C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6Q6_LEIMA

TriTrypDb:

LmjF.31.0080 , LMJLV39_310005700 , LMJSD75_310005700

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6Q6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Q6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.769
CLV_C14_Caspase3-7	20	24	PF00656	0.781
CLV_NRD_NRD_1	110	112	PF00675	0.631
CLV_PCSK_KEX2_1	110	112	PF00082	0.652
DEG_SCF_SKP2-CKS1_1	190	197	PF00560	0.722
DOC_USP7_MATH_1	190	194	PF00917	0.772
DOC_USP7_MATH_1	195	199	PF00917	0.726
DOC_USP7_UBL2_3	185	189	PF12436	0.755
DOC_USP7_UBL2_3	205	209	PF12436	0.550
DOC_USP7_UBL2_3	213	217	PF12436	0.707
DOC_WW_Pin1_4	191	196	PF00397	0.734
LIG_14-3-3_CanoR_1	128	136	PF00244	0.566
LIG_14-3-3_CanoR_1	18	22	PF00244	0.786
LIG_BIR_III_4	8	12	PF00653	0.781
LIG_BRCT_BRCA1_1	138	142	PF00533	0.525
LIG_CaM_IQ_9	133	149	PF13499	0.525
LIG_FHA_2	120	126	PF00498	0.625
LIG_FHA_2	167	173	PF00498	0.690
LIG_LIR_Gen_1	90	100	PF02991	0.704
LIG_PTB_Apo_2	55	62	PF02174	0.712
LIG_PTB_Phospho_1	55	61	PF10480	0.712
LIG_SH2_CRK	40	44	PF00017	0.688
LIG_SH2_CRK	48	52	PF00017	0.604
LIG_SH2_CRK	61	65	PF00017	0.710
LIG_SH2_NCK_1	16	20	PF00017	0.708
LIG_SH2_NCK_1	40	44	PF00017	0.674
LIG_SH2_NCK_1	61	65	PF00017	0.720
LIG_SH2_SRC	48	51	PF00017	0.692
LIG_SH2_STAT3	7	10	PF00017	0.722
LIG_SH3_3	212	218	PF00018	0.729
LIG_SH3_3	66	72	PF00018	0.723
LIG_TRAF2_1	220	223	PF00917	0.610
MOD_CDK_SPK_2	191	196	PF00069	0.589
MOD_CDK_SPxK_1	191	197	PF00069	0.726
MOD_CK1_1	87	93	PF00069	0.713
MOD_CK2_1	119	125	PF00069	0.631
MOD_GlcNHglycan	86	89	PF01048	0.707
MOD_GSK3_1	191	198	PF00069	0.721
MOD_N-GLC_1	26	31	PF02516	0.763
MOD_NEK2_1	136	141	PF00069	0.573
MOD_OFUCOSY	133	140	PF10250	0.516
MOD_PIKK_1	119	125	PF00454	0.550
MOD_PKA_2	127	133	PF00069	0.513
MOD_PKA_2	17	23	PF00069	0.793
MOD_Plk_1	199	205	PF00069	0.724
MOD_Plk_1	207	213	PF00069	0.618
MOD_Plk_2-3	207	213	PF00069	0.571
MOD_ProDKin_1	191	197	PF00069	0.734
MOD_SUMO_for_1	204	207	PF00179	0.723
TRG_ENDOCYTIC_2	93	96	PF00928	0.728
TRG_ER_diArg_1	109	111	PF00400	0.676
TRG_NLS_MonoExtN_4	108	115	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA54	Leptomonas seymouri	71%	100%
A0A1X0P7C1	Trypanosomatidae	42%	100%
A0A3Q8ISC2	Leishmania donovani	95%	100%
A4HIX2	Leishmania braziliensis	80%	100%
A4I6A1	Leishmania infantum	96%	100%
D0A543	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B1F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	96%