Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6Q8_LEIMA

TriTrypDb:

LmjF.31.0060 , LMJLV39_310005500 , LMJSD75_310005500

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q6Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Q8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.491
CLV_NRD_NRD_1	51	53	PF00675	0.449
CLV_PCSK_KEX2_1	51	53	PF00082	0.428
CLV_PCSK_PC7_1	47	53	PF00082	0.426
CLV_PCSK_SKI1_1	23	27	PF00082	0.450
CLV_PCSK_SKI1_1	7	11	PF00082	0.416
CLV_PCSK_SKI1_1	79	83	PF00082	0.308
DEG_MDM2_SWIB_1	104	111	PF02201	0.459
DOC_CYCLIN_RxL_1	75	83	PF00134	0.628
DOC_MAPK_gen_1	75	84	PF00069	0.610
DOC_USP7_MATH_1	85	89	PF00917	0.433
DOC_USP7_UBL2_3	23	27	PF12436	0.650
DOC_USP7_UBL2_3	75	79	PF12436	0.610
DOC_WW_Pin1_4	109	114	PF00397	0.395
LIG_14-3-3_CanoR_1	47	51	PF00244	0.633
LIG_APCC_ABBA_1	60	65	PF00400	0.613
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_EH1_1	75	83	PF00400	0.610
LIG_EVH1_1	127	131	PF00568	0.456
LIG_FHA_1	115	121	PF00498	0.459
LIG_FHA_1	40	46	PF00498	0.721
LIG_FHA_1	8	14	PF00498	0.607
LIG_FHA_2	110	116	PF00498	0.395
LIG_FHA_2	32	38	PF00498	0.712
LIG_LIR_Gen_1	100	106	PF02991	0.599
LIG_LIR_Nem_3	100	106	PF02991	0.599
LIG_Pex14_2	104	108	PF04695	0.458
LIG_SH2_STAT5	103	106	PF00017	0.375
LIG_SH2_STAT5	98	101	PF00017	0.334
LIG_SH3_3	125	131	PF00018	0.453
LIG_SH3_3	86	92	PF00018	0.346
LIG_WRC_WIRS_1	98	103	PF05994	0.485
LIG_WW_1	130	133	PF00397	0.476
MOD_CK2_1	31	37	PF00069	0.688
MOD_CK2_1	58	64	PF00069	0.626
MOD_GlcNHglycan	117	120	PF01048	0.720
MOD_N-GLC_1	21	26	PF02516	0.429
MOD_N-GLC_1	85	90	PF02516	0.369
MOD_NEK2_1	21	26	PF00069	0.629
MOD_PKA_2	46	52	PF00069	0.631
MOD_Plk_1	21	27	PF00069	0.631
MOD_Plk_1	31	37	PF00069	0.666
MOD_Plk_1	58	64	PF00069	0.609
MOD_Plk_1	85	91	PF00069	0.369
MOD_Plk_2-3	58	64	PF00069	0.626
MOD_Plk_4	58	64	PF00069	0.609
MOD_Plk_4	85	91	PF00069	0.433
MOD_ProDKin_1	109	115	PF00069	0.396
MOD_SUMO_rev_2	32	42	PF00179	0.736
MOD_SUMO_rev_2	58	68	PF00179	0.623
TRG_ENDOCYTIC_2	98	101	PF00928	0.344
TRG_ER_diArg_1	50	52	PF00400	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEH8	Leptomonas seymouri	89%	100%
A0A0S4JTI1	Bodo saltans	67%	100%
A0A1X0P7G0	Trypanosomatidae	78%	100%
A0A3Q8IIA2	Leishmania donovani	96%	100%
A4HIX0	Leishmania braziliensis	91%	100%
A4I699	Leishmania infantum	96%	100%
D0A540	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E9B1F4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%