Centrosomal protein of 162 kDa

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q6Q1_LEIMA

TriTrypDb:

LmjF.31.0130 , LMJLV39_310006300 , LMJSD75_310006300

Length:

826

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.772
CLV_C14_Caspase3-7	263	267	PF00656	0.742
CLV_C14_Caspase3-7	44	48	PF00656	0.754
CLV_NRD_NRD_1	284	286	PF00675	0.692
CLV_NRD_NRD_1	335	337	PF00675	0.566
CLV_NRD_NRD_1	380	382	PF00675	0.553
CLV_NRD_NRD_1	526	528	PF00675	0.595
CLV_NRD_NRD_1	546	548	PF00675	0.394
CLV_NRD_NRD_1	610	612	PF00675	0.434
CLV_NRD_NRD_1	619	621	PF00675	0.607
CLV_NRD_NRD_1	644	646	PF00675	0.556
CLV_PCSK_FUR_1	333	337	PF00082	0.691
CLV_PCSK_FUR_1	608	612	PF00082	0.439
CLV_PCSK_FUR_1	617	621	PF00082	0.531
CLV_PCSK_FUR_1	7	11	PF00082	0.708
CLV_PCSK_KEX2_1	100	102	PF00082	0.736
CLV_PCSK_KEX2_1	283	285	PF00082	0.679
CLV_PCSK_KEX2_1	335	337	PF00082	0.566
CLV_PCSK_KEX2_1	487	489	PF00082	0.553
CLV_PCSK_KEX2_1	511	513	PF00082	0.547
CLV_PCSK_KEX2_1	526	528	PF00082	0.573
CLV_PCSK_KEX2_1	601	603	PF00082	0.574
CLV_PCSK_KEX2_1	610	612	PF00082	0.391
CLV_PCSK_KEX2_1	619	621	PF00082	0.455
CLV_PCSK_KEX2_1	9	11	PF00082	0.663
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.736
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.553
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.581
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.570
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.652
CLV_PCSK_PC7_1	279	285	PF00082	0.650
CLV_PCSK_SKI1_1	38	42	PF00082	0.733
CLV_PCSK_SKI1_1	547	551	PF00082	0.637
CLV_PCSK_SKI1_1	601	605	PF00082	0.658
CLV_PCSK_SKI1_1	667	671	PF00082	0.548
DEG_APCC_DBOX_1	489	497	PF00400	0.500
DEG_SPOP_SBC_1	238	242	PF00917	0.745
DOC_CKS1_1	173	178	PF01111	0.746
DOC_MAPK_gen_1	473	482	PF00069	0.558
DOC_MAPK_gen_1	487	495	PF00069	0.435
DOC_MAPK_gen_1	553	561	PF00069	0.647
DOC_MAPK_MEF2A_6	30	37	PF00069	0.683
DOC_MAPK_MEF2A_6	372	379	PF00069	0.510
DOC_PIKK_1	787	795	PF02985	0.574
DOC_PP1_RVXF_1	385	392	PF00149	0.554
DOC_PP2B_LxvP_1	153	156	PF13499	0.738
DOC_PP2B_LxvP_1	225	228	PF13499	0.726
DOC_USP7_MATH_1	135	139	PF00917	0.703
DOC_USP7_MATH_1	156	160	PF00917	0.730
DOC_USP7_MATH_1	181	185	PF00917	0.669
DOC_USP7_MATH_1	186	190	PF00917	0.630
DOC_USP7_MATH_1	197	201	PF00917	0.710
DOC_USP7_MATH_1	239	243	PF00917	0.634
DOC_USP7_MATH_1	260	264	PF00917	0.788
DOC_USP7_MATH_1	299	303	PF00917	0.729
DOC_USP7_MATH_1	317	321	PF00917	0.691
DOC_USP7_MATH_1	326	330	PF00917	0.578
DOC_USP7_MATH_1	33	37	PF00917	0.717
DOC_USP7_MATH_1	365	369	PF00917	0.565
DOC_USP7_MATH_1	460	464	PF00917	0.420
DOC_USP7_MATH_1	819	823	PF00917	0.807
DOC_USP7_MATH_1	82	86	PF00917	0.745
DOC_USP7_MATH_2	161	167	PF00917	0.738
DOC_USP7_UBL2_3	435	439	PF12436	0.550
DOC_USP7_UBL2_3	572	576	PF12436	0.471
DOC_USP7_UBL2_3	597	601	PF12436	0.606
DOC_WW_Pin1_4	157	162	PF00397	0.807
DOC_WW_Pin1_4	172	177	PF00397	0.640
DOC_WW_Pin1_4	184	189	PF00397	0.747
DOC_WW_Pin1_4	254	259	PF00397	0.803
DOC_WW_Pin1_4	295	300	PF00397	0.692
DOC_WW_Pin1_4	322	327	PF00397	0.777
DOC_WW_Pin1_4	72	77	PF00397	0.768
LIG_14-3-3_CanoR_1	283	289	PF00244	0.695
LIG_14-3-3_CanoR_1	372	378	PF00244	0.537
LIG_14-3-3_CanoR_1	459	465	PF00244	0.466
LIG_14-3-3_CanoR_1	588	594	PF00244	0.581
LIG_14-3-3_CanoR_1	626	632	PF00244	0.611
LIG_14-3-3_CanoR_1	667	675	PF00244	0.574
LIG_14-3-3_CanoR_1	688	694	PF00244	0.456
LIG_14-3-3_CanoR_1	705	711	PF00244	0.551
LIG_14-3-3_CanoR_1	781	785	PF00244	0.624
LIG_14-3-3_CanoR_1	811	820	PF00244	0.723
LIG_Actin_WH2_2	344	361	PF00022	0.562
LIG_Actin_WH2_2	388	405	PF00022	0.549
LIG_Actin_WH2_2	532	549	PF00022	0.605
LIG_BIR_II_1	1	5	PF00653	0.702
LIG_BIR_III_4	752	756	PF00653	0.601
LIG_BRCT_BRCA1_1	216	220	PF00533	0.756
LIG_BRCT_BRCA1_1	47	51	PF00533	0.697
LIG_BRCT_BRCA1_1	689	693	PF00533	0.460
LIG_EVH1_1	225	229	PF00568	0.802
LIG_FHA_1	241	247	PF00498	0.826
LIG_FHA_1	249	255	PF00498	0.689
LIG_FHA_1	267	273	PF00498	0.612
LIG_FHA_1	590	596	PF00498	0.454
LIG_FHA_1	631	637	PF00498	0.643
LIG_FHA_1	709	715	PF00498	0.658
LIG_FHA_1	81	87	PF00498	0.721
LIG_FHA_2	158	164	PF00498	0.731
LIG_FHA_2	396	402	PF00498	0.591
LIG_FHA_2	42	48	PF00498	0.789
LIG_FHA_2	459	465	PF00498	0.423
LIG_FHA_2	594	600	PF00498	0.594
LIG_FHA_2	668	674	PF00498	0.572
LIG_FHA_2	711	717	PF00498	0.553
LIG_FHA_2	781	787	PF00498	0.653
LIG_Integrin_isoDGR_2	788	790	PF01839	0.626
LIG_LIR_Gen_1	166	174	PF02991	0.628
LIG_LIR_Nem_3	166	170	PF02991	0.632
LIG_LIR_Nem_3	396	402	PF02991	0.552
LIG_LIR_Nem_3	424	429	PF02991	0.504
LIG_NRBOX	443	449	PF00104	0.559
LIG_PTB_Apo_2	494	501	PF02174	0.395
LIG_SH2_CRK	167	171	PF00017	0.630
LIG_SH2_CRK	426	430	PF00017	0.562
LIG_SH2_STAP1	449	453	PF00017	0.623
LIG_SH2_STAP1	465	469	PF00017	0.397
LIG_SH2_STAP1	532	536	PF00017	0.658
LIG_SH2_STAP1	632	636	PF00017	0.586
LIG_SH2_STAT3	681	684	PF00017	0.654
LIG_SH2_STAT5	632	635	PF00017	0.646
LIG_SH2_STAT5	805	808	PF00017	0.563
LIG_SH3_1	100	106	PF00018	0.710
LIG_SH3_3	100	106	PF00018	0.759
LIG_SH3_3	134	140	PF00018	0.691
LIG_SH3_3	168	174	PF00018	0.749
LIG_SH3_3	182	188	PF00018	0.715
LIG_SH3_3	223	229	PF00018	0.809
LIG_SH3_3	61	67	PF00018	0.742
LIG_SUMO_SIM_par_1	135	141	PF11976	0.572
LIG_SUMO_SIM_par_1	591	596	PF11976	0.454
LIG_TRAF2_1	268	271	PF00917	0.650
LIG_TRAF2_1	719	722	PF00917	0.593
LIG_WW_3	227	231	PF00397	0.818
MOD_CDC14_SPxK_1	298	301	PF00782	0.731
MOD_CDC14_SPxK_1	325	328	PF00782	0.703
MOD_CDK_SPK_2	254	259	PF00069	0.587
MOD_CDK_SPK_2	72	77	PF00069	0.591
MOD_CDK_SPxK_1	295	301	PF00069	0.719
MOD_CDK_SPxK_1	322	328	PF00069	0.777
MOD_CDK_SPxxK_3	157	164	PF00069	0.733
MOD_CDK_SPxxK_3	172	179	PF00069	0.559
MOD_CDK_SPxxK_3	254	261	PF00069	0.802
MOD_CK1_1	166	172	PF00069	0.761
MOD_CK1_1	184	190	PF00069	0.674
MOD_CK1_1	241	247	PF00069	0.717
MOD_CK1_1	287	293	PF00069	0.793
MOD_CK1_1	36	42	PF00069	0.638
MOD_CK1_1	50	56	PF00069	0.754
MOD_CK1_1	627	633	PF00069	0.670
MOD_CK1_1	85	91	PF00069	0.659
MOD_CK2_1	135	141	PF00069	0.687
MOD_CK2_1	15	21	PF00069	0.708
MOD_CK2_1	157	163	PF00069	0.731
MOD_CK2_1	395	401	PF00069	0.590
MOD_CK2_1	458	464	PF00069	0.535
MOD_CK2_1	468	474	PF00069	0.592
MOD_CK2_1	667	673	PF00069	0.574
MOD_GlcNHglycan	132	135	PF01048	0.741
MOD_GlcNHglycan	144	147	PF01048	0.666
MOD_GlcNHglycan	262	265	PF01048	0.754
MOD_GlcNHglycan	301	304	PF01048	0.704
MOD_GlcNHglycan	363	366	PF01048	0.505
MOD_GlcNHglycan	503	507	PF01048	0.561
MOD_GlcNHglycan	519	522	PF01048	0.408
MOD_GlcNHglycan	636	639	PF01048	0.643
MOD_GlcNHglycan	735	738	PF01048	0.590
MOD_GSK3_1	193	200	PF00069	0.712
MOD_GSK3_1	237	244	PF00069	0.740
MOD_GSK3_1	287	294	PF00069	0.644
MOD_GSK3_1	295	302	PF00069	0.644
MOD_GSK3_1	322	329	PF00069	0.745
MOD_GSK3_1	36	43	PF00069	0.704
MOD_GSK3_1	361	368	PF00069	0.565
MOD_GSK3_1	391	398	PF00069	0.620
MOD_GSK3_1	439	446	PF00069	0.629
MOD_GSK3_1	517	524	PF00069	0.454
MOD_GSK3_1	589	596	PF00069	0.546
MOD_GSK3_1	630	637	PF00069	0.643
MOD_GSK3_1	683	690	PF00069	0.570
MOD_GSK3_1	706	713	PF00069	0.552
MOD_GSK3_1	72	79	PF00069	0.754
MOD_GSK3_1	768	775	PF00069	0.586
MOD_GSK3_1	805	812	PF00069	0.583
MOD_GSK3_1	819	826	PF00069	0.602
MOD_LATS_1	809	815	PF00433	0.710
MOD_N-GLC_1	248	253	PF02516	0.822
MOD_N-GLC_1	266	271	PF02516	0.741
MOD_N-GLC_1	521	526	PF02516	0.576
MOD_NEK2_1	193	198	PF00069	0.730
MOD_NEK2_1	312	317	PF00069	0.718
MOD_NEK2_1	395	400	PF00069	0.587
MOD_NEK2_1	402	407	PF00069	0.489
MOD_NEK2_1	495	500	PF00069	0.602
MOD_NEK2_1	675	680	PF00069	0.599
MOD_NEK2_1	689	694	PF00069	0.524
MOD_NEK2_2	307	312	PF00069	0.651
MOD_NEK2_2	33	38	PF00069	0.706
MOD_PIKK_1	169	175	PF00454	0.729
MOD_PIKK_1	241	247	PF00454	0.754
MOD_PIKK_1	287	293	PF00454	0.799
MOD_PIKK_1	402	408	PF00454	0.520
MOD_PIKK_1	439	445	PF00454	0.552
MOD_PIKK_1	495	501	PF00454	0.582
MOD_PIKK_1	55	61	PF00454	0.739
MOD_PIKK_1	625	631	PF00454	0.550
MOD_PIKK_1	683	689	PF00454	0.569
MOD_PKA_1	284	290	PF00069	0.738
MOD_PKA_2	163	169	PF00069	0.754
MOD_PKA_2	260	266	PF00069	0.690
MOD_PKA_2	284	290	PF00069	0.761
MOD_PKA_2	291	297	PF00069	0.701
MOD_PKA_2	312	318	PF00069	0.707
MOD_PKA_2	458	464	PF00069	0.418
MOD_PKA_2	625	631	PF00069	0.622
MOD_PKA_2	675	681	PF00069	0.621
MOD_PKA_2	687	693	PF00069	0.484
MOD_PKA_2	76	82	PF00069	0.696
MOD_PKA_2	768	774	PF00069	0.532
MOD_PKA_2	780	786	PF00069	0.528
MOD_Plk_1	24	30	PF00069	0.702
MOD_Plk_1	395	401	PF00069	0.551
MOD_Plk_1	772	778	PF00069	0.581
MOD_Plk_2-3	13	19	PF00069	0.702
MOD_Plk_2-3	214	220	PF00069	0.698
MOD_Plk_2-3	266	272	PF00069	0.664
MOD_Plk_2-3	780	786	PF00069	0.629
MOD_Plk_4	186	192	PF00069	0.726
MOD_Plk_4	307	313	PF00069	0.752
MOD_Plk_4	443	449	PF00069	0.630
MOD_Plk_4	677	683	PF00069	0.570
MOD_Plk_4	780	786	PF00069	0.653
MOD_Plk_4	85	91	PF00069	0.636
MOD_ProDKin_1	157	163	PF00069	0.809
MOD_ProDKin_1	172	178	PF00069	0.643
MOD_ProDKin_1	184	190	PF00069	0.748
MOD_ProDKin_1	254	260	PF00069	0.798
MOD_ProDKin_1	295	301	PF00069	0.692
MOD_ProDKin_1	322	328	PF00069	0.777
MOD_ProDKin_1	72	78	PF00069	0.761
MOD_SUMO_rev_2	383	389	PF00179	0.554
MOD_SUMO_rev_2	396	405	PF00179	0.557
MOD_SUMO_rev_2	594	603	PF00179	0.606
TRG_DiLeu_BaEn_1	780	785	PF01217	0.527
TRG_ENDOCYTIC_2	167	170	PF00928	0.636
TRG_ENDOCYTIC_2	426	429	PF00928	0.506
TRG_ER_diArg_1	258	261	PF00400	0.586
TRG_ER_diArg_1	283	285	PF00400	0.647
TRG_ER_diArg_1	332	335	PF00400	0.584
TRG_ER_diArg_1	544	547	PF00400	0.590
TRG_ER_diArg_1	608	611	PF00400	0.443
TRG_ER_diArg_1	617	620	PF00400	0.607
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	602	606	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE76	Leptomonas seymouri	55%	100%
A0A1X0NJ20	Trypanosomatidae	32%	93%
A0A3Q8IFY0	Leishmania donovani	88%	100%
A4HIX7	Leishmania braziliensis	70%	100%
A4I6A6	Leishmania infantum	88%	100%
E9B1G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%