Putative 60S acidic ribosomal protein P2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S acidic ribosomal protein P2, putative

Species:

Leishmania major

UniProt:

Q4Q6R5_LEIMA

TriTrypDb:

LmjF.30.3720 , LMJLV39_300046200 , LMJSD75_300045500

Length:

125

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	12
GO:0022625	cytosolic large ribosomal subunit	5	12
GO:0032991	protein-containing complex	1	12
GO:0044391	ribosomal subunit	3	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4Q6R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6R5

PDB structure(s): 1s4h_A

Function

Biological processes
Term	Name	Level	Count
GO:0002182	cytoplasmic translational elongation	6	12
GO:0006414	translational elongation	5	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.537
DOC_USP7_UBL2_3	34	38	PF12436	0.343
DOC_WW_Pin1_4	32	37	PF00397	0.482
LIG_BRCT_BRCA1_1	4	8	PF00533	0.377
LIG_FHA_1	12	18	PF00498	0.377
LIG_FHA_1	76	82	PF00498	0.490
LIG_LIR_Gen_1	58	69	PF02991	0.495
LIG_LIR_Nem_3	118	124	PF02991	0.471
LIG_LIR_Nem_3	5	9	PF02991	0.383
LIG_LIR_Nem_3	68	72	PF02991	0.511
LIG_MLH1_MIPbox_1	4	8	PF16413	0.377
LIG_Pex14_2	3	7	PF04695	0.382
LIG_PTB_Apo_2	16	23	PF02174	0.324
LIG_PTB_Phospho_1	16	22	PF10480	0.328
LIG_SH2_CRK	26	30	PF00017	0.434
LIG_SH2_NCK_1	26	30	PF00017	0.399
LIG_SH2_STAP1	26	30	PF00017	0.493
LIG_SH2_STAT5	22	25	PF00017	0.390
LIG_SH2_STAT5	6	9	PF00017	0.478
LIG_SUMO_SIM_par_1	27	32	PF11976	0.421
LIG_TRAF2_1	110	113	PF00917	0.470
MOD_CDK_SPxK_1	32	38	PF00069	0.481
MOD_CK1_1	11	17	PF00069	0.363
MOD_CK1_1	32	38	PF00069	0.446
MOD_GlcNHglycan	31	34	PF01048	0.464
MOD_GlcNHglycan	82	85	PF01048	0.312
MOD_NEK2_1	8	13	PF00069	0.446
MOD_NEK2_1	80	85	PF00069	0.527
MOD_Plk_1	52	58	PF00069	0.470
MOD_Plk_2-3	65	71	PF00069	0.564
MOD_Plk_4	2	8	PF00069	0.380
MOD_ProDKin_1	32	38	PF00069	0.481
MOD_SUMO_for_1	105	108	PF00179	0.505
MOD_SUMO_rev_2	63	69	PF00179	0.479
TRG_ENDOCYTIC_2	26	29	PF00928	0.434
TRG_ENDOCYTIC_2	6	9	PF00928	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR2	Leptomonas seymouri	73%	100%
A0A0S4JJB8	Bodo saltans	44%	100%
A0A1X0P2R9	Trypanosomatidae	65%	100%
A0A3Q8ICC2	Leishmania donovani	46%	100%
A0A3Q8IG52	Leishmania donovani	84%	100%
A0A422NR90	Trypanosoma rangeli	45%	100%
A4H884	Leishmania braziliensis	48%	100%
A4I5Z9	Leishmania infantum	83%	100%
A4I600	Leishmania infantum	84%	100%
C9ZRI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AGM1	Leishmania infantum	45%	100%
E9AQB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B1E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9B1E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
O01504	Caenorhabditis elegans	44%	100%
O01725	Branchiostoma floridae	37%	100%
O14317	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
O24415	Zea mays	33%	100%
O43940	Leishmania donovani	83%	100%
O44010	Leishmania braziliensis	82%	100%
O61463	Cryptochiton stelleri	44%	100%
P02399	Artemia salina	45%	100%
P02400	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
P05319	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P17478	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P22683	Dictyostelium discoideum	51%	100%
P23632	Trypanosoma cruzi	61%	100%
P42037	Alternaria alternata	45%	100%
P42899	Bos taurus	37%	100%
P46252	Zea mays	38%	100%
P51407	Arabidopsis thaliana	31%	100%
P51408	Trypanosoma brucei brucei	61%	100%
P90703	Brugia malayi	40%	100%
Q06382	Leishmania infantum	43%	100%
Q06383	Leishmania infantum	96%	100%
Q29315	Sus scrofa	37%	100%
Q4Q6R6	Leishmania major	100%	100%
Q4QF62	Leishmania major	43%	100%
Q8TFM9	Fusarium culmorum	46%	100%
Q96UQ7	Rhodotorula glutinis	47%	100%
Q9C3Z5	Podospora anserina	46%	100%
Q9HFQ4	Candida albicans	46%	100%
Q9HFQ5	Candida albicans	45%	100%
Q9LH85	Arabidopsis thaliana	33%	100%
Q9LXM8	Arabidopsis thaliana	35%	100%
Q9UUZ6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	48%	100%