	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0071900	regulation of protein serine/threonine kinase activity	7	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.470
CLV_NRD_NRD_1	19	21	PF00675	0.415
CLV_NRD_NRD_1	25	27	PF00675	0.416
CLV_NRD_NRD_1	375	377	PF00675	0.509
CLV_NRD_NRD_1	84	86	PF00675	0.280
CLV_PCSK_KEX2_1	375	377	PF00082	0.396
CLV_PCSK_KEX2_1	84	86	PF00082	0.241
CLV_PCSK_SKI1_1	21	25	PF00082	0.402
CLV_PCSK_SKI1_1	287	291	PF00082	0.401
CLV_PCSK_SKI1_1	375	379	PF00082	0.407
CLV_PCSK_SKI1_1	55	59	PF00082	0.329
DOC_CDC14_PxL_1	36	44	PF14671	0.425
DOC_MAPK_gen_1	314	324	PF00069	0.546
DOC_USP7_MATH_1	285	289	PF00917	0.310
DOC_USP7_MATH_1	307	311	PF00917	0.514
DOC_USP7_MATH_2	230	236	PF00917	0.470
DOC_USP7_UBL2_3	55	59	PF12436	0.492
LIG_14-3-3_CanoR_1	165	174	PF00244	0.536
LIG_14-3-3_CanoR_1	20	24	PF00244	0.483
LIG_14-3-3_CanoR_1	306	312	PF00244	0.347
LIG_14-3-3_CanoR_1	328	336	PF00244	0.437
LIG_AP2alpha_2	154	156	PF02296	0.470
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_BIR_III_4	183	187	PF00653	0.470
LIG_FHA_1	271	277	PF00498	0.441
LIG_FHA_1	281	287	PF00498	0.409
LIG_FHA_2	192	198	PF00498	0.397
LIG_FHA_2	279	285	PF00498	0.497
LIG_FHA_2	314	320	PF00498	0.313
LIG_FHA_2	364	370	PF00498	0.411
LIG_LIR_Gen_1	137	147	PF02991	0.500
LIG_LIR_Gen_1	31	40	PF02991	0.291
LIG_LIR_Nem_3	137	142	PF02991	0.514
LIG_LIR_Nem_3	31	35	PF02991	0.347
LIG_PDZ_Class_2	383	388	PF00595	0.507
LIG_Pex14_2	156	160	PF04695	0.436
LIG_SH2_CRK	139	143	PF00017	0.492
LIG_SH2_CRK	32	36	PF00017	0.337
LIG_SH2_GRB2like	138	141	PF00017	0.470
LIG_SH2_SRC	172	175	PF00017	0.470
LIG_SUMO_SIM_par_1	376	382	PF11976	0.424
LIG_TRAF2_1	123	126	PF00917	0.470
LIG_TRAF2_1	230	233	PF00917	0.390
LIG_TRAF2_1	63	66	PF00917	0.445
LIG_UBA3_1	208	214	PF00899	0.397
LIG_WRC_WIRS_1	286	291	PF05994	0.306
MOD_CK1_1	179	185	PF00069	0.495
MOD_CK1_1	22	28	PF00069	0.449
MOD_CK1_1	288	294	PF00069	0.522
MOD_CK2_1	165	171	PF00069	0.470
MOD_CK2_1	232	238	PF00069	0.410
MOD_CK2_1	256	262	PF00069	0.474
MOD_CK2_1	278	284	PF00069	0.497
MOD_CK2_1	289	295	PF00069	0.384
MOD_CK2_1	313	319	PF00069	0.403
MOD_CK2_1	363	369	PF00069	0.408
MOD_GlcNHglycan	106	109	PF01048	0.228
MOD_GlcNHglycan	200	206	PF01048	0.190
MOD_GlcNHglycan	249	252	PF01048	0.545
MOD_GlcNHglycan	291	294	PF01048	0.520
MOD_GSK3_1	285	292	PF00069	0.451
MOD_GSK3_1	352	359	PF00069	0.417
MOD_N-GLC_1	326	331	PF02516	0.440
MOD_NEK2_1	143	148	PF00069	0.476
MOD_NEK2_1	289	294	PF00069	0.525
MOD_NEK2_1	301	306	PF00069	0.375
MOD_NEK2_2	356	361	PF00069	0.296
MOD_PIKK_1	191	197	PF00454	0.390
MOD_PIKK_1	74	80	PF00454	0.470
MOD_PKA_2	19	25	PF00069	0.483
MOD_PKA_2	270	276	PF00069	0.469
MOD_PKA_2	307	313	PF00069	0.439
MOD_PKA_2	327	333	PF00069	0.265
MOD_Plk_1	232	238	PF00069	0.572
MOD_Plk_2-3	232	238	PF00069	0.541
MOD_Plk_2-3	278	284	PF00069	0.380
MOD_Plk_4	19	25	PF00069	0.535
MOD_Plk_4	307	313	PF00069	0.525
MOD_SUMO_rev_2	14	23	PF00179	0.439
TRG_DiLeu_BaEn_1	31	36	PF01217	0.349
TRG_ENDOCYTIC_2	10	13	PF00928	0.361
TRG_ENDOCYTIC_2	139	142	PF00928	0.455
TRG_ENDOCYTIC_2	32	35	PF00928	0.390
TRG_ER_diArg_1	305	308	PF00400	0.414
TRG_ER_diArg_1	375	377	PF00400	0.396
TRG_NLS_MonoExtC_3	25	31	PF00514	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA07	Leptomonas seymouri	58%	100%
A0A0S4JRC2	Bodo saltans	26%	92%
A0A1X0P1A0	Trypanosomatidae	34%	94%
A0A3R7KHJ9	Trypanosoma rangeli	33%	100%
A0A3S7X403	Leishmania donovani	90%	100%
A4I652	Leishmania infantum	89%	100%
C9ZRH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	98%
E9B1D5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BMP1	Trypanosoma cruzi	32%	94%