Disabled homolog 1-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6S6_LEIMA

TriTrypDb:

LmjF.30.3620 , LMJLV39_300045000 , LMJSD75_300044100

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	13	17	PF00082	0.641
CLV_PCSK_SKI1_1	55	59	PF00082	0.762
CLV_PCSK_SKI1_1	72	76	PF00082	0.550
DEG_APCC_DBOX_1	225	233	PF00400	0.753
DEG_Nend_UBRbox_2	1	3	PF02207	0.623
DOC_CKS1_1	288	293	PF01111	0.749
DOC_CKS1_1	294	299	PF01111	0.639
DOC_CYCLIN_yCln2_LP_2	294	300	PF00134	0.739
DOC_MAPK_gen_1	22	30	PF00069	0.622
DOC_MAPK_MEF2A_6	77	85	PF00069	0.583
DOC_PP2B_LxvP_1	66	69	PF13499	0.725
DOC_PP4_FxxP_1	156	159	PF00568	0.717
DOC_PP4_FxxP_1	199	202	PF00568	0.613
DOC_PP4_FxxP_1	211	214	PF00568	0.733
DOC_PP4_FxxP_1	244	247	PF00568	0.795
DOC_USP7_MATH_1	109	113	PF00917	0.721
DOC_USP7_MATH_1	119	123	PF00917	0.732
DOC_USP7_MATH_1	124	128	PF00917	0.650
DOC_USP7_MATH_1	159	163	PF00917	0.703
DOC_USP7_MATH_1	237	241	PF00917	0.734
DOC_USP7_MATH_2	159	165	PF00917	0.789
DOC_USP7_UBL2_3	218	222	PF12436	0.742
DOC_WW_Pin1_4	113	118	PF00397	0.688
DOC_WW_Pin1_4	134	139	PF00397	0.720
DOC_WW_Pin1_4	140	145	PF00397	0.677
DOC_WW_Pin1_4	217	222	PF00397	0.694
DOC_WW_Pin1_4	243	248	PF00397	0.791
DOC_WW_Pin1_4	256	261	PF00397	0.669
DOC_WW_Pin1_4	265	270	PF00397	0.633
DOC_WW_Pin1_4	287	292	PF00397	0.709
DOC_WW_Pin1_4	293	298	PF00397	0.700
DOC_WW_Pin1_4	328	333	PF00397	0.502
DOC_WW_Pin1_4	58	63	PF00397	0.751
LIG_14-3-3_CanoR_1	226	230	PF00244	0.754
LIG_14-3-3_CanoR_1	24	31	PF00244	0.666
LIG_Actin_WH2_2	210	228	PF00022	0.537
LIG_APCC_ABBA_1	196	201	PF00400	0.622
LIG_BRCT_BRCA1_1	166	170	PF00533	0.780
LIG_deltaCOP1_diTrp_1	201	211	PF00928	0.744
LIG_FHA_1	130	136	PF00498	0.693
LIG_FHA_1	185	191	PF00498	0.692
LIG_FHA_1	23	29	PF00498	0.678
LIG_FHA_1	300	306	PF00498	0.692
LIG_FHA_1	314	320	PF00498	0.688
LIG_FHA_1	35	41	PF00498	0.666
LIG_FHA_2	48	54	PF00498	0.560
LIG_LIR_Apic_2	153	159	PF02991	0.722
LIG_LIR_Apic_2	209	214	PF02991	0.725
LIG_LIR_Apic_2	241	247	PF02991	0.783
LIG_LIR_Gen_1	167	178	PF02991	0.767
LIG_LIR_Nem_3	167	173	PF02991	0.758
LIG_LIR_Nem_3	296	301	PF02991	0.692
LIG_NRBOX	80	86	PF00104	0.615
LIG_SH2_CRK	301	305	PF00017	0.688
LIG_SH2_CRK	320	324	PF00017	0.623
LIG_SH2_CRK	345	349	PF00017	0.757
LIG_SH2_NCK_1	233	237	PF00017	0.705
LIG_SH2_NCK_1	320	324	PF00017	0.645
LIG_SH2_NCK_1	345	349	PF00017	0.751
LIG_SH2_NCK_1	7	11	PF00017	0.652
LIG_SH2_SRC	345	348	PF00017	0.730
LIG_SH2_SRC	7	10	PF00017	0.653
LIG_SH2_STAP1	233	237	PF00017	0.746
LIG_SH2_STAT3	307	310	PF00017	0.696
LIG_SH2_STAT5	301	304	PF00017	0.690
LIG_SH3_1	360	366	PF00018	0.700
LIG_SH3_2	62	67	PF14604	0.791
LIG_SH3_3	115	121	PF00018	0.755
LIG_SH3_3	132	138	PF00018	0.677
LIG_SH3_3	148	154	PF00018	0.671
LIG_SH3_3	244	250	PF00018	0.746
LIG_SH3_3	254	260	PF00018	0.727
LIG_SH3_3	283	289	PF00018	0.702
LIG_SH3_3	309	315	PF00018	0.607
LIG_SH3_3	360	366	PF00018	0.648
LIG_SH3_3	59	65	PF00018	0.726
LIG_SH3_4	106	113	PF00018	0.718
LIG_SH3_4	218	225	PF00018	0.773
LIG_SUMO_SIM_anti_2	25	32	PF11976	0.673
LIG_SUMO_SIM_par_1	44	50	PF11976	0.530
LIG_TRAF2_1	93	96	PF00917	0.773
MOD_CDK_SPK_2	217	222	PF00069	0.775
MOD_CK1_1	152	158	PF00069	0.768
MOD_CK1_1	164	170	PF00069	0.619
MOD_CK1_1	23	29	PF00069	0.646
MOD_CK1_1	235	241	PF00069	0.602
MOD_CK1_1	99	105	PF00069	0.758
MOD_CK2_1	225	231	PF00069	0.677
MOD_CK2_1	47	53	PF00069	0.557
MOD_GlcNHglycan	101	104	PF01048	0.777
MOD_GlcNHglycan	111	114	PF01048	0.705
MOD_GlcNHglycan	121	124	PF01048	0.789
MOD_GlcNHglycan	126	129	PF01048	0.691
MOD_GlcNHglycan	163	166	PF01048	0.743
MOD_GlcNHglycan	234	237	PF01048	0.745
MOD_GlcNHglycan	241	244	PF01048	0.729
MOD_GSK3_1	109	116	PF00069	0.642
MOD_GSK3_1	160	167	PF00069	0.772
MOD_GSK3_1	213	220	PF00069	0.661
MOD_GSK3_1	22	29	PF00069	0.680
MOD_GSK3_1	235	242	PF00069	0.640
MOD_GSK3_1	261	268	PF00069	0.669
MOD_GSK3_1	269	276	PF00069	0.616
MOD_GSK3_1	47	54	PF00069	0.692
MOD_GSK3_1	95	102	PF00069	0.699
MOD_N-GLC_1	113	118	PF02516	0.716
MOD_N-GLC_1	238	243	PF02516	0.680
MOD_NEK2_1	1	6	PF00069	0.591
MOD_NEK2_1	225	230	PF00069	0.734
MOD_NEK2_1	232	237	PF00069	0.661
MOD_NEK2_1	274	279	PF00069	0.690
MOD_NEK2_1	333	338	PF00069	0.735
MOD_PIKK_1	249	255	PF00454	0.713
MOD_PIKK_1	333	339	PF00454	0.629
MOD_PKA_2	225	231	PF00069	0.746
MOD_PKA_2	23	29	PF00069	0.678
MOD_Plk_1	191	197	PF00069	0.721
MOD_Plk_1	26	32	PF00069	0.642
MOD_Plk_1	8	14	PF00069	0.702
MOD_Plk_4	26	32	PF00069	0.667
MOD_ProDKin_1	113	119	PF00069	0.691
MOD_ProDKin_1	134	140	PF00069	0.720
MOD_ProDKin_1	217	223	PF00069	0.694
MOD_ProDKin_1	243	249	PF00069	0.790
MOD_ProDKin_1	256	262	PF00069	0.667
MOD_ProDKin_1	265	271	PF00069	0.628
MOD_ProDKin_1	287	293	PF00069	0.710
MOD_ProDKin_1	328	334	PF00069	0.503
MOD_ProDKin_1	58	64	PF00069	0.749
MOD_SUMO_rev_2	152	162	PF00179	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGN6	Leptomonas seymouri	55%	98%
A0A3Q8IEJ9	Leishmania donovani	94%	100%
A0A422NME0	Trypanosoma rangeli	26%	99%
A4HIU8	Leishmania braziliensis	76%	100%
A4I653	Leishmania infantum	94%	100%
C9ZRH3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	96%
E9B1D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BX10	Trypanosoma cruzi	25%	99%