Putative CYC2-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CYC2-like protein, putative

Species:

Leishmania major

UniProt:

Q4Q6S5_LEIMA

TriTrypDb:

LmjF.30.3630 , LMJLV39_300045100 , LMJSD75_300044200

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6S5

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	13
GO:0001932	regulation of protein phosphorylation	7	13
GO:0019220	regulation of phosphate metabolic process	6	13
GO:0019222	regulation of metabolic process	3	13
GO:0031323	regulation of cellular metabolic process	4	13
GO:0031399	regulation of protein modification process	6	13
GO:0042325	regulation of phosphorylation	7	13
GO:0043549	regulation of kinase activity	5	13
GO:0045859	regulation of protein kinase activity	6	13
GO:0050789	regulation of biological process	2	13
GO:0050790	regulation of catalytic activity	3	13
GO:0050794	regulation of cellular process	3	13
GO:0051171	regulation of nitrogen compound metabolic process	4	13
GO:0051174	regulation of phosphorus metabolic process	5	13
GO:0051246	regulation of protein metabolic process	5	13
GO:0051338	regulation of transferase activity	4	13
GO:0051726	regulation of cell cycle	4	13
GO:0060255	regulation of macromolecule metabolic process	4	13
GO:0065007	biological regulation	1	13
GO:0065009	regulation of molecular function	2	13
GO:0071900	regulation of protein serine/threonine kinase activity	7	13
GO:0080090	regulation of primary metabolic process	4	13
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	13

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0019899	enzyme binding	3	13
GO:0019900	kinase binding	4	13
GO:0019901	protein kinase binding	5	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.602
CLV_NRD_NRD_1	180	182	PF00675	0.437
CLV_NRD_NRD_1	94	96	PF00675	0.284
CLV_PCSK_KEX2_1	180	182	PF00082	0.504
CLV_PCSK_KEX2_1	94	96	PF00082	0.284
CLV_PCSK_PC7_1	176	182	PF00082	0.348
CLV_PCSK_SKI1_1	110	114	PF00082	0.305
CLV_PCSK_SKI1_1	181	185	PF00082	0.495
CLV_PCSK_SKI1_1	74	78	PF00082	0.424
CLV_PCSK_SKI1_1	95	99	PF00082	0.281
DEG_APCC_DBOX_1	109	117	PF00400	0.284
DEG_SPOP_SBC_1	202	206	PF00917	0.588
DOC_CYCLIN_RxL_1	104	114	PF00134	0.285
DOC_CYCLIN_RxL_1	91	99	PF00134	0.360
DOC_MAPK_gen_1	142	151	PF00069	0.249
DOC_MAPK_HePTP_8	139	151	PF00069	0.266
DOC_MAPK_MEF2A_6	142	151	PF00069	0.353
DOC_PP2B_PxIxI_1	63	69	PF00149	0.293
DOC_PP4_FxxP_1	232	235	PF00568	0.455
DOC_PP4_FxxP_1	240	243	PF00568	0.425
DOC_USP7_MATH_1	235	239	PF00917	0.669
DOC_USP7_MATH_1	36	40	PF00917	0.508
DOC_USP7_MATH_1	5	9	PF00917	0.507
DOC_WW_Pin1_4	7	12	PF00397	0.420
DOC_WW_Pin1_4	79	84	PF00397	0.262
LIG_14-3-3_CanoR_1	110	120	PF00244	0.293
LIG_14-3-3_CanoR_1	150	158	PF00244	0.407
LIG_14-3-3_CanoR_1	176	183	PF00244	0.457
LIG_14-3-3_CanoR_1	195	203	PF00244	0.497
LIG_14-3-3_CanoR_1	74	79	PF00244	0.366
LIG_BRCT_BRCA1_1	53	57	PF00533	0.262
LIG_Clathr_ClatBox_1	155	159	PF01394	0.476
LIG_deltaCOP1_diTrp_1	230	240	PF00928	0.438
LIG_FHA_1	112	118	PF00498	0.308
LIG_FHA_1	202	208	PF00498	0.703
LIG_FHA_1	70	76	PF00498	0.413
LIG_FHA_2	138	144	PF00498	0.293
LIG_FHA_2	36	42	PF00498	0.602
LIG_LIR_Apic_2	230	235	PF02991	0.406
LIG_LIR_Apic_2	238	243	PF02991	0.411
LIG_LIR_Gen_1	131	139	PF02991	0.377
LIG_LIR_Gen_1	166	175	PF02991	0.422
LIG_LIR_Nem_3	131	136	PF02991	0.365
LIG_LIR_Nem_3	166	170	PF02991	0.352
LIG_LIR_Nem_3	230	236	PF02991	0.602
LIG_PCNA_yPIPBox_3	9	20	PF02747	0.481
LIG_Pex14_2	221	225	PF04695	0.498
LIG_SH2_CRK	167	171	PF00017	0.303
LIG_SH2_NCK_1	133	137	PF00017	0.330
LIG_SH2_SRC	133	136	PF00017	0.299
LIG_SH2_STAP1	71	75	PF00017	0.317
LIG_SH2_STAT5	23	26	PF00017	0.301
LIG_SH2_STAT5	71	74	PF00017	0.350
LIG_SH2_STAT5	92	95	PF00017	0.351
LIG_SH3_3	41	47	PF00018	0.525
LIG_SUMO_SIM_par_1	15	22	PF11976	0.396
LIG_SUMO_SIM_par_1	168	173	PF11976	0.315
LIG_UBA3_1	182	189	PF00899	0.434
MOD_CK1_1	187	193	PF00069	0.508
MOD_CK1_1	224	230	PF00069	0.534
MOD_CK1_1	238	244	PF00069	0.493
MOD_CK2_1	224	230	PF00069	0.433
MOD_GlcNHglycan	186	189	PF01048	0.566
MOD_GlcNHglycan	198	201	PF01048	0.594
MOD_GlcNHglycan	237	240	PF01048	0.484
MOD_GlcNHglycan	243	246	PF01048	0.489
MOD_GlcNHglycan	98	101	PF01048	0.249
MOD_N-GLC_1	184	189	PF02516	0.482
MOD_N-GLC_2	194	196	PF02516	0.463
MOD_NEK2_1	111	116	PF00069	0.293
MOD_NEK2_1	203	208	PF00069	0.526
MOD_NEK2_1	221	226	PF00069	0.515
MOD_NEK2_1	30	35	PF00069	0.469
MOD_NEK2_1	58	63	PF00069	0.410
MOD_NEK2_1	96	101	PF00069	0.410
MOD_NEK2_2	128	133	PF00069	0.377
MOD_NEK2_2	64	69	PF00069	0.353
MOD_PKA_1	69	75	PF00069	0.299
MOD_PKA_2	175	181	PF00069	0.396
MOD_Plk_1	160	166	PF00069	0.433
MOD_Plk_1	36	42	PF00069	0.490
MOD_Plk_4	128	134	PF00069	0.321
MOD_Plk_4	74	80	PF00069	0.377
MOD_ProDKin_1	7	13	PF00069	0.414
MOD_ProDKin_1	79	85	PF00069	0.262
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.317
TRG_ENDOCYTIC_2	127	130	PF00928	0.260
TRG_ENDOCYTIC_2	133	136	PF00928	0.303
TRG_ENDOCYTIC_2	167	170	PF00928	0.307
TRG_ER_diArg_1	180	182	PF00400	0.384
TRG_ER_diArg_1	93	95	PF00400	0.326
TRG_NES_CRM1_1	154	166	PF08389	0.384
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRS5	Leptomonas seymouri	62%	100%
A0A0S4JHS7	Bodo saltans	37%	78%
A0A1X0P2T0	Trypanosomatidae	45%	100%
A0A3Q8IFC8	Leishmania donovani	33%	100%
A0A3Q8IJQ6	Leishmania donovani	93%	98%
A4HIU9	Leishmania braziliensis	72%	100%
A4I654	Leishmania infantum	94%	98%
A4I7P8	Leishmania infantum	33%	100%
C9ZRH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B1D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B2K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%