Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6R8_LEIMA

TriTrypDb:

LmjF.30.3700 , LMJLV39_300045800 , LMJSD75_300045100

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q6R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6R8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.748
CLV_C14_Caspase3-7	807	811	PF00656	0.289
CLV_NRD_NRD_1	268	270	PF00675	0.539
CLV_NRD_NRD_1	324	326	PF00675	0.453
CLV_NRD_NRD_1	411	413	PF00675	0.388
CLV_NRD_NRD_1	460	462	PF00675	0.339
CLV_NRD_NRD_1	492	494	PF00675	0.392
CLV_NRD_NRD_1	530	532	PF00675	0.406
CLV_PCSK_KEX2_1	223	225	PF00082	0.334
CLV_PCSK_KEX2_1	239	241	PF00082	0.312
CLV_PCSK_KEX2_1	313	315	PF00082	0.355
CLV_PCSK_KEX2_1	323	325	PF00082	0.407
CLV_PCSK_KEX2_1	411	413	PF00082	0.406
CLV_PCSK_KEX2_1	462	464	PF00082	0.389
CLV_PCSK_KEX2_1	492	494	PF00082	0.393
CLV_PCSK_KEX2_1	530	532	PF00082	0.445
CLV_PCSK_KEX2_1	768	770	PF00082	0.546
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.334
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.312
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.355
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.374
CLV_PCSK_PC1ET2_1	768	770	PF00082	0.546
CLV_PCSK_PC7_1	235	241	PF00082	0.409
CLV_PCSK_SKI1_1	536	540	PF00082	0.418
CLV_PCSK_SKI1_1	544	548	PF00082	0.250
CLV_PCSK_SKI1_1	716	720	PF00082	0.541
CLV_PCSK_SKI1_1	724	728	PF00082	0.557
DEG_APCC_DBOX_1	147	155	PF00400	0.482
DEG_Nend_UBRbox_3	1	3	PF02207	0.671
DOC_CKS1_1	571	576	PF01111	0.322
DOC_CYCLIN_RxL_1	499	507	PF00134	0.637
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.683
DOC_CYCLIN_yCln2_LP_2	774	780	PF00134	0.338
DOC_MAPK_FxFP_2	14	17	PF00069	0.673
DOC_MAPK_gen_1	223	229	PF00069	0.552
DOC_MAPK_gen_1	269	276	PF00069	0.361
DOC_MAPK_gen_1	469	478	PF00069	0.645
DOC_MAPK_gen_1	768	776	PF00069	0.381
DOC_MAPK_JIP1_4	635	641	PF00069	0.339
DOC_MAPK_MEF2A_6	148	155	PF00069	0.542
DOC_MAPK_MEF2A_6	769	778	PF00069	0.334
DOC_MAPK_RevD_3	399	413	PF00069	0.391
DOC_PP1_RVXF_1	334	340	PF00149	0.644
DOC_PP1_RVXF_1	679	686	PF00149	0.302
DOC_PP2B_LxvP_1	143	146	PF13499	0.447
DOC_PP2B_LxvP_1	177	180	PF13499	0.322
DOC_PP2B_LxvP_1	476	479	PF13499	0.686
DOC_PP2B_LxvP_1	774	777	PF13499	0.443
DOC_PP2B_PxIxI_1	705	711	PF00149	0.350
DOC_PP4_FxxP_1	14	17	PF00568	0.673
DOC_PP4_FxxP_1	571	574	PF00568	0.336
DOC_PP4_FxxP_1	781	784	PF00568	0.301
DOC_SPAK_OSR1_1	531	535	PF12202	0.647
DOC_USP7_MATH_1	10	14	PF00917	0.724
DOC_USP7_MATH_1	17	21	PF00917	0.732
DOC_USP7_MATH_1	392	396	PF00917	0.378
DOC_USP7_MATH_1	579	583	PF00917	0.399
DOC_USP7_MATH_1	599	603	PF00917	0.277
DOC_USP7_MATH_1	745	749	PF00917	0.381
DOC_USP7_MATH_1	94	98	PF00917	0.651
DOC_WW_Pin1_4	108	113	PF00397	0.640
DOC_WW_Pin1_4	382	387	PF00397	0.424
DOC_WW_Pin1_4	485	490	PF00397	0.590
DOC_WW_Pin1_4	570	575	PF00397	0.416
DOC_WW_Pin1_4	584	589	PF00397	0.393
DOC_WW_Pin1_4	702	707	PF00397	0.301
LIG_14-3-3_CanoR_1	217	223	PF00244	0.539
LIG_14-3-3_CanoR_1	269	274	PF00244	0.413
LIG_14-3-3_CanoR_1	325	331	PF00244	0.716
LIG_14-3-3_CanoR_1	357	362	PF00244	0.465
LIG_14-3-3_CanoR_1	463	468	PF00244	0.663
LIG_14-3-3_CanoR_1	473	477	PF00244	0.699
LIG_14-3-3_CanoR_1	570	574	PF00244	0.366
LIG_14-3-3_CanoR_1	681	686	PF00244	0.293
LIG_14-3-3_CanoR_1	724	730	PF00244	0.400
LIG_14-3-3_CanoR_1	769	777	PF00244	0.372
LIG_14-3-3_CanoR_1	803	809	PF00244	0.316
LIG_14-3-3_CanoR_1	834	839	PF00244	0.321
LIG_Actin_WH2_2	208	225	PF00022	0.407
LIG_BRCT_BRCA1_1	143	147	PF00533	0.503
LIG_BRCT_BRCA1_1	359	363	PF00533	0.357
LIG_CSL_BTD_1	728	731	PF09270	0.382
LIG_EH1_1	246	254	PF00400	0.347
LIG_eIF4E_1	156	162	PF01652	0.275
LIG_eIF4E_1	247	253	PF01652	0.415
LIG_eIF4E_1	419	425	PF01652	0.280
LIG_FHA_1	150	156	PF00498	0.342
LIG_FHA_1	168	174	PF00498	0.175
LIG_FHA_1	287	293	PF00498	0.360
LIG_FHA_1	35	41	PF00498	0.787
LIG_FHA_1	383	389	PF00498	0.452
LIG_FHA_1	442	448	PF00498	0.309
LIG_FHA_1	473	479	PF00498	0.682
LIG_FHA_1	585	591	PF00498	0.387
LIG_FHA_1	751	757	PF00498	0.385
LIG_FHA_1	784	790	PF00498	0.373
LIG_FHA_2	327	333	PF00498	0.600
LIG_FHA_2	342	348	PF00498	0.513
LIG_FHA_2	466	472	PF00498	0.569
LIG_FHA_2	49	55	PF00498	0.733
LIG_FHA_2	707	713	PF00498	0.233
LIG_FHA_2	732	738	PF00498	0.356
LIG_FHA_2	835	841	PF00498	0.273
LIG_FHA_2	843	849	PF00498	0.319
LIG_GBD_Chelix_1	205	213	PF00786	0.355
LIG_GBD_Chelix_1	425	433	PF00786	0.355
LIG_Integrin_RGD_1	224	226	PF01839	0.324
LIG_LIR_Apic_2	125	129	PF02991	0.722
LIG_LIR_Apic_2	13	17	PF02991	0.672
LIG_LIR_Apic_2	728	732	PF02991	0.389
LIG_LIR_Gen_1	130	139	PF02991	0.521
LIG_LIR_Gen_1	170	179	PF02991	0.283
LIG_LIR_Gen_1	191	200	PF02991	0.302
LIG_LIR_Gen_1	202	211	PF02991	0.223
LIG_LIR_Gen_1	289	297	PF02991	0.387
LIG_LIR_Gen_1	355	365	PF02991	0.473
LIG_LIR_Gen_1	405	410	PF02991	0.407
LIG_LIR_Gen_1	421	430	PF02991	0.248
LIG_LIR_Gen_1	62	73	PF02991	0.567
LIG_LIR_Gen_1	662	671	PF02991	0.281
LIG_LIR_Gen_1	804	812	PF02991	0.357
LIG_LIR_Nem_3	120	126	PF02991	0.641
LIG_LIR_Nem_3	130	134	PF02991	0.505
LIG_LIR_Nem_3	144	150	PF02991	0.501
LIG_LIR_Nem_3	170	174	PF02991	0.274
LIG_LIR_Nem_3	191	197	PF02991	0.269
LIG_LIR_Nem_3	202	206	PF02991	0.255
LIG_LIR_Nem_3	289	293	PF02991	0.311
LIG_LIR_Nem_3	355	361	PF02991	0.526
LIG_LIR_Nem_3	387	393	PF02991	0.297
LIG_LIR_Nem_3	405	409	PF02991	0.207
LIG_LIR_Nem_3	421	425	PF02991	0.235
LIG_LIR_Nem_3	62	68	PF02991	0.576
LIG_LIR_Nem_3	660	664	PF02991	0.272
LIG_LIR_Nem_3	668	674	PF02991	0.283
LIG_LIR_Nem_3	684	689	PF02991	0.267
LIG_LIR_Nem_3	74	79	PF02991	0.628
LIG_LIR_Nem_3	804	809	PF02991	0.383
LIG_LIR_Nem_3	85	91	PF02991	0.545
LIG_MYND_1	584	588	PF01753	0.265
LIG_NRBOX	150	156	PF00104	0.322
LIG_PCNA_PIPBox_1	213	222	PF02747	0.555
LIG_Pex14_2	195	199	PF04695	0.336
LIG_Pex14_2	628	632	PF04695	0.278
LIG_Pex14_2	725	729	PF04695	0.340
LIG_Pex14_2	788	792	PF04695	0.261
LIG_PTB_Apo_2	75	82	PF02174	0.620
LIG_PTB_Phospho_1	75	81	PF10480	0.622
LIG_REV1ctd_RIR_1	683	691	PF16727	0.223
LIG_SH2_CRK	126	130	PF00017	0.631
LIG_SH2_CRK	178	182	PF00017	0.365
LIG_SH2_CRK	280	284	PF00017	0.279
LIG_SH2_CRK	358	362	PF00017	0.496
LIG_SH2_CRK	65	69	PF00017	0.573
LIG_SH2_CRK	671	675	PF00017	0.262
LIG_SH2_GRB2like	280	283	PF00017	0.349
LIG_SH2_GRB2like	67	70	PF00017	0.681
LIG_SH2_GRB2like	76	79	PF00017	0.644
LIG_SH2_NCK_1	126	130	PF00017	0.631
LIG_SH2_NCK_1	280	284	PF00017	0.346
LIG_SH2_NCK_1	91	95	PF00017	0.691
LIG_SH2_PTP2	664	667	PF00017	0.367
LIG_SH2_SRC	121	124	PF00017	0.672
LIG_SH2_SRC	126	129	PF00017	0.598
LIG_SH2_SRC	178	181	PF00017	0.294
LIG_SH2_SRC	280	283	PF00017	0.349
LIG_SH2_SRC	65	68	PF00017	0.719
LIG_SH2_SRC	664	667	PF00017	0.356
LIG_SH2_SRC	71	74	PF00017	0.626
LIG_SH2_SRC	808	811	PF00017	0.285
LIG_SH2_STAP1	169	173	PF00017	0.381
LIG_SH2_STAP1	27	31	PF00017	0.781
LIG_SH2_STAP1	280	284	PF00017	0.322
LIG_SH2_STAP1	35	39	PF00017	0.754
LIG_SH2_STAP1	419	423	PF00017	0.371
LIG_SH2_STAP1	480	484	PF00017	0.722
LIG_SH2_STAP1	648	652	PF00017	0.353
LIG_SH2_STAP1	766	770	PF00017	0.294
LIG_SH2_STAT3	275	278	PF00017	0.351
LIG_SH2_STAT3	374	377	PF00017	0.385
LIG_SH2_STAT3	480	483	PF00017	0.614
LIG_SH2_STAT3	79	82	PF00017	0.650
LIG_SH2_STAT5	150	153	PF00017	0.293
LIG_SH2_STAT5	156	159	PF00017	0.279
LIG_SH2_STAT5	169	172	PF00017	0.305
LIG_SH2_STAT5	194	197	PF00017	0.435
LIG_SH2_STAT5	200	203	PF00017	0.438
LIG_SH2_STAT5	236	239	PF00017	0.577
LIG_SH2_STAT5	247	250	PF00017	0.300
LIG_SH2_STAT5	275	278	PF00017	0.340
LIG_SH2_STAT5	296	299	PF00017	0.311
LIG_SH2_STAT5	35	38	PF00017	0.757
LIG_SH2_STAT5	382	385	PF00017	0.408
LIG_SH2_STAT5	402	405	PF00017	0.280
LIG_SH2_STAT5	480	483	PF00017	0.724
LIG_SH2_STAT5	497	500	PF00017	0.572
LIG_SH2_STAT5	618	621	PF00017	0.255
LIG_SH2_STAT5	648	651	PF00017	0.434
LIG_SH2_STAT5	664	667	PF00017	0.236
LIG_SH2_STAT5	67	70	PF00017	0.586
LIG_SH2_STAT5	742	745	PF00017	0.310
LIG_SH2_STAT5	808	811	PF00017	0.267
LIG_SH2_STAT5	841	844	PF00017	0.379
LIG_SH2_STAT5	91	94	PF00017	0.717
LIG_SH3_3	177	183	PF00018	0.411
LIG_SH3_3	252	258	PF00018	0.410
LIG_SH3_3	37	43	PF00018	0.728
LIG_SH3_3	385	391	PF00018	0.302
LIG_SH3_3	641	647	PF00018	0.393
LIG_SUMO_SIM_anti_2	289	295	PF11976	0.403
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.516
LIG_SUMO_SIM_anti_2	572	579	PF11976	0.312
LIG_SUMO_SIM_anti_2	609	614	PF11976	0.239
LIG_SUMO_SIM_anti_2	753	760	PF11976	0.305
LIG_SUMO_SIM_par_1	672	678	PF11976	0.357
LIG_SUMO_SIM_par_1	705	713	PF11976	0.236
LIG_SUMO_SIM_par_1	753	760	PF11976	0.292
LIG_TYR_ITIM	245	250	PF00017	0.334
LIG_TYR_ITIM	356	361	PF00017	0.597
LIG_UBA3_1	505	510	PF00899	0.632
LIG_Vh1_VBS_1	198	216	PF01044	0.306
LIG_WRC_WIRS_1	139	144	PF05994	0.544
LIG_WRC_WIRS_1	189	194	PF05994	0.353
LIG_WRC_WIRS_1	200	205	PF05994	0.219
LIG_WW_1	128	131	PF00397	0.602
MOD_CDK_SPxxK_3	485	492	PF00069	0.593
MOD_CDK_SPxxK_3	584	591	PF00069	0.271
MOD_CK1_1	188	194	PF00069	0.337
MOD_CK1_1	380	386	PF00069	0.407
MOD_CK1_1	405	411	PF00069	0.448
MOD_CK1_1	564	570	PF00069	0.403
MOD_CK1_1	634	640	PF00069	0.348
MOD_CK1_1	804	810	PF00069	0.352
MOD_CK2_1	326	332	PF00069	0.613
MOD_CK2_1	341	347	PF00069	0.513
MOD_CK2_1	465	471	PF00069	0.572
MOD_CK2_1	48	54	PF00069	0.726
MOD_CK2_1	834	840	PF00069	0.230
MOD_CMANNOS	298	301	PF00535	0.370
MOD_Cter_Amidation	490	493	PF01082	0.346
MOD_GlcNHglycan	143	146	PF01048	0.277
MOD_GlcNHglycan	308	311	PF01048	0.383
MOD_GlcNHglycan	600	604	PF01048	0.590
MOD_GlcNHglycan	748	751	PF01048	0.673
MOD_GlcNHglycan	770	773	PF01048	0.540
MOD_GlcNHglycan	799	802	PF01048	0.534
MOD_GlcNHglycan	848	852	PF01048	0.584
MOD_GlcNHglycan	96	99	PF01048	0.538
MOD_GSK3_1	106	113	PF00069	0.635
MOD_GSK3_1	23	30	PF00069	0.764
MOD_GSK3_1	34	41	PF00069	0.753
MOD_GSK3_1	357	364	PF00069	0.475
MOD_GSK3_1	378	385	PF00069	0.366
MOD_GSK3_1	627	634	PF00069	0.402
MOD_GSK3_1	702	709	PF00069	0.298
MOD_GSK3_1	746	753	PF00069	0.447
MOD_GSK3_1	797	804	PF00069	0.312
MOD_N-GLC_1	10	15	PF02516	0.505
MOD_N-GLC_1	106	111	PF02516	0.486
MOD_N-GLC_1	167	172	PF02516	0.308
MOD_N-GLC_1	185	190	PF02516	0.547
MOD_N-GLC_1	54	59	PF02516	0.559
MOD_N-GLC_1	564	569	PF02516	0.444
MOD_N-GLC_1	579	584	PF02516	0.584
MOD_N-GLC_1	657	662	PF02516	0.555
MOD_N-GLC_1	746	751	PF02516	0.553
MOD_N-GLC_1	794	799	PF02516	0.579
MOD_N-GLC_1	825	830	PF02516	0.604
MOD_N-GLC_2	830	832	PF02516	0.531
MOD_NEK2_1	167	172	PF00069	0.333
MOD_NEK2_1	199	204	PF00069	0.316
MOD_NEK2_1	286	291	PF00069	0.404
MOD_NEK2_1	431	436	PF00069	0.462
MOD_NEK2_1	472	477	PF00069	0.671
MOD_NEK2_1	532	537	PF00069	0.672
MOD_NEK2_1	561	566	PF00069	0.462
MOD_NEK2_1	578	583	PF00069	0.413
MOD_NEK2_1	616	621	PF00069	0.291
MOD_NEK2_1	725	730	PF00069	0.367
MOD_NEK2_1	842	847	PF00069	0.381
MOD_NEK2_2	10	15	PF00069	0.680
MOD_NEK2_2	369	374	PF00069	0.391
MOD_PIKK_1	48	54	PF00454	0.761
MOD_PIKK_1	564	570	PF00454	0.274
MOD_PIKK_1	794	800	PF00454	0.337
MOD_PK_1	357	363	PF00069	0.465
MOD_PKA_1	269	275	PF00069	0.365
MOD_PKA_1	463	469	PF00069	0.649
MOD_PKA_1	768	774	PF00069	0.377
MOD_PKA_2	472	478	PF00069	0.729
MOD_PKA_2	569	575	PF00069	0.397
MOD_PKA_2	768	774	PF00069	0.364
MOD_PKA_2	833	839	PF00069	0.281
MOD_PKB_1	461	469	PF00069	0.588
MOD_Plk_1	106	112	PF00069	0.584
MOD_Plk_1	167	173	PF00069	0.308
MOD_Plk_1	185	191	PF00069	0.386
MOD_Plk_1	23	29	PF00069	0.710
MOD_Plk_1	564	570	PF00069	0.281
MOD_Plk_1	579	585	PF00069	0.428
MOD_Plk_1	657	663	PF00069	0.352
MOD_Plk_2-3	122	128	PF00069	0.656
MOD_Plk_2-3	23	29	PF00069	0.787
MOD_Plk_4	10	16	PF00069	0.700
MOD_Plk_4	138	144	PF00069	0.520
MOD_Plk_4	149	155	PF00069	0.291
MOD_Plk_4	199	205	PF00069	0.340
MOD_Plk_4	269	275	PF00069	0.324
MOD_Plk_4	286	292	PF00069	0.353
MOD_Plk_4	341	347	PF00069	0.562
MOD_Plk_4	357	363	PF00069	0.470
MOD_Plk_4	402	408	PF00069	0.298
MOD_Plk_4	493	499	PF00069	0.634
MOD_Plk_4	627	633	PF00069	0.281
MOD_Plk_4	634	640	PF00069	0.286
MOD_Plk_4	681	687	PF00069	0.292
MOD_Plk_4	71	77	PF00069	0.710
MOD_Plk_4	725	731	PF00069	0.379
MOD_Plk_4	738	744	PF00069	0.338
MOD_Plk_4	834	840	PF00069	0.348
MOD_ProDKin_1	108	114	PF00069	0.637
MOD_ProDKin_1	382	388	PF00069	0.425
MOD_ProDKin_1	485	491	PF00069	0.591
MOD_ProDKin_1	570	576	PF00069	0.411
MOD_ProDKin_1	584	590	PF00069	0.393
MOD_ProDKin_1	702	708	PF00069	0.296
MOD_SUMO_rev_2	733	741	PF00179	0.263
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.355
TRG_DiLeu_BaLyEn_6	703	708	PF01217	0.395
TRG_ENDOCYTIC_2	131	134	PF00928	0.549
TRG_ENDOCYTIC_2	150	153	PF00928	0.172
TRG_ENDOCYTIC_2	194	197	PF00928	0.410
TRG_ENDOCYTIC_2	200	203	PF00928	0.410
TRG_ENDOCYTIC_2	247	250	PF00928	0.298
TRG_ENDOCYTIC_2	280	283	PF00928	0.282
TRG_ENDOCYTIC_2	296	299	PF00928	0.279
TRG_ENDOCYTIC_2	358	361	PF00928	0.509
TRG_ENDOCYTIC_2	65	68	PF00928	0.745
TRG_ENDOCYTIC_2	664	667	PF00928	0.277
TRG_ENDOCYTIC_2	671	674	PF00928	0.260
TRG_ER_diArg_1	322	325	PF00400	0.662
TRG_ER_diArg_1	410	412	PF00400	0.596
TRG_ER_diArg_1	492	494	PF00400	0.634
TRG_ER_diArg_1	530	532	PF00400	0.646
TRG_ER_diArg_1	722	725	PF00400	0.440
TRG_NLS_MonoCore_2	460	465	PF00514	0.600
TRG_NLS_MonoExtN_4	461	466	PF00514	0.649
TRG_Pf-PMV_PEXEL_1	502	507	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	687	691	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB4	Leptomonas seymouri	69%	100%
A0A1X0P1U6	Trypanosomatidae	48%	100%
A0A3S7X3Y7	Leishmania donovani	92%	100%
A0A422NAB6	Trypanosoma rangeli	44%	100%
A4HIV7	Leishmania braziliensis	78%	100%
A4I5Z7	Leishmania infantum	92%	100%
C9ZRI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B1E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BX06	Trypanosoma cruzi	45%	100%