Structural maintenance of chromosomes protein 5

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6S0_LEIMA

TriTrypDb:

LmjF.30.3680 , LMJLV39_300045600 , LMJSD75_300044800

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6S0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.562
CLV_C14_Caspase3-7	227	231	PF00656	0.588
CLV_NRD_NRD_1	122	124	PF00675	0.643
CLV_NRD_NRD_1	193	195	PF00675	0.552
CLV_NRD_NRD_1	421	423	PF00675	0.586
CLV_NRD_NRD_1	61	63	PF00675	0.619
CLV_PCSK_KEX2_1	122	124	PF00082	0.635
CLV_PCSK_KEX2_1	192	194	PF00082	0.536
CLV_PCSK_KEX2_1	288	290	PF00082	0.512
CLV_PCSK_KEX2_1	421	423	PF00082	0.587
CLV_PCSK_KEX2_1	61	63	PF00082	0.606
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.577
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.536
CLV_PCSK_SKI1_1	115	119	PF00082	0.633
CLV_PCSK_SKI1_1	133	137	PF00082	0.528
CLV_PCSK_SKI1_1	142	146	PF00082	0.609
CLV_PCSK_SKI1_1	170	174	PF00082	0.502
CLV_PCSK_SKI1_1	2	6	PF00082	0.667
CLV_PCSK_SKI1_1	274	278	PF00082	0.497
CLV_PCSK_SKI1_1	288	292	PF00082	0.555
CLV_PCSK_SKI1_1	295	299	PF00082	0.513
CLV_PCSK_SKI1_1	431	435	PF00082	0.527
DEG_Nend_UBRbox_1	1	4	PF02207	0.682
DOC_CYCLIN_RxL_1	428	436	PF00134	0.518
DOC_MAPK_gen_1	178	186	PF00069	0.544
DOC_MAPK_gen_1	353	362	PF00069	0.525
DOC_MAPK_gen_1	64	72	PF00069	0.508
DOC_USP7_MATH_1	241	245	PF00917	0.631
DOC_USP7_UBL2_3	188	192	PF12436	0.557
DOC_USP7_UBL2_3	291	295	PF12436	0.596
LIG_14-3-3_CanoR_1	193	200	PF00244	0.618
LIG_14-3-3_CanoR_1	422	428	PF00244	0.421
LIG_EH1_1	328	336	PF00400	0.584
LIG_FHA_1	160	166	PF00498	0.580
LIG_FHA_1	185	191	PF00498	0.624
LIG_FHA_1	354	360	PF00498	0.601
LIG_FHA_1	376	382	PF00498	0.603
LIG_FHA_2	194	200	PF00498	0.584
LIG_FHA_2	254	260	PF00498	0.613
LIG_FHA_2	262	268	PF00498	0.617
LIG_FHA_2	349	355	PF00498	0.545
LIG_FHA_2	364	370	PF00498	0.550
LIG_FHA_2	377	383	PF00498	0.547
LIG_Integrin_RGD_1	45	47	PF01839	0.491
LIG_LIR_Gen_1	201	210	PF02991	0.591
LIG_LIR_Nem_3	201	207	PF02991	0.592
LIG_LIR_Nem_3	52	56	PF02991	0.559
LIG_LIR_Nem_3	73	78	PF02991	0.660
LIG_SH2_CRK	346	350	PF00017	0.527
LIG_SH2_CRK	75	79	PF00017	0.661
LIG_SH2_STAT5	58	61	PF00017	0.550
LIG_SH3_3	316	322	PF00018	0.593
LIG_SUMO_SIM_par_1	182	187	PF11976	0.598
LIG_SUMO_SIM_par_1	358	364	PF11976	0.605
LIG_TRAF2_1	17	20	PF00917	0.423
LIG_TRAF2_1	217	220	PF00917	0.616
LIG_TRAF2_1	336	339	PF00917	0.512
LIG_TRAF2_1	391	394	PF00917	0.486
LIG_UBA3_1	143	150	PF00899	0.673
LIG_UBA3_1	183	188	PF00899	0.545
LIG_UBA3_1	362	370	PF00899	0.509
LIG_UBA3_1	78	87	PF00899	0.605
LIG_WRC_WIRS_1	33	38	PF05994	0.687
MOD_CK1_1	35	41	PF00069	0.715
MOD_CK1_1	361	367	PF00069	0.599
MOD_CK2_1	151	157	PF00069	0.571
MOD_CK2_1	253	259	PF00069	0.585
MOD_CK2_1	261	267	PF00069	0.593
MOD_CK2_1	312	318	PF00069	0.605
MOD_CK2_1	348	354	PF00069	0.571
MOD_CK2_1	363	369	PF00069	0.560
MOD_CK2_1	376	382	PF00069	0.529
MOD_CK2_1	429	435	PF00069	0.577
MOD_Cter_Amidation	59	62	PF01082	0.672
MOD_GlcNHglycan	251	256	PF01048	0.618
MOD_GlcNHglycan	399	402	PF01048	0.520
MOD_GlcNHglycan	435	438	PF01048	0.591
MOD_GSK3_1	211	218	PF00069	0.557
MOD_GSK3_1	28	35	PF00069	0.622
MOD_GSK3_1	429	436	PF00069	0.518
MOD_N-GLC_1	68	73	PF02516	0.607
MOD_NEK2_1	184	189	PF00069	0.516
MOD_NEK2_1	36	41	PF00069	0.630
MOD_NEK2_1	363	368	PF00069	0.579
MOD_NEK2_1	433	438	PF00069	0.537
MOD_NEK2_1	49	54	PF00069	0.613
MOD_NEK2_1	82	87	PF00069	0.561
MOD_PIKK_1	115	121	PF00454	0.678
MOD_PIKK_1	312	318	PF00454	0.590
MOD_PK_1	358	364	PF00069	0.613
MOD_PKA_1	192	198	PF00069	0.600
MOD_PKA_2	192	198	PF00069	0.600
MOD_PKA_2	211	217	PF00069	0.550
MOD_Plk_1	151	157	PF00069	0.608
MOD_Plk_1	212	218	PF00069	0.543
MOD_Plk_1	261	267	PF00069	0.619
MOD_Plk_1	68	74	PF00069	0.686
MOD_Plk_2-3	253	259	PF00069	0.586
MOD_Plk_4	199	205	PF00069	0.581
MOD_Plk_4	32	38	PF00069	0.699
MOD_Plk_4	358	364	PF00069	0.597
MOD_Plk_4	423	429	PF00069	0.473
MOD_SUMO_for_1	257	260	PF00179	0.568
MOD_SUMO_rev_2	126	135	PF00179	0.669
MOD_SUMO_rev_2	166	172	PF00179	0.597
TRG_DiLeu_BaEn_1	102	107	PF01217	0.635
TRG_DiLeu_BaEn_2	31	37	PF01217	0.668
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.657
TRG_DiLeu_LyEn_5	102	107	PF01217	0.629
TRG_ENDOCYTIC_2	204	207	PF00928	0.537
TRG_ENDOCYTIC_2	346	349	PF00928	0.503
TRG_ENDOCYTIC_2	75	78	PF00928	0.646
TRG_ER_diArg_1	122	124	PF00400	0.670
TRG_ER_diArg_1	161	164	PF00400	0.633
TRG_ER_diArg_1	408	411	PF00400	0.598
TRG_ER_diArg_1	61	64	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II28	Leptomonas seymouri	67%	100%
A0A0S4JHV1	Bodo saltans	26%	72%
A0A1X0P1A4	Trypanosomatidae	40%	99%
A0A3Q8ISB1	Leishmania donovani	92%	100%
A0A422NMD4	Trypanosoma rangeli	36%	98%
A4HIV4	Leishmania braziliensis	69%	100%
A4I659	Leishmania infantum	92%	100%
C9ZRH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	97%
C9ZYW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B1E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5B747	Trypanosoma cruzi	37%	98%