Putative V-type ATPase, C subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

V-type ATPase, C subunit, putative

Species:

Leishmania major

UniProt:

Q4Q6S2_LEIMA

TriTrypDb:

LmjF.30.3660 , LMJLV39_300045400 , LMJSD75_300044600

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0016020	membrane	2	11
GO:0032991	protein-containing complex	1	11
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3	11
GO:0033179	proton-transporting V-type ATPase, V0 domain	4	11
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q6S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6S2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005215	transporter activity	1	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015078	proton transmembrane transporter activity	5	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0015399	primary active transmembrane transporter activity	4	11
GO:0016787	hydrolase activity	2	8
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	11
GO:0022804	active transmembrane transporter activity	3	11
GO:0022853	active monoatomic ion transmembrane transporter activity	4	11
GO:0022857	transmembrane transporter activity	2	11
GO:0022890	inorganic cation transmembrane transporter activity	4	11
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	11
GO:0042626	ATPase-coupled transmembrane transporter activity	2	11
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	11
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	11
GO:0140657	ATP-dependent activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	28	32	PF00082	0.281
DEG_APCC_DBOX_1	27	35	PF00400	0.301
DEG_MDM2_SWIB_1	52	59	PF02201	0.347
DEG_SPOP_SBC_1	135	139	PF00917	0.414
DEG_SPOP_SBC_1	187	191	PF00917	0.436
DOC_CDC14_PxL_1	38	46	PF14671	0.261
DOC_CKS1_1	8	13	PF01111	0.672
DOC_MAPK_gen_1	105	114	PF00069	0.431
DOC_MAPK_MEF2A_6	105	114	PF00069	0.431
DOC_MAPK_MEF2A_6	28	37	PF00069	0.284
DOC_PP1_SILK_1	56	61	PF00149	0.321
DOC_USP7_MATH_1	135	139	PF00917	0.378
DOC_USP7_MATH_1	187	191	PF00917	0.431
DOC_USP7_MATH_1	66	70	PF00917	0.243
DOC_USP7_UBL2_3	220	224	PF12436	0.308
DOC_WW_Pin1_4	60	65	PF00397	0.334
DOC_WW_Pin1_4	7	12	PF00397	0.671
LIG_BRCT_BRCA1_1	110	114	PF00533	0.261
LIG_BRCT_BRCA1_1	189	193	PF00533	0.431
LIG_BRCT_BRCA1_2	189	195	PF00533	0.431
LIG_EH1_1	20	28	PF00400	0.591
LIG_FHA_1	211	217	PF00498	0.394
LIG_LIR_Gen_1	190	201	PF02991	0.431
LIG_LIR_Gen_1	53	64	PF02991	0.335
LIG_LIR_Nem_3	190	196	PF02991	0.431
LIG_LIR_Nem_3	47	52	PF02991	0.332
LIG_LIR_Nem_3	53	59	PF02991	0.310
LIG_Pex14_2	52	56	PF04695	0.326
LIG_SH2_CRK	121	125	PF00017	0.261
LIG_SH2_PTP2	29	32	PF00017	0.301
LIG_SH2_STAP1	148	152	PF00017	0.311
LIG_SH2_STAP1	155	159	PF00017	0.250
LIG_SH2_STAT5	155	158	PF00017	0.294
LIG_SH2_STAT5	29	32	PF00017	0.285
LIG_SH3_3	45	51	PF00018	0.415
LIG_SUMO_SIM_par_1	195	200	PF11976	0.261
LIG_TYR_ITIM	27	32	PF00017	0.278
LIG_UBA3_1	124	132	PF00899	0.261
MOD_CDK_SPxK_1	7	13	PF00069	0.671
MOD_CK1_1	136	142	PF00069	0.433
MOD_CK1_1	69	75	PF00069	0.405
MOD_CK1_1	90	96	PF00069	0.464
MOD_GlcNHglycan	141	144	PF01048	0.628
MOD_GlcNHglycan	203	206	PF01048	0.261
MOD_GlcNHglycan	52	55	PF01048	0.564
MOD_GlcNHglycan	89	92	PF01048	0.276
MOD_GlcNHglycan	94	97	PF01048	0.247
MOD_GSK3_1	135	142	PF00069	0.434
MOD_GSK3_1	50	57	PF00069	0.420
MOD_GSK3_1	86	93	PF00069	0.290
MOD_NEK2_1	147	152	PF00069	0.395
MOD_NEK2_1	44	49	PF00069	0.460
MOD_NEK2_2	153	158	PF00069	0.258
MOD_Plk_4	123	129	PF00069	0.256
MOD_Plk_4	147	153	PF00069	0.360
MOD_Plk_4	188	194	PF00069	0.443
MOD_Plk_4	44	50	PF00069	0.446
MOD_Plk_4	76	82	PF00069	0.301
MOD_ProDKin_1	60	66	PF00069	0.333
MOD_ProDKin_1	7	13	PF00069	0.671
TRG_ENDOCYTIC_2	121	124	PF00928	0.261
TRG_ENDOCYTIC_2	148	151	PF00928	0.350
TRG_ENDOCYTIC_2	155	158	PF00928	0.285
TRG_ENDOCYTIC_2	29	32	PF00928	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3G9	Leptomonas seymouri	86%	100%
A0A0N1HSG6	Leptomonas seymouri	27%	100%
A0A0N1I3H6	Leptomonas seymouri	32%	100%
A0A0S4IU71	Bodo saltans	27%	100%
A0A0S4JFM4	Bodo saltans	31%	100%
A0A0S4JKG0	Bodo saltans	68%	86%
A0A1X0NGC8	Trypanosomatidae	30%	100%
A0A1X0NHL5	Trypanosomatidae	27%	100%
A0A1X0NZ73	Trypanosomatidae	22%	100%
A0A1X0P179	Trypanosomatidae	76%	100%
A0A3Q8II19	Leishmania donovani	25%	100%
A0A3Q8II88	Leishmania donovani	99%	100%
A0A3Q8ILV9	Leishmania donovani	33%	100%
A0A3R7MQK8	Trypanosoma rangeli	78%	100%
A0A3R7RFU6	Trypanosoma rangeli	28%	100%
A0A3S7WX01	Leishmania donovani	27%	100%
A0A422NW00	Trypanosoma rangeli	28%	100%
A4HCM7	Leishmania braziliensis	32%	100%
A4HGG2	Leishmania braziliensis	26%	100%
A4HIV2	Leishmania braziliensis	92%	100%
A4HLC1	Leishmania braziliensis	26%	100%
A4HZI5	Leishmania infantum	27%	100%
A4I051	Leishmania infantum	33%	100%
A4I3J4	Leishmania infantum	24%	100%
A4I657	Leishmania infantum	99%	100%
C0HLB3	Caenorhabditis elegans	28%	100%
C0HLB4	Caenorhabditis elegans	28%	100%
C0HLB5	Caenorhabditis briggsae	29%	100%
C0HLB6	Caenorhabditis briggsae	29%	100%
C9ZRH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
D0A0Y8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A7U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	89%
E9AVH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AW14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AZT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
G5EDB8	Caenorhabditis elegans	49%	100%
O14046	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
O16110	Aedes aegypti	31%	100%
O18882	Ovis aries	29%	100%
O22552	Vigna radiata var. radiata	28%	100%
O24011	Solanum lycopersicum	28%	100%
P0DH92	Arabidopsis thaliana	28%	100%
P0DH93	Arabidopsis thaliana	28%	100%
P0DH94	Arabidopsis thaliana	28%	100%
P23380	Drosophila melanogaster	31%	100%
P23956	Bos taurus	29%	100%
P23957	Avena sativa	28%	100%
P23968	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P25515	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P27449	Homo sapiens	29%	100%
P31403	Manduca sexta	32%	100%
P31413	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	100%
P32842	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P50515	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P54642	Dictyostelium discoideum	31%	100%
P55277	Heliothis virescens	32%	100%
P59228	Arabidopsis thaliana	29%	100%
P59229	Arabidopsis thaliana	29%	100%
P63081	Rattus norvegicus	26%	100%
P63082	Mus musculus	26%	100%
P68161	Mesembryanthemum crystallinum	28%	100%
P68162	Beta vulgaris	28%	100%
Q00607	Candida tropicalis	27%	100%
Q03105	Torpedo marmorata	27%	100%
Q17046	Ascaris suum	29%	100%
Q24808	Entamoeba dispar	27%	100%
Q24810	Entamoeba histolytica	26%	100%
Q26250	Nephrops norvegicus	31%	100%
Q2TA24	Bos taurus	45%	100%
Q40585	Nicotiana tabacum	29%	100%
Q43362	Chrysotila carterae	32%	100%
Q43434	Gossypium hirsutum	29%	100%
Q4Q8F0	Leishmania major	25%	100%
Q4QBG2	Leishmania major	33%	100%
Q4QC03	Leishmania major	28%	100%
Q6CT28	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	100%
Q6FUY5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	29%	100%
Q755G4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	100%
Q91V37	Mus musculus	46%	100%
Q96473	Kalanchoe daigremontiana	29%	100%
Q99437	Homo sapiens	46%	100%
Q9SLA2	Arabidopsis thaliana	57%	100%
Q9SZY7	Arabidopsis thaliana	57%	100%