Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6P9_LEIMA

TriTrypDb:

LmjF.31.0150 , LMJLV39_310006500 , LMJSD75_310006500

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6P9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.432
CLV_NRD_NRD_1	185	187	PF00675	0.515
CLV_NRD_NRD_1	258	260	PF00675	0.510
CLV_NRD_NRD_1	282	284	PF00675	0.369
CLV_NRD_NRD_1	292	294	PF00675	0.412
CLV_NRD_NRD_1	61	63	PF00675	0.417
CLV_PCSK_KEX2_1	18	20	PF00082	0.441
CLV_PCSK_KEX2_1	185	187	PF00082	0.495
CLV_PCSK_KEX2_1	257	259	PF00082	0.518
CLV_PCSK_KEX2_1	292	294	PF00082	0.449
CLV_PCSK_KEX2_1	61	63	PF00082	0.493
CLV_PCSK_PC7_1	14	20	PF00082	0.534
CLV_PCSK_PC7_1	57	63	PF00082	0.533
CLV_PCSK_SKI1_1	172	176	PF00082	0.504
CLV_PCSK_SKI1_1	18	22	PF00082	0.432
CLV_PCSK_SKI1_1	186	190	PF00082	0.484
CLV_PCSK_SKI1_1	307	311	PF00082	0.511
CLV_PCSK_SKI1_1	315	319	PF00082	0.480
DEG_APCC_DBOX_1	17	25	PF00400	0.437
DEG_APCC_DBOX_1	291	299	PF00400	0.504
DEG_Nend_UBRbox_1	1	4	PF02207	0.705
DOC_AGCK_PIF_1	248	253	PF00069	0.477
DOC_CKS1_1	67	72	PF01111	0.573
DOC_CYCLIN_RxL_1	14	25	PF00134	0.556
DOC_MAPK_gen_1	314	320	PF00069	0.440
DOC_PP1_RVXF_1	313	320	PF00149	0.462
DOC_PP4_FxxP_1	64	67	PF00568	0.550
DOC_USP7_MATH_1	112	116	PF00917	0.354
DOC_USP7_MATH_1	302	306	PF00917	0.435
DOC_USP7_MATH_1	83	87	PF00917	0.427
DOC_USP7_UBL2_3	310	314	PF12436	0.385
DOC_WW_Pin1_4	242	247	PF00397	0.519
DOC_WW_Pin1_4	298	303	PF00397	0.487
DOC_WW_Pin1_4	66	71	PF00397	0.528
LIG_14-3-3_CanoR_1	141	146	PF00244	0.366
LIG_14-3-3_CanoR_1	263	273	PF00244	0.472
LIG_14-3-3_CanoR_1	283	287	PF00244	0.508
LIG_14-3-3_CanoR_1	34	44	PF00244	0.572
LIG_14-3-3_CanoR_1	61	65	PF00244	0.505
LIG_Actin_WH2_2	41	59	PF00022	0.527
LIG_Actin_WH2_2	9	24	PF00022	0.497
LIG_BRCT_BRCA1_1	244	248	PF00533	0.473
LIG_deltaCOP1_diTrp_1	269	278	PF00928	0.505
LIG_eIF4E_1	108	114	PF01652	0.438
LIG_FHA_1	212	218	PF00498	0.422
LIG_FHA_1	30	36	PF00498	0.603
LIG_LIR_Apic_2	46	52	PF02991	0.528
LIG_LIR_Apic_2	63	67	PF02991	0.544
LIG_LIR_Gen_1	191	199	PF02991	0.357
LIG_LIR_Gen_1	232	240	PF02991	0.470
LIG_LIR_Gen_1	275	286	PF02991	0.388
LIG_LIR_Gen_1	38	48	PF02991	0.464
LIG_LIR_Gen_1	74	83	PF02991	0.399
LIG_LIR_Gen_1	95	103	PF02991	0.577
LIG_LIR_Nem_3	103	108	PF02991	0.443
LIG_LIR_Nem_3	15	20	PF02991	0.421
LIG_LIR_Nem_3	191	196	PF02991	0.358
LIG_LIR_Nem_3	230	236	PF02991	0.430
LIG_LIR_Nem_3	275	281	PF02991	0.466
LIG_LIR_Nem_3	38	43	PF02991	0.409
LIG_LIR_Nem_3	74	80	PF02991	0.404
LIG_LIR_Nem_3	95	99	PF02991	0.479
LIG_NRBOX	194	200	PF00104	0.411
LIG_PCNA_yPIPBox_3	136	146	PF02747	0.467
LIG_SH2_CRK	17	21	PF00017	0.486
LIG_SH2_CRK	273	277	PF00017	0.557
LIG_SH2_NCK_1	68	72	PF00017	0.541
LIG_SH2_STAP1	119	123	PF00017	0.296
LIG_SH2_STAT5	145	148	PF00017	0.470
LIG_SH2_STAT5	207	210	PF00017	0.433
LIG_SH2_STAT5	68	71	PF00017	0.546
LIG_SH3_3	296	302	PF00018	0.444
LIG_SH3_3	64	70	PF00018	0.565
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.390
LIG_TRAF2_1	152	155	PF00917	0.496
LIG_WRC_WIRS_1	212	217	PF05994	0.398
MOD_CK1_1	130	136	PF00069	0.469
MOD_CK1_1	194	200	PF00069	0.383
MOD_CK1_1	301	307	PF00069	0.480
MOD_CK1_1	86	92	PF00069	0.462
MOD_CK2_1	149	155	PF00069	0.482
MOD_CK2_1	178	184	PF00069	0.456
MOD_CK2_1	22	28	PF00069	0.531
MOD_GlcNHglycan	114	117	PF01048	0.331
MOD_GlcNHglycan	119	122	PF01048	0.373
MOD_GlcNHglycan	179	183	PF01048	0.449
MOD_GlcNHglycan	24	27	PF01048	0.513
MOD_GlcNHglycan	303	307	PF01048	0.496
MOD_GSK3_1	298	305	PF00069	0.501
MOD_N-GLC_1	242	247	PF02516	0.511
MOD_N-GLC_2	201	203	PF02516	0.399
MOD_NEK2_1	12	17	PF00069	0.484
MOD_NEK2_2	229	234	PF00069	0.499
MOD_NEK2_2	83	88	PF00069	0.468
MOD_PIKK_1	29	35	PF00454	0.552
MOD_PKA_2	282	288	PF00069	0.460
MOD_PKA_2	60	66	PF00069	0.542
MOD_Plk_1	178	184	PF00069	0.504
MOD_Plk_1	191	197	PF00069	0.213
MOD_Plk_1	229	235	PF00069	0.479
MOD_Plk_2-3	158	164	PF00069	0.558
MOD_Plk_4	194	200	PF00069	0.398
MOD_Plk_4	211	217	PF00069	0.336
MOD_Plk_4	222	228	PF00069	0.419
MOD_Plk_4	282	288	PF00069	0.453
MOD_Plk_4	83	89	PF00069	0.450
MOD_ProDKin_1	242	248	PF00069	0.510
MOD_ProDKin_1	298	304	PF00069	0.492
MOD_ProDKin_1	66	72	PF00069	0.524
MOD_SUMO_for_1	188	191	PF00179	0.431
MOD_SUMO_for_1	8	11	PF00179	0.413
MOD_SUMO_rev_2	181	190	PF00179	0.503
TRG_DiLeu_BaEn_1	191	196	PF01217	0.443
TRG_DiLeu_BaEn_1	260	265	PF01217	0.499
TRG_DiLeu_LyEn_5	260	265	PF01217	0.432
TRG_ENDOCYTIC_2	108	111	PF00928	0.388
TRG_ENDOCYTIC_2	17	20	PF00928	0.428
TRG_ENDOCYTIC_2	253	256	PF00928	0.454
TRG_ENDOCYTIC_2	273	276	PF00928	0.552
TRG_ER_diArg_1	140	143	PF00400	0.478
TRG_ER_diArg_1	17	19	PF00400	0.470
TRG_ER_diArg_1	256	259	PF00400	0.508
TRG_ER_diArg_1	291	293	PF00400	0.547
TRG_ER_diArg_1	60	62	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X3	Leptomonas seymouri	57%	100%
A0A1X0NJP2	Trypanosomatidae	28%	100%
A0A3S5H7P2	Leishmania donovani	92%	100%
A0A422N5I6	Trypanosoma rangeli	30%	99%
A4HIX9	Leishmania braziliensis	76%	100%
A4I6A7	Leishmania infantum	92%	100%
C9ZN34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B1G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DEV4	Trypanosoma cruzi	30%	100%