Putative 60S acidic ribosomal protein P2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S acidic ribosomal protein P2, putative

Species:

Leishmania major

UniProt:

Q4Q6R6_LEIMA

TriTrypDb:

LmjF.30.3720 , LMJLV39_300046100 , LMJSD75_300045500

Length:

106

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	12
GO:0022625	cytosolic large ribosomal subunit	5	12
GO:0032991	protein-containing complex	1	12
GO:0044391	ribosomal subunit	3	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4Q6R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6R6

PDB structure(s): 1s4h_A

Function

Biological processes
Term	Name	Level	Count
GO:0002182	cytoplasmic translational elongation	6	12
GO:0006414	translational elongation	5	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.558
DEG_Nend_UBRbox_3	1	3	PF02207	0.523
DOC_USP7_UBL2_3	15	19	PF12436	0.378
DOC_WW_Pin1_4	13	18	PF00397	0.474
LIG_FHA_1	57	63	PF00498	0.544
LIG_LIR_Gen_1	39	50	PF02991	0.506
LIG_LIR_Nem_3	49	53	PF02991	0.497
LIG_LIR_Nem_3	99	105	PF02991	0.495
LIG_SH2_CRK	7	11	PF00017	0.425
LIG_SH2_NCK_1	7	11	PF00017	0.425
LIG_SH2_STAP1	7	11	PF00017	0.514
LIG_SH2_STAT5	3	6	PF00017	0.410
LIG_SUMO_SIM_par_1	8	13	PF11976	0.447
LIG_TRAF2_1	91	94	PF00917	0.495
MOD_CDK_SPxK_1	13	19	PF00069	0.472
MOD_CK1_1	13	19	PF00069	0.472
MOD_GlcNHglycan	12	15	PF01048	0.492
MOD_GlcNHglycan	63	66	PF01048	0.334
MOD_NEK2_1	61	66	PF00069	0.550
MOD_Plk_1	33	39	PF00069	0.495
MOD_Plk_2-3	46	52	PF00069	0.567
MOD_ProDKin_1	13	19	PF00069	0.472
MOD_SUMO_for_1	86	89	PF00179	0.571
MOD_SUMO_rev_2	44	50	PF00179	0.500
TRG_ENDOCYTIC_2	7	10	PF00928	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR2	Leptomonas seymouri	73%	99%
A0A0S4JJB8	Bodo saltans	45%	98%
A0A1X0P2R9	Trypanosomatidae	65%	100%
A0A3Q8ICC2	Leishmania donovani	47%	95%
A0A3Q8IG52	Leishmania donovani	84%	100%
A0A422NR90	Trypanosoma rangeli	46%	95%
A4H884	Leishmania braziliensis	50%	95%
A4I5Z9	Leishmania infantum	83%	100%
A4I600	Leishmania infantum	84%	100%
C9ZRI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	99%
E9AGM1	Leishmania infantum	46%	95%
E9AQB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	95%
E9B1E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	85%
E9B1E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
O01504	Caenorhabditis elegans	44%	99%
O01725	Branchiostoma floridae	37%	91%
O14317	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	96%
O24415	Zea mays	33%	94%
O43940	Leishmania donovani	83%	100%
O44010	Leishmania braziliensis	82%	100%
O61463	Cryptochiton stelleri	44%	96%
P02399	Artemia salina	45%	95%
P02400	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	96%
P05319	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P17478	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	96%
P22683	Dictyostelium discoideum	51%	100%
P23632	Trypanosoma cruzi	61%	99%
P42037	Alternaria alternata	45%	94%
P42899	Bos taurus	37%	92%
P46252	Zea mays	38%	95%
P51407	Arabidopsis thaliana	31%	92%
P51408	Trypanosoma brucei brucei	61%	99%
P90703	Brugia malayi	41%	93%
Q06382	Leishmania infantum	44%	95%
Q06383	Leishmania infantum	96%	100%
Q29315	Sus scrofa	37%	92%
Q4Q6R5	Leishmania major	100%	100%
Q4QF62	Leishmania major	44%	95%
Q8TFM9	Fusarium culmorum	46%	97%
Q96UQ7	Rhodotorula glutinis	47%	96%
Q9C3Z5	Podospora anserina	46%	95%
Q9HFQ4	Candida albicans	46%	95%
Q9HFQ5	Candida albicans	45%	98%
Q9LH85	Arabidopsis thaliana	33%	92%
Q9LXM8	Arabidopsis thaliana	35%	95%
Q9UUZ6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	48%	95%