MFS general substrate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MFS/sugar transport protein, putative

Species:

Leishmania major

UniProt:

Q4Q6R0_LEIMA

TriTrypDb:

LmjF.31.0040 , LMJLV39_310005300 , LMJSD75_310005300

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

Q4Q6R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6R0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008643	carbohydrate transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	579	583	PF00656	0.670
CLV_C14_Caspase3-7	85	89	PF00656	0.667
CLV_NRD_NRD_1	325	327	PF00675	0.432
CLV_NRD_NRD_1	351	353	PF00675	0.435
CLV_NRD_NRD_1	70	72	PF00675	0.585
CLV_NRD_NRD_1	80	82	PF00675	0.433
CLV_PCSK_KEX2_1	317	319	PF00082	0.348
CLV_PCSK_KEX2_1	325	327	PF00082	0.420
CLV_PCSK_KEX2_1	80	82	PF00082	0.596
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.392
CLV_PCSK_SKI1_1	326	330	PF00082	0.494
CLV_PCSK_SKI1_1	353	357	PF00082	0.314
CLV_PCSK_SKI1_1	359	363	PF00082	0.310
CLV_PCSK_SKI1_1	485	489	PF00082	0.425
DEG_APCC_DBOX_1	121	129	PF00400	0.335
DEG_SPOP_SBC_1	37	41	PF00917	0.600
DOC_CDC14_PxL_1	556	564	PF14671	0.399
DOC_CYCLIN_RxL_1	48	59	PF00134	0.620
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.612
DOC_MAPK_gen_1	184	193	PF00069	0.570
DOC_MAPK_MEF2A_6	184	193	PF00069	0.584
DOC_MAPK_MEF2A_6	466	475	PF00069	0.362
DOC_MAPK_MEF2A_6	485	494	PF00069	0.387
DOC_PP2B_LxvP_1	32	35	PF13499	0.658
DOC_PP2B_PxIxI_1	188	194	PF00149	0.529
DOC_PP4_FxxP_1	371	374	PF00568	0.369
DOC_PP4_FxxP_1	43	46	PF00568	0.613
DOC_USP7_MATH_1	23	27	PF00917	0.671
DOC_USP7_MATH_1	443	447	PF00917	0.395
DOC_USP7_MATH_1	474	478	PF00917	0.343
DOC_USP7_MATH_1	528	532	PF00917	0.425
DOC_USP7_MATH_1	84	88	PF00917	0.793
DOC_USP7_MATH_1	93	97	PF00917	0.567
DOC_USP7_UBL2_3	466	470	PF12436	0.326
LIG_14-3-3_CanoR_1	18	24	PF00244	0.702
LIG_14-3-3_CanoR_1	330	334	PF00244	0.677
LIG_14-3-3_CanoR_1	339	343	PF00244	0.641
LIG_14-3-3_CanoR_1	48	55	PF00244	0.622
LIG_Actin_WH2_2	471	487	PF00022	0.336
LIG_BRCT_BRCA1_1	39	43	PF00533	0.599
LIG_deltaCOP1_diTrp_1	94	102	PF00928	0.607
LIG_EH_1	435	439	PF12763	0.520
LIG_eIF4E_1	294	300	PF01652	0.269
LIG_FHA_1	127	133	PF00498	0.369
LIG_FHA_1	206	212	PF00498	0.488
LIG_FHA_1	227	233	PF00498	0.436
LIG_FHA_1	27	33	PF00498	0.828
LIG_FHA_1	489	495	PF00498	0.438
LIG_FHA_1	50	56	PF00498	0.628
LIG_FHA_1	591	597	PF00498	0.644
LIG_FHA_1	60	66	PF00498	0.615
LIG_FHA_2	349	355	PF00498	0.619
LIG_FHA_2	83	89	PF00498	0.672
LIG_LIR_Apic_2	40	46	PF02991	0.594
LIG_LIR_Gen_1	161	172	PF02991	0.419
LIG_LIR_Gen_1	212	222	PF02991	0.410
LIG_LIR_Gen_1	229	239	PF02991	0.323
LIG_LIR_Gen_1	367	376	PF02991	0.478
LIG_LIR_Gen_1	99	110	PF02991	0.654
LIG_LIR_Nem_3	161	167	PF02991	0.382
LIG_LIR_Nem_3	185	190	PF02991	0.565
LIG_LIR_Nem_3	367	373	PF02991	0.478
LIG_LIR_Nem_3	452	456	PF02991	0.436
LIG_LIR_Nem_3	505	511	PF02991	0.561
LIG_LIR_Nem_3	539	545	PF02991	0.396
LIG_LIR_Nem_3	99	105	PF02991	0.587
LIG_NRBOX	405	411	PF00104	0.369
LIG_Pex14_1	97	101	PF04695	0.664
LIG_Pex14_2	356	360	PF04695	0.426
LIG_Pex14_2	362	366	PF04695	0.367
LIG_Pex14_2	450	454	PF04695	0.346
LIG_PTB_Apo_2	376	383	PF02174	0.371
LIG_SH2_CRK	164	168	PF00017	0.369
LIG_SH2_NCK_1	388	392	PF00017	0.277
LIG_SH2_NCK_1	503	507	PF00017	0.552
LIG_SH2_STAP1	160	164	PF00017	0.416
LIG_SH2_STAP1	215	219	PF00017	0.363
LIG_SH2_STAP1	388	392	PF00017	0.369
LIG_SH2_STAP1	415	419	PF00017	0.342
LIG_SH2_STAP1	503	507	PF00017	0.552
LIG_SH2_STAP1	511	515	PF00017	0.294
LIG_SH2_STAP1	594	598	PF00017	0.665
LIG_SH2_STAT3	420	423	PF00017	0.592
LIG_SH2_STAT5	138	141	PF00017	0.394
LIG_SH2_STAT5	148	151	PF00017	0.424
LIG_SH2_STAT5	168	171	PF00017	0.313
LIG_SH2_STAT5	321	324	PF00017	0.600
LIG_SH2_STAT5	370	373	PF00017	0.381
LIG_SH2_STAT5	388	391	PF00017	0.424
LIG_SH2_STAT5	420	423	PF00017	0.615
LIG_SH3_3	304	310	PF00018	0.359
LIG_SH3_3	31	37	PF00018	0.617
LIG_SH3_3	468	474	PF00018	0.404
LIG_SH3_3	554	560	PF00018	0.408
LIG_SUMO_SIM_par_1	52	59	PF11976	0.621
LIG_TYR_ITIM	162	167	PF00017	0.398
LIG_Vh1_VBS_1	247	265	PF01044	0.536
LIG_WRC_WIRS_1	140	145	PF05994	0.385
LIG_WRC_WIRS_1	450	455	PF05994	0.431
MOD_CK1_1	130	136	PF00069	0.463
MOD_CK1_1	142	148	PF00069	0.440
MOD_CK1_1	150	156	PF00069	0.396
MOD_CK1_1	251	257	PF00069	0.709
MOD_CK1_1	26	32	PF00069	0.816
MOD_CK1_1	44	50	PF00069	0.635
MOD_CK1_1	523	529	PF00069	0.394
MOD_CK1_1	56	62	PF00069	0.621
MOD_CK1_1	592	598	PF00069	0.700
MOD_CK1_1	66	72	PF00069	0.681
MOD_CK1_1	96	102	PF00069	0.551
MOD_CK2_1	247	253	PF00069	0.637
MOD_CK2_1	348	354	PF00069	0.705
MOD_CK2_1	70	76	PF00069	0.709
MOD_GlcNHglycan	253	257	PF01048	0.404
MOD_GlcNHglycan	43	46	PF01048	0.390
MOD_GlcNHglycan	445	448	PF01048	0.386
MOD_GlcNHglycan	480	483	PF01048	0.389
MOD_GlcNHglycan	515	518	PF01048	0.433
MOD_GlcNHglycan	522	525	PF01048	0.444
MOD_GSK3_1	126	133	PF00069	0.388
MOD_GSK3_1	139	146	PF00069	0.383
MOD_GSK3_1	24	31	PF00069	0.660
MOD_GSK3_1	247	254	PF00069	0.627
MOD_GSK3_1	270	277	PF00069	0.418
MOD_GSK3_1	37	44	PF00069	0.645
MOD_GSK3_1	386	393	PF00069	0.370
MOD_GSK3_1	398	405	PF00069	0.336
MOD_GSK3_1	47	54	PF00069	0.608
MOD_GSK3_1	474	481	PF00069	0.302
MOD_GSK3_1	509	516	PF00069	0.540
MOD_GSK3_1	519	526	PF00069	0.368
MOD_GSK3_1	529	536	PF00069	0.327
MOD_GSK3_1	56	63	PF00069	0.594
MOD_GSK3_1	66	73	PF00069	0.625
MOD_GSK3_1	93	100	PF00069	0.655
MOD_LATS_1	51	57	PF00433	0.624
MOD_N-GLC_1	24	29	PF02516	0.420
MOD_N-GLC_1	66	71	PF02516	0.442
MOD_NEK2_1	110	115	PF00069	0.714
MOD_NEK2_1	126	131	PF00069	0.352
MOD_NEK2_1	143	148	PF00069	0.414
MOD_NEK2_1	149	154	PF00069	0.433
MOD_NEK2_1	17	22	PF00069	0.794
MOD_NEK2_1	24	29	PF00069	0.611
MOD_NEK2_1	247	252	PF00069	0.695
MOD_NEK2_1	274	279	PF00069	0.424
MOD_NEK2_1	313	318	PF00069	0.479
MOD_NEK2_1	364	369	PF00069	0.418
MOD_NEK2_1	377	382	PF00069	0.322
MOD_NEK2_1	460	465	PF00069	0.490
MOD_NEK2_1	49	54	PF00069	0.621
MOD_NEK2_1	502	507	PF00069	0.603
MOD_NEK2_1	529	534	PF00069	0.377
MOD_NEK2_2	449	454	PF00069	0.353
MOD_PIKK_1	130	136	PF00454	0.358
MOD_PIKK_1	260	266	PF00454	0.511
MOD_PIKK_1	70	76	PF00454	0.725
MOD_PKA_2	17	23	PF00069	0.604
MOD_PKA_2	329	335	PF00069	0.694
MOD_PKA_2	338	344	PF00069	0.641
MOD_PKA_2	47	53	PF00069	0.621
MOD_PKA_2	70	76	PF00069	0.709
MOD_PKA_2	82	88	PF00069	0.721
MOD_PKB_1	81	89	PF00069	0.659
MOD_Plk_1	110	116	PF00069	0.520
MOD_Plk_1	567	573	PF00069	0.705
MOD_Plk_1	577	583	PF00069	0.735
MOD_Plk_1	93	99	PF00069	0.620
MOD_Plk_4	214	220	PF00069	0.406
MOD_Plk_4	226	232	PF00069	0.354
MOD_Plk_4	270	276	PF00069	0.407
MOD_Plk_4	398	404	PF00069	0.411
MOD_Plk_4	449	455	PF00069	0.513
MOD_Plk_4	474	480	PF00069	0.307
MOD_Plk_4	93	99	PF00069	0.684
TRG_ENDOCYTIC_2	164	167	PF00928	0.398
TRG_ENDOCYTIC_2	215	218	PF00928	0.399
TRG_ENDOCYTIC_2	233	236	PF00928	0.377
TRG_ENDOCYTIC_2	294	297	PF00928	0.320
TRG_ENDOCYTIC_2	370	373	PF00928	0.387
TRG_ENDOCYTIC_2	469	472	PF00928	0.375
TRG_ER_diArg_1	324	326	PF00400	0.653
TRG_ER_diArg_1	80	83	PF00400	0.808

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC7	Leptomonas seymouri	57%	100%
A0A0N1I3H1	Leptomonas seymouri	28%	89%
A0A3Q8IF44	Leishmania donovani	93%	100%
A0A3Q8ILR5	Leishmania donovani	26%	100%
A4HIW8	Leishmania braziliensis	77%	100%
A4HL09	Leishmania braziliensis	27%	100%
A4I8J0	Leishmania infantum	26%	100%
E9AHK6	Leishmania infantum	93%	100%
E9B1F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B3F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q4Q0	Leishmania major	26%	100%