Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6P7_LEIMA

TriTrypDb:

LmjF.31.0170 , LMJLV39_310006800 , LMJSD75_310006800

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0031090	organelle membrane	3	2

Expansion

Sequence features

Q4Q6P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6P7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0034389	lipid droplet organization	5	2
GO:0044238	primary metabolic process	2	2
GO:0070925	organelle assembly	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0140042	lipid droplet formation	6	2
GO:0140694	non-membrane-bounded organelle assembly	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	476	478	PF00675	0.524
CLV_NRD_NRD_1	494	496	PF00675	0.388
CLV_NRD_NRD_1	6	8	PF00675	0.579
CLV_NRD_NRD_1	67	69	PF00675	0.358
CLV_PCSK_FUR_1	474	478	PF00082	0.402
CLV_PCSK_KEX2_1	476	478	PF00082	0.524
CLV_PCSK_KEX2_1	494	496	PF00082	0.388
CLV_PCSK_KEX2_1	6	8	PF00082	0.572
CLV_PCSK_KEX2_1	67	69	PF00082	0.323
CLV_PCSK_SKI1_1	383	387	PF00082	0.577
CLV_PCSK_SKI1_1	397	401	PF00082	0.583
CLV_PCSK_SKI1_1	71	75	PF00082	0.220
DEG_APCC_DBOX_1	293	301	PF00400	0.294
DEG_APCC_DBOX_1	66	74	PF00400	0.611
DOC_MAPK_gen_1	160	169	PF00069	0.384
DOC_MAPK_gen_1	303	313	PF00069	0.385
DOC_MAPK_gen_1	378	387	PF00069	0.353
DOC_MAPK_gen_1	67	76	PF00069	0.553
DOC_MAPK_MEF2A_6	294	301	PF00069	0.341
DOC_MAPK_MEF2A_6	338	346	PF00069	0.418
DOC_MAPK_MEF2A_6	349	356	PF00069	0.342
DOC_MAPK_NFAT4_5	294	302	PF00069	0.409
DOC_PP1_RVXF_1	301	308	PF00149	0.378
DOC_PP1_RVXF_1	381	388	PF00149	0.343
DOC_PP2B_LxvP_1	9	12	PF13499	0.654
DOC_PP4_FxxP_1	146	149	PF00568	0.483
DOC_PP4_FxxP_1	309	312	PF00568	0.358
DOC_PP4_FxxP_1	350	353	PF00568	0.307
DOC_PP4_FxxP_1	455	458	PF00568	0.714
DOC_PP4_MxPP_1	470	473	PF00568	0.632
DOC_USP7_MATH_1	2	6	PF00917	0.733
DOC_USP7_MATH_1	268	272	PF00917	0.389
DOC_USP7_MATH_1	333	337	PF00917	0.446
DOC_USP7_MATH_1	419	423	PF00917	0.457
DOC_USP7_MATH_1	53	57	PF00917	0.698
DOC_WW_Pin1_4	208	213	PF00397	0.474
DOC_WW_Pin1_4	348	353	PF00397	0.391
DOC_WW_Pin1_4	499	504	PF00397	0.689
DOC_WW_Pin1_4	7	12	PF00397	0.703
LIG_14-3-3_CanoR_1	202	212	PF00244	0.465
LIG_14-3-3_CanoR_1	250	255	PF00244	0.414
LIG_14-3-3_CanoR_1	397	404	PF00244	0.388
LIG_14-3-3_CanoR_1	41	47	PF00244	0.668
LIG_14-3-3_CanoR_1	476	485	PF00244	0.781
LIG_14-3-3_CanoR_1	494	500	PF00244	0.597
LIG_14-3-3_CanoR_1	58	63	PF00244	0.572
LIG_Actin_WH2_2	26	43	PF00022	0.569
LIG_Actin_WH2_2	481	496	PF00022	0.720
LIG_Actin_WH2_2	56	73	PF00022	0.596
LIG_BRCT_BRCA1_1	327	331	PF00533	0.455
LIG_BRCT_BRCA1_1	495	499	PF00533	0.745
LIG_DLG_GKlike_1	163	170	PF00625	0.391
LIG_eIF4E_1	69	75	PF01652	0.486
LIG_EVH1_2	442	446	PF00568	0.556
LIG_FHA_1	114	120	PF00498	0.430
LIG_FHA_1	151	157	PF00498	0.475
LIG_FHA_1	159	165	PF00498	0.476
LIG_FHA_1	195	201	PF00498	0.347
LIG_FHA_1	234	240	PF00498	0.356
LIG_FHA_1	287	293	PF00498	0.327
LIG_FHA_1	349	355	PF00498	0.424
LIG_FHA_1	387	393	PF00498	0.404
LIG_FHA_1	404	410	PF00498	0.308
LIG_FHA_1	43	49	PF00498	0.671
LIG_FHA_1	462	468	PF00498	0.766
LIG_FHA_1	488	494	PF00498	0.718
LIG_FHA_2	59	65	PF00498	0.639
LIG_GBD_Chelix_1	297	305	PF00786	0.561
LIG_GBD_Chelix_1	87	95	PF00786	0.306
LIG_LIR_Apic_2	145	149	PF02991	0.485
LIG_LIR_Apic_2	366	371	PF02991	0.383
LIG_LIR_Apic_2	452	458	PF02991	0.711
LIG_LIR_Gen_1	179	189	PF02991	0.422
LIG_LIR_Gen_1	295	304	PF02991	0.354
LIG_LIR_Gen_1	315	323	PF02991	0.391
LIG_LIR_Gen_1	345	354	PF02991	0.337
LIG_LIR_Gen_1	405	415	PF02991	0.328
LIG_LIR_Gen_1	483	493	PF02991	0.661
LIG_LIR_Gen_1	57	64	PF02991	0.559
LIG_LIR_Nem_3	179	185	PF02991	0.427
LIG_LIR_Nem_3	295	299	PF02991	0.358
LIG_LIR_Nem_3	315	319	PF02991	0.377
LIG_LIR_Nem_3	328	334	PF02991	0.315
LIG_LIR_Nem_3	345	350	PF02991	0.242
LIG_LIR_Nem_3	405	410	PF02991	0.293
LIG_LIR_Nem_3	483	488	PF02991	0.689
LIG_LIR_Nem_3	57	63	PF02991	0.705
LIG_LIR_Nem_3	66	72	PF02991	0.504
LIG_NRBOX	296	302	PF00104	0.296
LIG_NRBOX	425	431	PF00104	0.355
LIG_Pex14_1	314	318	PF04695	0.392
LIG_Pex14_1	398	402	PF04695	0.421
LIG_SH2_PTP2	72	75	PF00017	0.306
LIG_SH2_PTP2	77	80	PF00017	0.267
LIG_SH2_STAP1	235	239	PF00017	0.297
LIG_SH2_STAP1	316	320	PF00017	0.377
LIG_SH2_STAT5	199	202	PF00017	0.371
LIG_SH2_STAT5	235	238	PF00017	0.381
LIG_SH2_STAT5	318	321	PF00017	0.412
LIG_SH2_STAT5	60	63	PF00017	0.639
LIG_SH2_STAT5	69	72	PF00017	0.583
LIG_SH2_STAT5	77	80	PF00017	0.371
LIG_SH3_3	206	212	PF00018	0.405
LIG_SH3_3	327	333	PF00018	0.413
LIG_SH3_3	8	14	PF00018	0.678
LIG_Sin3_3	82	89	PF02671	0.306
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.386
LIG_SUMO_SIM_anti_2	295	302	PF11976	0.286
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.311
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.348
LIG_SUMO_SIM_par_1	295	302	PF11976	0.325
LIG_SUMO_SIM_par_1	84	90	PF11976	0.392
LIG_TRAF2_1	244	247	PF00917	0.367
LIG_TRAF2_1	504	507	PF00917	0.587
LIG_TRFH_1	222	226	PF08558	0.462
LIG_TYR_ITIM	70	75	PF00017	0.461
LIG_WRC_WIRS_1	404	409	PF05994	0.259
LIG_WRC_WIRS_1	59	64	PF05994	0.601
LIG_WW_2	11	14	PF00397	0.643
LIG_WW_3	457	461	PF00397	0.603
LIG_WW_3	471	475	PF00397	0.553
MOD_CDC14_SPxK_1	502	505	PF00782	0.650
MOD_CDK_SPK_2	208	213	PF00069	0.485
MOD_CDK_SPxK_1	499	505	PF00069	0.690
MOD_CK1_1	183	189	PF00069	0.431
MOD_CK1_1	422	428	PF00069	0.391
MOD_CK1_1	98	104	PF00069	0.409
MOD_CK2_1	2	8	PF00069	0.735
MOD_CK2_1	333	339	PF00069	0.447
MOD_CK2_1	448	454	PF00069	0.655
MOD_CK2_1	477	483	PF00069	0.679
MOD_CK2_1	58	64	PF00069	0.572
MOD_GlcNHglycan	205	208	PF01048	0.693
MOD_GlcNHglycan	257	260	PF01048	0.534
MOD_GlcNHglycan	320	323	PF01048	0.598
MOD_GlcNHglycan	327	330	PF01048	0.583
MOD_GlcNHglycan	417	420	PF01048	0.308
MOD_GlcNHglycan	90	94	PF01048	0.469
MOD_GSK3_1	188	195	PF00069	0.326
MOD_GSK3_1	277	284	PF00069	0.333
MOD_GSK3_1	386	393	PF00069	0.330
MOD_GSK3_1	415	422	PF00069	0.295
MOD_GSK3_1	484	491	PF00069	0.718
MOD_GSK3_1	495	502	PF00069	0.700
MOD_GSK3_1	54	61	PF00069	0.649
MOD_GSK3_1	94	101	PF00069	0.445
MOD_N-GLC_1	363	368	PF02516	0.482
MOD_N-GLC_1	499	504	PF02516	0.489
MOD_NEK2_1	156	161	PF00069	0.421
MOD_NEK2_1	188	193	PF00069	0.338
MOD_NEK2_1	279	284	PF00069	0.325
MOD_NEK2_1	292	297	PF00069	0.341
MOD_NEK2_1	363	368	PF00069	0.347
MOD_NEK2_1	386	391	PF00069	0.345
MOD_NEK2_1	415	420	PF00069	0.324
MOD_NEK2_1	488	493	PF00069	0.717
MOD_NEK2_1	62	67	PF00069	0.570
MOD_NEK2_1	95	100	PF00069	0.445
MOD_NEK2_2	194	199	PF00069	0.407
MOD_PIKK_1	158	164	PF00454	0.414
MOD_PIKK_1	488	494	PF00454	0.718
MOD_PK_1	281	287	PF00069	0.360
MOD_PKA_2	150	156	PF00069	0.469
MOD_PKA_2	48	54	PF00069	0.602
MOD_PKA_2	493	499	PF00069	0.731
MOD_Plk_1	138	144	PF00069	0.476
MOD_Plk_1	31	37	PF00069	0.612
MOD_Plk_1	363	369	PF00069	0.282
MOD_Plk_1	488	494	PF00069	0.699
MOD_Plk_2-3	448	454	PF00069	0.702
MOD_Plk_4	165	171	PF00069	0.415
MOD_Plk_4	194	200	PF00069	0.279
MOD_Plk_4	217	223	PF00069	0.409
MOD_Plk_4	250	256	PF00069	0.274
MOD_Plk_4	403	409	PF00069	0.252
MOD_Plk_4	422	428	PF00069	0.194
MOD_Plk_4	462	468	PF00069	0.742
MOD_Plk_4	58	64	PF00069	0.647
MOD_ProDKin_1	208	214	PF00069	0.474
MOD_ProDKin_1	348	354	PF00069	0.395
MOD_ProDKin_1	499	505	PF00069	0.690
MOD_ProDKin_1	7	13	PF00069	0.702
MOD_SUMO_for_1	231	234	PF00179	0.387
MOD_SUMO_for_1	244	247	PF00179	0.272
MOD_SUMO_for_1	504	507	PF00179	0.639
MOD_SUMO_rev_2	175	183	PF00179	0.289
TRG_DiLeu_BaEn_1	152	157	PF01217	0.396
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.380
TRG_ENDOCYTIC_2	316	319	PF00928	0.355
TRG_ENDOCYTIC_2	347	350	PF00928	0.297
TRG_ENDOCYTIC_2	485	488	PF00928	0.664
TRG_ENDOCYTIC_2	60	63	PF00928	0.606
TRG_ENDOCYTIC_2	72	75	PF00928	0.231
TRG_ENDOCYTIC_2	77	80	PF00928	0.180
TRG_ER_diArg_1	358	361	PF00400	0.336
TRG_ER_diArg_1	473	476	PF00400	0.675
TRG_ER_diArg_1	493	495	PF00400	0.573
TRG_ER_diArg_1	67	69	PF00400	0.558
TRG_NES_CRM1_1	24	38	PF08389	0.600
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U6	Leptomonas seymouri	56%	100%
A0A0S4J1Q7	Bodo saltans	24%	100%
A0A1X0NJH4	Trypanosomatidae	36%	100%
A0A3Q8IEM5	Leishmania donovani	93%	100%
A4HIZ2	Leishmania braziliensis	72%	100%
A4I6A9	Leishmania infantum	93%	100%
C9ZN36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B1G5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BN41	Trypanosoma cruzi	40%	100%