Leucine rich repeat family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Component of motile flagella protein 46

Species:

Leishmania major

UniProt:

Q4Q6S4_LEIMA

TriTrypDb:

LmjF.30.3640 , LMJLV39_300045200 , LMJSD75_300044400

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000164	protein phosphatase type 1 complex	5	2
GO:0005929	cilium	4	12
GO:0008287	protein serine/threonine phosphatase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:1902494	catalytic complex	2	2
GO:1903293	phosphatase complex	3	2

Expansion

Sequence features

Q4Q6S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6S4

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010562	positive regulation of phosphorus metabolic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0019220	regulation of phosphate metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031399	regulation of protein modification process	6	2
GO:0031401	positive regulation of protein modification process	7	2
GO:0035303	regulation of dephosphorylation	7	2
GO:0035304	regulation of protein dephosphorylation	7	2
GO:0035306	positive regulation of dephosphorylation	8	2
GO:0035307	positive regulation of protein dephosphorylation	8	2
GO:0045937	positive regulation of phosphate metabolic process	7	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0048870	cell motility	2	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051174	regulation of phosphorus metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051247	positive regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0060285	cilium-dependent cell motility	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	2
GO:0004864	protein phosphatase inhibitor activity	5	2
GO:0004865	protein serine/threonine phosphatase inhibitor activity	6	2
GO:0019208	phosphatase regulator activity	3	2
GO:0019212	phosphatase inhibitor activity	4	2
GO:0019888	protein phosphatase regulator activity	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0098772	molecular function regulator activity	1	2
GO:0140678	molecular function inhibitor activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.494
CLV_C14_Caspase3-7	145	149	PF00656	0.513
CLV_C14_Caspase3-7	325	329	PF00656	0.557
CLV_C14_Caspase3-7	548	552	PF00656	0.522
CLV_NRD_NRD_1	326	328	PF00675	0.487
CLV_NRD_NRD_1	458	460	PF00675	0.583
CLV_NRD_NRD_1	498	500	PF00675	0.378
CLV_NRD_NRD_1	534	536	PF00675	0.560
CLV_PCSK_FUR_1	324	328	PF00082	0.429
CLV_PCSK_FUR_1	498	502	PF00082	0.389
CLV_PCSK_FUR_1	531	535	PF00082	0.491
CLV_PCSK_KEX2_1	326	328	PF00082	0.430
CLV_PCSK_KEX2_1	377	379	PF00082	0.665
CLV_PCSK_KEX2_1	458	460	PF00082	0.561
CLV_PCSK_KEX2_1	498	500	PF00082	0.394
CLV_PCSK_KEX2_1	533	535	PF00082	0.506
CLV_PCSK_KEX2_1	79	81	PF00082	0.384
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.665
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.398
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.514
CLV_PCSK_SKI1_1	207	211	PF00082	0.347
CLV_PCSK_SKI1_1	226	230	PF00082	0.202
CLV_PCSK_SKI1_1	314	318	PF00082	0.499
CLV_PCSK_SKI1_1	396	400	PF00082	0.494
CLV_PCSK_SKI1_1	448	452	PF00082	0.412
CLV_PCSK_SKI1_1	76	80	PF00082	0.464
CLV_PCSK_SKI1_1	88	92	PF00082	0.329
DEG_APCC_DBOX_1	162	170	PF00400	0.531
DEG_APCC_DBOX_1	229	237	PF00400	0.553
DOC_CDC14_PxL_1	150	158	PF14671	0.526
DOC_CDC14_PxL_1	176	184	PF14671	0.526
DOC_CYCLIN_RxL_1	201	213	PF00134	0.469
DOC_MAPK_gen_1	419	427	PF00069	0.438
DOC_MAPK_gen_1	55	65	PF00069	0.566
DOC_MAPK_MEF2A_6	421	429	PF00069	0.429
DOC_PP1_RVXF_1	199	206	PF00149	0.460
DOC_USP7_MATH_1	346	350	PF00917	0.467
DOC_USP7_MATH_1	383	387	PF00917	0.519
LIG_14-3-3_CanoR_1	25	31	PF00244	0.522
LIG_14-3-3_CanoR_1	304	313	PF00244	0.479
LIG_14-3-3_CanoR_1	314	323	PF00244	0.564
LIG_14-3-3_CanoR_1	343	350	PF00244	0.510
LIG_APCC_ABBA_1	269	274	PF00400	0.557
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_BRCT_BRCA1_1	1	5	PF00533	0.668
LIG_Clathr_ClatBox_1	109	113	PF01394	0.501
LIG_Clathr_ClatBox_1	233	237	PF01394	0.439
LIG_Clathr_ClatBox_1	275	279	PF01394	0.383
LIG_Clathr_ClatBox_1	436	440	PF01394	0.473
LIG_FHA_1	156	162	PF00498	0.535
LIG_FHA_1	337	343	PF00498	0.474
LIG_FHA_1	382	388	PF00498	0.530
LIG_FHA_1	68	74	PF00498	0.389
LIG_FHA_2	143	149	PF00498	0.494
LIG_FHA_2	184	190	PF00498	0.535
LIG_FHA_2	233	239	PF00498	0.508
LIG_FHA_2	33	39	PF00498	0.554
LIG_FHA_2	488	494	PF00498	0.483
LIG_LIR_Gen_1	113	122	PF02991	0.459
LIG_LIR_Gen_1	431	439	PF02991	0.365
LIG_LIR_Nem_3	113	117	PF02991	0.448
LIG_LIR_Nem_3	118	122	PF02991	0.429
LIG_LIR_Nem_3	2	8	PF02991	0.596
LIG_LIR_Nem_3	258	263	PF02991	0.449
LIG_LIR_Nem_3	431	436	PF02991	0.363
LIG_LIR_Nem_3	465	471	PF02991	0.613
LIG_LIR_Nem_3	493	497	PF02991	0.413
LIG_LIR_Nem_3	74	78	PF02991	0.371
LIG_LRP6_Inhibitor_1	95	101	PF00058	0.467
LIG_PCNA_yPIPBox_3	405	419	PF02747	0.435
LIG_PCNA_yPIPBox_3	484	495	PF02747	0.376
LIG_Pex14_2	451	455	PF04695	0.392
LIG_Rb_LxCxE_1	96	118	PF01857	0.418
LIG_RPA_C_Fungi	515	527	PF08784	0.480
LIG_SH2_CRK	263	267	PF00017	0.488
LIG_SH2_GRB2like	140	143	PF00017	0.447
LIG_SH2_NCK_1	119	123	PF00017	0.422
LIG_SH2_NCK_1	263	267	PF00017	0.460
LIG_SH2_SRC	175	178	PF00017	0.447
LIG_SH2_STAP1	140	144	PF00017	0.447
LIG_SH2_STAT3	470	473	PF00017	0.622
LIG_SH2_STAT5	175	178	PF00017	0.301
LIG_SH2_STAT5	340	343	PF00017	0.558
LIG_SH2_STAT5	470	473	PF00017	0.565
LIG_SH2_STAT5	542	545	PF00017	0.482
LIG_SH3_3	365	371	PF00018	0.641
LIG_SUMO_SIM_anti_2	407	413	PF11976	0.480
LIG_SUMO_SIM_anti_2	424	429	PF11976	0.279
LIG_SUMO_SIM_par_1	183	189	PF11976	0.422
LIG_SUMO_SIM_par_1	231	241	PF11976	0.558
LIG_SUMO_SIM_par_1	69	74	PF11976	0.483
LIG_TRAF2_1	251	254	PF00917	0.551
LIG_TYR_ITIM	117	122	PF00017	0.422
LIG_UBA3_1	477	484	PF00899	0.519
LIG_WRC_WIRS_1	72	77	PF05994	0.501
MOD_CK1_1	26	32	PF00069	0.574
MOD_CK1_1	33	39	PF00069	0.641
MOD_CK1_1	349	355	PF00069	0.514
MOD_CK1_1	381	387	PF00069	0.538
MOD_CK2_1	10	16	PF00069	0.583
MOD_CK2_1	183	189	PF00069	0.417
MOD_CK2_1	232	238	PF00069	0.557
MOD_CK2_1	428	434	PF00069	0.383
MOD_CK2_1	487	493	PF00069	0.499
MOD_GlcNHglycan	25	28	PF01048	0.508
MOD_GlcNHglycan	344	347	PF01048	0.562
MOD_GSK3_1	26	33	PF00069	0.561
MOD_GSK3_1	338	345	PF00069	0.505
MOD_GSK3_1	67	74	PF00069	0.419
MOD_GSK3_1	82	89	PF00069	0.400
MOD_N-GLC_1	413	418	PF02516	0.495
MOD_N-GLC_1	82	87	PF02516	0.412
MOD_NEK2_1	10	15	PF00069	0.646
MOD_NEK2_1	115	120	PF00069	0.313
MOD_NEK2_1	23	28	PF00069	0.461
MOD_NEK2_1	342	347	PF00069	0.571
MOD_NEK2_1	443	448	PF00069	0.428
MOD_NEK2_1	71	76	PF00069	0.395
MOD_NEK2_2	383	388	PF00069	0.342
MOD_PIKK_1	378	384	PF00454	0.593
MOD_PK_1	421	427	PF00069	0.494
MOD_PK_1	520	526	PF00069	0.520
MOD_PKA_2	342	348	PF00069	0.539
MOD_Plk_1	115	121	PF00069	0.332
MOD_Plk_1	169	175	PF00069	0.447
MOD_Plk_1	413	419	PF00069	0.533
MOD_Plk_1	512	518	PF00069	0.463
MOD_Plk_1	82	88	PF00069	0.479
MOD_Plk_4	105	111	PF00069	0.456
MOD_Plk_4	135	141	PF00069	0.301
MOD_Plk_4	512	518	PF00069	0.479
MOD_Plk_4	520	526	PF00069	0.502
MOD_Plk_4	67	73	PF00069	0.383
MOD_SUMO_for_1	510	513	PF00179	0.460
MOD_SUMO_rev_2	48	56	PF00179	0.611
TRG_ENDOCYTIC_2	119	122	PF00928	0.422
TRG_ENDOCYTIC_2	406	409	PF00928	0.390
TRG_ER_diArg_1	198	201	PF00400	0.336
TRG_ER_diArg_1	40	43	PF00400	0.563
TRG_ER_diArg_1	497	499	PF00400	0.391
TRG_ER_diArg_1	531	534	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB70	Leptomonas seymouri	70%	99%
A0A0S4JNZ9	Bodo saltans	39%	99%
A0A1X0P2D5	Trypanosomatidae	44%	100%
A0A3Q8IF34	Leishmania donovani	95%	100%
A0A422NMM2	Trypanosoma rangeli	42%	100%
A4HIV0	Leishmania braziliensis	83%	100%
A4I655	Leishmania infantum	95%	100%
C9ZRH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B1D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q9H069	Homo sapiens	27%	100%
V5DNR7	Trypanosoma cruzi	43%	100%