Putative intergrin alpha chain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intergrin alpha chain protein, putative

Species:

Leishmania major

UniProt:

Q4Q6Q3_LEIMA

TriTrypDb:

LmjF.31.0110 , LMJLV39_310006100 , LMJSD75_310006100

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q6Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Q3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	734	738	PF00656	0.396
CLV_C14_Caspase3-7	77	81	PF00656	0.281
CLV_NRD_NRD_1	181	183	PF00675	0.635
CLV_PCSK_KEX2_1	146	148	PF00082	0.571
CLV_PCSK_KEX2_1	181	183	PF00082	0.595
CLV_PCSK_KEX2_1	215	217	PF00082	0.674
CLV_PCSK_KEX2_1	289	291	PF00082	0.669
CLV_PCSK_KEX2_1	682	684	PF00082	0.597
CLV_PCSK_KEX2_1	771	773	PF00082	0.434
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.571
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.612
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.662
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.579
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.435
CLV_PCSK_SKI1_1	289	293	PF00082	0.722
CLV_PCSK_SKI1_1	305	309	PF00082	0.539
CLV_PCSK_SKI1_1	65	69	PF00082	0.468
DEG_APCC_DBOX_1	272	280	PF00400	0.441
DEG_APCC_DBOX_1	712	720	PF00400	0.351
DEG_Nend_Nbox_1	1	3	PF02207	0.658
DEG_SCF_FBW7_1	164	170	PF00400	0.418
DEG_SCF_FBW7_1	323	330	PF00400	0.388
DEG_SPOP_SBC_1	28	32	PF00917	0.449
DOC_CDC14_PxL_1	137	145	PF14671	0.396
DOC_CKS1_1	164	169	PF01111	0.488
DOC_CKS1_1	324	329	PF01111	0.295
DOC_CKS1_1	404	409	PF01111	0.379
DOC_CKS1_1	51	56	PF01111	0.278
DOC_CYCLIN_yClb5_NLxxxL_5	546	555	PF00134	0.238
DOC_CYCLIN_yCln2_LP_2	404	410	PF00134	0.316
DOC_CYCLIN_yCln2_LP_2	445	451	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	755	761	PF00134	0.357
DOC_MAPK_DCC_7	752	762	PF00069	0.357
DOC_MAPK_DCC_7	98	108	PF00069	0.315
DOC_MAPK_gen_1	179	188	PF00069	0.408
DOC_MAPK_gen_1	302	312	PF00069	0.432
DOC_MAPK_gen_1	682	689	PF00069	0.315
DOC_MAPK_MEF2A_6	273	280	PF00069	0.444
DOC_MAPK_MEF2A_6	682	691	PF00069	0.350
DOC_MAPK_MEF2A_6	718	727	PF00069	0.287
DOC_MAPK_MEF2A_6	752	759	PF00069	0.398
DOC_MAPK_NFAT4_5	273	281	PF00069	0.445
DOC_MAPK_RevD_3	758	772	PF00069	0.410
DOC_PP1_RVXF_1	495	501	PF00149	0.368
DOC_PP2B_LxvP_1	138	141	PF13499	0.403
DOC_PP2B_LxvP_1	727	730	PF13499	0.336
DOC_PP2B_LxvP_1	755	758	PF13499	0.410
DOC_PP4_FxxP_1	702	705	PF00568	0.369
DOC_PP4_FxxP_1	92	95	PF00568	0.333
DOC_USP7_MATH_1	272	276	PF00917	0.379
DOC_USP7_MATH_1	480	484	PF00917	0.330
DOC_USP7_MATH_1	630	634	PF00917	0.325
DOC_USP7_MATH_1	681	685	PF00917	0.454
DOC_WW_Pin1_4	163	168	PF00397	0.418
DOC_WW_Pin1_4	266	271	PF00397	0.428
DOC_WW_Pin1_4	323	328	PF00397	0.292
DOC_WW_Pin1_4	403	408	PF00397	0.297
DOC_WW_Pin1_4	449	454	PF00397	0.322
DOC_WW_Pin1_4	50	55	PF00397	0.276
DOC_WW_Pin1_4	620	625	PF00397	0.345
DOC_WW_Pin1_4	650	655	PF00397	0.344
DOC_WW_Pin1_4	677	682	PF00397	0.378
DOC_WW_Pin1_4	99	104	PF00397	0.295
LIG_14-3-3_CanoR_1	273	277	PF00244	0.437
LIG_14-3-3_CanoR_1	497	501	PF00244	0.362
LIG_14-3-3_CanoR_1	683	688	PF00244	0.402
LIG_14-3-3_CanoR_1	718	724	PF00244	0.311
LIG_14-3-3_CanoR_1	96	101	PF00244	0.361
LIG_BRCT_BRCA1_1	344	348	PF00533	0.260
LIG_BRCT_BRCA1_1	424	428	PF00533	0.327
LIG_BRCT_BRCA1_1	652	656	PF00533	0.334
LIG_BRCT_BRCA1_1	739	743	PF00533	0.325
LIG_FHA_1	120	126	PF00498	0.273
LIG_FHA_1	168	174	PF00498	0.487
LIG_FHA_1	324	330	PF00498	0.298
LIG_FHA_1	370	376	PF00498	0.310
LIG_FHA_1	404	410	PF00498	0.361
LIG_FHA_1	461	467	PF00498	0.426
LIG_FHA_1	51	57	PF00498	0.302
LIG_FHA_1	514	520	PF00498	0.283
LIG_FHA_1	581	587	PF00498	0.331
LIG_FHA_1	633	639	PF00498	0.366
LIG_FHA_1	664	670	PF00498	0.361
LIG_FHA_1	684	690	PF00498	0.309
LIG_FHA_1	705	711	PF00498	0.364
LIG_FHA_1	734	740	PF00498	0.365
LIG_FHA_1	752	758	PF00498	0.322
LIG_FHA_2	170	176	PF00498	0.501
LIG_FHA_2	187	193	PF00498	0.318
LIG_FHA_2	229	235	PF00498	0.434
LIG_FHA_2	290	296	PF00498	0.564
LIG_FHA_2	309	315	PF00498	0.323
LIG_FHA_2	328	334	PF00498	0.372
LIG_FHA_2	452	458	PF00498	0.375
LIG_FHA_2	497	503	PF00498	0.281
LIG_FHA_2	656	662	PF00498	0.400
LIG_FHA_2	670	676	PF00498	0.239
LIG_FHA_2	81	87	PF00498	0.369
LIG_LIR_Apic_2	48	54	PF02991	0.307
LIG_LIR_Apic_2	99	103	PF02991	0.335
LIG_LIR_Gen_1	383	390	PF02991	0.303
LIG_LIR_Gen_1	622	632	PF02991	0.346
LIG_LIR_Gen_1	71	79	PF02991	0.354
LIG_LIR_Gen_1	717	727	PF02991	0.306
LIG_LIR_LC3C_4	122	127	PF02991	0.292
LIG_LIR_LC3C_4	606	609	PF02991	0.270
LIG_LIR_Nem_3	32	38	PF02991	0.422
LIG_LIR_Nem_3	383	389	PF02991	0.304
LIG_LIR_Nem_3	440	445	PF02991	0.323
LIG_LIR_Nem_3	499	503	PF02991	0.287
LIG_LIR_Nem_3	533	537	PF02991	0.382
LIG_LIR_Nem_3	644	650	PF02991	0.328
LIG_LIR_Nem_3	653	659	PF02991	0.342
LIG_LIR_Nem_3	670	674	PF02991	0.241
LIG_LIR_Nem_3	71	75	PF02991	0.308
LIG_LIR_Nem_3	717	723	PF02991	0.314
LIG_LYPXL_yS_3	35	38	PF13949	0.335
LIG_MLH1_MIPbox_1	344	348	PF16413	0.260
LIG_PDZ_Class_2	780	785	PF00595	0.647
LIG_Pex14_2	428	432	PF04695	0.355
LIG_Pex14_2	667	671	PF04695	0.337
LIG_Pex14_2	743	747	PF04695	0.298
LIG_SH2_CRK	100	104	PF00017	0.340
LIG_SH2_CRK	51	55	PF00017	0.363
LIG_SH2_CRK	720	724	PF00017	0.301
LIG_SH2_CRK	753	757	PF00017	0.357
LIG_SH2_GRB2like	556	559	PF00017	0.348
LIG_SH2_PTP2	647	650	PF00017	0.284
LIG_SH2_STAP1	219	223	PF00017	0.453
LIG_SH2_STAP1	556	560	PF00017	0.334
LIG_SH2_STAP1	685	689	PF00017	0.337
LIG_SH2_STAP1	753	757	PF00017	0.392
LIG_SH2_STAT3	617	620	PF00017	0.293
LIG_SH2_STAT5	121	124	PF00017	0.305
LIG_SH2_STAT5	137	140	PF00017	0.368
LIG_SH2_STAT5	346	349	PF00017	0.266
LIG_SH2_STAT5	572	575	PF00017	0.266
LIG_SH2_STAT5	6	9	PF00017	0.391
LIG_SH2_STAT5	617	620	PF00017	0.367
LIG_SH2_STAT5	625	628	PF00017	0.388
LIG_SH2_STAT5	647	650	PF00017	0.284
LIG_SH2_STAT5	685	688	PF00017	0.318
LIG_SH2_STAT5	753	756	PF00017	0.350
LIG_SH3_2	164	169	PF14604	0.417
LIG_SH3_2	678	683	PF14604	0.380
LIG_SH3_3	161	167	PF00018	0.414
LIG_SH3_3	529	535	PF00018	0.298
LIG_SH3_3	64	70	PF00018	0.329
LIG_SH3_3	648	654	PF00018	0.228
LIG_SH3_3	675	681	PF00018	0.361
LIG_SH3_3	709	715	PF00018	0.355
LIG_SH3_3	85	91	PF00018	0.396
LIG_SUMO_SIM_anti_2	275	280	PF11976	0.487
LIG_SUMO_SIM_anti_2	337	342	PF11976	0.304
LIG_SUMO_SIM_par_1	115	122	PF11976	0.348
LIG_SUMO_SIM_par_1	13	18	PF11976	0.575
LIG_SUMO_SIM_par_1	242	250	PF11976	0.404
LIG_SUMO_SIM_par_1	582	588	PF11976	0.394
LIG_SUMO_SIM_par_1	684	690	PF11976	0.431
LIG_TYR_ITIM	751	756	PF00017	0.357
LIG_WRC_WIRS_1	656	661	PF05994	0.369
LIG_WRC_WIRS_1	69	74	PF05994	0.389
MOD_CDC14_SPxK_1	680	683	PF00782	0.379
MOD_CDK_SPK_2	50	55	PF00069	0.276
MOD_CDK_SPK_2	677	682	PF00069	0.361
MOD_CDK_SPxK_1	163	169	PF00069	0.404
MOD_CDK_SPxK_1	677	683	PF00069	0.372
MOD_CDK_SPxxK_3	266	273	PF00069	0.424
MOD_CDK_SPxxK_3	650	657	PF00069	0.347
MOD_CK1_1	266	272	PF00069	0.477
MOD_CK2_1	169	175	PF00069	0.493
MOD_CK2_1	186	192	PF00069	0.314
MOD_CK2_1	228	234	PF00069	0.529
MOD_CK2_1	289	295	PF00069	0.480
MOD_CK2_1	308	314	PF00069	0.278
MOD_DYRK1A_RPxSP_1	163	167	PF00069	0.477
MOD_DYRK1A_RPxSP_1	677	681	PF00069	0.374
MOD_GlcNHglycan	189	192	PF01048	0.667
MOD_GlcNHglycan	42	45	PF01048	0.564
MOD_GlcNHglycan	449	452	PF01048	0.540
MOD_GlcNHglycan	480	483	PF01048	0.566
MOD_GlcNHglycan	516	519	PF01048	0.512
MOD_GlcNHglycan	577	580	PF01048	0.541
MOD_GlcNHglycan	641	644	PF01048	0.569
MOD_GlcNHglycan	762	765	PF01048	0.355
MOD_GSK3_1	163	170	PF00069	0.483
MOD_GSK3_1	323	330	PF00069	0.378
MOD_GSK3_1	342	349	PF00069	0.207
MOD_GSK3_1	390	397	PF00069	0.356
MOD_GSK3_1	447	454	PF00069	0.308
MOD_GSK3_1	456	463	PF00069	0.341
MOD_GSK3_1	46	53	PF00069	0.296
MOD_GSK3_1	478	485	PF00069	0.328
MOD_GSK3_1	619	626	PF00069	0.333
MOD_GSK3_1	669	676	PF00069	0.306
MOD_GSK3_1	677	684	PF00069	0.369
MOD_GSK3_1	731	738	PF00069	0.325
MOD_LATS_1	94	100	PF00433	0.373
MOD_N-GLC_1	28	33	PF02516	0.613
MOD_N-GLC_1	308	313	PF02516	0.527
MOD_N-GLC_1	395	400	PF02516	0.561
MOD_N-GLC_1	478	483	PF02516	0.597
MOD_N-GLC_2	568	570	PF02516	0.426
MOD_NEK2_1	186	191	PF00069	0.503
MOD_NEK2_1	284	289	PF00069	0.444
MOD_NEK2_1	342	347	PF00069	0.261
MOD_NEK2_1	369	374	PF00069	0.316
MOD_NEK2_1	389	394	PF00069	0.209
MOD_NEK2_1	40	45	PF00069	0.297
MOD_NEK2_1	421	426	PF00069	0.350
MOD_NEK2_1	5	10	PF00069	0.427
MOD_NEK2_1	513	518	PF00069	0.285
MOD_NEK2_1	554	559	PF00069	0.306
MOD_NEK2_1	607	612	PF00069	0.261
MOD_NEK2_1	619	624	PF00069	0.285
MOD_NEK2_1	641	646	PF00069	0.301
MOD_NEK2_1	719	724	PF00069	0.316
MOD_NEK2_1	735	740	PF00069	0.249
MOD_NEK2_1	760	765	PF00069	0.342
MOD_PIKK_1	29	35	PF00454	0.458
MOD_PIKK_1	70	76	PF00454	0.298
MOD_PKA_1	289	295	PF00069	0.448
MOD_PKA_2	198	204	PF00069	0.481
MOD_PKA_2	228	234	PF00069	0.471
MOD_PKA_2	272	278	PF00069	0.477
MOD_PKA_2	289	295	PF00069	0.540
MOD_PKA_2	496	502	PF00069	0.341
MOD_PKA_2	523	529	PF00069	0.337
MOD_PKA_2	574	580	PF00069	0.342
MOD_Plk_1	184	190	PF00069	0.428
MOD_Plk_1	295	301	PF00069	0.477
MOD_Plk_1	308	314	PF00069	0.330
MOD_Plk_1	414	420	PF00069	0.459
MOD_Plk_1	669	675	PF00069	0.339
MOD_Plk_1	687	693	PF00069	0.327
MOD_Plk_2-3	234	240	PF00069	0.505
MOD_Plk_2-3	414	420	PF00069	0.360
MOD_Plk_2-3	496	502	PF00069	0.328
MOD_Plk_4	169	175	PF00069	0.460
MOD_Plk_4	342	348	PF00069	0.259
MOD_Plk_4	46	52	PF00069	0.283
MOD_Plk_4	538	544	PF00069	0.318
MOD_Plk_4	589	595	PF00069	0.277
MOD_Plk_4	751	757	PF00069	0.344
MOD_ProDKin_1	163	169	PF00069	0.422
MOD_ProDKin_1	266	272	PF00069	0.425
MOD_ProDKin_1	323	329	PF00069	0.293
MOD_ProDKin_1	403	409	PF00069	0.295
MOD_ProDKin_1	449	455	PF00069	0.322
MOD_ProDKin_1	50	56	PF00069	0.276
MOD_ProDKin_1	620	626	PF00069	0.347
MOD_ProDKin_1	650	656	PF00069	0.344
MOD_ProDKin_1	677	683	PF00069	0.372
MOD_ProDKin_1	99	105	PF00069	0.299
MOD_SUMO_rev_2	314	319	PF00179	0.369
MOD_SUMO_rev_2	470	475	PF00179	0.379
MOD_SUMO_rev_2	585	591	PF00179	0.359
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.383
TRG_ENDOCYTIC_2	137	140	PF00928	0.408
TRG_ENDOCYTIC_2	35	38	PF00928	0.370
TRG_ENDOCYTIC_2	6	9	PF00928	0.391
TRG_ENDOCYTIC_2	625	628	PF00928	0.388
TRG_ENDOCYTIC_2	647	650	PF00928	0.284
TRG_ENDOCYTIC_2	720	723	PF00928	0.288
TRG_ENDOCYTIC_2	753	756	PF00928	0.357
TRG_ER_diArg_1	181	183	PF00400	0.416
TRG_ER_diArg_1	694	697	PF00400	0.356
TRG_ER_diArg_1	698	701	PF00400	0.382
TRG_NES_CRM1_1	717	733	PF08389	0.347
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U3	Leptomonas seymouri	67%	100%
A0A0S4JVN8	Bodo saltans	41%	90%
A0A3S7X408	Leishmania donovani	94%	100%
A0A422NXM6	Trypanosoma rangeli	46%	92%
A4HIX5	Leishmania braziliensis	83%	100%
A4I6A4	Leishmania infantum	95%	100%
C9ZTY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	93%
E9B1F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
V5AJ13	Trypanosoma cruzi	45%	95%