Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania major

UniProt:

Q4Q6Q0_LEIMA

TriTrypDb:

LmjF.31.0140 , LMJLV39_310006400 , LMJSD75_310006400

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q6Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Q0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009894	regulation of catabolic process	4	2
GO:0009987	cellular process	1	11
GO:0010498	proteasomal protein catabolic process	5	11
GO:0016579	protein deubiquitination	6	11
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0030162	regulation of proteolysis	6	2
GO:0030163	protein catabolic process	4	11
GO:0036211	protein modification process	4	11
GO:0042176	regulation of protein catabolic process	5	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0050789	regulation of biological process	2	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061136	regulation of proteasomal protein catabolic process	6	2
GO:0065007	biological regulation	1	2
GO:0070646	protein modification by small protein removal	5	11
GO:0070647	protein modification by small protein conjugation or removal	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0080090	regulation of primary metabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901565	organonitrogen compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004843	cysteine-type deubiquitinase activity	5	11
GO:0005488	binding	1	2
GO:0008233	peptidase activity	3	11
GO:0008234	cysteine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0019783	ubiquitin-like protein peptidase activity	4	11
GO:0044877	protein-containing complex binding	2	2
GO:0070628	proteasome binding	3	2
GO:0101005	deubiquitinase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.446
CLV_NRD_NRD_1	343	345	PF00675	0.312
CLV_NRD_NRD_1	350	352	PF00675	0.322
CLV_PCSK_FUR_1	341	345	PF00082	0.357
CLV_PCSK_KEX2_1	343	345	PF00082	0.309
CLV_PCSK_KEX2_1	350	352	PF00082	0.318
CLV_PCSK_KEX2_1	427	429	PF00082	0.312
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.289
CLV_PCSK_SKI1_1	129	133	PF00082	0.370
CLV_PCSK_SKI1_1	27	31	PF00082	0.311
CLV_PCSK_SKI1_1	305	309	PF00082	0.317
CLV_PCSK_SKI1_1	311	315	PF00082	0.305
DEG_APCC_KENBOX_2	9	13	PF00400	0.507
DEG_COP1_1	73	83	PF00400	0.657
DOC_MAPK_DCC_7	156	164	PF00069	0.355
DOC_MAPK_DCC_7	305	315	PF00069	0.314
DOC_MAPK_gen_1	229	237	PF00069	0.424
DOC_MAPK_gen_1	305	315	PF00069	0.314
DOC_MAPK_gen_1	7	17	PF00069	0.459
DOC_MAPK_MEF2A_6	10	19	PF00069	0.449
DOC_MAPK_MEF2A_6	156	164	PF00069	0.385
DOC_PP1_RVXF_1	3	9	PF00149	0.312
DOC_PP1_RVXF_1	309	316	PF00149	0.312
DOC_PP4_FxxP_1	263	266	PF00568	0.424
DOC_USP7_MATH_1	419	423	PF00917	0.424
DOC_USP7_UBL2_3	27	31	PF12436	0.539
DOC_USP7_UBL2_3	3	7	PF12436	0.223
DOC_USP7_UBL2_3	330	334	PF12436	0.370
DOC_WW_Pin1_4	358	363	PF00397	0.447
DOC_WW_Pin1_4	449	454	PF00397	0.590
LIG_14-3-3_CanoR_1	282	290	PF00244	0.269
LIG_14-3-3_CanoR_1	296	300	PF00244	0.367
LIG_Actin_WH2_2	316	332	PF00022	0.388
LIG_Actin_WH2_2	414	432	PF00022	0.424
LIG_BIR_II_1	1	5	PF00653	0.462
LIG_FHA_1	110	116	PF00498	0.424
LIG_FHA_1	12	18	PF00498	0.470
LIG_FHA_1	164	170	PF00498	0.351
LIG_FHA_1	243	249	PF00498	0.393
LIG_FHA_1	319	325	PF00498	0.333
LIG_FHA_1	407	413	PF00498	0.354
LIG_FHA_1	450	456	PF00498	0.580
LIG_FHA_1	65	71	PF00498	0.463
LIG_FHA_1	75	81	PF00498	0.549
LIG_FHA_2	172	178	PF00498	0.304
LIG_FHA_2	219	225	PF00498	0.360
LIG_Integrin_RGD_1	136	138	PF01839	0.424
LIG_Integrin_RGD_1	300	302	PF01839	0.379
LIG_LIR_Apic_2	260	266	PF02991	0.424
LIG_LIR_Gen_1	206	216	PF02991	0.418
LIG_LIR_Gen_1	234	244	PF02991	0.331
LIG_LIR_Gen_1	288	297	PF02991	0.341
LIG_LIR_Nem_3	206	211	PF02991	0.418
LIG_LIR_Nem_3	234	240	PF02991	0.312
LIG_LIR_Nem_3	288	292	PF02991	0.313
LIG_LIR_Nem_3	314	318	PF02991	0.306
LIG_LIR_Nem_3	378	384	PF02991	0.315
LIG_LIR_Nem_3	408	413	PF02991	0.321
LIG_MAD2	308	316	PF02301	0.312
LIG_NRBOX	192	198	PF00104	0.385
LIG_PDZ_Class_2	452	457	PF00595	0.528
LIG_Pex14_2	259	263	PF04695	0.424
LIG_PTB_Apo_2	108	115	PF02174	0.312
LIG_PTB_Apo_2	169	176	PF02174	0.355
LIG_PTB_Phospho_1	108	114	PF10480	0.312
LIG_SH2_GRB2like	114	117	PF00017	0.302
LIG_SH2_PTP2	289	292	PF00017	0.447
LIG_SH2_PTP2	439	442	PF00017	0.424
LIG_SH2_SRC	114	117	PF00017	0.424
LIG_SH2_STAP1	208	212	PF00017	0.424
LIG_SH2_STAP1	96	100	PF00017	0.724
LIG_SH2_STAT5	114	117	PF00017	0.326
LIG_SH2_STAT5	289	292	PF00017	0.314
LIG_SH2_STAT5	400	403	PF00017	0.304
LIG_SH2_STAT5	439	442	PF00017	0.312
LIG_SH2_STAT5	96	99	PF00017	0.660
LIG_SH3_3	220	226	PF00018	0.457
LIG_SH3_3	360	366	PF00018	0.420
LIG_SH3_3	450	456	PF00018	0.550
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.473
LIG_TRAF2_1	366	369	PF00917	0.412
LIG_TYR_ITIM	437	442	PF00017	0.424
LIG_UBA3_1	43	47	PF00899	0.473
MOD_CDK_SPxxK_3	358	365	PF00069	0.377
MOD_CK1_1	281	287	PF00069	0.367
MOD_CK1_1	73	79	PF00069	0.665
MOD_CK2_1	121	127	PF00069	0.385
MOD_CK2_1	171	177	PF00069	0.304
MOD_Cter_Amidation	403	406	PF01082	0.397
MOD_GlcNHglycan	116	119	PF01048	0.385
MOD_GlcNHglycan	378	381	PF01048	0.322
MOD_GlcNHglycan	393	396	PF01048	0.312
MOD_GlcNHglycan	57	60	PF01048	0.340
MOD_GlcNHglycan	72	75	PF01048	0.350
MOD_GSK3_1	164	171	PF00069	0.461
MOD_GSK3_1	238	245	PF00069	0.424
MOD_GSK3_1	318	325	PF00069	0.422
MOD_GSK3_1	70	77	PF00069	0.641
MOD_GSK3_1	90	97	PF00069	0.641
MOD_N-GLC_1	11	16	PF02516	0.346
MOD_N-GLC_1	242	247	PF02516	0.424
MOD_N-GLC_1	376	381	PF02516	0.316
MOD_N-GLC_1	90	95	PF02516	0.664
MOD_N-GLC_2	111	113	PF02516	0.312
MOD_NEK2_1	121	126	PF00069	0.403
MOD_NEK2_1	151	156	PF00069	0.382
MOD_NEK2_1	164	169	PF00069	0.304
MOD_NEK2_1	19	24	PF00069	0.467
MOD_NEK2_1	216	221	PF00069	0.335
MOD_NEK2_1	319	324	PF00069	0.408
MOD_PIKK_1	186	192	PF00454	0.355
MOD_PKA_1	343	349	PF00069	0.223
MOD_PKA_2	275	281	PF00069	0.269
MOD_PKA_2	295	301	PF00069	0.282
MOD_PKA_2	343	349	PF00069	0.223
MOD_PKB_1	341	349	PF00069	0.447
MOD_Plk_1	11	17	PF00069	0.475
MOD_Plk_1	319	325	PF00069	0.379
MOD_Plk_1	53	59	PF00069	0.473
MOD_Plk_2-3	11	17	PF00069	0.562
MOD_Plk_2-3	247	253	PF00069	0.355
MOD_Plk_4	164	170	PF00069	0.360
MOD_Plk_4	319	325	PF00069	0.437
MOD_Plk_4	406	412	PF00069	0.348
MOD_Plk_4	64	70	PF00069	0.473
MOD_ProDKin_1	358	364	PF00069	0.447
MOD_ProDKin_1	449	455	PF00069	0.589
MOD_SUMO_for_1	30	33	PF00179	0.454
MOD_SUMO_rev_2	364	372	PF00179	0.379
MOD_SUMO_rev_2	422	429	PF00179	0.339
TRG_DiLeu_BaEn_1	39	44	PF01217	0.539
TRG_DiLeu_BaEn_2	179	185	PF01217	0.411
TRG_DiLeu_LyEn_5	369	374	PF01217	0.340
TRG_ENDOCYTIC_2	208	211	PF00928	0.424
TRG_ENDOCYTIC_2	289	292	PF00928	0.323
TRG_ENDOCYTIC_2	381	384	PF00928	0.312
TRG_ENDOCYTIC_2	439	442	PF00928	0.312
TRG_ER_diArg_1	350	353	PF00400	0.376
TRG_ER_diArg_1	443	446	PF00400	0.403
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH5	Leptomonas seymouri	80%	100%
A0A1X0NJ77	Trypanosomatidae	49%	97%
A0A3R7RDZ6	Trypanosoma rangeli	50%	98%
A0A3S7X418	Leishmania donovani	95%	100%
A4HIX8	Leishmania braziliensis	85%	92%
C9ZN32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
E9AHK7	Leishmania infantum	95%	100%
E9B1G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O57429	Gallus gallus	23%	100%
P40826	Oryctolagus cuniculus	32%	93%
P43593	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	92%
P54578	Homo sapiens	31%	93%
P60051	Pan troglodytes	31%	93%
Q0IIF7	Bos taurus	32%	93%
Q17361	Caenorhabditis elegans	31%	93%
Q4R6D3	Macaca fascicularis	23%	100%
Q84WC6	Arabidopsis thaliana	30%	96%
Q92353	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	98%
Q949Y0	Arabidopsis thaliana	30%	95%
Q9JMA1	Mus musculus	32%	93%
V5BIL0	Trypanosoma cruzi	51%	98%